Succinate-CoA ligase (ADP-forming)
... a succinate-CoA ligase (ADP-forming) (EC 6.2.1.5) is an enzyme that catalyzes the chemical reaction ATP + succinate + CoA ⇌ {\ ... The systematic name of this enzyme class is succinate:CoA ligase (ADP-forming). Other names in common use include succinyl-CoA ... succinate, and CoA, whereas its 3 products are ADP, phosphate, and succinyl-CoA. This enzyme belongs to the family of ligases, ... Portal: Biology v t e (EC 6.2.1, Enzymes of known structure, All stub articles, Ligase stubs). ...
Succinate-CoA ligase (GDP-forming)
... a succinate-CoA ligase (GDP-forming) (EC 6.2.1.4) is an enzyme that catalyzes the chemical reaction GTP + succinate + CoA ⇌ {\ ... The systematic name of this enzyme class is succinate:CoA ligase (GDP-forming). Other names in common use include succinyl-CoA ... succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA. This enzyme belongs to the family of ligases, ... succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, ...
SUCLG2
"Entrez Gene: SUCLA2 succinate-CoA ligase, GDP-forming, beta subunit". Miller C, Wang L, Ostergaard E, Dan P, Saada A (May 2011 ... Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate ... Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial is an enzyme that in humans is encoded by the SUCLG2 gene on ... provided by RefSeq, Apr 2010] SCS, also known as succinyl CoA ligase (SUCL), is a heterodimer composed of a catalytic α subunit ...
SUCLA2
"Entrez Gene: SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit". Matilainen S, Isohanni P, Euro L, Lönnqvist T, Pihko H, ... Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2), also known as ADP-forming succinyl-CoA synthetase (SCS- ... "Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients". ... A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008] SCS, also known as succinyl CoA ligase ...
SUCLG1
"Entrez Gene: SUCLG1 succinate-CoA ligase, GDP-forming, alpha subunit". Fraser ME, James MN, Bridger WA, Wolodko WT (Jun 2000 ... Succinate-CoA ligase deficiency is responsible for encephalomyopathy with mitochondrial DNA depletion and mild methylmalonic ... Overview of all the structural information available in the PDB for UniProt: O19069 (Pig Succinate--CoA ligase [ADP/GDP-forming ... Overview of all the structural information available in the PDB for UniProt: P53597 (Human Succinate--CoA ligase [ADP/GDP- ...
Mitochondrial DNA depletion syndrome
March 2016). "Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 ... Other causes are mutations of thymidine phosphorylase (TyMP), succinate-CoA ligase, alpha sub unit (SUCLG1) and TWNK (also ... This enzyme catalyzes the synthesis of succinate and coenzyme A into succinyl-CoA, but is also associated with the complex ... "Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA ...
Substrate-level phosphorylation
... or a GDP-forming succinate-CoA ligase (G-SUCL, EC 6.2.1.4). The ADP-forming succinate-CoA ligase is potentially the only matrix ... Succinate-CoA ligase is a heterodimer composed of an invariant α-subunit and a substrate-specific ß-subunit, encoded by either ... This combination results in either an ADP-forming succinate-CoA ligase (A-SUCL, EC 6.2.1.5) ... utilizing either phosphoenolpyruvate carboxykinase or succinate-CoA ligase, or monofunctional C1-tetrahydrofolate synthase. ...
Aquifex aeolicus
... succinate-CoA ligase, aconitase and citratesynthase. Moreover, this bacterium uses oxygen, hydrogen, and mineral salts as its ...
Energy charge
... by the succinate-CoA ligase and phosphoenolpyruvate carboxylkinase, and by adenylate kinase, an enzyme that maintains the three ...
Succinyl coenzyme A synthetase
Biology portal Citric acid cycle Succinate dehydrogenase Succinate-CoA ligase (ADP-forming) Succinate-CoA ligase (GDP-forming) ... Succinyl coenzyme A synthetase (SCS, also known as succinyl-CoA synthetase or succinate thiokinase or succinate-CoA ligase) is ... Succinyl CoA synthetase catalyzes the following reversible reaction: Succinyl CoA + Pi + NDP ↔ Succinate + CoA + NTP where Pi ... The crystal structure of Succinyl-CoA synthetase alpha subunit (succinyl-CoA-binding isoform) was determined by Joyce et al. to ...
