Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... has some good regulatory details Protein Data Base (PDB), Sterol Regulatory Element Binding 1A structure. (Articles with short ... These proteins work with asymmetric sterol regulatory element (StRE). SREBPs have a structure similar to E-box-binding helix- ... Sterol+Regulatory+Element+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) The Brown ...

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 ( ... CREB-binding protein, DAX1 LMNA, and TWIST2. BHLHE40 BHLHE41 Sterol regulatory element-binding protein GRCh38: Ensembl release ... Kotzka J, Müller-Wieland D (Apr 2004). "Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin ... Ericsson J, Edwards PA (Jul 1998). "CBP is required for sterol-regulated and sterol regulatory element-binding protein- ...

... (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ( ... SREBF2 has been shown to interact with INSIG1 and CREB-binding protein. Sterol regulatory element-binding protein GRCh38: ... "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2". The Journal of Biological ... Nagoshi E, Imamoto N, Sato R, Yoneda Y (Jul 1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic ...

Foretz, M.; Guichard, C.; Ferré, P.; Foufelle, F. (1999-10-26). "Sterol regulatory element binding protein-1c is a major ... Horton, J. D.; Shimomura, I. (1999-04-01). "Sterol regulatory element-binding proteins: activators of cholesterol and fatty ... "Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level". The Journal of Biological ... "Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes ...

Examples include Microphthalmia-associated transcription factor and Sterol regulatory element binding protein (SREBP). Basic+ ...

"Identification of a zinc finger protein that binds to the sterol regulatory element". Science. 245 (4918): 640-3. Bibcode: ... Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene. The ZNF9 protein contains 7 zinc ... "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein". Rajavashisth TB, Taylor AK, Andalibi A, Svenson KL, ... McGrath CF, Buckman JS, Gagliardi TD, Bosche WJ, Coren LV, Gorelick RJ (Aug 2003). "Human cellular nucleic acid-binding protein ...

"Identification of a zinc finger protein that binds to the sterol regulatory element". Science. 245 (4918): 640-3. Bibcode: ... Vasa is an RNA binding protein with an ATP-dependent RNA helicase that is a member of the DEAD box family of proteins. The vasa ... The protein product in humans has 724 amino acids, a molecular mass of 79 kDa and 8 conserved domains in all DEAD-box proteins ... Translation can be inhibited by cis regulatory elements in the transcript's 5' and 3' UTRs. They may inhibit translation by ...

... purified the Sterol Regulatory Element-Binding Proteins (SREBPs), a family of membrane-bound transcription factors. Since 1993 ... June 5, 1993). "Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. ... April 8, 1994). "SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.". Cell. Retrieved ... Joseph L. Goldstein (September 2021). "The surprise element: A hallmark of creativity in scientists, artists, and comedians". ...

Takagi M, Suto F, Suga T, Yamada J (2006). "Sterol Regulatory Element-Binding Protein-2 modulates human brain acyl-CoA ... The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 ... 2000). "The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation". J. Biol. Chem. 275 ( ... The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids ...

S1P cleaves the endoplasmic reticulum loop of sterol regulatory element-binding protein (SREBP) transcription factors. This ... Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme ... The encoded protein undergoes an initial autocatalytic processing event in the endoplasmic reticulum (ER) to generate a ... "Entrez Gene: Membrane-bound transcription factor peptidase, site 1". Brown MS, Goldstein JL (1999). "A proteolytic pathway that ...

"Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin". The Journal of ... The CYP4F2 enzyme protein presents in endoplasmic reticulum. The enzyme CYP4F2 is involved in the metabolism of various ... This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4 ... The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of ...

"Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The ... Prostasin is a protein that in humans is encoded by the PRSS8 gene. This gene encodes a trypsinogen, which is a member of the ... The protein is implicated in epithelial sodium channel regulation and may help regulate a variety of tissue functions that ... Regulatory, Integrative and Comparative Physiology. 284 (4): R1031-6. doi:10.1152/ajpregu.00660.2002. PMID 12626364. Colland F ...

Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress". The Journal of ... The protein is associated with the endoplasmic reticulum and lipid droplets. Increases in the protein relate to cell stress. ... StAR-related lipid transfer protein 4 (STARD4) is a soluble protein involved in cholesterol transport. It can transfer up to 7 ... "Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in ...

Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes ... an enzyme regulated by sterol regulatory element-binding proteins". The Journal of Biological Chemistry. 275 (34): 26458-66. ... The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. It is also essential for ... In the mouse hippocampus, ACSS2 binds directly to immediate early genes to 'fuel' local histone acetylation and, in turn, their ...

It is downregulated by sterol regulatory element-binding proteins (SREBP) when plasma cholesterol levels are low. Bile acids ... In the liver, bile acids bound to FXR induce small heterodimer partner, SHP which binds to LRH-1 and so inhibits the ... a non-DNA binding protein. The increased abundance of SHP causes it to associate with liver receptor homolog (LRH)-1, an ... However, the membrane-associated and hydrophobic nature of the enzyme system impeded purification, and the number of proteins ...

... an enzyme regulated by sterol regulatory element-binding proteins". J Biol Chem. 275 (34): 26458-66. doi:10.1074/jbc.M004160200 ... Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene. Solute carrier ...

... by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1) and by liver X receptors (e.g., LXRA). Upon sterol depletion ... Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress". The Journal of ... Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR ... StAR-related lipid transfer protein 5 is a protein that in humans is encoded by the STARD5 gene. The protein is a 213 amino ...

"Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The ... The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin ... Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes the ... This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. It regulates differentiation and ...

In 1993, their trainees Xiaodong Wang and Michael Briggs purified the sterol regulatory element binding proteins (SREBPs). ... Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that ... Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS (May 1985). "Membrane-bound domain of HMG CoA reductase is required for sterol ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...

... and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This protein binds to the sterol-sensing ... a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins". ... Lee JN, Ye J (Oct 2004). "Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress ... Both functions require the binding of INSIG1 protein via the same site. There are two other proteins whose sterol-binding sites ...

Sterol Regulatory Element Binding Protein 1c ChREBP - Carbohydrate Regulatory Element Binding Protein The importance of LXRs in ... LXRs regulate fatty acid synthesis by modulating the expression of sterol regulatory element binding protein-1c (SREBP-1c). ... "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ". Genes ... "Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene ...

2004). "Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase ... CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in ... The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of ... 2005). "Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern". Histochem. Cell Biol ...

Although liver X receptors (LXRs) modulate the expression of sterol regulatory element binding protein-1c (SREBP-1c) in feeding ... "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta ... and sterol regulatory element binding protein-1c (SREBP-1c) in response to feeding/insulin in living animals. ... "Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene ...

Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional ... encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) ... This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response ... Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC ...

sphaeroides Kützing, a Blue-Green Alga, Inhibits the Activation of Sterol Regulatory Element Binding Proteins in HepG2 Cells1-3 ...

SCAP is a regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element-binding protein ( ... Sterol regulatory element-binding protein cleavage-activating protein, also known as SREBP cleavage-activating protein or SCAP ... In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their ... 2007). "The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene ...

... is responsible for activating the sterol regulatory element-binding proteins (SREBP). By selectively inhibiting S1P, AEBSF can ... AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site- ... and the protein N-terminal amino group, have also been reported. Due to the substantial frequency of modification of these off- ... AEBSF A Link to the ABRF group usegroup archive with an informative discussion of covalent modifications to proteins resulting ...

... a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins". Proc. ... a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins". ... Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element ... REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP) activity, and ...

... transcription of genes with sterol response elements by proteolytically activating sterol regulatory element-binding proteins ( ... Upon binding to cholesterol, this protein undergoes endoplasmic-reticulum-associated protein degradation. The SSD is not ... is a protein domain which consists of 180 amino acids forming five transmembrane segments capable of binding sterol groups. ... Sterol-sensing domains are present in various proteins involved in key aspects of cholesterol homeostasis and signalling. ...

Two highly characterized sterol-regulatory element binding proteins, SrbA and SrbB, along with their processing pathways, have ... "A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and ... "The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in ... The loss of any of the above SrbA processing proteins results in a dysfunctional copy of SrbA and a subsequent loss of in vitro ...