Kossor DC, Kominami S, Takemori S, Colby HD (August 1991). "Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated ... via a reactive metabolite formed by 17α-hydroxylase, is a suicide inhibitor of 17α-hydroxylase, and is thought to be involved ... Pugeat MM, Dunn JF, Nisula BC (1981). "Transport of steroid hormones: interaction of 70 drugs with testosterone-binding ... A potent mineralocorticoid antagonist with reduced affinity for the 5 alpha-dihydrotestosterone receptor of human and rat ...

... steroid 16-alpha-hydroxylase MeSH D08.244.453.915.748 - steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 - steroid 21- ... steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.170.915.748 - steroid 17-alpha-hydroxylase MeSH D08.811.682.690.708.170. ... steroid 16-alpha-hydroxylase MeSH D08.811.682.690.708.783.745 - steroid 17-alpha-hydroxylase MeSH D08.811.682.690.708.783.760 ... 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D08.811.682.690.708.783.720 - steroid 11-beta-hydroxylase MeSH D08.811.682.690. ...

... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... Type XII collagen MeSH D12.776.860.300.250.600 - procollagen MeSH D12.776.860.300.250.700 - tropocollagen MeSH D12.776.860.300. ... 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D12.776.422.220.453.915.720 - steroid 11-beta-hydroxylase MeSH D12.776.422.220. ... alpha 1-antichymotrypsin MeSH D12.776.377.715.085.085 - alpha 1-antitrypsin MeSH D12.776.377.715.085.100 - alpha-macroglobulins ...

Payne AH, Hales DB (Dec 2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". ... 25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 ( ... or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. VD 1A hydroxylase is ... 25-Hydroxyvitamin+D3+1-alpha-Hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CYP27B1 ...

Zhang M, Chiang JY (2001). "Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of ... steroids and other lipids. CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy- ... 2004). "Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase ... "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome ...

17 alpha-hydroxylase and 17,20 lyase by progestins and danazol". Endocrinologia Japonica. 36 (3): 387-394. doi:10.1507/ ... "Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data". J. Steroid Biochem. Mol. ... Tamaya T, Fujimoto J, Watanabe Y, Arahori K, Okada H (1986). "Gestrinone (R2323) binding to steroid receptors in human uterine ... Raynaud JP, Bouton MM, Moguilewsky M, Ojasoo T, Philibert D, Beck G, Labrie F, Mornon JP (January 1980). "Steroid hormone ...

17-alpha-hydroxylase/17,20-lyase deficiency". The Turkish Journal of Pediatrics. 57 (3): 277-281. ISSN 2791-6421. PMID 26701948 ... also inhibits the 21-hydroxylase activity of CYP21A2". The Journal of Steroid Biochemistry and Molecular Biology. 174: 192-200 ... Steroids. 95: 80-87. doi:10.1016/j.steroids.2014.12.021. ISSN 1878-5867. PMC 4323677. PMID 25560485. Media related to CYP17A1 ... It may inhibit both of the functions of the enzyme, 17α-hydroxylase and 17,20-lyase, or may be selective for inhibition of one ...

12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, sterol ... Mechanism of oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,27-tetrol into 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta- ... Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids". J. Biol. Chem. 259 ... Okuda K, Hoshita N (1968). "Oxidation of 5-beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol by rat-liver mitochondria". Biochim ...

... or alpha-) methylacyl-CoA racemase (AMACR) deficiency; cholesterol 7 alpha-hydroxylase (CYP7A1) deficiency. The most common ... It is indicated for the treatment of inborn errors in primary bile-acid synthesis due to 3β-hydroxy-Δ5-C27-steroid ... Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the ... sterol 27-hydroxylase deficiency (presenting as cerebrotendinous xanthomatosis, CTX); 2- ( ...

... steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and disease associations". The ... The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is ... Blom AM, Webb J, Villoutreix BO, Dahlbäck B (Jul 1999). "A cluster of positively charged amino acids in the C4BP alpha-chain is ... The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma ...

The cells of the zona glomerulosa do not express 11β-hydroxylase and 17α-hydroxylase. This is the reason zona glomerulosa ... The precursor of steroids synthesized in the adrenal cortex is cholesterol that is stored in vesicles. Cholesterol can be ... 17-alpha-hydroxyprogesterone → (hydroxylation at C21) → 11-Deoxycortisol → (hydroxylation at C11) → Cortisol The adrenal cortex ... The zona reticularis has more of the cofactors required for the 17,20-lyase activity of 17α-hydroxylase than zona fasciculata. ...

