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*  PTK2
"The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases". The Journal of Biological Chemistry ... Two of these domains, the N-terminal FERM domain and the Kinase domain form an auto-inhibitory interaction. This interaction- ... The amino-terminal domains of FAK share a significant sequence similarity with the band 4.1 domain first identified in ... "Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src ...
*  G protein-coupled receptor
When the receptor is inactive, the GEF domain may be bound to an also inactive α-subunit of a heterotrimeric G-protein. These " ... Gu Q, Ding YS, Zhang TL (May 2010). "Prediction of G-protein-coupled receptor classes in low homology using Chou's pseudo amino ... Another target of c-SRC are the dynamin molecules involved in endocytosis. Dynamins polymerize around the neck of an incoming ... This is made possible by a guanine-nucleotide exchange factor (GEF) domain primarily formed by a combination of IL-2 and IL-3 ...
*  Janus kinase
The JH3-JH4 domains of JAKs share homology with Src-homology-2 (SH2) domains. The amino terminal (NH2) end (JH4-JH7) of Jaks is ... JAKs range from 120-140 kDa in size and have seven defined regions of homology called Janus homology domains 1 to 7 (JH1-7). ... This domain may be involved in regulating the activity of JH1, and was likely a duplication of the JH1 domain which has ... JH2 is a "pseudokinase domain", a domain structurally similar to a tyrosine kinase and essential for a normal kinase activity, ...
*  Enah/Vasp-like
2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin ... 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP ... via a novel carboxyl-terminal zyxin-like domain". J Biol Chem. 275 (50): 39647-53. doi:10.1074/jbc.M006316200. PMID 10993894. " ... regulates its interaction with actin and SH3 domains". J Biol Chem. 275 (46): 36143-51. doi:10.1074/jbc.M006274200. PMID ...
*  ELMO1
... domain (301-492) C-terminal pleckstrin homology domain (residues 527-674) ELMO1 also has a pro-rich motif at the extreme C ... Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (August 2002). "Identification of novel SH3 domain ligands for the Src ... The structure of the pleckstrin homology domain of ELMO1 has been determine by X-ray crystallography. The protein encoded by ... 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP ...
*  MPDZ
"Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain ... a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229-41. doi:10.1101/gad.888601. PMC 313800 . ... "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain ... Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene. MPDZ has been shown to interact with: 5- ...
*  IQGAP1
The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with ... proliferation Src PTPmu (PTPRM) complete list at Protein binding does not by itself construct an interesting story. Far more ... The WW domain is followed by 4 IQ motifs which form an IQ domain. This domain binds calmodulin, a protein known as a calcium ... A GRD (rasGAP-related domain) follows the IQ domain. This domain is highly similar to the functional subunit of Ras GTPase- ...
*  PLXNB1
"A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2 ... Src, and the phosphatidylinositol 3-kinase-Akt pathway". Molecular and Cellular Biology. 25 (16): 6889-98. doi:10.1128/mcb. ... "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. ... "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. ...
*  MAP2K7
Plenty of Src-homology-3 (POSH) has also been shown to be a partner of JIP1/2. All these JNK pathway regulators assemble ... A special extension to the C-terminal kinase domain core, the so-called "Domain for Versatile Docking" (DVD) is a region found ... These special MAPKK:MAPKKK kinase-domain/kinase-domain interactions facilitate the phosphorylation of MKK7. In addition to the ... that adds onto the back side of the catalytic core of the MAP2K kinase domains. This domain extension is both required for the ...
*  RASA3
The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with ... 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine ... 2000). "GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association". J ... is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. UNITED STATES. 270 (24 ...
*  TYRO3
Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994). "rse, a novel receptor-type tyrosine kinase with homology to ... Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (1996). "Characterization of Gas6, a member of the superfamily of G domain- ... Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky ... a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785-9. doi ...
*  Espin (protein)
2003). "Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter ... 2006). "Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells". J. Cell ...
*  SYNJ2
This article incorporates text from the United States National Library of Medicine, which is in the public domain.. ... "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle ... phosphatase activity by Src". Cell Adhesion & Migration. 6 (6): 518-25. doi:10.4161/cam.22139. PMC 3547897 . PMID 23076136. ...
*  ROCK1
... containing the Rho-binding domain, and a pleckstrin-homology domain(residues 1118-1317) with a cysteine-rich domain. When a ... Additionally, ROCK1 phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma ... Enzyme activity of ROCK1 is inhibited when the pleckstrin-homology and Rho-binding domains in the C-terminus independently bind ... These two lipids interact with the pleckstrin-homology domain, thus disrupting its ability to inhibit ROCK1. G-protein RhoE ...
