The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. These ... "Voltage-gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... coli K+ channel and demonstration of its presence in the human BK channel". Neuron. 29 (3): 593-601. doi:10.1016/s0896-6273(01) ... Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, Zhou M (April 2013). "Gating of the TrkH ion channel by its associated RCK ...
"Glucose transporters serve as water channels". Proceedings of the National Academy of Sciences of the United States of America ... The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small ... The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the ... Västermark A, Lunt B, Saier M (2014). "Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to ...
"1.A.1 The Voltage-gated Ion Channel (VIC) Superfamily". Transporter Classification Database. Retrieved 2016-04-05. "2.A.70 The ... The cation:proton antiporter (CPA) superfamily is a superfamily of transport proteins named after one of its constituent ... "A superfamily of voltage-gated sodium channels in bacteria". The Journal of Biological Chemistry. 279 (10): 9532-9538. doi: ... when it was discovered to in fact be a member of the VIC superfamily. As of April 2016, the CPA superfamily consists of four ...
It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel ... The CAP superfamily (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)) is a large ... Gibbs, G. M.; Roelants, K.; O'Bryan, M. K. (2008). "The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and ... The overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP ...
... is a member of the voltage-gated ion channel (VIC) superfamily and consists of cation channels conserved from worms to humans. ... Voltage sensing in thermo-TRP channels has been reviewed by Brauchi et al. TRP channels have six TMS helices. These channels ... 2F37​ Transient receptor potential cation channel subfamily A member 1: PDB: 3J9P​ Voltage-gated ion channel Ion channel ... The founding members of the TRP superfamily are the TRPC (TRP canonical) channels, which can be activated following the ...
They belong to the superfamily of cation channels. They are classified into 2 types: In excitable cells such as neurons, ... As the cardiac sodium channel is the most pH-sensitive sodium channel, most of what is known is based on this channel. ... In addition to regulating channel gating, sodium channel beta subunits also modulate channel expression and form links to the ... Most channels of this type are permeable to potassium to some degree as well as to sodium. Voltage-gated sodium channels play ...
... belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 2 subfamily. There ... Hongotoxin (HgTX) is an ion channel toxin, which blocks Shaker-type (Kv1) K+ channels. The toxin is derived from the venom of ... K+ channels. HgTX1 shows high affinity with Kv1.1, Kv1.2, Kv1.3 voltage-gated potassium channels, but much lower affinity with ... The first high affinity fluorescence probes for voltage-gated K+ channels". Bioconjugate Chemistry. 13 (3): 416-25. doi:10.1021 ...
Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE (March 2004). "A superfamily of voltage-gated sodium channels ... this type of channel differs in function between cell types. Ca2+ channels produce action potentials similarly to Na+ channels ... polycystin cation channels, glutamate-gated ion channels, calcium-dependent chloride channels, monovalent cation:proton ... Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the ...
"Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels". Biochemistry. 29 (50): 11009-11023. doi:10.1021/ ...
Major intrinsic proteins comprise a large superfamily of transmembrane protein channels that are grouped together on the basis ... The phylogeny of insect MIP family channels has been published. There are two families that belong to the MIP Superfamily. 1.A. ... All channel-lining residues in the four monomeric channels are orientated in nearly identical positions except at the narrowest ... MIP family channels consist of homotetramers (e.g., GlpF of E. coli; TC #1.A.8.1.1, AqpZ of E. coli; TC #1.A.8.3.1, and MIP or ...
AKR1 Steroidogenic enzyme Bohren KM, Bullock B, Wermuth B, Gabbay KH (June 1989). "The aldo-keto reductase superfamily. cDNAs ... Some proteins of this family contain a potassium channel beta chain regulatory domain; these are reported to have ... "Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels". Science. 289 (5476): 123-7. Bibcode: ...
Cyclic nucleotide-gated channels: This superfamily of channels contains two families: the cyclic nucleotide-gated (CNG) ... Sodium channels Voltage-gated sodium channels (NaVs) Epithelial sodium channels (ENaCs) Calcium channels (CaVs) Proton channels ... Plasma membrane channels Examples: Voltage-gated potassium channels (Kv), Sodium channels (Nav), Calcium channels (Cav) and ... Chloride channels: This superfamily of channels consists of approximately 13 members. They include ClCs, CLICs, Bestrophins and ...
The K+ Transporter (Trk) Family is a member of the voltage-gated ion channel (VIC) superfamily. The proteins of the Trk family ... Folding pattern seen in Trk proteins resembles quadruplicated primitive K+ channels of the VIC superfamily (TC #1.A.1) instead ... This folding pattern resembles quadruplicated primitive K+ channels of the VIC superfamily (TC #1.A.1) instead of typical 12 ... "Overview of molecular relationships in the voltage-gated ion channel superfamily". Pharmacological Reviews. 57 (4): 387-95. doi ...