In normal conditions, 21-hydroxylase has higher activity on progesterone than steroid 11β-hydroxylase (CYP11B1) and aldosterone ... Souness GW, Latif SA, Laurenzo JL, Morris DJ (April 1995). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 ... In 21-hydroxylase deficiency, progesterone and 17α-hydroxyprogesterone accumulate and are the substrates of steroid 11β- ... Syntheses of 11β-OHP from progesterone is catalyzed by the steroid 11β-hydroxylase (CYP11B1) enzyme, and, to a lesser extent, ...

17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2". Journal of Medicinal Chemistry. 43 (22): 4266-77. doi: ... "Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors". The Journal of Steroid ... a novel compound with alpha 1-adrenoceptor antagonistic and steroid 5 alpha-reductase inhibitory actions: pharmacological ... Guarna A, Occhiato EG, Danza G, Conti A, Serio M (1998). "5 alpha-reductase inhibitors, chemical and clinical models". Steroids ...

... as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells". Endocr. ... Steroid Biochem. Mol. Biol. 103 (3-5): 742-6. doi:10.1016/j.jsbmb.2006.12.014. PMID 17207994. S2CID 30600875. Nakazawa Y, ... in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney ... 34 (3): 308-12. doi:10.1038/ng1170. PMC 2832179. PMID 12778173. McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN ...

"DHEA metabolites activate estrogen receptors alpha and beta". Steroids. 78 (1): 15-25. doi:10.1016/j.steroids.2012.10.002. PMC ... steroid 7α-hydroxylase) in tissues such as the prostate gland and by CYP3A4 in the liver. The major metabolic pathway of DHEA ... Steroids. 70 (14): 970-3. doi:10.1016/j.steroids.2005.07.006. PMID 16143359. S2CID 53294855. he major metabolic pathway for ... "Increased total 7 alpha-hydroxy-dehydroepiandrosterone in serum of patients with Alzheimer's disease". J. Gerontol. A Biol. Sci ...

A. Jaworski; L. Sedlaczek; J. Dlugoński; Ewa Zajaczkowska (1985). "Inducible nature of the steroid 11-hydroxylases in spores of ... Lanosterol 14-alpha demethylase from Cunninghamella elegans on www.uniprot.org Cha, C. J.; Kim, S. J.; Kim, Y. H.; Stingley, R ... Cunninghamella elegans can be used for phenanthrene bioconversion or for steroid transformation. It has been used to produce ... C. elegans also possesses a lanosterol 14-alpha demethylase, another enzyme in the cytochrome P450 family. Cunninghamella ...

Akhtar MK, Kelly SL, Kaderbhai MA (November 2005). "Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17 ... Gonadal steroids (estrogens and androgens) generally have negative feedback effects on GnRH-1 release at the level of the ... labeled alpha- and beta- subunits) that are non-covalently associated: The alpha subunits of LH, FSH, TSH, and hCG are ... The gene for the alpha subunit is located on chromosome 6q12.21. The luteinizing hormone beta subunit gene is localized in the ...

Ayub M, Levell MJ (July 1987). "Inhibition of rat testicular 17 alpha-hydroxylase and 17,20-lyase activities by anti-androgens ... 5 alpha-dihydrotestosterone and [3H]cortisol binding to plasma proteins". J. Steroid Biochem. 33 (2): 251-5. doi:10.1016/0022- ... February 2004). "Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals". Toxicology. 195 ... 5 alpha-dihydrotestosterone and [3H]cortisol binding to plasma proteins". Journal of Steroid Biochemistry. 33 (2): 251-255. doi ...

... is the addition of a hydroxyl group of the 7th position of the steroid nucleus by the enzyme cholesterol 7 alpha-hydroxylase. ... Minor pathways initiated by 25-hydroxylase in the liver and 24-hydroxylase in the brain also may contribute to bile acid ... 7α-hydroxylase (CYP7B1) generates oxysterols, which may be further converted in the liver to CDCA. Cholic acid, 3α,7α,12α- ... Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are ...

25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans ... Schwarz M, Lund EG, Russell DW (1998). "Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis". Curr. Opin. Lipidol. 9 (2 ... Tang W, Norlin M (2006). "Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells". ... Li-Hawkins J, Lund EG, Turley SD, Russell DW (June 2000). "Disruption of the oxysterol 7alpha-hydroxylase gene in mice". J. ...

