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*  Structure-activity relationship
The structure-activity relationship (SAR) is the relationship between the chemical or 3D structure of a molecule and its ... Combinatorial chemistry Congener Conformation activity relationship Quantitative structure-activity relationship Sims, Gerald; ... known as quantitative structure-activity relationships (QSAR). A related term is structure affinity relationship (SAFIR). The ... Mani, S.V.; D.W. Connell; R.D. Braddock (1991). "Structure activity relationships for the prediction of biodegradability of ...
*  Quantitative structure-activity relationship
Some examples are quantitative structure-reactivity relationships (QSRRs), quantitative structure-chromatography relationships ... one can find a mathematical relationship, or quantitative structure-activity relationship, between the two. The mathematical ... While many quantitative structure activity relationship analyses involve the interactions of a family of molecules with an ... Quantitative structure-activity relationship models (QSAR models) are regression or classification models used in the chemical ...
*  N,N-Dimethyldopamine
Structure-activity relationships. I. Sympathomimetic and related amines." J. Med. Chem. 9 273-280. L. I. Goldberg, P. F. ... The pressor activity of DMDA was partially inhibited by the α-antagonist phentolamine. From these and other observations, the ... J. M. Kitzen, M. Ilhan, J. G. Cannon and J. P. Long (1976). "α-Adrenergic activity of N,N-dimethyldopamine (DMDA)." Eur. J. ... In another assay, 6 mg/kg of DMDA (i.p. in mice) only slightly antagonized the reduced locomotor activity resulting from pre- ...
*  Hordenine
Structure-activity relationships. I. Sympathomimetic and related amines." J. Med. Chem. 9 273-280. C. J. Barwell et al. (1989 ... Ernst Späth subsequently showed that these alkaloids were identical and proposed the correct molecular structure for this ...
*  Discovery and development of dipeptidyl peptidase-4 inhibitors
Important structure-activity relationship: 1. Strict steric constraint exists around the pyrrolidine ring of cyanopyrrolidine- ... Each inhibitor was important to establish an early structure activity relationship (SAR) for subsequent investigation. It ... It is a potent and selective DPP-4 inhibitor with a 2D-structure very similar to sitagliptin. However, the 3D-structure is ... Existing X-ray structures show that there is not much difference in size and shape of the pocket that indicates that the S1- ...
*  5-MeO-DET
P.K. Gessner; D.D. Godse; A.H. Krull; J.M. McMullan (March 1968). "Structure-activity relationships among 5-methoxy-N:N- ... Quantitative Structure-Activity Relationships. 18 (6): 548-560. doi:10.1002/(SICI)1521-3838(199912)18:6. 3.0.CO;2-B. Michael B ...
*  Partition coefficient
"Atomic Physicochemical Parameters for Three-Dimensional Structure-Directed Quantitative Structure-Activity Relationships I. ... Quantitative Structure-Activity Relationships. 7 (3): 133-144. doi:10.1002/qsar.19880070304. Andrés A, Rosés M, Ràfols C, Bosch ... "Use of distribution coefficients in quantitative structure-activity relationships". (primary). Journal of Medicinal Chemistry. ... The IUPAC further recommends "partition ratio" for cases where transfer activity coefficients can be determined, and " ...
*  Sufentanil
... structure-activity-relationship study". Curr Med Chem. 16 (9): 2468-2474. PMID 19601792. Niemegeers CJ, Schellekens KH, Van ...
*  Etoxadrol
Synthesis and structure activity relationships". Journal of Medicinal Chemistry. 35 (8): 1323-1329. doi:10.1021/jm00086a001. ... Sax, M.; Wunsch, B. (2006). "Relationships Between the Structure of Dexoxadrol and Etoxadrol Analogues and their NMDA Receptor ... Aepkers, M.; Wünsch, B. (2005). "Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived ... Because of its lipophilic structure, etoxadrol can be absorbed by fat tissues and organs (e.g. the liver). Etoxadrol also acts ...
*  Macrolide
ISBN 0-12-526451-8. Structure Activity Relationships "Antibacterial Agents; Structure Activity Relationships", André Bryskier ... They have similar activity to ciclosporin. Polyene antimycotics, such as amphotericin B, nystatin etc., are a subgroup of ... Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. US FDA-approved : Azithromycin - ... Schultz, M. J. (2004). "Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and ...
*  Chlorotrianisene
198-. ISBN 978-0-471-89979-2. Jordan VC, Mittal S, Gosden B, Koch R, Lieberman ME (1985). "Structure-activity relationships of ... Structures and Bibliographies. Springer. pp. 263-. ISBN 978-1-4757-2085-3. Index Nominum 2000: International Drug Directory. ...
*  Discovery and development of TRPV1 antagonists
Structure-activity relationship of N-aryl cinnamides". Journal of Medicinal Chemistry. 48 (1): 71-90. doi:10.1021/jm049485i. ... Gore VK, Ma VV, Tamir R, Gavva NR, Treanor JJ, Norman MH (November 2007). "Structure-activity relationship (SAR) investigations ... "Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl] ... structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents". Journal of Medicinal ...
*  LPAR2
Structure-activity relationship of cloned LPA receptors". FEBS Lett. 478 (1-2): 159-65. doi:10.1016/S0014-5793(00)01827-5. PMID ...
*  Dinoseb
Dinoterb Topliss, John (2012-12-02). Quantitative Structure-Activity Relationships of Drugs. Elsevier. p. 427. ISBN ... 2-(1-methylpropyl)phenol takes up the nitronium ion to form the arenium ion, which has three resonance structures. Water can ... This compound had a superior contact and stomach activity on insects and mites. Dinoseb became commercially available in 1945 ...
