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*  Src homology domain
Homologs of both the Src homology 2 and Src homology 3 domains are found in numerous other proteins. The Src homology 1 domain ... In biology, a Src homology domain is one of the two small protein binding domains found in the Src oncoprotein. ... In terms of initiating the cell cycle when growth factor signals are present, "Src homology domains" are found on Grb2 proteins ... was an early name of the protein kinase domain. ...
*  NPHP1
This gene encodes a protein with src homology domain 3 (SH3) patterns. Mutations in this gene cause familial juvenile ... "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile ... Donaldson JC, Dise RS, Ritchie MD, Hanks SK (Aug 2002). "Nephrocystin-conserved domains involved in targeting to epithelial ... Donaldson JC, Dise RS, Ritchie MD, Hanks SK (Aug 2002). "Nephrocystin-conserved domains involved in targeting to epithelial ...
*  SLC9A2
Binding of Src homology domain 3 and role in apical targeting in epithelia". J. Biol. Chem. 274 (15): 10481-8. doi:10.1074/jbc. ...
*  CISH
"Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes". ... The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced ...
*  WBP11
Src homology domain 3) domains. The C-terminal proline-rich sequences of SNP70/NpwBP/Wbp11, which binds to the WW domain of ... and more weakly to the SH3 domains from c-src and p85α. p47phox. Furthermore, it has been shown to interact with PP1(protein ... Wbp11 was found to bind strongly to the tandem SH3 domains of p47phox and to the N-terminal SH3 domain of p47phox, ... WW domain binding protein 11 (WBP11) Npw38-binding protein (NpwBP) Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1) ...
*  HNRPK
Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ (1996). "Identification of Itk/Tsk Src homology 3 domain ... "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains". Mol. Cell. Biol. 14 (7 ... The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is ... Baber JL, Libutti D, Levens D, Tjandra N (1999). "High precision solution structure of the C-terminal KH domain of ...
*  FYN
... possible involvement of Src homology 2 domains". J. Cereb. Blood Flow Metab. 19 (8): 880-8. doi:10.1097/00004647-199908000- ... "The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases". J. Biol. Chem. 276 (20): 17199-205. ... "Identification of Itk/Tsk Src homology 3 domain ligands". J. Biol. Chem. 271 (41): 25646-56. doi:10.1074/jbc.271.41.25646. PMID ... "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Mol. Cell. Biol. 15 (10): 5725 ...
*  ITK (gene)
Src homology 3) SH2 - (Src homology 2) C-terminus - tyrosine kinase, catalytic domain ITK (gene) has been shown to interact ... pleckstrin homology domain) TH - Tec family homology domain (including Bruton's tyrosine kinase Cys-rich motif and Proline rich ... Shim EK, Moon CS, Lee GY, Ha YJ, Chae SK, Lee JR (2004). "Association of the Src homology 2 domain-containing leukocyte ... Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ (1996). "Identification of Itk/Tsk Src homology 3 domain ...
*  Wiskott-Aldrich syndrome protein
"Identification of Itk/Tsk Src homology 3 domain ligands". The Journal of Biological Chemistry. 271 (41): 25646-56. doi:10.1074/ ... "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology ... a C-terminal VCA domain and central B and GBD (GTP binding domain) domains. WASp, is expressed exclusively in hematopoietic ... of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The ...
*  KHDRBS1
1996). "Identification of Itk/Tsk Src homology 3 domain ligands". J. Biol. Chem. 271 (41): 25646-56. doi:10.1074/jbc.271.41. ... 1994). "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains". Mol. Cell. Biol ... Sam68 (the Src-Associated substrate in Mitosis of 68 kDa) is officially called KHDRBS1 (KH domain containing, RNA binding, ... This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The ...
*  Amphiphysin
"Specificity of the binding of synapsin I to Src homology 3 domains". The Journal of Biological Chemistry. 275 (38): 29857-67. ... a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be ... "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding ... "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding ...
*  VAV1
Ye ZS, Baltimore D (1995). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proc. Natl. Acad. Sci. U.S. ... Ye ZS, Baltimore D (Dec 1994). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proc. Natl. Acad. Sci. ... "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619- ... Katzav S, Cleveland JL, Heslop HE, Pulido D (1991). "Loss of the amino-terminal helix-loop-helix domain of the vav proto- ...
*  GRB2
"5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and ... Okkenhaug K, Rottapel R (Aug 1998). "Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline ... Ye ZS, Baltimore D (Dec 1994). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proceedings of the ... Braverman LE, Quilliam LA (Feb 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein ...
