Sulfhydryl-containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl ... Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a ...
Tumor-binding sulfhydryl boron compounds". Journal of Medicinal Chemistry. 10 (4): 714-7. doi:10.1021/jm00316a042. PMID 6037065 ... Second, gadolinium compounds, such as Gd-DTPA (gadopentetate dimeglumine Magnevist), have been used routinely as contrast ... Ono K (August 2016). "An analysis of the structure of the compound biological effectiveness factor". Journal of Radiation ... 1 and a compound biological effectiveness (CBE) factor for BPA in skin of 2.5. A relative biological effectiveness (RBE) or CBE ...
Bremer J; Greenberg DM (1961). "Enzymic methylation of foreign sulfhydryl compounds". Biochim. Biophys. Acta. 46 (2): 217-224. ...
Jaffe IA (March 1986). "Adverse effects profile of sulfhydryl compounds in man". The American Journal of Medicine. 80 (3): 471- ... which are broadly similar to those of D-penicillamine and other compounds containing active sulfhydryl groups. Its ... In 2016 Imprimis Pharmaceuticals introduced a lower cost version marketed as a compounded drug. It may also be used for ... Portal: Medicine (Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical ...
... is an organosulfur compound containing carboxyl and sulfhydryl functional groups. Its molecular formula is ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without InChI ...
"In vitro proteoglycan sulfation derived from sulfhydryl compounds in sulfate transporter chondrodysplasias". Pediatric ...
Budwig believed sulphydryl compounds were important to cellular metabolism and cellular respiration. Budwig researched the ... theory that a low oxygen environment would develop in the absence of sulphydryl groups and/or fatty acid partners that would ... a researcher at the German Federal Health Office she noted many cancer drugs being evaluated in the 1950s contained sulphydryl ...
The pattern of resistance and sensitivity correlates with the level of sulfhydryl compounds in the cell. Sulfhydryls are ...
The activity of PTGES2 is thought to be increased in the presence of sulfhydryl compounds, in particular dithiothreitol. The ...
... prostaglandins and sulfhydryl compounds". Pharmacology. 54 (4): 193-202. doi:10.1159/000139487. PMID 9211565. Alarcón de la ...
Kunin, Calvin A. (September 10, 1976). "Effect of organic mercurials and sulfhydryl compounds on the urease activity of Proteus ... Studies in the late 1970s showed the compound had antimicrobial effect against Proteus bacteria responsible for urinary tract ... Studies from Japan showed the compound caused ventricular fibrillation in a high percentage of animals when compared to ...
... reacts with primary amines efficiently at pH 7 to 9, creating amidine compounds with a sulfhydryl group. Thus ... It is a thiolating reagent that reacts with primary amine groups, such as those of amino acids, to form sulfhydryl groups. ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with ... 2-Iminothiolane is a cyclic thioimidate compound also known as Traut's reagent. ...
... did not deplete sulfhydryl-group containing compounds. The isopropyl radical formed as a result of the metabolism of iproniazid ... In contrast, the compounds cobalt chloride, piperonyl butoxide and alpha-naphthylisothiocyanate inhibit microsomal enzymes ... Alkylating agents have the capability to bind to chemical groups such as amino, phosphate hydroxyl, imidazole and sulfhydryl ... Rat models and other animal models have shown that cytochrome P450 enzymes convert isopropyl hydrazine to alkylating compounds ...
He pursued biochemical research on the metabolic and developmental roles of sulfhydryl compounds, working initially with ... Rapkine, L. (1938). "Sulfhydryl groups and enzymic oxido-reduction". Biochemical Journal. 32 (10): 1729-1739. doi:10.1042/ ...
Her studies with laboratory animals showed that sulfhydryl compounds may protect against toxicity from x-irradiation and ... alkylating agents by a distribution pattern which causes more of a protective compound to accumulate in the sensitive tissues ...
For example, via epoxide hydratase (EH) or via interactions with a sulfhydryl compound, which leads to the formation of a ... Methacrylonitrile (or 2-Methylprop-2-enenitrile), MeAN in short, is a chemical compound that is an unsaturated aliphatic ... "unsaturated compounds formed by a burning cigarette. Anal. Proc. 21, 135 Farooqui, M. Y. H. and M. M. Mumtaz (1991). " ...
... is an organosulfur compound. It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the ... Mesna assists to detoxify these metabolites by reaction of its sulfhydryl group with α,β-unsaturated carbonyl containing ... Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration. Mesna is a water-soluble ... This conjugation reaction inactivates the urotoxic compounds to harmless metabolites. The metabolites are then excreted in the ...
Organic mercurial compounds, such as methylmercury, have a high affinity for sulfhydryl groups, which causes dysfunction of the ... Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as ... In 1926, Loewi and E. Navratil deduced that the compound is probably acetylcholine, as vagusstoff and synthetic acetylcholine ... Acetylcholine is synthesized in certain neurons by the enzyme choline acetyltransferase from the compounds choline and acetyl- ...
