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*  Triterpene
Animals, plants and fungi all create triterpenes, with arguably the most important example being squalene as it forms the basis ... via the cyclization of squalene. Steroids have two principal biological functions, being either key components of cell ...
*  Squalene monooxygenase
In humans, squalene epoxidase is encoded by the SQLE gene. Squalene monooxygenase (SqMO) was formerly referred to as squalene ... Squalene monooxygenase (also called squalene epoxidase) is an enzyme that uses NADPH and molecular oxygen to oxidize squalene ... Squalene monooxygenase differs from other flavin monooxygenases in that the oxygen is inserted as an epoxide rather than as a ... Squalene monooxygenase contains a loosely bound FAD flavin and obtains electrons from NADPH-cytochrome P450 reductase, rather ...
*  Farnesyl pyrophosphate
... as well as being the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a ...
*  Farnesyl-diphosphate farnesyltransferase
SQS belongs to squalene/phytoene synthase family of proteins. Squalene synthase has been characterized in animals, plants, and ... and farnesylated proteins Development of squalene synthase knockout mice has demonstrated that loss of squalene synthase is ... Squalene synthase is a target for the regulation of cholesterol levels. Increased expression of SQS has been shown to elevate ... Squalene synthase (SQS) is localized exclusively to the membrane of the endoplasmic reticulum (ER). SQS is anchored to the ...
*  Naftifine
... but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is ...
*  Nasal sebum
The grease is a particularly oily form of sebum, thought to contain more squalene (C30H50) than the secretions from other parts ...
*  Squalene
Oxidation (via squalene monooxygenase) of one of the terminal double bonds of squalene yields 2,3-squalene oxide, which ... Squalene is an ancient molecule. In plants, squalene is the precursor to stigmasterol. In certain fungi, it is the precursor to ... Another method found no squalene in 37 of the 38 lots tested. One lot contained traces of squalene, at less than ten parts per ... Two molecules of farnesyl pyrophosphate condense with reduction by NADPH to form squalene - by squalene synthase. Click on ...
*  Squalene methyltransferase
... (EC 2.1.1.262, TMT-1, TMT-2) is an enzyme with systematic name S-adenosyl-L-methionine:squalene C- ... Squalene methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... This enzyme catalyses the following chemical reaction 2 S-adenosyl-L-methionine + squalene ⇌ {\displaystyle \rightleftharpoons ... squalene ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene (1b) S- ...
*  Squalene-hopene cyclase
... functions in a hypoxic environment suggesting a much earlier presence. Squalene-hopene cyclase is a ... Squalene-hopene cyclase catalyses the conversion of the acyclic molecule of squalene into the pentacyclic triterpenes of hopene ... squalene ⇌ {\displaystyle \rightleftharpoons } hop-22(29)-ene squalene + H2O ⇌ {\displaystyle \rightleftharpoons } hopan-22-ol ... Squalene-hopene cyclase (SHC) (EC 5.4.99.17) or hopan-22-ol hydro-lyase is a prokaryotic enzyme in the terpene cyclase/mutase ...
*  Botryococcus squalene synthase
... (EC 1.3.1.96, SSL-2 (gene)) is an enzyme with systematic name squalene:NADP+ oxidoreductase. ... Botryococcus squalene synthase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... This enzyme catalyses the following chemical reaction squalene + diphosphate + NADP+ ⇌ {\displaystyle \rightleftharpoons } ...
*  Squalene--hopanol cyclase
... (EC 4.2.1.129, squalene--hopene cyclase) is an enzyme with systematic name hopan-22-ol hydro-lyase. ... Squalene---hopanol cyclase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Hoshino, T.; Nakano, S.; Kondo, T.; Sato, T.; Miyoshi, A. (2004). "Squalene-hopene cyclase: final deprotonation reaction, ... This enzyme catalyses the following chemical reaction hopan-22-ol ⇌ {\displaystyle \rightleftharpoons } squalene + H2O The ...
*  Squalene/phytoene synthase family
... to form squalene: 2 FPP -> presqualene diphosphate + NADP -> squalene SQS is found in eukaryotes. In yeast it is encoded by the ... Squalene synthase EC (farnesyl-diphosphate farnesyltransferase) (SQS) and Phytoene synthase EC (PSY) are enzymes that share a ... SQS catalyzes the conversion of two molecules of farnesyl diphosphate (FPP) into squalene. It is the first committed step in ... Robinson GW, Tsay YH, Kienzle BK, Smith-Monroy CA, Bishop RW (May 1993). "Conservation between human and fungal squalene ...
