The canonical squalene monooxygenase is a flavoprotein monooxygenase. Flavoprotein monooxygenase form flavin hydroperoxides at ... Squalene monooxygenase differs from other flavin monooxygenases in that the oxygen is inserted into the substrate as an epoxide ... Squalene monooxygenase (also called squalene epoxidase) is a eukaryotic enzyme that uses NADPH and diatomic oxygen to oxidize ... In humans, squalene epoxidase is encoded by the SQLE gene. Several eukaryote genomes lack a squalene monooxygenase encoding ...

It is formed when squalene is oxidized by the enzyme squalene monooxygenase. 2,3-Oxidosqualene is the substrate of various ...

Mokashi V, Singh DK, Porter TD (2004). "Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is ... The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in metabolism of cholesterol. GRCh38: ... "Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase". J. Biol. ... which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol ...

This is then further oxygenated by the squalene monooxygenase (ERG1) to squalene 2,3-epoxide. This is cyclized to lupeol by the ... Acetyl-CoA is converted to squalene through use of the 3-hydroxyl-3-methylglutaryl-CoA reductase (HMGR) and the bifunctional ... Saccharomyces cerevisiae has been engineered to produce betulinic acid from the mevalonate pathway, with squalene 2,3-epoxide ... lupeol is converted to betulinic acid through the Catharanthus roseus P450 monooxygenase (CrAO) with the oxidation of NADPH to ...

Squalene monooxygenase in the next step oxidases the squalene and forms an epoxide resulting in 2,3-oxidosqualene. Beta-amyrin ... Oleanolic acid biosynthesis starts with mevalonate to create squalene. ...

For sterols, the squalene conversion begins with oxidation (via squalene monooxygenase) of one of its terminal double bonds, ... Squalene has a role in topical skin lubrication and protection. Most plants, fungi, and animals produce squalene as biochemical ... Squalene is an organic compound. It is a triterpenoid with the formula C30H50. It is a colourless oil, although impure samples ... Squalene is not itself an adjuvant, but it has been used in conjunction with surfactants in certain adjuvant formulations. An ...

... monooxygenase EC 1.14.14.16: steroid 21-monooxygenase EC 1.14.14.17: squalene monooxygenase EC 1.14.14.18: heme oxygenase ( ... EC 1.14.15.3: alkane 1-monooxygenase EC 1.14.15.4: steroid 11β-monooxygenase EC 1.14.15.5: corticosterone 18-monooxygenase EC ... squalene monooxygenase EC 1.14.99.8: Now included with EC 1.14.14.1 unspecific monooxygenase EC 1.14.99.9: Now classified as EC ... dimethyl-sulfide monooxygenase EC 1.14.13.132: Now EC 1.14.14.17, squalene monooxygenase EC 1.14.13.133: Now EC 1.14.15.32, ...

... squalene monooxygenase MeSH D08.811.682.690.708.783 - steroid hydroxylases MeSH D08.811.682.690.708.783.050 - aldosterone ... camphor 5-monooxygenase MeSH D08.811.682.690.708.170.500 - alkane 1-monooxygenase MeSH D08.811.682.690.708.170.915 - steroid ... 4-hydroxybenzoate 3-monooxygenase MeSH D08.811.682.690.708.557 - kynurenine 3-monooxygenase MeSH D08.811.682.690.708.601 - ... trans-cinnamate 4-monooxygenase MeSH D08.622.509.700 - pepsinogen a MeSH D08.622.509.725 - pepsinogen c MeSH D08.622.610.500 - ...

... which reacts with squalene in a reaction catalyzed by squalene monooxygenase during sterol biosynthesis. Furthermore, squalene ... Next, a squalene-hopene cyclase catalyzes an elaborate cyclization reaction, engaging squalene in an energetically favorable ... before oxidizing NADPH to release squalene. However, some hopanoid-producing bacteria lack squalene synthase and instead use ... Squalene-hopene cyclase mutants derived from a wild type capable of multidrug efflux, a drug-resistance mechanism mediated by ...

Determination of protein effects of the O2 molecule binding to the active site of methane monooxygenase. Discovery of frequent ... Detailed explanation of the mechanism of squalene epoxidase inhibition by terbinafine and elucidation of a fully atomic three- ... February 2011). "Detailed mechanism of squalene epoxidase inhibition by terbinafine". Journal of Chemical Information and ... "Protein effects on the O2 binding to the active site of the methane monooxygenase: ONIOM studies". International Journal of ...

Like many other CYP enzymes that act on cholesterol, cholesterol-24 hydroxylase is a monooxygenase that hydroxylates the side- ... squalene synthase, and FPP synthase. Variable expression of cholesterol-24 hydroxylase has been linked to the onset of ... Cholesterol 24-hydroxylase (EC 1.14.13.98), also commonly known as cholesterol 24S-hydroxylase, cholesterol 24-monooxygenase, ...

These encode for brassinolide biosynthetic enzymes, thus the CPD gene encodes for the cytochrome P450 monooxygenase, which in ... "From Squalene to Brassinolide: The Steroid Metabolic and Signaling Pathways across the Plant Kingdom", Molecular Plant, vol. 6 ...

... tyrosine 3-monooxygenase] kinase EC 2.7.1.125: Now EC 2.7.11.14, rhodopsin kinase EC 2.7.1.126: Now EC 2.7.11.15, β-adrenergic- ... squalene synthase EC 2.5.1.22: spermine synthase EC 2.5.1.23: sym-norspermidine synthase EC 2.5.1.24: discadenine synthase EC ... tyrosine 3-monooxygenase] kinase EC 2.7.11.7: myosin-heavy-chain kinase EC 2.7.11.8: Fas-activated serine/threonine kinase EC ... squalene methyltransferase EC 2.1.1.263: botryococcene C-methyltransferase EC 2.1.1.264: 23S rRNA (guanine2069-N7)- ...