A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types". Journal of Medicinal Chemistry. 29 ( ... and is metabolized in the liver to form the pharmacologically active compound moexiprilat. Formation of moexiprilat is caused ... "Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. ...
... sulfhydryl, or Cu2+ or Co2+ reagents/compounds Enzyme catalyzes reaction best with branched chain amino acids (in order from ... In Cucumis melo (melon), BCATs have been found to play a role in developing aroma volatile compounds that give melons their ... As fermentation proceeds, these α-ketoacids degrade into a class of compounds known as methyl-branched volatiles that include ... The branched-chain amino acid aminotransferases help to produce compounds like isovaleric acid, isobutyric acid, 2- and 3- ...
... s also describes a class of compounds formally derived from thiophenol itself. All have a sulfhydryl group (-SH) ... The prefix thio- implies a sulfur-containing compound and when used before a root word name for a compound which would normally ... Thiophenol is an organosulfur compound with the formula C6H5SH, sometimes abbreviated as PhSH. This foul-smelling colorless ... There are several methods of synthesis for thiophenol and related compounds, although thiophenol itself is usually purchased ...
However, the monomethylated compound was shown to be more reactive and more toxic than the inorganic arsenic compounds to human ... Enzymes and receptors that contain thiol or sulfhydryl functional groups are actively targeted by arsenite (III) metabolites. ... This compound is then converted to a mono-methylated arsenic (III) compound using Glutathione S-Transferase Omega-1 (GSTO1). ... Representative organoarsenic compounds found in nature. Arsenobetaine, one of the most common arsenic compound in nature. Also ...
He settled on using a sulfhydryl group which binds strongly to zinc. Ondetti had discovered Captopril, an ACE inhibitor with ... U.S. Patent 3,740,385 "N-Terminal Derivatives of Secretin", filed May 1970, issued June 1973 U.S. Patent 4,199,512 "Compounds ... "Compounds for alleviating angiotensin related hypertension", filed February 1978, issued July 1982 U.S. Patent 4,722,810 " ... His group tried thousands of compounds from the Squibb library, but none yielded satisfying results. After reading literature ...
... of GSH-via a sulfhydryl group-to electrophilic centers on a wide variety of substrates in order to make the compounds more ... However, some endogenous compounds, e.g., bilirubin, can inhibit the activity of GSTs. In mammals, GST isoforms have cell ... The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, ... Because the GST protein has a strong binding affinity for GSH, beads coated with the compound can be added to the protein ...
The mechanism of action of an isolated compound can also be misidentified if a single assay is used because some compounds ... For example, the sulfhydryl-scavenging assay used to detect histone acetyltransferase inhibition can give a false positive ... to include reference compounds (ie. pure chemical compounds for which accurate bioactivity and toxicity data are available), to ... Using just a single assay, especially a single in vitro assay, gives a very incomplete picture of an extract or compound's ...
... is an organic compound with the molecular formula C3H8S. It belongs to the group of thiols. It is a colorless ... except that sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group in the molecule. ... Propanethiol is chemically classified among the thiols, which are organic compounds with molecular formulas and structural ... 21, 1962, Preparation of Organic Sulfur Compounds (Webarchive template wayback links, Articles without InChI source, Articles ...
The term sulfhydryl- or mercapto- is used as a prefix, e.g. mercaptopurine. Many thiols have strong odors resembling that of ... These compounds are detectable by the human nose at concentrations of only 10 parts per billion. Human sweat contains (R)/(S)-3 ... Sulfhydryl groups in the active site of an enzyme can form noncovalent bonds with the enzyme's substrate as well, contributing ... The −SH functional group itself is referred to as either a thiol group or a sulfhydryl group, or a sulfanyl group. Thiols are ...
... is a very noxious and caustic chemical compound, and at sufficiently high concentrations, it produces serious ... except that the sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group (-OH) in the molecule. 1 ... which are organic compounds with molecular formulas and structural formulas similar to alcohols, ...
The double bond in the carbonyl group can undergo a Michael addition with a thiol group, also called a sulfhydryl group. ... For this reason the compound or its derivatives may have potential medical applications. Helenalin belongs to the group of ... Depending on the dose of helenalin, thiol-bearing compounds such as glutathione may provide some protection to cells from ... Most of these derivatives occur naturally, such as the compound dihydrohelenalin, but there are also some semi-synthetic ...
... reactive iodacetyl function group which labels sulfhydryl-(-SH) groups (iodoTMT) and (3) reactive alkoxyamine functional group ... which provides covalent labeling of carbonyl-containing compounds (aminoxyTMT). A key benefit of isobaric labeling over other ...