*  Quinolone antibiotic
... entry page for Fluoroquinolones Structure Activity Relationships "Antibacterial Agents; Structure Activity Relationships," ... High activity against the eukaryotic type II enzyme is exhibited by drugs containing aromatic substituents at their C-7 ... The addition of the C6 fluorine atom has since been demonstrated not to be required for the antibacterial activity of this ... A quinolone antibiotic is any member of a large group of broad-spectrum bactericides that share a bicyclic core structure ...
*  2,5-Dimethoxy-4-isopropylamphetamine
Analysis by quantitative structure-activity relationships". ACS Symposium Series. 413: 264-280. doi:10.1021/bk-1989-0413.ch018 ... "Structure-activity relations in psychotomimetic phenylalkylamines". Journal of Medicinal Chemistry. 17 (10): 1100-1111. doi: ... "A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin ...
*  Fenobam
... and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure". ... A structure-activity relationship study of fenobam analogues". Bioorganic & Medicinal Chemistry Letters. 16 (5): 1142-5. doi: ... Carroll, FI (2008). "Antagonists at metabotropic glutamate receptor subtype 5: Structure activity relationships and therapeutic ... Fenobam is known to exist in five crystalline forms, all of them exhibiting a tautomeric structure with the proton attached to ...
*  Mechanism of anoxic depolarization in the brain
Goyal, R; Chaudhury, A (2013). "Structure activity relationship of synaptic and junctional neurotransmission". Autonomic ... The decrease in neuronal activity renders the turtle comatose for the duration of anoxia. Another anoxia-tolerant animal that ... Hyperpolarization, on the other hand, is employed to reduce neuronal activity by establishing a high threshold potential for ... which are capable of a high degree of independent activity from birth-employ hyperpnoea (abnormally rapid or deep breathing). ...
*  Polymyxin
Tsubery, H.; Ofek, I.; Cohen, S.; Fridkin, M. (2000-01-01). "Structure activity relationship study of polymyxin B nonapeptide ... Gram-negative bacteria can develop resistance to polymyxins through various modifications of the LPS structure that inhibit the ... Poirel, L; Jayol, A; Nordmann, P (April 2017). "Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance ...
*  Yuehchukene
Extensive structure-activity relationship investigations have been undertaken. Activity was found to be abolished by nitrogen ... 1992). "Structure-function relationship of Yuehchukene II. The effect of C-6 indole rotation on anti-implantation activity". ... 1991). "Structure function relationship study of yuehchukene. I. Anti-implantation and estrogenic activities of substituted ... The activity was unaffected by saturation of the C9-C10 double bond. It was concluded that biological activity is dependent ...
*  List of benzodiazepines
Quantitative Structure-Activity Relationships, January 1998; 17(01): 14-19. Thakur A, Thakur M, Khadikar P (Nov 2003). " ... ISSN 1723-8617 Blair T, Webb GA (Sep 1977). "Electronic factors in the structure-activity relationship of some 1,4- ... A large number of benzodiazepine derivatives have been synthesised and their structure-activity relationships explored in ... Hadjipavlou-Litina D, Hansch C (1994). "Quantitative structure-activity relationships of the benzodiazepines. a review and ...
*  Neuroeffector junction
June 2013). "Structure activity relationship of synaptic and junctional neurotransmission". Auton Neurosci. 176: 11-31. doi: ... The structure of the autonomic neuromuscular junction consists of several essential features including that: the terminal ... In skeletal muscles, the junctions are mostly of the same distance and size because they innervate such definite structures of ... that are connected by gap junctions which allow electrotonic spread of activity between cells. Many smooth muscle cells in a ...
*  Nonsteroidal antiandrogen
Singh SM, Gauthier S, Labrie F (2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr ... structure-activity relationships". Curr. Med. Chem. 7 (2): 211-47. doi:10.2174/0929867003375371. PMID 10637363. Migliari R, ... show no off-target hormonal activity such as progestogenic, glucocorticoid, or antimineralocorticoid activity, and lack ... Cimetidine (Tagamet): An over-the-counter histamine H2 receptor antagonist that also shows very weak activity as an AR ...
*  Pharmacology of bicalutamide
... structure-activity relationships". Current Medicinal Chemistry. 7 (2): 211-47. doi:10.2174/0929867003375371. PMID 10637363. ... and this action may also be involved in its activity as an antiandrogen. The activity of bicalutamide lies in the (R)-isomer, ... Bicalutamide, as well as enzalutamide, have been found to act as inhibitors of P-glycoprotein efflux and ATPase activity. This ... This is largely a consequence of their antigonadotropic activity. Antigonadotropic agents like high-dose CPA, high-dose ...
*  Methyl-MMDA-2
ISBN 0-9630096-0-5. Nichols DE, Oberlender R (1989). "Structure-activity relationships of MDMA-like substances". NIDA Research ... This reduction in hallucinogenic activity relative to MMDA-2 parallels that of MDA and MDMA, indicating that with ...
*  Classical Anatolia
The remaining members of the dynasty, which eventually petered out in 1 BC, had an uneasy relationship with both Rome to the ... Put together these various Pauline sources suggest considerable missionary activity by Paul and Barnabas throughout Anatolia, ... Another innovation was the establishment of Dioceses, an intermediate administrative structure that combined together several ... where the people urged Agrippa to expel Jews because they were not active in their religious activities. The Romans provided ...