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*  Src family kinase
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the ... a tyrosine kinase domain, and C-terminal tail. Src family kinases interact with many cellular cytosolic, nuclear and membrane ... Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker ... Zhang S, Yu D (March 2012). "Targeting Src family kinases in anti-cancer therapies: turning promise into triumph". Trends in ...
*  Proto-oncogene tyrosine-protein kinase Src
It belongs to a family of non-receptor tyrosine kinases called Src family kinases. This gene is similar to the v-Src gene of ... and a tyrosine kinase domain. c-Src stands for "cellular Src kinase" and should not be confused with "C-terminal Src kinase" ( ... Thus, c-Src plays a key role in the tumor progression of breast cancers. Members of the Src family kinases Src, Lyn and Fgr are ... src Gene at the US National Library of Medicine Medical Subject Headings (MeSH) src-Family Kinases at the US National Library ...
*  Oncogene
Thomas SM, Brugge JS (1 November 1997). "Cellular functions regulated by Src family kinases". Annual Review of Cell and ... Downstream effectors of Ras include three mitogen-activated protein kinases Raf a MAP Kinase Kinase Kinase (MAPKKK), MEK a MAP ... Summy JM, Gallick GE (December 2003). "Src family kinases in tumor progression and metastasis". Cancer Metastasis Reviews. 22 ( ... Receptor tyrosine kinases add phosphate groups to other proteins to turn them on or off. Receptor kinases add phosphate groups ...
*  Endostatin
Thomas, S.M.; Brugge, J.S. (1997). "Cellular functions regulated by Src family kinases". Annu. Rev. Cell Dev. Biol. 13: 513-609 ... Tatosyan, A.G; Mizenina, O.A. (2000). "Kinases of the Src family: structure and functions". Biochemistry. 65 (1): 49-58. PMID ... clustering of integrins causes co-localization with caveolin-1 and activates non-receptor tyrosine kinases of the Src family ... By binding integrin α5β1 on endothelia cells it inhibits the signaling pathways of Ras and Raf kinases and decreases ERK-1 and ...
*  FYN
... is a member of the Src-family of kinases (SFK), the first proto-oncogene to be identified. The discovery of the Src-family ... This family also includes Abl, Src, focal adhesion kinase and Janus kinase.) Fyn is located downstream of several cell surface ... pharmacologic inhibitors of Src family kinases, such as PP2; note that PP2 also inhibits other tyrosine protein kinases such as ... "The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases". J. Biol. Chem. 276 (20): 17199-205. ...
*  Lck
It is a member of the Src family of tyrosine kinases. Lck is most commonly found in T cells. It associates with the cytoplasmic ... Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B (Feb 2003). "The influence of the src-family kinases, Lck and Fyn ... Palacios EH, Weiss A (Oct 2004). "Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation". ... 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase". ...
*  LYN
The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family. ... Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are ... "Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein". Proceedings ... Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene. Lyn is a member of the Src family ...
*  MAP2K7
Nihalani D, Wong H, Verma R, Holzman LB (April 2007). "Src family kinases directly regulate JIP1 module dynamics and activation ... Stress-activated protein kinase kinase 4 (SAPK kinase 4, SAPKK4) c-Jun N-terminal kinase kinase 2 (JNK kinase 2, JNKK2) Stress- ... Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in ... and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, ...
*  NMDA receptor
Reelin modulates NMDA function through Src family kinases and DAB1. significantly enhancing LTP in the hippocampus. Src kinase ... Yu XM, Askalan R, Keil GJ, Salter MW (January 1997). "NMDA channel regulation by channel-associated protein tyrosine kinase Src ... A related gene family of NR3 A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoforms with ... Neuroscience portal Calcium/calmodulin-dependent protein kinases Laube B, Hirai H, Sturgess M, Betz H, Kuhse J (1997). " ...
*  Lipid raft
Csk may then suppress the Src-family kinases through phosphorylation. B cell antigen receptor (BCR) is a complex between a ... After that, Syk family tyrosine kinases bind these phosphotyrosine residues of ITAMs to initiate the signaling cascade. Syk can ... This crosslinking, similar to IgE signaling, then recruit doubly acylated non-receptor Src-like tyrosine kinases to ... This crosslinking then recruits doubly acylated non-receptor Src-like tyrosine kinase Lyn to phosphorylate ITAMs. ...
