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*  Stem cell marker
Nemetz C, Hocke GM (March 1998). "Transcription factor Stat5 is an early marker of differentiation of murine embryonic stem ... 2005). "Leukemia inhibitory factor as an anti-apoptotic mitogen for pluripotent mouse embryonic stem cells in a serum-free ... Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ (November 1999). "Removal of LIF (leukemia inhibitory factor) results in ... March 1997). "Factors predicting morbidity following hematopoietic stem cell transplantation". Bone Marrow Transplantation. 19 ...
*  Vitamin A receptor
This is because STRA6 signaling results in activation of transcription factor STAT5 target genes. One of these target genes is ... resulting in the activation of transcription factor, STAT5. These two functions-retinol transporter and cytokine receptor-while ... This phosphorylation activates STAT5 which then makes its way to the nucleus to induce expression of target genes including ... Following the release of holo-CRBP-I from intercellular STRA6, STAT5 is recruited to STRA6 phosphorylated Y643 region where it ...
*  Janus kinase 2
Prolactin signals through JAK2 are dependent on STAT5, and on the RUSH transcription factors. Janus kinase inhibitor, medical ... because the receptors for these growth factors require JAK2 for signal transduction. An inhibitor of JAK2-STAT5, AZD1480, was ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ... Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". The Journal of ...
*  Memory T cell
... display a capacity for self-renewal due to high levels of phosphorylation of an important transcription factor known as STAT5. ...
*  PIM1
Direct binding of transcription factors STAT3 and STAT5 to the Pim-1 promoter results in the transcription of Pim-1. The Pim-1 ... Because Pim-1 transcription is initiated by STAT3 and STAT5, its production is regulated by the cytokines that regulate the ... a transcription factor believed to regulate 15% of all genes, and their synergy has been in prostate tumorigenesis. Pim-1 is ... Other known substrates/binding partners of Pim-1 include proteins involved in transcription regulation (nuclear adaptor protein ...
*  ETS2
"IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in ... Pastorcic M, Das HK (Nov 2000). "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and ... The protein encoded by this gene belongs to the ETS family of transcription factors. ETS2 has been shown to interact with: C- ... Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the ...
*  Thymic stromal lymphopoietin
After binding STAT5 phosphorylation is induced resulting in the expression of upstream transcription factors. TSLP expression ... The factors inducing the activation of TSLP release are not clearly defined. Expression of TSLP is enhanced under asthma-like ... Isaksen DE, Baumann H, Trobridge PA, Farr AG, Levin SD, Ziegler SF (December 1999). "Requirement for stat5 in thymic stromal ... The TH2 cells then release factors promoting an inflammatory reaction following the repeated contact with a specific antigen in ...
*  FOXP3
While CD4+ cells are heavily regulated and require multiple transcription factors such as STAT-5 and AhR in order to become ... Due to this, Foxp3 could no longer properly suppress the transcription factors NF-kB and NFAT; both of which are protein ... Murine studies point to IL-6 whereas human studies have shown IL-21.[citation needed] Foxp3 is the major transcription factor ... Schmidt-Weber CB, Blaser K (September 2005). "The role of the FOXP3 transcription factor in the immune regulation of allergic ...
*  KIAA1958
... was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth ...
*  Interleukin-1 family
These signaling pathways lead to activation of many transcription factors, such as NF-κB, AP-1, c-Jun N-terminal kinase (JNK) ... IL-33 in combination with some STAT5 activators, such as IL-2, IL-7 or TSLP, up-regulates expression of its own receptor on ... Its expression is induced by transcription factor NF-κB after exposure of innate immune cells to alarmins. This occurs, for ... This up-regulation is directly controlled by GATA3 transcription factor. IL-33 combined with IL-2, IL-7 or TSLP also stimulates ...
*  Erythropoietin receptor
EpoR induced Jak2-Stat5 signaling, together with transcriptional factor GATA-1, induces the transcription of pro-survival ... "Activation of the erythropoietin receptor promoter by transcription factor GATA-1". Proceedings of the National Academy of ... phosphatidylinositol 3-kinase/AKT pathway and STAT transcription factors, phosphotyrosines also serve as docking sites for ... Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle JN, Miura O (Dec 1996). "Physical and functional interactions between Stat5 ...
*  ETS1
When Ets1 interacts with other transcription factors (Runx1, Pax5, TFE3, and USF1) its final effect on transcription depends on ... AP1, STAT5 and VDR bind to C-terminal domain. Also, ETS1 has been shown to interact with TTRAP, UBE2I and Death associated ... epidermal growth factor ligands, and inflammatory mediators. Ets1 directly interacts with various transcription factors. Their ... The protein encoded by this gene belongs to the ETS family of transcription factors. There are 28 ETS genes in humans and 27 ...
