*  Janus kinase 2
The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) ... and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of ... homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full ... VanderKuur JA, Wang X, Zhang L, Campbell GS, Allevato G, Billestrup N, Norstedt G, Carter-Su C (August 1994). "Domains of the ...
*  Janus kinase
The JH3-JH4 domains of JAKs share homology with Src-homology-2 (SH2) domains. The amino terminal (NH2) end (JH4-JH7) of Jaks is ... JAKs range from 120-140 kDa in size and have seven defined regions of homology called Janus homology domains 1 to 7 (JH1-7). ... This domain may be involved in regulating the activity of JH1, and was likely a duplication of the JH1 domain which has ... JH2 is a "pseudokinase domain", a domain structurally similar to a tyrosine kinase and essential for a normal kinase activity, ...
*  Multiple system atrophy
2011). "Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in ...
*  Protein methylation
"Arginine Methylation Inhibits the Binding of Proline-rich Ligands to Src Homology 3, but Not WW, Domains". Journal of ... Different SET domain-containing proteins possess distinct substrate specificities. For example, SET1, SET7 and MLL methylate ... Other lysine residues on histone H3 and histone H4 are also important sites of methylation by specific SET domain-containing ... Most lysine methyltransferases contain an evolutionarily conserved SET domain, which possess S-adenosylmethionine-dependent ...
*  Cyclopentenone prostaglandins
... and Src homology 2 domain-containg protein phosphatase 2 pathways to inhibit the actions of pro-inflammatory cytokines; c) ...
*  SHC
... may refer to: Src homology 2 domain-containing, in structural biology, a structural domain in signal transduction proteins ...
*  WBP4
2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. ... WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene. This gene encodes WW domain-containing ... "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains". EMBO J. 15 ... "Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)". Takahara T, Tasic B, Maniatis T, et al. (2005). " ...
*  FNBP4
2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. ... 2000). "A novel pro-Arg motif recognized by WW domains". J. Biol. Chem. 275 (14): 10359-69. doi:10.1074/jbc.275.14.10359. PMID ... 2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of ...
*  PDGFRB
Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... a transmembrane domain and an intracellular tyrosine kinase domain. The molecular mass of the mature, glycosylated PDGFRβ ... Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J (December 1992). "The SH2 and SH3 domain-containing Nck protein is oncogenic ... An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. 152 (2): 325-34. doi:10.1083/jcb. ...
*  PAK1
Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... The core domains of the PAK family include a kinase domain in the C-terminal region, a p21-binding domain (PBD), and an auto- ... Kim YB, Shin YJ, Roy A, Kim JH (August 2015). "The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in ... PAK1 contains an autoinhibitory domain that suppresses the catalytic activity of its kinase domain. PAK1 activators relieve ...
*  PKN2
Braverman LE, Quilliam LA (1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein ... Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding ... "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding ...
*  SOS1
Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains". J. Biol ... Okada S, Pessin JE (October 1996). "Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide ... Okada S, Pessin JE (1996). "Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange ...
*  Epidermal growth factor receptor
Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... critical roles for the Dbl and pleckstrin homology domains". Molecular and Cellular Biology. 18 (2): 771-8. doi:10.1128/mcb. ... The kinase domain of EGFR can also cross-phosphorylate tyrosine residues of other receptors it is aggregated with, and can ... Tu Y, Li F, Wu C (December 1998). "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only ...
*  NCK2
Braverman LE, Quilliam LA (Feb 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein ... Braverman LE, Quilliam LA (Feb 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein ... NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three SH3 domains and one SH2 domain ... a novel C1 domain-containing protein with homology to tensin". Biochemical and Biophysical Research Communications. 299 (5): ...
*  Formins
Src homology 3) domain proteins, and WW domain proteins. The actin nucleation-promoting activity of S. cerevisiae formins has ... Another commonly found domain is an armadillo repeat region (ARR) located in the FH3 domain. The FH2 domain, has been shown by ... In addition, other domains are usually present, such as PDZ, DAD, WH2, or FHA domains. The proline-rich FH1 domain mediates ... Dia-autoregulatory domain) (DAD). The GBD domain is a bifunctional autoinhibitory domain that interacts with and is regulated ...
