Nemetz C, Hocke GM (March 1998). "Transcription factor Stat5 is an early marker of differentiation of murine embryonic stem ... 2005). "Leukemia inhibitory factor as an anti-apoptotic mitogen for pluripotent mouse embryonic stem cells in a serum-free ... Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ (November 1999). "Removal of LIF (leukemia inhibitory factor) results in ... March 1997). "Factors predicting morbidity following hematopoietic stem cell transplantation". Bone Marrow Transplantation. 19 ...
This is because STRA6 signaling results in activation of transcription factor STAT5 target genes. One of these target genes is ... resulting in the activation of transcription factor, STAT5. These two functions-retinol transporter and cytokine receptor-while ... This phosphorylation activates STAT5 which then makes its way to the nucleus to induce expression of target genes including ... Following the release of holo-CRBP-I from intercellular STRA6, STAT5 is recruited to STRA6 phosphorylated Y643 region where it ...
After binding STAT5 phosphorylation is induced, resulting in the expression of downstream transcription factors. TSLP ... The factors inducing the activation of TSLP release are not clearly defined. Expression of TSLP is enhanced under asthma-like ... Isaksen DE, Baumann H, Trobridge PA, Farr AG, Levin SD, Ziegler SF (December 1999). "Requirement for stat5 in thymic stromal ... The TH2 cells then release factors promoting an inflammatory reaction following the repeated contact with a specific antigen in ...
"The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8". ... The Watowich laboratory turned attention to the cytokine-activated transcription factor STAT3, which has critical roles in ... as well as roles for the signal transducers STAT5 and STAT5 in erythropoiesis. ... Watowich's laboratory also revealed key roles for STAT3 and STAT5 in governing the development and function of specific ...
When Ets1 interacts with other transcription factors (Runx1, Pax5, TFE3, and USF1) its final effect on transcription depends on ... AP1, STAT5 and VDR bind to C-terminal domain. Also, ETS1 has been shown to interact with TTRAP, UBE2I and Death associated ... epidermal growth factor ligands, and inflammatory mediators. Ets1 directly interacts with various transcription factors. Their ... The protein encoded by this gene belongs to the ETS family of transcription factors. There are 28 ETS genes in humans and 27 in ...
IL-3/Receptor complex induces JAK2/STAT5 cell signalization pathway. It can stimulate transcription factor c‑myc (activation of ... Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: the ... It has been shown that combination of IL-3, GM-CSF and stem cell factor enhances peripheral blood stem cells during high-dose ... IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). This β subunit sharing ...
Transcription factors, Signal transduction). ... STAT5-STAT5, or heterodimers, STAT5-STATX, with other STAT ... Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are ... Once in the nucleus, the dimers bind to STAT5 response elements, inducing transcription of specific sets of genes. Upregulation ... Direct inhibition of STAT5 activity makes use of small molecule inhibitors that prevent STAT5 from properly binding to DNA or ...
Direct binding of transcription factors STAT3 and STAT5 to the Pim-1 promoter results in the transcription of Pim-1. The Pim-1 ... Because Pim-1 transcription is initiated by STAT3 and STAT5, its production is regulated by the cytokines that regulate the ... a transcription factor believed to regulate 15% of all genes, and their synergy has been in prostate tumorigenesis. Pim-1 is ... Other known substrates/binding partners of Pim-1 include proteins involved in transcription regulation (nuclear adaptor protein ...
EpoR induced Jak2-Stat5 signaling, together with transcriptional factor GATA-1, induces the transcription of pro-survival ... "Activation of the erythropoietin receptor promoter by transcription factor GATA-1". Proceedings of the National Academy of ... phosphatidylinositol 3-kinase/AKT pathway and STAT transcription factors, phosphotyrosines also serve as docking sites for ... Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle JN, Miura O (Dec 1996). "Physical and functional interactions between Stat5 ...
STAT5, and STAT6 transcription factors are activated to elicit downstream signaling events. IL-15 and its receptor subunit ... Phosphorylation STATs form transcription factors and activate transcription of appropriate genes. The β chain of IL-15R ... It also activates phosphatidylinositol 3-kinase (PI3K) and AKT signaling pathway and induce expression of transcription factors ... which leads to phosphorylation and activation of signal transducer and activator of transcription 3 (STAT3) and STAT5. Due to ...
This phosphorylation recruits STAT transcription factors, predominantly STAT5, which dimerize and migrate to the cell nucleus ... PLC activates 3 major transcription factors and their pathways: NFAT, NFkB and AP-1. In addition and after costimulation from ... It cooperates with other transcription factors including NFkB and Oct. NFkB is translocated to the nucleus after costimulation ... 712 The key factor was isolated from cultured mouse cells in 1979 and from cultured human cells in 1980. The gene for human IL- ...
"IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in ... Pastorcic M, Das HK (Nov 2000). "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and ... The protein encoded by this gene belongs to the ETS family of transcription factors. ETS2 has been shown to interact with: C- ... Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the ...
These signaling pathways lead to activation of many transcription factors, such as NF-κB, AP-1, c-Jun N-terminal kinase (JNK) ... IL-33 in combination with some STAT5 activators, such as IL-2, IL-7 or TSLP, up-regulates expression of its own receptor on ... Its expression is induced by transcription factor NF-κB after exposure of innate immune cells to alarmins. This occurs, for ... This up-regulation is directly controlled by GATA3 transcription factor. IL-33 combined with IL-2, IL-7 or TSLP also stimulates ...
