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*  Let-7 microRNA precursor
2009). "MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in ... This binding is facilitated by the conserved loop sequence of primary let-7 family members and RNA-binding domains of LIN28 ...
*  PTK2B
"Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... "Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, ... Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J (October 1996). "A role for Pyk2 and Src in linking G-protein-coupled ... and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks ...
*  DLG4
"Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... The PDZ domain which are contained in the MAGUKs in varying numbers, is replicated three times over in PSD-95. PDZ domains are ... The SH3 domain is again a protein-protein interaction domain. Its family generally bind to PXXP sites, but in MAGUKs it is ... Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like ...
*  GRIN2A
... possible involvement of Src homology 2 domains". J. Cereb. Blood Flow Metab. 19 (8): 880-8. doi:10.1097/00004647-199908000- ... "Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... Lim IA, Hall DD, Hell JW (June 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse- ... GRIN2A has been shown to interact with: DLG1 DLG3 DLG4 FYN Interleukin 16 PTK2B Src Glutamate receptor NMDA receptor GRCh38: ...
*  GAB2
... the Src homology domain-containing transforming protein 1 (SHC1), before being able to recruit SH2 domain-containing molecules ... It acts as a docking station for the Src homology 2(SH2) domain that is contained in the adaptor protein families Crk, Grb2, ... Adjacent to the PH domain is a central, proline-rich domain that contains many PXXP motifs for binding to the SH3 domains of ... Zhao C, Yu DH, Shen R, Feng GS (July 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to ...
*  HSH2D
The main feature of the protein is the SH2 (Src homology) domain, which is a region that has phosphotyrosine receptors and is ... Hematopoietic SH2 Domain Containing (HSH2D) protein is a protein encoded by the hematopoietic SH2 domain containing (HSH2D) ... This domain is located from residues 26-127. The secondary structure of the protein contains a helical section around residues ... The four paralogs of HSH2D in humans are other proteins containing SH2 domains. They do not have a high level of conservation ...
*  CD2AP
... protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain ... Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (2002). "Identification of novel SH3 domain ligands for the Src family ... protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain ... SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ...
*  ADAM12
Kang Q, Cao Y, Zolkiewska A (2001). "Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain ... "Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src". Oncogene. 19 (51 ... "Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates ... Disintegrin and metalloproteinase domain-containing protein 12 is an enzyme that in humans is encoded by the ADAM12 gene. ...
*  AKT1
This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains. It is ... The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown ... French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein ...
*  PTPN11
This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the ... domain. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the ... Zhao C, Yu DH, Shen R, Feng GS (July 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to ... Freeman RM, Plutzky J, Neel BG (December 1992). "Identification of a human Src homology 2-containing protein-tyrosine- ...
*  Signal transducing adaptor molecule
Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs ... Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs ... "Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1". Rual JF, Venkatesan K, Hao T, Hirozane- ... The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein ...
*  FCAR
Consequently, Src homology region 2 domain-containing phosphatase-1 (SHP-1) is recruited by Syk to the FcR γ-chain. A tyrosine ... The FcαRI α-chain consists of two extracellular domains, EC1 and EC2, at a right angle to each other, a transmembrane domain, ... The FcαRI EC1 domain binds the hinge between the IgA-Fc regions Ca2 and Ca3 regions. Signaling and the resulting cellular ... on the intracellular domain of the FcαRI α-chain. The priming of FcαRI to be able to bind IgA does not depend on FcαRI ...
*  MTA1
The C-terminal divergent region of MTA1 has an Src homology 3-binding domain, acidic regions, and nuclear localization signals ... The conserved domains of MTA1 include a BAH (Bromo-Adjacent Homology), a ELM2 (egl-27 and MTA1 homology), a SANT (SWI, ADA2, N- ... The presence of these domains revealed the role of MTA1 in interactions with modified or unmodified histone and non-histone ... The structural insights of MTA1 domains are deduced from studies involving complexes with HDAC1 or RbAp48 subunits of the NuRD ...
*  STAMBP
Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs ... The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role ... Maytal-Kivity V, Reis N, Hofmann K, Glickman MH (2006). "MPN+, a putative catalytic motif found in a subset of MPN domain ... One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. ...
*  SPTAN1
Nedrelow JH, Cianci CD, Morrow JS (Feb 2003). "c-Src binds alpha II spectrin's Src homology 3 (SH3) domain and blocks calpain ... "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association ... Bennett PM, Maggs AM, Baines AJ, Pinder JC (Apr 2006). "The transitional junction: a new functional subcellular domain at the ... Hirai H, Matsuda S (September 1999). "Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the ...
*  ABL (gene)
Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is ... "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association ... Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... Warmuth M, Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M (December 1997). "The Src family kinase Hck interacts with ...
*  Spectrin, alpha 1
"Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association ...
*  LASP1
This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region ... LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene. ... "Entrez Gene: LASP1 LIM and SH3 protein 1". Li, Bo; Zhuang Lei; Trueb Beat (May 2004). "Zyxin interacts with the SH3 domains of ... Li B, Zhuang L, Trueb B (2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J ...
*  SORBS2
Wang B, Golemis EA, Kruh GD (Jul 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is ... and the sorbin homology (SoHo) domain is N-terminal. The SH3 domains interact with Arg/Abl, vinculin. The SOHO domain interacts ... a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and ... ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains and three SH3 domains, which ...
*  ABL2
Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is ... Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is ... SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans. ... The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 ...
*  MiR-155
"Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B ... "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B ...
*  SH2B2
... an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in ... an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in ... The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) ... Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange ...
*  ARAF
"Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of ... In addition, the A-Raf protein has amino acid substitutions in a negatively charged region upstream of the kinase domain (N- ... Fang Y, Johnson LM, Mahon ES, Anderson DH (2002). "Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf ...
*  Signal transducing adaptor protein
SH2 domain containing 3A SH2D3C - SH2 domain containing 3C SHB - Src homology 2 domain containing adaptor protein B SLC4A1AP - ... Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) that allow ... SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains ... There are many other types of interaction domains found within adaptor and other signalling proteins that allow a rich ...
*  ABI gene family member 3
Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) ... domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished ...
*  Drebrin-like
Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein ... Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (1999). "A novel src homology 3 domain-containing adaptor protein, ... Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH (Dec 2003). "The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal ... Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH (2004). "The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal ...
*  Akt/PKB signaling pathway
The regulatory subunit p85 binds to phosphorylated tyrosine residues on the activated receptor via its Src homology 2 (SH2) ... binding to pleckstrin homology domains". Proc. Natl. Acad. Sci. USA. 107 (46): 20126-20131. doi:10.1073/pnas.1004522107. PMC ... where they can directly bind intracellular proteins containing a pleckstrin homology (PH) or FYVE domain. For example, the ... "IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to ...