*  Nephrin
"Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases". Kidney Int. 64 (2): 404-13. doi:10.1046/j.1523- ...
*  Formins
... and Src family kinases". The Journal of Biological Chemistry. 271 (52): 33525-30. doi:10.1074/jbc.271.52.33525. PMID 8969217. ... Kitayama C, Uyeda TQ (February 2003). "ForC, a novel type of formin family protein lacking an FH1 domain, is involved in ... Chalkia D, Nikolaidis N, Makalowski W, Klein J, Nei M (December 2008). "Origins and evolution of the formin multigene family ... Src homology 3) domain proteins, and WW domain proteins. The actin nucleation-promoting activity of S. cerevisiae formins has ...
*  Owen Witte
February 9, 1996). "Activation of Btk by a phosphorylation mechanism initiated by src family kinases". Science. 271 (5250): 822 ... His discovery of the tyrosine kinase activity in the ABL1 protein and the demonstration of the BCR-ABL oncoproteins in ... Witte also co-discovered the gene for Bruton's tyrosine kinase, a protein essential for normal B-lymphocyte development that, ... David Baltimore (MIT; 1976 to 1980). 1990 Milken Family Medical Foundation Award in Basic Cancer Research 1991 Richard and ...
*  CD2AP
"Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP- ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ...
*  TEC (gene)
Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are ... "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822-5. doi:10.1126/ ... Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, ... Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity. 12 (4): ...
*  SKAP2
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated ... "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2". Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, ... Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene. ... "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): ...
*  Tyrosine-protein kinase CSK
"C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases". ... CSK acts by suppressing the activity of the Src family of protein kinases by phosphorylation of Src family members at a ... "C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family ... This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN ...
*  IRF2BPL
"Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP- ...
*  MED28
Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V (Sep 2006). "Magicin associates with the Src-family kinases and is ... Lu M, Zhang L, Sartippour MR, Norris AJ, Brooks MN (Oct 2006). "EG-1 interacts with c-Src and activates its signaling pathway ...
*  Interleukin-7 receptor-α
Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7". J. Immunol. 153 (1): 97-109. ... Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 ...
*  Megakaryocyte-associated tyrosine kinase
1992). "CSK: a protein-tyrosine kinase involved in regulation of src family kinases". J. Biol. Chem. 266 (36): 24249-52. PMID ... It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell ... 1994). "Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes". Oncogene. 9 (7 ... 1994). "Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)". ...
*  DAB1
... function depends on its tyrosine phosphorylation by Src family kinases, especially Fyn. Dab encodes a phosphoprotein that ... These findings established novel signaling functions for the LDL receptor gene family and suggested that VLDLR and APOER2 ... binds nonreceptor tyrosine kinases and that has been implicated in neuronal development in flies. Sheldon et al. (1997) found ...
*  PTPRA
This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of ... Harder KW, Moller NP, Peacock JW, Jirik FR (1998). "Protein-tyrosine phosphatase alpha regulates Src family kinases and alters ... Somani AK, Bignon JS, Mills GB, Siminovitch KA, Branch DR (1997). "Src kinase activity is regulated by the SHP-1 protein- ... Stover DR, Furet P, Lydon NB (1996). "Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine ...
*  DDEF1
2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP ... DDEF1 has been shown to interact with Src. GRCh38: Ensembl release 89: ENSG00000153317 - Ensembl, May 2017 GRCm38: Ensembl ... 2006). "Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast ... 2002). "The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes ...
*  Enah/Vasp-like
2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP ... Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene. GRCh38: Ensembl ... "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 ... that shows high expression in the neonatal brain revealed a member of Ena/VASP family". Biochem. Biophys. Res. Commun. 237 (2 ...
*  Rocky Mountain spotted fever
CDC42, protein tyrosine kinase, phosphoinositide 3-kinase, and Src-family kinases then activate Arp2/3. This causes the ... Both rOmpA and rOmpB are members of a family of surface cell antigens (Sca) which are autotransporter proteins; they act as ...