*  RAR-related orphan receptor alpha
The DNA-binding domains of the DHR3 orphan receptor in Drosophila shows especially close homology within amino and carboxy ... Co-activators: SRC-1, CBP, p300, TRIP-l, TRIP-230, transcription intermediary protein-1 (TIF-1), peroxisome proliferator- ... a hinge domain, and a C-terminal ligand-binding domain. Within the ROR family, the DNA-binding domain is highly conserved, and ... The protein structure of RORα consists of four canonical functional groups: an N-terminal (A/B) domain, a DNA-binding domain ...
*  RANKL
... 's extracellular domains are similar to other TNF family members in regards to the structural homology and are able to ... Yogo K, Ishida-Kitagawa N, Takeya T (2007). "Negative autoregulation of RANKL and c-Src signaling in osteoclasts". J. Bone ... Exon 1 encoded the intracellular and transmembrane protein domains and Exon 2-5 encoded the extracellular domains. ... This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor ...
*  MDia1
Rho GTPase-binding domain/formin homology 3)domain (366 amino acids long): positions 75-440 FH1 (formin homology 1) domain (162 ... "The Rho-mDia1 Pathway Regulates Cell Polarity and Focal Adhesion Turnover in Migrating Cells through Mobilizing Apc and c-Src ... The N terminus consists of a Rho GTPase-binding domain (GBD), which is joint to the formin homology 3 (FH3). DAD can mediate ... The adjacent FH2 domain forms together with the FH2 domain of a second mDia1 molecule a head-to-tail doughnut shaped dimer that ...
*  TLN2
Vyas YM, Maniar H, Dupont B (Apr 2002). "Cutting edge: differential segregation of the SRC homology 2-containing protein ... Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH (Oct 1999). "The Talin head domain binds to integrin beta ... The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". The Journal of ... The C-terminal domain of FAK confers response to cell adhesion". The Journal of Biological Chemistry. 273 (4): 2384-9. doi: ...
*  Middle tumor antigen
... forming a protein domain called the J domain which has sequence homology to DnaJ molecular chaperone proteins. MTag and STag ... and in turn is phosphorylated by Src on tyrosine residues in the MTag C-terminus. Preference for members of the Src family ... MTag is also well known from the hamster polyomavirus, although the sequence C-terminal to the J domain has little homology ... Through its J domain, MTag can bind and activate Hsc70, a function shared with the other tumor antigens; however, MTag ...
*  PLCE1
Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T (2001). "Role of the CDC25 homology domain of phospholipase ... "Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk ...
*  DOK1
Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. ... Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are ... Songyang Z, Yamanashi Y, Liu D, Baltimore D (2001). "Domain-dependent function of the rasGAP-binding protein p62Dok in cell ...
*  Protein unc-119 homolog
Cen O, Gorska MM, Stafford SJ, Sur S, Alam R (Mar 2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine ... The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans ... 2004). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1-3 ... 2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. 278 (10): 8837-45. doi: ...
*  MPP1
Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other ... 1997). "The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. ... "Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif". Proc Natl ... Kusunoki H, Kohno T (2006). "Solution structure of human erythroid p55 PDZ domain". Proteins. 64 (3): 804-7. doi:10.1002/prot. ...
*  TAF15
Bertolotti A, Lutz Y, Heard DJ, Chambon P, Tora L (1996). "hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the ... Lee HJ, Kim S, Pelletier J, Kim J (2004). "Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src". FEBS Lett. 564 (1- ... Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ...
*  Estrogen receptor
... alpha and beta show significant overall sequence homology, and both are composed of five domains designated A ... Src). Through striatin, some of this membrane bound ER may lead to increased levels of Ca2+ and nitric oxide (NO). Through the ... The D domain is a hinge region that connects the C and E domains. The E domain contains the ligand binding cavity as well as ... The E-domain in the presence of bound ligand is able to activate gene transcription. The C-terminal F domain function is not ...
*  XB130
... (gene) has been known to interact with SH2 domain of Src SH3 domain of Src c-Src p85a subunit of PI3K RET/PTC GTPase- ... Two pleckstrin-homology domains are located in the middle portion, giving XB130 its lipid-binding ability. The C-terminal ... XB130 mediated c-Src binding and activation increases Interleukin-8 (IL-8), a chemokine produce by lung epithelial cells, which ... When tyrosine phosphorylated, XB130 has the ability to interact with the p85ɑ subunit of PI3K through its SH2 domains. This ...
*  Tumor necrosis factor alpha
The sequential and functional homology of TNF and LT led to the renaming of TNF as TNFα (this article) and LT as TNFβ. In 1985 ... This dissociation enables the adaptor protein TRADD to bind to the death domain, serving as a platform for subsequent protein ... SRC- Vav- Rac axis activates MLK2/MLK3 and these kinases phosphorylate MKK7, which then activates JNK. JNK translocates to the ... The binding of TNF to its receptor and its displacement by LT confirmed the functional homology between the two factors. ...