Loading...
*  Hydroxylation
17α-Hydroxylase Cholesterol 7 alpha-hydroxylase Dopamine β-hydroxylase Phenylalanine hydroxylase Tyrosine hydroxylase Nelson, D ... Some drugs (for example, steroids) are activated or deactivated by hydroxylation. The hydroxylation process involves conversion ... multi-subunit enzymes prolyl 4-hydroxylase, prolyl 3-hydroxylase and lysyl 5-hydroxylase, respectively. These reactions require ... In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step ...
*  Steroid hydroxylase
A steroid hydroxylase is a class of hydroxylase enzymes involved in the biosynthesis of steroids. Steroidogenic enzyme ... Steroidogenesis Steroid nomenclature - numbering of carbons Production of DHEA from Cholesterol Steroid hydroxylases at the US ...
*  Steroid 11β-hydroxylase
... is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata. Named officially the ... "Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in ... Steroid 11-beta-hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH) Metabolism portal. ... Chua SC, Szabo P, Vitek A, Grzeschik KH, John M, White PC (October 1987). "Cloning of cDNA encoding steroid 11 beta-hydroxylase ...
*  Adrenodoxin-NADP+ reductase
doi:10.1016/0003-9861(66)90108-1. Chu, J.W.; Kimura, T. (1973). "Studies on adrenal steroid hydroxylases. Molecular and ... electron transfer for steroid biosynthesis". J. Mol. Biol. 289: 981-990. doi:10.1006/jmbi.1999.2807. PMID 10369776. Adrenodoxin ...
*  Steroid 15beta-monooxygenase
... (EC 1.14.15.8, cytochrome P-450meg, cytochrome P450meg, steroid 15beta-hydroxylase, CYP106A2, ... Berg, A.; Gustafsson, J.A.; Ingelman-Sundberg, M. (1976). "Characterization of a cytochrome P-450-dependent steroid hydroxylase ... Steroid 15beta-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... H2O The enzyme from Bacillus megaterium hydroxylates a variety of 3-oxo-Delta4-steroids in position 15beta. Berg, A.; Ingelman- ...
*  CYP7B1
25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans ... Tang W, Norlin M (2006). "Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells". ... Li-Hawkins J, Lund EG, Turley SD, Russell DW (June 2000). "Disruption of the oxysterol 7alpha-hydroxylase gene in mice". J. ... Kim SB, Chalbot S, Pompon D, Jo DH, Morfin R (2005). "The human cytochrome P4507B1: catalytic activity studies". J. Steroid ...
*  Aldosterone synthase
1992). "Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and ... Mornet E, Dupont J, Vitek A, White PC (June 1989). "Characterization of two genes encoding human steroid 11-beta-hydroxylase (P ... Mornet E, Dupont J, Vitek A, White PC (1990). "Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450( ... Martsev SP, Chashchin VL, Akhrem AA (1985). "[Reconstruction and study of a multi-enzyme system by 11 beta-hydroxylase steroids ...
*  Steroidogenic factor 1
It was originally identified as a regulator of genes encoding cytochrome P450 steroid hydroxylases, however, further roles in ... First identified as a regulator of steroid hydroxylases within adrenocortical cells, studies aimed to define localization and ... SF-1 expression is localized to adult steroidogenic tissues correlating with known expression profiles of steroid hydroxylases ...
*  Ferredoxin
"A new electron transport mechanism in mitochondrial steroid hydroxylase systems based on structural changes upon the reduction ...
*  Adrenal ferredoxin
Martsev SP, Chashchin VL, Akhrem AA (1985). "[Reconstruction and study of a multi-enzyme system by 11 beta-hydroxylase steroids ... "Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel ...
*  Steroid 9alpha-monooxygenase
This enzyme is also called steroid 9alpha-hydroxylase. It has 2 cofactors: FMN, and Iron-sulfur. Strijewski A (1982). "The ... In enzymology, a steroid 9alpha-monooxygenase (EC 1.14.99.24) is an enzyme that catalyzes the chemical reaction pregna-4,9(11)- ... The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing). ... steroid-9 alpha-hydroxylation system from Nocardia species". Eur. J. Biochem. 128 (1): 125-35. doi:10.1111/j.1432-1033.1982. ...
*  Maria New
New described a form of mild steroid 21-hydroxylase deficiency called nonclassical 21-hydroxylase deficiency, which is ... New continues to study three monogenic disorders: 21-hydroxylase deficiency, 11β-hydroxylase deficiency, and apparent ... "High frequency of nonclassical steroid 21-hydroxylase deficiency". American Journal of Human Genetics. 37 (4): 650-67. PMC ... Although steroid physiology was well understood when Dr. New began her scientific career, little of the knowledge had been ...
*  Genetics of infertility
... receptor that was first identified following the search for a common regulator of the cytochrome P450 steroid hydroxylase ...
