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*  Lymphocyte cytosolic protein 2
Shim EK, Moon CS, Lee GY, Ha YJ, Chae SK, Lee JR (September 2004). "Association of the Src homology 2 domain-containing ... SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been ... Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (April 1999). "Cbl functions downstream of Src kinases in Fc ... Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (1999). "Cbl functions downstream of Src kinases in Fc gamma ...
*  SH2B3
... a C-terminal Src homology 2 (SH2) domain, a pleckstrin homology (PH) domain, and a dimerization domain. The SH2 domain spans ... an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation". Journal of ... an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation". Journal of ... This protein belongs to the Src homology 2-B (SH2B) adapter family. LNK contains 3 functional domains: ...
*  XB130
... (gene) has been known to interact with SH2 domain of Src SH3 domain of Src c-Src p85a subunit of PI3K RET/PTC GTPase- ... Two pleckstrin-homology domains are located in the middle portion, giving XB130 its lipid-binding ability. The C-terminal ... XB130 mediated c-Src binding and activation increases Interleukin-8 (IL-8), a chemokine produce by lung epithelial cells, which ... When tyrosine phosphorylated, XB130 has the ability to interact with the p85ɑ subunit of PI3K through its SH2 domains. This ...
*  MAP3K11
Zhang H, Gallo KA (2002). "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain". J. Biol. Chem. 276 (49 ... a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): ... identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene. ... This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and ...
*  SH3GLB1
A novel Src homology 3 domain-containing protein that associates with Bax". J Biol Chem. 276 (23): 20559-65. doi:10.1074/jbc. ... Masuda M, Takeda S, Sone M, Ohki T, Mori H, Kamioka Y, Mochizuki N (2006). "Endophilin BAR domain drives membrane curvature by ... "Entrez Gene: SH3GLB1 SH3-domain GRB2-like endophilin B1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ... a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222-34. doi:10.1006/geno.2000.6378. PMID ...
*  Bcl-2-associated X protein
A novel Src homology 3 domain-containing protein that associates with Bax". J. Biol. Chem. 276 (23): 20559-65. doi:10.1074/jbc. ... Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains ... These domains are composed of nine α-helices, with a hydrophobic α-helix core surrounded by amphipathic helices and a ... In the protein's inactive form, the groove binds its transmembrane domain, transitioning it from a membrane-bound to a ...
*  SHB (gene)
"Entrez Gene: SHB Src homology 2 domain containing adaptor protein B". Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore ... Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T ... Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T ... Karlsson T, Kullander K, Welsh M (Sep 1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- ...
*  Brain-derived neurotrophic factor
Fyn associates with the pICD-TrkB through its Src homology domain 2 (SH2) and is phosphorylated at its Y416 site. Once ... Iwasaki Y, Gay B, Wada K, Koizumi S (July 1998). "Association of the Src family tyrosine kinase Fyn with TrkB". Journal of ... PSD-95 localizes the actin-remodeling GTPases, Rac and Rho, to synapses through the binding of its PDZ domain to kalirin, ... BDNF can reduce capping activities by upregulating PKC, which can bind to the adducing MRCKS domain, inhibit capping activity, ...
*  Aurora B kinase
2002). "Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins". J. Biol. Chem. 277 (26): 23742-6. ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. Molecular ... Wordeman, L; Wagenbach, M; Maney, T (1999). "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic ...
*  Intersectin 1
... a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". The Journal of Biological Chemistry. 273 (47 ... Sengar AS, Wang W, Bishay J, Cohen S, Egan SE (Mar 1999). "The EH and SH3 domain Ese proteins regulate endocytosis by linking ... Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin ... Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin ...
*  ABI1
Xu J, Ziemnicka D, Merz GS, Kotula L (2001). "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis ... "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association ...
*  Neutrophil cytosolic factor 4
Leto TL, Adams AG, de Mendez I (1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline- ... a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains". Biochem. J. 296 ... The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase- ... down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. 272 (14): 9141-6. doi:10.1074/ ...
*  Neutrophil cytosolic factor 2
Leto TL, Adams AG, de Mendez I (1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline- ... 1990). "Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src". Science. 248 (4956 ... down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. 272 (14): 9141-6. doi:10.1074/ ...