*  Th 9 cells
STAT5, downstream factor of IL-2, induce TH9 cells IL-9. STAT5 directly bind to Il-9 gene promoter, although it has not yet ... STAT6 repress the expression of transcription factors T-bet and Foxp3 in TH9 cells, that normally block IL-9 production. GATA-3 ... There are numbers of cytokines, transcription factors and other molecules, that have a role in TH9 differentiation. Cytokines ... All mentioned cytokines then signal through specific transcription factors, which are later on required for a TH9 polarization ...
*  Granulocyte-macrophage colony-stimulating factor
GM-CSF signals via signal transducer and activator of transcription, STAT5. In macrophages, it has also been shown to signal ... Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric ... CFU-GM Granulocyte-macrophage colony-stimulating factor receptor Filgrastim (Neupogen, a granulocyte colony-stimulating factor ... "Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use ...
*  Janus kinase 3
STATs (signal transduction and activators of transcription) are members of a family of transcription factors, and they have src ... IL-2 and IL-4 activate JAK1, JAK3 and STAT5. JAK3 activating mutations are found in 16% of T-cell acute lymphoblastic leukemia ... Once activated, the JAKs create docking sites for the STAT transcription factors by phosphorylation of specific tyrosine ... After undergoing JAK-mediated phosphorylation, the STAT transcription factors dimerize, translocate to the nucleus, bind DNA at ...
*  Interleukin 15
STAT5, and STAT6 transcription factors are activated to elicit downstream signaling events. As a myokine, IL-15 appears to play ... Phosphorylation STATs form transcription factors and activate transcription of appropriate genes. The β chain of IL-15R ... It also activates phosphatidylinositol 3-kinase (PI3K) and AKT signaling pathway and induce expression of transcription factors ... which leads to phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5. Due to ...
*  Heat shock protein 90kDa alpha (cytosolic), member A1
These include transcription factors that initiate gene expression, kinases that transmit information by post-translationally ... In breast cancer cells the growth hormone prolactin induces HSP90AA1 expression through STAT5. NF-κB or RELA also induces ... Indeed, a recent study utilizing the LUMIER method has shown that human Hsp90B interacts with 7% of all transcription factors, ... Hsp90 is exploited by cancer cells to support activated oncoproteins, including many kinases and transcription factors. These ...
*  USF2
... and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich ... Kolonics A, Apáti A, Nahajevszky S, Gáti R, Brózik A, Magócsi M (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may ... "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, ... Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and ...
*  Glucocorticoid receptor
In the absence of activated GR, other transcription factors such as NF-κB or AP-1 themselves are able to transactivate target ... Stöcklin E, Wissler M, Gouilleux F, Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid ... However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... Chang CJ, Chen YL, Lee SC (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and ...
*  STAT3 GOF
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which is encoded by the STAT3 gene in ... SOCS3 negatively regulates STAT3 and inhibits other STAT proteins like STAT5 and STAT1. STAT5 is important for regulatory T ... STAT3 is a transcription factor that once activated, moves into the nucleus and binds to specific areas of DNA. By binding to ... This indicates that more research must be done to further understand the role that environmental or other genetic factors may ...
*  STAT5B
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 ... Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs ... Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. 273 (20 ...
*  STAT protein
Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors ... There are seven mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B ... STAT Transcription Factors at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Signal-transducer ... Originally, STAT proteins were described as latent cytoplasmic transcription factors as phosphorylation was thought to be ...
*  PDGFRB
The ETV6 gene codes for a transcription factor protein that in mice appears to be required for hematopoiesis and maintenance of ... therefore over-stimulates cell signaling pathways such as STAT5, NF-κB, and Extracellular signal-regulated kinases which ... The gene is flanked by the genes for granulocyte-macrophage colony-stimulating factor and Colony stimulating factor 1 receptor ... platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see ...
*  Erythropoietin
Constitutively synthesized transcription factors for EPO, known as hypoxia-inducible factors, are hydroxylated and ... This initiates the STAT5, PIK3 and Ras MAPK pathways. This results in differentiation, survival and proliferation of the ... Erythropoietin is the primary erythropoietic factor that cooperates with various other growth factors (e.g., IL-3, IL-6, ... Hemopoietic growth factors Jehovah's Witnesses and blood transfusions GRCh38: Ensembl release 89: ENSG00000130427 - Ensembl, ...
*  STAT5A
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... Buitenhuis M, Coffer PJ, Koenderman L (2004). "Signal transducer and activator of transcription 5 (STAT5)". Int. J. Biochem. ... "OrthoMaM phylogenetic marker: STAT5A coding sequence". Liao, Z; Lutz, J; Nevalainen, MT (February 2010). "Transcription factor ... Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 ...
*  Interferon
As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms-this contains STAT1, STAT2 and a third transcription factor ... a nuclear adaptor for STAT5 that also regulates signaling through the C3G/Rap1 pathway. Type I IFNs further activate p38 ... They described these observations in a 1959 publication, naming the responsible factor viral inhibitory factor (VIF). It took ... Other cytokines, such as interleukin 1, interleukin 2, interleukin-12, tumor necrosis factor and colony-stimulating factor, can ...