... succinate dehydrogenase deficient renal carcinoma and succinate dehydrogenase deficient gastrointestinal stromal tumor (GIST). ... Succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR) or respiratory complex II is an enzyme complex, found in ... Further research is required to determine which elimination mechanism succinate undergoes in Succinate Dehydrogenase. Oxidized ... Mammalian succinate dehydrogenase functions not only in mitochondrial energy generation, but also has a role in oxygen sensing ...
Other names in common use include succinate semialdehyde dehydrogenase, succinic semialdehyde dehydrogenase, succinyl ... a succinate-semialdehyde dehydrogenase (SSADH) (EC 1.2.1.24) is an enzyme that catalyzes the chemical reaction succinate ... Succinate-semialdehyde dehydrogenase is found in organisms ranging across the tree of life from bacteria to humans. It is ... 2 H+ The 3 substrates of this enzyme are succinate semialdehyde, NAD+, and H2O, whereas its 3 products are succinate, NADH, and ...
... (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate- ... semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating). This ... "Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri". ... Succinate-semialdehyde+dehydrogenase+(acylating) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ...
... (EC 1.2.1.79, succinic semialdehyde dehydrogenase (NADP+), succinyl semialdehyde ... dehydrogenase (NADP+), succinate semialdehyde:NADP+ oxidoreductase, NADP-dependent succinate-semialdehyde dehydrogenase, GabD) ... Succinate-semialdehyde+dehydrogenase+(NADP+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... This enzyme catalyses the following chemical reaction succinate semialdehyde + NADP+ + H2O ⇌ {\displaystyle \rightleftharpoons ...
... , also known as succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is a ... Because the mutated SDH enzyme cannot convert succinate to fumarate, succinate accumulates in the cell. The excess succinate ... "Entrez Gene: succinate dehydrogenase complex". Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya ... The SDHC protein is one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as Complex II of the ...
... a succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) is an enzyme that catalyzes the chemical reaction succinate ... Other names in common use include succinate semialdehyde dehydrogenase (nicotinamide adenine, dinucleotide (phosphate)), and ... 2 H+ The 4 substrates of this enzyme are succinate semialdehyde, NAD+, NADP+, and H2O, whereas its 4 products are succinate, ... succinate-semialdehyde dehydrogenase [NAD(P)+]. This enzyme participates in 3 metabolic pathways: glutamate metabolism, ...
... and succinate dehydrogenase. See electron transport chain. 3.D.1 The H+ or Na+-translocating NADH Dehydrogenase ("complex I") ... Family 3.D.9 The H+-translocating F420H2 Dehydrogenase (F420H2DH) Family 3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) ... formate dehydrogenase, respiratory nitrate reductase; succinate - coenzyme Q reductase (fumarate reductase); ... Quinone Dehydrogenase (Na-NDH or NQR) Family 3.D.6 The Putative Ion (H+ or Na+)-translocating NADH:Ferredoxin Oxidoreductase ( ...
... succinate - coenzyme Q reductase (fumarate reductase); and succinate dehydrogenase. See electron transport chain. Cytochrome c ... protein Monoamine oxidases A and B Fatty acid amide hydrolase Cytochrome P450 oxidases Corticosteroid 11β-dehydrogenases . ...
... is the classic example of a competitive inhibitor of the enzyme succinate dehydrogenase (complex II), in the ... This observation was used to deduce the structure of the active site in succinate dehydrogenase. Inhibition of this enzyme ... Dervartanian DV, Veeger C (1964). "Studies on succinate dehydrogenase". Biochimica et Biophysica Acta (BBA) - Specialized ... It binds to the active site of the enzyme without reacting, competing with the usual substrate succinate but lacking the − ...
Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ... carboxylic acid is used in the manufacture of six commercial fungicides which are inhibitors of succinate dehydrogenase. 3,5- ...