Citric acid cycle
Most organisms utilize EC 6.2.1.5, succinate-CoA ligase (ADP-forming) (despite its name, the enzyme operates in the pathway in ... Acyl-CoA is oxidized to trans-Enoyl-CoA while FAD is reduced to FADH2, which is similar to the oxidation of succinate to ... succinate-CoA ligase (GDP-forming) (EC 6.2.1.4) also operates. The level of utilization of each isoform is tissue dependent. In ... bypass succinyl-CoA entirely, and convert 2-oxoglutarate to succinate via succinate semialdehyde, using EC 4.1.1.71, 2- ...
List of EC numbers (EC 6)
... succinate-CoA ligase (GDP-forming) EC 6.2.1.5: succinate-CoA ligase (ADP-forming) EC 6.2.1.6: glutarate-CoA ligase EC 6.2.1.7: ... cholate-CoA ligase EC 6.2.1.8: oxalate-CoA ligase EC 6.2.1.9: malate-CoA ligase EC 6.2.1.10: carboxylic acid-CoA ligase (GDP- ... cholate-CoA ligase EC 6.2.1.30: phenylacetate-CoA ligase EC 6.2.1.31: 2-furoate-CoA ligase EC 6.2.1.32: anthranilate-CoA ligase ... arachidonate-CoA ligase EC 6.2.1.16: acetoacetate-CoA ligase EC 6.2.1.17: propionate-CoA ligase EC 6.2.1.18: citrate-CoA ligase ...
Thiokinase
Butyrate-CoA ligase Citrate-CoA ligase Malate-CoA ligase Succinate-CoA ligase (ADP-forming) Succinate-CoA ligase (GDP-forming) ... A thiokinase is a ligase that synthesizes CoA thioesters. They are classified under EC number 6.2, but often have primary names ... Types include: Acetate-CoA ligase (ADP-forming) ...
List of MeSH codes (D08)
... coenzyme a ligases MeSH D08.811.464.267.500.200 - acetate-coa ligase MeSH D08.811.464.267.500.600 - succinate-coa ligases MeSH ... acyl-coa dehydrogenase, long-chain MeSH D08.811.682.660.150.200 - acyl-CoA oxidase MeSH D08.811.682.660.150.300 - butyryl-coa ... alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ligase MeSH D08.811.464.263.200.150 - aspartate-tRNA ligase ... glycine-trna ligase MeSH D08.811.464.263.200.400 - histidine-trna ligase MeSH D08.811.464.263.200.450 - isoleucine-trna ligase ...
List of enzymes
Succinate-CoA ligase (GDP-forming) EC 6.2.1.5: Succinate-CoA ligase (ADP-forming) EC 6.2.1.6: Glutarate-CoA ligase EC 6.2.1.7: ... Cholate-CoA ligase EC 6.2.1.8: Oxalate-CoA ligase EC 6.2.1.9: Malate-CoA ligase EC 6.2.1.10: Acid-CoA ligase (GDP-forming) EC ... Arachidonate-CoA ligase EC 6.2.1.16: Acetoacetate-CoA ligase EC 6.2.1.17: Propionate-CoA ligase EC 6.2.1.18: Citrate-CoA ligase ... ligase EC 6.2.1.23: Dicarboxylate-CoA ligase EC 6.2.1.24: Phytanate-CoA ligase EC 6.2.1.25: Benzoate-CoA ligase EC 6.2.1.26: o- ...
Index of molecular biology articles
... succinate-citramalate CoA-transferase - suicide gene - sulfate-transporting ATPase - supercoil - SurE, survival protein E - Syb ... DNA ligase -DNA Bank - DNA polymerase - DNA replication - DNA sequencing - DNase - dominant - dot blot - double helix - ... myristoyl-CoA 11-(E) desaturase - myristoyl-CoA 11-(Z) desaturase - N terminus - N-acetylhexosamine 1-dehydrogenase - N- ... ubiquitin-calmodulin ligase - UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase - undecaprenyl-phosphate 4- ...