The nAChRs are ligand-gated ion channels, and, like other members of the "cys-loop" ligand-gated ion channel superfamily, are ... In contrast, the mAChRs are not ion channels, but belong instead to the superfamily of G-protein-coupled receptors that ... Ortells, M. O.; Lunt, G. G. (March 1995). "Evolutionary history of the ligand-gated ion-channel superfamily of receptors". ... Both Nm and Nn are Na+ and Ca2+ channel linked but Nn is also linked with an extra K+ channel. ...
"Overview of molecular relationships in the voltage-gated ion channel superfamily". Pharmacological Reviews. 57 (4): 387-95. doi ... Calcium channel Potassium channel Sodium channel Schrempf H, Schmidt O, Kümmerlen R, Hinnah S, Müller D, Betzler M, Steinkamp T ... The KcsA channel is considered a model channel because the KcsA structure provides a framework for understanding K+ channel ... KcsA studies are focused on using the prokaryotic channel as a model for the channel dynamics of larger eukaryotic K+ channels ...
Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many ... CFTR is a chloride channel belonging to the superfamily of ABC transporters. Each channel has two transmembrane domains and two ... The structure of these channels are not like other known channels. The chloride channel subunits contain between 1 and 12 ... The CLC channels allow chloride to flow down its electrochemical gradient, when open. These channels are expressed on the cell ...
Ortells MO, Lunt GG (March 1995). "Evolutionary history of the ligand-gated ion-channel superfamily of receptors". Trends in ... The acetylcholine molecules then bind to nicotinic ion-channel receptors on the muscle cell membrane, causing the ion channels ... do not affect P-channels. These drugs affect L-type calcium channels. The autonomic nervous system controls a wide range of ... inhibits P-type calcium channels Myasthenia gravis Botulinum toxin: inhibits SNARE proteins Calcium channel blockers ( ...
... are members of the voltage-sensitive ion channel (VIC) superfamily (TC# 1.A.1). Dihydropyridine-sensitive channels are present ... This family belongs to the Voltage-gated ion channel (VIC) superfamily. Ry receptors occur primarily in muscle cell ... The channel domains possess six putative TMSs and a putative channel lining region between TMSs 5 and 6. Both the large N- ... Channels are activated by IP3 binding, and like the Ry receptors, the activities of the IP3 receptor channels are regulated by ...
Montell C (July 2001). "Physiology, phylogeny, and functions of the TRP superfamily of cation channels". Science's STKE. 2001 ( ... Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of ... Like TRPA1 and other TRP channels, these function as ion channels in a number of sensory systems. TRPA- or TRPA1-like channels ... including yeast channels and a number of Group 1 and Group 2 channels present in non-animals. Many of these channels mediate a ...
"The TRP superfamily of cation channels". Sci. STKE. 2005 (272): re3. doi:10.1126/stke.2722005re3. PMID 15728426. S2CID 7326120 ... TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of ... "Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... "Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties ...
... are part of the long (4 C-C) scorpion toxin superfamily. Bactridine 1-2 also fall under the sodium channel ... The specific sodium channel isoforms on which bactridine 1 acts are not yet known. Bactridines act on sodium channels in ... They exclusively target sodium channels. Bactridines are unique in that this scorpion toxin acts on sodium channels of both ... In bacteria, bactridines cause an outward sodium leak by increasing the sodium channel permeability. In contrast, as an attack ...
Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1 ... This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium ... The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel ... The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in ...
Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel ... This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium ... with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". The Biochemical ... "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel ...
Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is ... This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium ... The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel ... The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in ...
Transmembrane channels Major facilitator superfamily Pratt CA, Voet D, Voet JG (2002). Fundamentals of biochemistry upgrade. ... Hence, small polar molecules are transported by proteins in the form of transmembrane channels. These channels are gated, ... the transport relies on molecular binding between the cargo and the membrane-embedded channel or carrier protein. the rate of ...
The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus). The pore of the channel ... This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium ... ASIC5 gene is one of the five paralogous genes that encode proteins that form trimeric Acid-sensing ion channels (ASICs) in ... v t e (Articles with short description, Short description matches Wikidata, Ion channels, Human proteins, All stub articles, ...
Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel ... This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium ... with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt ... with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt ...
The epithelial sodium (Na+) channel (ENaC) family belongs to the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-d ... The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that ... Ion Channel Diseases Epithelial+sodium+channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This ... The cryoEM structure of ENaC indicates that the channel is a heterotrimeric protein like the acid-sensing ion channel 1 (ASIC1 ...
ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels. These genes have splice variants that encode for ... ASIC1a channels additionally facilitate the activation of voltage-gated Ca2+ channels and NMDA receptor channels upon initial ... The presence of matured N-linked glycans on the surface of the channel is said to allow the channel to preferentially traffic ... Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable ...
... are homologous members of the TRP superfamily of cation channels but have different physiological functions. TRPP2 is part of a ... Voltage-gated ion channel Ion channel Transporter Classification Database "1.A.5 The Polycystin Cation Channel (PCC) Family". ... PKD1 and 2 interact to form the non-selective cation channel in vitro, but PKD2 can form channels in the absence of any other ... Noben-Trauth K (1 January 2011). "The TRPML3 Channel: From Gene to Function". Transient Receptor Potential Channels. Advances ...