The squalene-hopene cyclase (SHC) catalyzes cyclization of squalene into the monocyclic 3-deoxyachilleol A. Tetraprenyl-beta- ... Ambrein is synthesized from common triterpenoid precursor squalene. ...

Detailed explanation of the mechanism of squalene epoxidase inhibition by terbinafine and elucidation of a fully atomic three- ... February 2011). "Detailed mechanism of squalene epoxidase inhibition by terbinafine". Journal of Chemical Information and ...

Two molecules of farnesyl pyrophosphate then condense to form squalene by the action of squalene synthase in the endoplasmic ... Oxidosqualene cyclase then cyclizes squalene to form lanosterol. Finally, lanosterol is converted to cholesterol via either of ...

Squalene epoxidase contributes to the formation of ergosterol. Terbinafine inhibits squalene epoxidase thereby preventing cell ...

AS03, another squalene based adjuvant O'Hagan, Derek T; Ott, Gary S; Nest, Gary Van; Rappuoli, Rino; Giudice, Giuseppe Del ( ... MF59 is an immunologic adjuvant that uses squalene. It is Novartis' proprietary adjuvant that is added to influenza vaccines to ...

Daly, M.M. (May 1971). "Biosynthesis of squalene and sterols by rat aorta". Journal of Lipid Research. 12 (3): 367-375. doi: ...

This compound, classified as a member of the hopanoid family, is synthesized from triterpenoid precursor squalene. It is ... The proposed biosynthesis of diplopterol involves a cascade cyclization of terpenoid precursor squalene by the enzyme hopane- ... Shinozaki, Junichi; Shibuya, Masaaki; Masuda, Kazuo; Ebizuka, Yutaka (2008). "Squalene cyclase and oxidosqualene cyclase from a ... squalene cyclase. This highly efficient reaction forms nine stereogenic centers and five rings simultaneously. The oxygen atom ...

Cycloartenol, betulin and squalene are triterpenoids purified from hardwood. Examples of wood polyterpenes are rubber (cis- ...

The precursor for the biosynthesis of taraxasterol is squalene. In the first step of this formation squalene is cyclized with ... molecular oxygen, FAD, and NADPH via the enzyme squalene epoxidase a flavoprotein to yield (2S)-2,3-oxidosqualene. In the ...

... (EC 5.4.99.37) is an enzyme with systematic name squalene mutase (cyclizing, dammara-20,24-diene-forming ... a squalene cyclase, from Dryopteris crassirhizoma Nakai". Phytochemistry. 69 (14): 2559-64. Bibcode:2008PChem..69.2559S. doi: ... This enzyme catalyses the following chemical reaction: squalene ⇌ {\displaystyle \rightleftharpoons } dammara-20,24-diene ...

A recent study on the metabolomics of Camellia japonica leaf revealed that lupeol is produced from squalene epoxide where ... Lupeol is produced by several organisms from squalene epoxide. Dammarane and baccharane skeletons are formed as intermediates. ... squalene play the role as a precursor. Lupeol has a complex pharmacology, displaying antiprotozoal, antimicrobial, ...

Squalene monooxygenase in the next step oxidases the squalene and forms an epoxide resulting in 2,3-oxidosqualene. Beta-amyrin ... Oleanolic acid biosynthesis starts with mevalonate to create squalene. ...

Squalene, a triterpene and universal precursor to natural steroids. Although the nomenclature is not followed widely, according ...

The biosynthesis of cycloartenol starts from the triterpenoid squalene. It is the first precursor in the biosynthesis of other ...

It belongs to squalene/phytoene synthase family of proteins. Phytoene synthase Gregonis DE, Rilling HC (March 1974). "The ...

The large, squalene-rich liver of this shark allows it to maintain neutral buoyancy and hover with minimal effort; males ... It is mainly valued for its liver, which contains 22-49% squalene by weight and is processed for vitamins. The meat may also be ... contain more squalene in their livers than females. A tracking study in the Porcupine Seabight has found that the Portuguese ...

The linear triterpene squalene, the major constituent of shark liver oil, is derived from the reductive coupling of two ... Squalene, a triterpene and universal precursor to natural steroids. Geosmin is a sesquiterpenoid. Terpenes may be classified by ... Squalene is then processed biosynthetically to generate either lanosterol or cycloartenol, the structural precursors to all the ... Steroids, for example, are derivatives of the triterpene squalene. Terpenes and terpenoids are also the primary constituents of ...

There are high levels of squalene in this catshark's liver. The reproduction of this catshark is oviparous. Rigby, C.L.; Walls ...

Abe, Ikuro.; Rohmer, Michel.; Prestwich, Glenn D. (1 September 1993). "Enzymatic cyclization of squalene and oxidosqualene to ... an Intermediate in the Biological Synthesis of Sterols from Squalene". Journal of the American Chemical Society. 88 (20): 4750- ...

Triterpenoids commonly purified from hardwoods include cycloartenol, betulin and squalene. Hardwood polyterpenes are rubber, ...

... catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic ... Do R, Kiss RS, Gaudet D, Engert JC (January 2009). "Squalene synthase: a critical enzyme in the cholesterol biosynthesis ... Ness GC, Zhao Z, Keller RK (June 1994). "Effect of squalene synthase inhibition on the expression of hepatic cholesterol ... Zaragozic acids are potent inhibitors of S. cervisiae, fungal and mammalian squalene synthase and therefore inhibitors of ...

They both inhibit the enzyme squalene-epoxidase, which converts squalene to lanosterol, the raw material for producing ... They inhibit the enzyme squalene epoxidase which converts squalene into ergosterol. This inhibition results in decreased ... allylamines disrupt the fungal cell wall synthesis through inhibition of the squalene epoxidase enzyme that converts squalene ...

Squalene leads to the creation of lanosterol, from which there are multiple pathways that lead to cholesterol biosynthesis. The ... The combination of two FPP leads to the formation of squalene; this represents the first committed step towards cholesterol ...

Wasko BM, Smits JP, Shull LW, Wiemer DF, Hohl RJ (2011). "A novel bisphosphonate inhibitor of squalene synthase combined with a ... Data from knockout mouse studies suggests that accumulation of high levels of the metabolic substrate of squalene synthase and ... 2015). "Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver". J Lipid ... Davidson MH (January 2007). "Squalene synthase inhibition: a novel target for the management of dyslipidemia". Curr Atheroscler ...

Sobel, Harry; Marmorston, Jessie (1956-07-01). "The Possible Role of Squalene as a Protective Agent in Sebum". Cancer Research ... "The Possible Role of Squalene as a Protective Agent in Sebum" (1956, with Harry Sobel) "Effects of Long-Term Estrogen Therapy ...

Cholesterol is bio-synthesised from mevalonate via a squalene cyclisation of terpenoids. Cell membranes require high levels of ...

Yue Jiang; King-Wai Fan; Raymond Tsz-Yeung Wong & Feng Chen (2004). "Fatty acid composition and squalene content of the marine ...

Other compounds found in stomach oil include glycerol ethers, pristane and squalene. Stomach oil has low viscosity and will ...

Furthermore, inhibition of squalene epoxidase leads to a toxic buildup of squalene. This double action of butenafine (increased ... Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, ... membrane permeability and toxic buildup of squalene) makes butenafine fungicidal rather than merely fungistatic. In addition to ...

ISBN 978-0-87893-243-6. Weschler CJ, Langer S, Fischer A, Bekö G, Toftum J, Clausen G (May 2011). "Squalene and cholesterol in ...