In the early 1960s, P450 was thought to be one enzyme, and by the mid 1960s it was associated with drug and steroid metabolism ... Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme ... Cholesterol 7 alpha hydroxylase consists of 491 amino acids, which on folding forms 23 alpha helices and 26 beta sheets. ... The enzyme cholesterol 7 alpha hydroxylase catalyzes the reaction that converts cholesterol into cholesterol 7 alpha ...

X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase ... Steroids. 68 (7-8): 685-91. doi:10.1016/S0039-128X(03)00100-4. PMID 12957674. S2CID 6023862. NR1H3 human gene location in the ... Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor ... peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha". Molecular and Cellular Endocrinology. 146 (1-2): ...

One study has reported the expression of a fungal 11 alpha-steroid hydroxylase from R. oryzae which can be used to perform the ... Petrič, Š.; Hakki, T.; Bernhardt, R.; Žigon, D.; Črešnar, B. (2010-11-01). "Discovery of a steroid 11α-hydroxylase from ... 11 alpha-hydroxylation of the steroid skeleton which has simplified steroid drug production.R. oryzae can produce intracellular ... Rhizopus oryzae is involved in steroid transformations and it produces 4-desmethyl steroids which has been useful in the ...

Ayub M, Levell MJ (July 1987). "Inhibition of rat testicular 17 alpha-hydroxylase and 17,20-lyase activities by anti-androgens ... "Distribution and percentages of non-protein bound contraceptive steroids in human serum". Journal of Steroid Biochemistry. 17 ( ... However, in contrast to many other steroid esters hydrolysis is not extensive, and much of the pharmacological activity is ... Laschet U, Laschet L (June 1975). "Antiandrogens in the treatment of sexual deviations of men". J. Steroid Biochem. 6 (6): 821- ...

17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer". Journal of Medicinal Chemistry. 38 ... also inhibits the 21-hydroxylase activity of CYP21A2" (PDF). The Journal of Steroid Biochemistry and Molecular Biology. 174: ... Abiraterone acetate, also known as 17-(3-pyridinyl)androsta-5,16-dien-3β-ol acetate, is a synthetic androstane steroid and a ... Potter GA, Barrie SE, Jarman M, Rowlands MG (June 1995). "Novel steroidal inhibitors of human cytochrome P45017 alpha ( ...

Zuber MX, Simpson ER, Waterman MR (December 1986). "Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in ... Schwarz S, Onken D, Schubert A (July 1999). "The steroid story of Jenapharm: from the late 1940s to the early 1970s". Steroids ... Bryan MB, Scott AP, Li W (2008). "Sex steroids and their receptors in lampreys". Steroids. 73 (1): 1-12. doi:10.1016/j.steroids ... Testosterone is a steroid from the androstane class containing a ketone and a hydroxyl group at positions three and seventeen ...

This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock ... Davies TH, Ning YM, Sánchez ER (February 2002). "A new first step in activation of steroid receptors: hormone-induced switching ... the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein". Proceedings of the National Academy ... Sanchez ER, Faber LE, Henzel WJ, Pratt WB (May 1990). "The 56-59-kilodalton protein identified in untransformed steroid ...

Steroid 21-hydroxylase (also known as steroid 21-monooxygenase, cytochrome P450C21, 21α-hydroxylase and less commonly 21β- ... Sharquie KE, Noaimi AA, Saleh BO, Anbar ZN (December 2009). "The frequency of 21-alpha hydroxylase enzyme deficiency and ... The steroid 21-hydroxylase enzyme hydroxylates steroids at the C21 position. The enzyme catalyzes the chemical reaction in ... Steroid 21-hydroxylase is a member of the cytochrome P450 family of monooxygenase enzymes that uses an iron containing heme ...

Combined 17α-hydroxylase/17,20-lyase deficiency - A condition which presents as a combination of the symptoms of congenital ... 5α-reductase deficiency (5-ARD) - An autosomal recessive condition caused by a mutation of the 5-alpha reductase type 2 gene. ... Clitoromegaly may also be caused by females using testosterone or anabolic steroids for purposes related to female to male ... Lipoid congenital adrenal hyperplasia - An endocrine disorder that arises from defects in the earliest stages of steroid ...

21-hydroxylase, 17α-hydroxylase, 11β-hydroxylase and 3β-hydroxysteroid dehydrogenase), lipoid CAH due to deficiency of StAR and ... Lifelong, continuous steroid replacement therapy is required, with regular follow-up treatment and monitoring for other health ... The subunit ACTH undergoes further cleavage to produce alpha-MSH, the most important MSH for skin pigmentation. In secondary ... Addison's disease arises from problems with the adrenal gland such that not enough of the steroid hormone cortisol and possibly ...