*  S)-squalene-2,3-epoxide hydro-lyase
... may refer to: Arabidiol synthase, an enzyme Dammarenediol II synthase, an enzyme Lupan- ...
*  Steroid
Here, the isoprene units are joined to make squalene and folded into a set of rings to make lanosterol. Lanosterol can then be ... Siedenburg G, Jendrossek D (Jun 2011). "Squalene-hopene cyclases". Applied and Environmental Microbiology. 77 (12): 3905-15. ... Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene. Gonane, also known as steran or ... Lanosterol and cycloartenol derive from cyclization of the triterpenoid squalene. Steroid biosynthesis is an anabolic pathway ...
*  Claisen rearrangement
Synthesis of squalene". Journal of the American Chemical Society. 92 (3): 741-743. doi:10.1021/ja00706a074. ISSN 0002-7863. ...
*  Orthoester
Synthesis of squalene". Journal of the American Chemical Society. 92 (3): 741-743. doi:10.1021/ja00706a074. Kocieński, Philip J ...
*  Lipid-lowering agent
It is expected that these drugs will mainly increase HDL while lowering LDL; Squalene synthase inhibitor; ApoA-1 Milano ...
*  Geranyltranstransferase
Tansey TR, Shechter I (2001). "Squalene synthase: structure and regulation". Prog. Nucleic Acid Res. Mol. Biol. 65: 157-95. doi ... Through several more biosynthetic steps, squalene is transformed into lanosterol, a direct precursor for cholesterol. Notably, ... tail-to-tail condensation with another farnesyl pyrophosphate to form a 30-carbon compound called squalene by squalene synthase ...
*  Squalane
The hydrogenation of squalene to produce squalane was first reported in 1916. Squalene was traditionally sourced from the ... Squalane is a hydrocarbon derived by hydrogenation of squalene. In contrast to squalene, due to the complete saturation of ... While squalane can be found in small quantities in sebaceous secretions (sebum), it is squalene that is most commonly found in ... "Final report on the safety assessment of squalane and squalene". Journal of the American College of Toxicology. 1 (2): 37-56. ...
*  Desulfonylation reactions
Application to the synthesis of squalene". Chemistry Letters (4): 451. doi:10.1246/cl.1985.451. Chan, Man Chor; Cheng, Kwok Man ...
*  Lanosterol synthase
Wendt KU, Poralla K, Schulz GE (Sep 1997). "Structure and function of a squalene cyclase". Science. 277 (5333): 1811-15. doi: ... Nelson JA, Steckbeck SR, Spencer TA (Feb 1981). "Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide". The ... evolved from bacterial squalene-hopene cyclase (SHC), which is involved with the formation of hopanoids. Phylogenetic trees ... which are also present in the highly analogous bacterial enzyme squalene-hopene cyclase. Residues of these fingerprint regions ...
*  Prenyltransferase
Squalene-hopene cyclase is a bacterial enzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid ( ... Prestwich GD, Poralla K, Hewelt A, Abe I, Reipen I, Sprenger G (1994). "A specific amino acid repeat in squalene and ... FNTB; LSS; PGGT1B; RABGGTB Wendt KU, Poralla K, Schulz GE (September 1997). "Structure and function of a squalene cyclase". ... Schulz GE, Wendt KU, Poralla K (1997). "Structure and function of a squalene cyclase". Science. 277 (5333): 1811-1815. doi: ...
*  Oxidosqualene cyclase
OSC enzymes' catalytic mechanism is similar to the prokaryotic squalene-hopene cyclase. Directed evolution and protein design ... Wendt, KU; Poralla, K; Schulz, GE (19 September 1997). "Structure and function of a squalene cyclase". Science. 277 (5333): ...
*  Influenza vaccine
The vaccine contains the MF59C.1 adjuvant which is an oil-in-water emulsion of squalene oil. It is the first adjuvanted ... "Influenza vaccine with squalene adjuvant: new preparation. No better than available products". Prescrire Int. 13 (74): 206-8. ...
*  Amaranth
"Squalene Market Size to Exceed USD 240 Million by 2022". Global Market Insights Inc. 27 April 2016. Retrieved 14 December 2016 ... Making up about 5% of the total fatty acids of amaranth, squalene is extracted as a vegetable-based alternative to the more ... "Extraction and Purification of Squalene from Amaranthus Grain". Journal of Agricultural and Food Chemistry. 50 (2): 368-372. ...