*  Neutrophil cytosolic factor 1
Leto TL, Adams AG, de Mendez I (1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline- ... "Specificity of the binding of synapsin I to Src homology 3 domains". J. Biol. Chem. 275 (38): 29857-67. doi:10.1074/jbc. ... Finan PM, Hall A, Kellie S (1996). "Sam68 from an immortalised B-cell line associates with a subset of SH3 domains". FEBS Lett ... bind to moesin through their PX domain". Biochem. Biophys. Res. Commun. 289 (2): 382-8. doi:10.1006/bbrc.2001.5982. PMID ...
*  SAM domain, SH3 domain and nuclear localization signals 1
von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S (2011). "Immunoinhibitory adapter protein Src homology domain 3 ... SAM domain, SH3 domain and nuclear localization signals 1 is a protein that in humans is encoded by the SAMSN1 gene. SAMSN1 is ... SAM domain, SH3 domain and nuclear localization signals 1". Retrieved 2017-09-28. Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, ... This article incorporates text from the United States National Library of Medicine, which is in the public domain.. ...
*  SH2 domain
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many ... SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains ... One of the more prominent domains is the SH2 domain. SH2 domains play a vital role in cellular communication. Its length is ... "Defining the specificity space of the human SRC homology 2 domain". Molecular & Cellular Proteomics. 7 (4): 768-84. doi:10.1074 ...
*  NEDD9
Alexandropoulos K, Cheng G, Baltimore D (1995). "Proline-rich sequences that bind to Src homology 3 domains with individual ... This allows SRC or SRC family kinase to bind NEDD9 via its SH2 domain. Phosphorylation of the NEDD9 substrate domain by Src and ... "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)". J. ... which contains a Src homology 3 domain and associates with Fyn". Oncogene. 11 (11): 2331-8. PMID 8570184. ...
*  FGR (gene)
"Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology ... of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The ... a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine- ... This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for ...
*  NCK1
Shim EK, Moon CS, Lee GY, Ha YJ, Chae SK, Lee JR (September 2004). "Association of the Src homology 2 domain-containing ... Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter ... "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Mol. Cell. Biol. 15 (10): 5725 ... "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Mol. Cell. Biol. 15 (10): 5725 ...
*  DNM1
1994). "Association of Ash/Grb-2 with dynamin through the Src homology 3 domain". J. Biol. Chem. 269 (8): 5489-92. PMID 8119878 ... binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain". Proc. Natl. Acad. Sci. U.S.A. 94 (16): ... "Association of Ash/Grb-2 with dynamin through the Src homology 3 domain". J. Biol. Chem. 269 (8): 5489-92. PMID 8119878. Sastry ... 1997). "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding ...
*  Arachidonate 5-lipoxygenase
"5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and ... and Dicer protein A PLAT domain within its C2-like domain; this domain, by analogy to other PLAT domain-bearing proteins, may ... VanderNoot VA, Fitzpatrick FA (1995). "Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase ... Structurally, ALOX5 possesses: A C-terminal catalytic domain (residues 126-673) An N-terminal C2-like domain which promotes its ...
*  USO1
"Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular ... membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains ...
*  Aurora A kinase
Gigoux V, L'Hoste S, Raynaud F, Camonis J, Garbay C (2002). "Identification of Aurora kinases as RasGAP Src homology 3 domain- ... The family members have highly conserved C-terminal catalytic domains. Their N-terminal domains, however, exhibit a large ...
*  SHC3
1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is ... "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3". Nakamura, Takeshi; Komiya Misako; Sone ... 2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene. 24 (19): 3206-15. doi:10.1038/sj. ... Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. UNITED STATES ...
*  SHC2
"Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2". Warner, A J; Lopez-Dee J; Knight E L; ... Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960-7 ... SHC2 has been shown to interact with Kinase insert domain receptor. GRCh38: Ensembl release 89: ENSG00000129946 - Ensembl, May ... "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862-5. doi:10.1126/science. ...
*  Proto-oncogene tyrosine-protein kinase Src
c-Src is made up of 6 functional regions: Src homology (SH) 4 domain (SH4 domain), unique region, SH3 domain, SH2 domain, ... c-Src includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. c-Src stands for "cellular Src kinase" and should ... Thus, c-Src plays a key role in the tumor progression of breast cancers. Members of the Src family kinases Src, Lyn and Fgr are ... EGFR activates c-Src while EGF also increases the activity of c-Src. In addition, overexpression of c-Src increases the ...