Flavin adenine dinucleotide
... isovaleryl-CoA dehydrogenase), isoleucine, (short/branched-chain acyl-CoA dehydrogenase), valine (isobutyryl-CoA dehydrogenase ... One well-known reaction is part of the citric acid cycle (also known as the TCA or Krebs cycle); succinate dehydrogenase ( ... Of all flavoproteins, 90% perform redox reactions and the other 10% are transferases, lyases, isomerases, ligases. Monoamine ... Some redox flavoproteins non-covalently bind to FAD like Acetyl-CoA-dehydrogenases which are involved in beta-oxidation of ...
Butyric acid
... also known as butyrate-CoA ligase. The metabolite produced by this reaction is butyryl-CoA, and is produced as follows: ... The balanced equation for this fermentation is C6H12O6 → C4H8O2 + 2CO2 + 2H2 Other pathways to butyrate include succinate ... This intermediate then takes two possible pathways: acetoacetyl CoA → acetoacetate → acetone acetoacetyl CoA → butyryl CoA → ... omnivores and herbivores have butyrate-producing bacterial communities dominated by the butyryl-CoA:acetate CoA-transferase ...
Housekeeping gene
004168 Succinate Dehydrogenase subunit A SDHAF2 NM_017841 SDHB NM_002973 Iron-sulfur protein (IP) subunit of succinate ... PRKAG1 Senses energy level and inactivates HMGCoA reductase and Acetyl CoA Carboxylase PRKAA1 NM_006251 Catalytic subunit of ... 021178 E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression ... 003000 Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron ...
Mitochondrion
... kynurenine hydroxylase and fatty acid Co-A ligase. Disruption of the outer membrane permits proteins in the intermembrane space ... The enzymes of the citric acid cycle are located in the mitochondrial matrix, with the exception of succinate dehydrogenase, ... Acetyl-CoA, on the other hand, derived from pyruvate oxidation, or from the beta-oxidation of fatty acids, is the only fuel to ... It is the oxidation of the acetate portion of acetyl-CoA that produces CO2 and water, with the energy thus released captured in ...
Beta oxidation
Long-chain-fatty-acid-CoA ligase catalyzes the reaction between a fatty acid with ATP to give a fatty acyl adenylate, plus ... succinyl-CoA enters the cycle as a principal in its own right. Thus the succinate just adds to the population of circulating ... Trans-delta2-enoyl CoA is hydrated at the double bond to produce L-3-hydroxyacyl CoA by enoyl-CoA hydratase. L-3-hydroxyacyl ... The overall reaction for one cycle of beta oxidation is: Cn-acyl-CoA + FAD + NAD+ + H 2O + CoA → Cn-2-acyl-CoA + FADH 2 + NADH ...
List of EC numbers (EC 3)
... acetyl-CoA hydrolase EC 3.1.2.2: palmitoyl-CoA hydrolase EC 3.1.2.3: succinyl-CoA hydrolase EC 3.1.2.4: 3-hydroxyisobutyryl-CoA ... glutamateammonia ligase] phosphorylase EC 3.1.4.16: 2′,3′-cyclic-nucleotide 2′-phosphodiesterase EC 3.1.4.17: 3′,5′-cyclic- ... succinate hydrolase EC 3.5.1.30: 5-aminopentanamidase EC 3.5.1.31: formylmethionine deformylase EC 3.5.1.32: hippurate ... EC 3.1.2.25: phenylacetyl-CoA hydrolase EC 3.1.2.26: Now EC 2.8.3.25, bile acid CoA transferase EC 3.1.2.27: choloyl-CoA ...
List of EC numbers (EC 2)
... succinate-hydroxymethylglutarate CoA-transferase EC 2.8.3.14: 5-hydroxypentanoate CoA-transferase EC 2.8.3.15: succinyl-CoA:(R ... glutamate-tRNA ligase, EC 1.2.1.70, glutamyl-tRNA reductase and EC 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase EC 2.7.2.14 ... cinnamoyl-CoA:phenyllactate CoA-transferase EC 2.8.3.18: succinyl-CoA:acetate CoA-transferase (*) EC 2.8.3.19: CoA:oxalate CoA- ... succinyl-CoA-L-malate CoA-transferase and EC 2.8.3.20, succinyl-CoA-Dcitramalate CoA-transferase EC 2.8.3.8: acetate CoA- ...