Succinate dehydrogenase inhibitors (SDHI) of this type act by binding at the quinone reduction site of the enzyme complex, ... Inhibition of succinate dehydrogenase, the complex II in the mitochondrial respiration chain, has been known as a fungicidal ... Walter, Harald; Lamberth, Clemens; Corsi, Camilla (2018). "Synthesis of fungicidally active succinate dehydrogenase inhibitors ... Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ...
The compound is an anilide which combines a heterocyclic acid with aniline to give an inhibitor of succinate dehydrogenase ( ... Carboxin and oxycarboxin act by inhibition of succinate dehydrogenase (SDHI): they bind to the quinone reduction site of the ... Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ... "The Quaternary Structure of the Saccharomyces cerevisiae Succinate Dehydrogenase". Journal of Biological Chemistry. 279 (10): ...
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as succinate dehydrogenase ... "Entrez Gene: succinate dehydrogenase complex". Heutink P, van der Mey AG, Sandkuijl LA, van Gils AP, Bardoel A, Breedveld GJ, ... Succinate dehydrogenase is an important enzyme in both the citric acid cycle and the electron transport chain. Hereditary PGL- ... Brière JJ, Favier J, El Ghouzzi V, Djouadi F, Bénit P, Gimenez AP, Rustin P (October 2005). "Succinate dehydrogenase deficiency ...
Inhibition of succinate dehydrogenase, the complex II in the mitochondrial respiration chain, has been known as a fungicidal ... The compound is an amide which combines a pyrazole acid with an aryl amine to give an inhibitor of succinate dehydrogenase. The ... Walter, Harald; Lamberth, Clemens; Corsi, Camilla (2018). "Synthesis of fungicidally active succinate dehydrogenase inhibitors ... Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ...
The succinate dehydrogenase (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ... "Entrez Gene: succinate dehydrogenase complex". Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, et al. (October 2013). " ... Succinate dehydrogenase complex, subunit A, flavoprotein variant is a protein that in humans is encoded by the SDHA gene. This ... Brière JJ, Favier J, El Ghouzzi V, Djouadi F, Bénit P, Gimenez AP, Rustin P (October 2005). "Succinate dehydrogenase deficiency ...
The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ... succinate dehydrogenase complex". Kita K, Oya H, Gennis RB, Ackrell BA, Kasahara M (January 1990). "Human complex II (succinate ... Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II ... 2005). "Succinate dehydrogenase deficiency in human". Cell. Mol. Life Sci. 62 (19-20): 2317-24. doi:10.1007/s00018-005-5237-6. ...
The compound is an biphenyl amide derived inhibitor of succinate dehydrogenase. Inhibition of succinate dehydrogenase, the ... Succinate dehydrogenase inhibitors (SDHI) of this type act by binding at the quinone reduction site of the enzyme complex, ... Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ... "The Quaternary Structure of the Saccharomyces cerevisiae Succinate Dehydrogenase". Journal of Biological Chemistry. 279 (10): ...
Inhibition of succinate dehydrogenase, the complex II in the mitochondrial respiration chain, has been known as a fungicidal ... Pan, Yuemin; Ye, Tao; Gao, Zhimou (2017). "Cloning and functional analysis of succinate dehydrogenase gene PsSDHA in ... Walter, Harald; Lamberth, Clemens; Corsi, Camilla (2018). "Synthesis of fungicidally active succinate dehydrogenase inhibitors ... Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ...
... is a succinate dehydrogenase inhibitor (SDHI). It interferes with a number of key fungal life functions, including ... It stunts fungus growth by inhibiting the succinate dehydrogenase (SQR) enzyme. Application of fluxapyroxad helps prevent many ... Specifically it interferes with the production of succinate dehydrogenase, the complex II in the mitochondrial respiration ... abstract Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, ...
The compound is an anilide which combines a heterocyclic acid with aniline to give an inhibitor of succinate dehydrogenase ( ... In the period 1971-1975, evidence grew that it acted by inhibition of succinate dehydrogenase (SDHI), and later work showed ... Walter, Harald (2016). "Fungicidal Succinate-Dehydrogenase-Inhibiting Carboxamides". In Lamberth, Clemens; Dinges, Jürgen (eds ... "The Quaternary Structure of the Saccharomyces cerevisiae Succinate Dehydrogenase". Journal of Biological Chemistry. 279 (10): ...