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... Buitenhuis M, Coffer PJ, Koenderman L (2004). "Signal transducer and activator of transcription 5 (STAT5)". Int. J. Biochem. ... Liao, Z; Lutz, J; Nevalainen, MT (February 2010). "Transcription factor Stat5a/b as a therapeutic target protein for prostate ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 17, Transcription factors). ...
GM-CSF signals via signal transducer and activator of transcription, STAT5. In macrophages, it has also been shown to signal ... Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric ... Root RK, Dale DC (March 1999). "Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: ... "Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor". Medical Oncology. 31 (1): 774 ...
While CD4+ cells are heavily regulated and require multiple transcription factors such as STAT-5 and AhR in order to become ... Due to this, Foxp3 could no longer properly suppress the transcription factors NF-kB and NFAT; both of which are protein ... Murine studies point to IL-6 whereas human studies have shown IL-21.[citation needed] Foxp3 is the major transcription factor ... Schmidt-Weber CB, Blaser K (September 2005). "The role of the FOXP3 transcription factor in the immune regulation of allergic ...
STAT5, STAT1 and STAT3 and after dimerisation, they translocate to nucleus to perform transcription factor functions. All three ... Regarding JAK-STAT pathway, particular signal transducers and activators of transcription participate in this signalling ... Growth Factor Reviews. 67: 80-88. doi:10.1016/j.cytogfr.2022.06.003. PMID 35803833. Leonard WJ, Donlon TA, Lebo RV, Greene WC ( ... Growth Factor Reviews. 67: 66-79. doi:10.1016/j.cytogfr.2022.06.004. PMID 35803834. El-Maraghy N, Ghaly MS, Dessouki O, Nasef ...
"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ... Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". The Journal of ... and on the RUSH transcription factors. Janus kinase inhibitor, medical drugs under development Ruxolitinib GRCh38: Ensembl ... Fak is not required for stat-mediated transcription". The Journal of Biological Chemistry. 273 (17): 10682-9. doi:10.1074/jbc. ...
STAT5, downstream factor of IL-2, induce TH9 cells IL-9. STAT5 directly bind to Il-9 gene promoter, although it has not yet ... STAT6 repress the expression of transcription factors T-bet and Foxp3 in TH9 cells, that normally block IL-9 production. GATA-3 ... There are numbers of cytokines, transcription factors and other molecules, that have a role in TH9 differentiation. Cytokines ... All mentioned cytokines then signal through specific transcription factors, which are later on required for a TH9 polarization ...
... was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth ...
... mainly because of high level of phosphorylation on key transcription factor STAT5. In mice, TCM proved to confer more powerful ...
This family of transcription factors consists of five members: Ikaros (Ikzf1), Helios (Ikzf2), Aiolos (Ikzf3), Eos (Ikzf4), and ... Helios is also said to be part of the positive feedback loop of IL-2. It positively affects the IL-2Rα-STAT5 pathway. IL-2 ... This protein is a member of Ikaros family of transcription factors. This gene encodes a member of the Ikaros family of zinc- ... Since Ikaros family members can interact with each other, it is probable that when one transcription factor is defected, others ...
It is a positive regulator for gene transcription. It has been shown that associates with Host cell factor C1, CREB binding ... STAT5, 1, and 6 has been reported that is a major molecular signaling event activated by BCR/ABL. Some focal adhesion complex ( ... Many factors, such viruses, hereditary factors, and radiation, might have a relationship with BAL. BAL is hard to treat. ... BCR/ABL pathway could also active PI64K/Akt/STAT5 pathway which has anti-apoptotic activity. BCR/ABL induce cell adhesive and ...
STATs (signal transduction and activators of transcription) are members of a family of transcription factors, and they have src ... IL-2 and IL-4 activate JAK1, JAK3 and STAT5. JAK3 activating mutations are found in 16% of T-cell acute lymphoblastic leukemia ... Once activated, the JAKs create docking sites for the STAT transcription factors by phosphorylation of specific tyrosine ... After undergoing JAK-mediated phosphorylation, the STAT transcription factors dimerize, translocate to the nucleus, bind DNA at ...
These include transcription factors that initiate gene expression, kinases that transmit information by post-translationally ... In breast cancer cells the growth hormone prolactin induces HSP90AA1 expression through STAT5. NF-κB or RELA also induces ... Indeed, a recent study utilizing the LUMIER method has shown that human Hsp90B interacts with 7% of all transcription factors, ... Hsp90 is exploited by cancer cells to support activated oncoproteins, including many kinases and transcription factors. These ...
"O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies". ... Like many other transcription factors, STATs are capable of recruiting co-activators such as CBP and p300, and these co- ... Also, since many cytokines function through the STAT3 transcription factor, STAT3 plays a significant role in maintaining skin ... At least STAT5 requires glycosylation at threonine 92 for strong STAT5 tyrosine phosphorylation. These activated STATs form ...
... and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich ... Kolonics A, Apáti A, Nahajevszky S, Gáti R, Brózik A, Magócsi M (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may ... "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, ... Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and ...
The biological response depends on the cell type.[citation needed] In the absence of activated GR, other transcription factors ... Stöcklin E, Wissler M, Gouilleux F, Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid ... However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... Chang CJ, Chen YL, Lee SC (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and ...
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which is encoded by the STAT3 gene in ... SOCS3 negatively regulates STAT3 and inhibits other STAT proteins like STAT5 and STAT1. STAT5 is important for regulatory T ... STAT3 is a transcription factor that once activated, moves into the nucleus and binds to specific areas of DNA. By binding to ... This indicates that more research must be done to further understand the role that environmental or other genetic factors may ...
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ... Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 ... Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs ... Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. 273 (20 ...