*  Btk-type zinc finger
... domain between the N-terminal pleckstrin homology (PH) domain and the Src homology 3 (SH3) domain. The N-terminal of the TH ... usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains ... Vihinen M, Nilsson L, Smith CI (August 1994). "Tec homology (TH) adjacent to the PH domain". FEBS Lett. 350 (2-3): 263-5. doi: ... The TH domain may be of functional importance in various signalling pathways in different species. A complete TH domain, ...
*  CD79A
... are critical for binding of Src-homology 2 domain-containing kinases such as spleen tyrosine kinase (Syk) and signal ... a single span transmembrane region and a short cytoplasmic domain. The cytoplasmic domain contains multiple phosphorylation ... The CD79a cytoplasmic domain further contains a non-ITAM tyrosine distal of the CD79a ITAM (human CD79a Tyr210, mouse CD79a ... This article incorporates text from the United States National Library of Medicine, which is in the public domain.. ...
*  Linker for Activation of T cells
Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T ... Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (1999). "Requirement of the Src homology 2 domain protein Shb for T cell ... This article incorporates text from the United States National Library of Medicine, which is in the public domain.. ... and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor ...
*  STAT5A
Linker domain (aa497-592): stabilizes DNA binding Src Homology 2 domain (aa593-685): mediates receptor-specific recruitment and ... The six functional domains and their corresponding amino acid positions are as follows: N-Terminal domain (aa1-144): stabilized ... STAT5a shares the same six functional domains as the other members of the STAT family. It contains 20 amino acids unique to its ... interacts with critical co-activators In addition to the six functional domains, specific amino acids have been identified as ...
*  RhoG
Another GEF, known as SGEF (Src homology 3 domain-containing Guanine nucleotide Exchange Factor), is thought to be RhoG- ... Booden MA, Campbell SL, Der CJ (April 2002). "Critical but distinct roles for the pleckstrin homology and cysteine-rich domains ... via its GEFD1 domain) and also on RhoA via a separate GEF domain (GEFD2). Activation of RhoG by TRIO has been shown to promote ... RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein (G protein), and is an ...
*  SH2D2A
... containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites". J Biol Chem. 273 (8): 4539-46. ... SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene. SH2D2A has been shown to interact ... "Entrez Gene: SH2D2A SH2 domain protein 2A". Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; ... Choi YB; Kim CK; Yun Y (1999). "Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell ...
*  TNS1
This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved ... 2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase- ...
*  CASK
... and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions". J. ... and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions". J. ... "Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition". Nat. Struct ... "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1". J. Biol. Chem. 275 (36): 27979- ...
*  AKT2
Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins ... "Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain". EMBO J. 20 (13): 3484-94. doi: ...
*  GRB10
... and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the ... and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the ... and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein ... 1999). "Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its ...
*  FCAR
Consequently, Src homology region 2 domain-containing phosphatase-1 (SHP-1) is recruited by Syk to the FcR γ-chain. A tyrosine ... The FcαRI α-chain consists of two extracellular domains, EC1 and EC2, at a right angle to each other, a transmembrane domain, ... The FcαRI EC1 domain binds the hinge between the IgA-Fc regions Ca2 and Ca3 regions. Signaling and the resulting cellular ... on the intracellular domain of the FcαRI α-chain. The priming of FcαRI to be able to bind IgA does not depend on FcαRI ...
*  Non-receptor tyrosine kinase
One of the protein-protein interaction domains in nRTKs are the Src homology 2 (SH2) and 3 (SH3) domains. The longer SH2 domain ... Btk/Tec subfamily of nRTKs possess another modular domain, a pleckstrin homology (PH) domain. These PH domains bind to ... Both the SH2 and SH3 domains are important for a negative regulation of Src activity. Mutations in the SH2 and SH3 domains that ... a short region with low sequence homology, SH3 and SH2 domains, a tyrosine kinase domain, and a short carboxy-terminal tail. ...