*  GRB7
... and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein ... "Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7". The Journal of ... "High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains". ... "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". The ...
*  CYBB
Leto TL, Adams AG, de Mendez I (October 1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to ... Nox2 itself is composed of an N-terminal transmembrane domain that binds two heme groups, and a C-terminal domain that is able ... down-regulates NADPH oxidase activity through interactions with its SH3 domain". The Journal of Biological Chemistry. 272 (14 ...
*  EPN2
1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". J. Biol. Chem. 273 (47 ... 2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". J. Biol. Chem. ... 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 ( ... 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation ...
*  Anthony Pawson
He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 ... Moran, M. F. (1990). "Src Homology Region 2 Domains Direct Protein-Protein Interactions in Signal Transduction". Proceedings of ... Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins. Born in Maidstone, ... Pawson, T.; Nash, P. (2003). "Assembly of Cell Regulatory Systems Through Protein Interaction Domains". Science. 300 (5618): ...
*  BAIAP2
Fujiwara T, Mammoto A, Kim Y, Takai Y (2000). "Rho small G-protein-dependent binding of mDia to an Src homology 3 domain- ... whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenet Cell Genet. 84 (1-2): 75-82. doi:10.1159/000015219. ... 2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and ... 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation ...
*  RAPGEF1
It belongs to the adaptor-type Src homology (SH)2-containing molecules. Src homology 2 domains are globular protein modules ... binds to the Src homology 3 domains of CRK and GRB2/ASH proteins". Proceedings of the National Academy of Sciences of the ... sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk ... "Transformation suppressor activity of C3G is independent of its CDC25-homology domain". Oncogene. 16 (5): 613-24. doi:10.1038/ ...
*  INPPL1
Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C (2001). "The Src homology 2 domain ... Tridandapani S, Wang Y, Marsh CB, Anderson CL (2002). "Src homology 2 domain-containing inositol polyphosphate phosphatase ... src-homology domain 2) motif. INPPL1 has been shown to interact with: BCAR1, FLNC, SHC1, and SORBS1. GRCh38: Ensembl release 89 ... "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor ...
*  C10orf76
Jia CY, Nie J, Wu C, Li C, Li SS (Aug 2005). "Novel Src homology 3 domain-binding motifs identified from proteomic screen of a ... NCBI identifies a protein domain of unknown function between amino acids Asp435 and Leu671, known as DUF1741 (Domain of Unknown ... specifically via the SH3 protein binding domain. The potential SH3-binding domain exists within a low complexity region with an ... The protein coded by the largest mRNA variant of c10orf76 encodes a proline-rich motif containing two PxxP domains, where "P" ...
*  CD28
Okkenhaug K, Rottapel R (August 1998). "Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain- ... forms a high affinity-binding site for the SH2 domain of the src kinase Lck which in turn binds to the serine kinase PKC-θ. The ... Kong KF, Yokosuka T, Canonigo-Balancio AJ, Isakov N, Saito T, Altman A (Nov 2011). "A motif in the V3 domain of the kinase PKC- ... Binding of Tec to CD28 enhances IL-2 production, dependent on binding of its SH3 and PH domains to CD28 and PIP3 respectively. ...
*  BAG3
"Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochem ... "Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain ... "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in ... Hao S, August A (August 2002). "The proline rich region of the Tec homology domain of ITK regulates its activity". FEBS Lett. ...
*  PLCG1
"Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". ... "Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain ... "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in ... tandem SH2 domains, and an SH3 domain. The SH2 domains bind phosphorylated tyrosine residues on target proteins via their FLVR ...
*  PTPN6
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), ... "Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk ... N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding ... Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the ...
*  PDGFRB
Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... a transmembrane domain and an intracellular tyrosine kinase domain. The molecular mass of the mature, glycosylated PDGFRβ ... Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J (December 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic ... An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. 152 (2): 325-34. doi:10.1083/jcb. ...
*  Syk
"Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk ... These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain. However, ... Fasbender F, Claus M, Wingert S, Sandusky M, Watzl C (2017-07-07). "Differential Requirements for Src-Family Kinases in SYK or ... Sidorenko SP, Law CL, Chandran KA, Clark EA (January 1995). "Human spleen tyrosine kinase p72Syk associates with the Src-family ...