*  Cunninghamella elegans
A. Jaworski; L. Sedlaczek; J. Dlugoński; Ewa Zajaczkowska (1985). "Inducible nature of the steroid 11-hydroxylases in spores of ... C. elegans can be used for phenanthrene bioconversion or for steroid transformation. It has been used to produce isoapocodeine ... Długoński, J.; Sedlaczek, L.; Jaworski, A. (1984). "Protoplast release from fungi capable of steroid transformation". Canadian ...
*  Glucocorticoid remediable aldosteronism
The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and other steroids. Aldosterone synthase is found ... Aldosterone synthase is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone. It is ... Steroid hormones are synthesized from cholesterol within the adrenal cortex. Aldosterone and corticosterone share the first ... The last part is either mediated by the aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). ...
*  Alternatives to animal testing
A. Jaworski; L. Sedlaczek; J. Dlugoński; Ewa Zajaczkowska (1985). "Inducible nature of the steroid 11-hydroxylases in spores of ...
*  21-Hydroxylase
Steroid 21-hydroxylase, also called steroid 21-monooxygenase, 21α-Hydroxylase, P450 21A2, and, less commonly 21β-Hydroxylase, ... 21-Hydroxylase catalyzes the addition of hydroxyl (-OH) to the C21 position of two steroids: progesterone and 17α- ... Jan 1996). "Molecular analysis of CYP21 and C4 genes in Brazilian families with the classical form of steroid 21-hydroxylase ... White PC, Tusie-Luna MT, New MI, Speiser PW (1994). "Mutations in steroid 21-hydroxylase (CYP21)". Human Mutation. 3 (4): 373-8 ...
*  Finnish heritage disease
... genealogy of steroid 21-hydroxylase (CYP21) gene mutations in Finland". European Journal of Human Genetics. 7 (2): 188-96. doi: ...
*  List of MeSH codes (D12.776)
... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... steroid 21-hydroxylase MeSH D12.776.422.512.380.440 - hemoglobin a, glycosylated MeSH D12.776.422.512.380.450 - hemoglobin A2 ... steroid hydroxylases MeSH D12.776.422.220.453.915.050 - aldosterone synthase MeSH D12.776.422.220.453.915.099 - aromatase MeSH ...
*  List of MeSH codes (D08)
... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16- ... alpha-hydroxylase MeSH D08.244.453.915.748 --- steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 --- steroid 21-hydroxylase ... steroid 11-beta-hydroxylase MeSH D08.811.682.690.708.170.915.730 --- steroid 12-alpha-hydroxylase MeSH D08.811.682.690.708.170. ... steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.170.915.748 --- steroid 17-alpha-hydroxylase MeSH D08.811.682.690.708.170 ...
*  Colin Skinner
J. Steroid. Biochem. 41:827-829. Skinner, C.A. & Rumsby, G. (1994). Steroid 11β-hydroxylase deficiency caused by a five base ... Rumsby, G., Skinner, C. and Honour, J.W. (1992). Genetic analysis of the steroid 21-hydroxylase gene following in vitro ... Combined 17α-hydroxylase/ 17,20 lyase deficiency caused by heterozygous stop codons in the cytochrome P450 17α-hydroxylase gene ...
*  Hydroxysteroid dehydrogenase
Steroidogenic enzyme Steroid hydroxylase Hydroxysteroid Dehydrogenases at the US National Library of Medicine Medical Subject ...
*  Walter L. Miller (endocrinologist)
"Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline". The ... Miller is expert in the field of human steroid biosynthesis and disorders of steroid metabolism. Over the past 40 years ... Miller's reviews on the molecular biology of steroid hormone synthesis are among the most widely cited papers in the field. SB ... In collaboration with AA Portale, Miller's group was first to clone the vitamin D 1α-hydroxylase (CYP27B1), which is the ...
*  PITX1
... a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase". Hormone and Metabolic Research = Hormon- ...
*  Metyrapone
... blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in ... This results in an increase of the steroid precursors in the pathway. Therefore, if 11-deoxycortisol levels do not rise and ... A plasma cortisol less than 220 nmol/l indicates adequate inhibition of 11β-hydroxylase. In patients with intact Hypothalamo- ...
*  List of diseases (C)
Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency Congenital adrenal hyperplasia due to 17 alpha-hydroxylase ... x-linked recessive Chondrodysplasia punctata with steroid sulfatase deficiency Chondrodysplasia punctata, brachytelephalangic ... deficiency Congenital adrenal hyperplasia due to 21-hydroxylase deficiency Congenital adrenal hyperplasia due to 3 beta- ...
*  Steroid 11beta-monooxygenase
Other names in common use include steroid 11beta-hydroxylase, steroid 11beta/18-hydroxylase, and oxygenase, steroid 11beta - ... In enzymology, a steroid 11beta-monooxygenase (EC 1.14.15.4) is an enzyme that catalyzes the chemical reaction a steroid + ... HAYANO M, DORFMAN RI (1954). "On the mechanism of the C11 beta-hydroxylation of steroids". J. Biol. Chem. 211 (1): 227-35. PMID ... GRANT JK, BROWNIE AC (1955). "The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation". Biochim. Biophys. Acta. 18 ...