2002). "Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase". Journal of Neurochemistry ... "Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (γ-hydroxybutyric aciduria). ... Succinate semialdehyde is considered a reactive carbonyl and may lead to increased oxidative stress. This stress is believed to ... Finally, succinic semialdehyde dehydrogenase levels can be measured in cultured leukocytes of the patient. This occurs due to ...
"Entrez Gene: ALDH5A1 aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)". Human ALDH5A1 genome ... "A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is ... Succinate-semialdehyde dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ALDH5A1 gene. This protein ... Overview of all the structural information available in the PDB for UniProt: P51649 (Succinate-semialdehyde dehydrogenase, ...
"Entrez Gene: Succinate dehydrogenase complex assembly factor 2". Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim ... Succinate dehydrogenase complex assembly factor 2, formerly known as SDH5 and also known as SDH assembly factor 2 or SDHAF2 is ... This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for ... The SDHAF2 gene encodes a mitochondrial protein associated with the succinate dehydrogenase (SDH) complex (mitochondrial ...
Succinate dehydrogenase (SQR) is a key enzyme in both the citric acid cycle and the electron transport chain in the ... Succinate dehydrogenase Iverson TM, Luna-Chavez C, Cecchini G, Rees DC (June 1999). "Structure of the Escherichia coli fumarate ... Fumarate reductase / succinate dehydrogenase FAD-binding site in PROSITE Fumarate+reductase+(menaquinone) at the U.S. National ... Rutter J, Winge DR, Schiffman JD (June 2010). "Succinate dehydrogenase - Assembly, regulation and role in human disease". ...
Succinate-Q oxidoreductase, also known as complex II or succinate dehydrogenase, is a second entry point to the electron ... NADH dehydrogenase succinate dehydrogenase Coenzyme Q - cytochrome c reductase cytochrome c oxidase (CS1 errors: periodical ... 2003). "Architecture of succinate dehydrogenase and reactive oxygen species generation". Science. 299 (5607): 700-4. Bibcode: ... Dervartanian DV, Veeger C (November 1964). "Studies on succinate dehydrogenase: I. Spectral properties of the purified enzyme ...
Succinate dehydrogenase complex assembly factor 1 (SDHAF1), also known as LYR motif-containing protein 8 (LYRM8), is a protein ... The succinate dehydrogenase (SDH) complex of the mitochondrial respiratory chain is composed of 4 individual subunits. The ... SDHAF1 is essential for the assembly of the succinate dehydrogenase (SDH) complex (complex II), an enzyme complex that is a ... SDHAF1 is a chaperone protein involved in the assembly of the succinate dehydrogenase (SDH) complex (complex II). Mutations in ...
... components of the succinate dehydrogenase complex, α-ketoglutarate dehydrogenase, and a component of the pyruvate dehydrogenase ... isovaleryl-CoA dehydrogenase), isoleucine, (short/branched-chain acyl-CoA dehydrogenase), valine (isobutyryl-CoA dehydrogenase ... One well-known reaction is part of the citric acid cycle (also known as the TCA or Krebs cycle); succinate dehydrogenase ( ... Kim HJ, Winge DR (May 2013). "Emerging concepts in the flavinylation of succinate dehydrogenase". Biochimica et Biophysica Acta ...
A proposed mechanism for this connection is that decreased Fe-S activity in aconitase and succinate dehydrogenase is correlated ... "Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins". ... which is caused when the Fe-S proteins in aconitase and succinate dehydrogenase have decreased activity. ...
It is an inhibitor of succinate dehydrogenase (SDHI fungicide). Developed and produced by Bayer, it was approved in 2012 by the ...
Sang, Hyunkyu; Lee, Hyang Burm (2020). "Molecular Mechanisms of Succinate Dehydrogenase Inhibitor Resistance in Phytopathogenic ...