"Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1". Burda P, Laslo P, Stopka T (July 2010 ... October 1997). "Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through ... form homo, heterodimers and ternary complexes via two distinct domains". Oncogene. 16 (25): 3261-3268. doi:10.1038/sj.onc. ... Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus ...
"Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse ... erythroleukemia cells transformed by spleen focus-forming virus". Proc Natl Acad Sci U S A. 72 (5): 1863-7. Bibcode:1975PNAS... ...
... radiation leukemia virus MeSH B04.820.650.375.525.770 - rauscher virus MeSH B04.820.650.375.525.850 - spleen focus-forming ... spleen focus-forming viruses MeSH B04.909.574.807.375.700 - reticuloendotheliosis viruses, avian MeSH B04.909.574.807.375.700. ... spleen focus-forming viruses MeSH B04.909.777.731.375.700 - reticuloendotheliosis viruses, avian MeSH B04.909.777.731.375.700. ... yellow fever virus MeSH B04.820.250.400 - gb virus a MeSH B04.820.250.405 - gb virus b MeSH B04.820.250.410 - GB virus C MeSH ...
... that L forms can adhere to red blood cells and thereby disseminate from foci within internal organs such as the spleen, or from ... viruses-became the entities expected in the theory of focal infection. Yet until the 1980s, such researchers were scarce, ... Sometimes forming elsewhere in bones after injury or ischemia, jawbone cavitations are recognized as foci also in osteopathy ... "many patients with these same systemic diseases have no evident focus of infection", and that "foci of infection are as common ...
The gene has 12 common splice variants and one unspliced form. The longest transcribed mRNA is made up of 3048 base pairs and ... Its expression is concentrated in related tissues including the spleen, lungs, white blood cells, and heart. In situ ... For comparison, expression in the mouse brain is focused in the isocortex, olfactory region, hippocampus, cortical subplate, ... interacting protein involved in classical swine fever virus growth". Journal of Virology. 87 (4): 2072-80. doi:10.1128/JVI. ...
... a cytokine known to play a role in other forms of Castleman disease.[citation needed] The HHV-8 virus contains a gene coding ... The Castleman Disease Collaborative Network is the largest organization focused on the disease and is involved in research, ... enlargement of the liver and/or spleen; and extravascular fluid accumulation in the extremities (edema), abdomen (ascites), or ... Patients with HHV-8-associated MCD are often found to have Kaposi sarcoma, a cancer caused by the HHV-8 virus and most commonly ...
Many other viruses, such as the SARS virus, seem to use DC-SIGN to 'hitchhike' to its target cells. However, most work with ... The monocytes in turn are formed from stem cells in the bone marrow. Monocyte-derived dendritic cells can be generated in vitro ... In addition, an immediate precursor to myeloid and lymphoid dendritic cells of the spleen has been identified. This precursor, ... as dendritic cells are so rare and difficult to isolate that only in recent years they have become subject of focused research ...
These two iso forms of LMP2 only differ in that LMP2A contains an extra 119 residue N-terminal domain encoded in exon 1. ... Most LMP2 research is focused on LMP2A isoform due to its unique expression in latently infected B lymphocytes in situ. LMP2B ... as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction. Latent Membrane Protein 2 ( ... Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein-Barr virus. LMP2A/LMP2B are ...
Virus particles can range between 70 and 80 nm. Morphologically, the virus is a double stranded RNA virus that is composed of ... If infected into the yolk sac, the embryo will succumb to death accompanied by hemorrhaging of the embryos and cause the foci ... Syncytia is a single cell or cytoplasmic mass containing several nuclei, formed by fusion of cells or by division of nuclei. ... It causes intramuscular and subcutaneous hemorrhages and atrophy of the spleen, bursa of Fabricius, and thymus. When young ...
The virus then enters a latency phase in which the infected individual becomes a lifetime asymptomatic carrier of the virus. ... thrombi formed in large arteries, and myxomas. Also unlike DLBCL-CI, the lesions in FA-DLBCL do not form masses and, in almost ... Microscopically, these tissues are composed of small foci of infiltrates composed of large lymphoid cells embedded in a ... spleen, ovary, adrenal gland, retroperitoneal space, or other tissue; and e) intravascular thrombi; f) implants of a foreign ...
Possible pathogens include viruses (e.g. cytomegalovirus, rubella virus, HIV), bacteria (e.g. Staphylococcus spp., Enterococcus ... Treatment focuses on eliminating the underlying problem, whether that means discontinuing drugs suspected to cause it or ... Painless, round, and pinpoint (1 to 3 mm in diameter) petechiae usually appear and fade, and sometimes group to form ecchymoses ... Thrombocytopenia in hospitalized alcoholics may be caused by spleen enlargement, folate deficiency, and most frequently, the ...
As the energy is applied in a more focused fashion, it requires less energy to cause significant injury. Any body organ, ... Platelets are small blood components that form a plug in the blood vessel wall that stops bleeding. Platelets also produce a ... Bleeding may not be readily apparent; internal organs such as the liver, kidney and spleen may bleed into the abdominal cavity ... Infectious diseases such as Ebola, Marburg virus disease and yellow fever can cause bleeding.[citation needed] Dioxaborolane ...
Hepatitis C virus (HCV) is a blood-borne pathogen associated with several morbidities and mortality. The state of the infection ... Around 15,000 people die annually from various forms of cancer. Around 1,000 or more die in traffic collision each year. Around ... HCV prevention efforts in Afghanistan should focus on expanding access to and coverage of harm reduction services among people ... Visceral leishmaniasis infections are often recognised by fever, swelling of the liver and spleen, and anemia. They are known ...
The typical incubation period for the virus is between 5-10 days. CNPV symptoms often show two main forms. That is either dry ( ... It has also been observed that some birds may also experience thickened eyelids, air-sacks and enlarged spleens. Observations ... Although veterinary CNPV recombinant vaccines exist, recent attention has focussed on its use in human medicine with several ... Juncopox virus, Mynahpox virus, Psittacinepox virus, Sparrowpox virus, Starlingpox virus, Pigeonpox virus, Turkeypox virus and ...
The cause of CTCL is unknown.[citation needed] A point-based algorithm for the diagnosis for early forms of cutaneous T-cell ... There is some evidence of a relationship with human T-lymphotropic virus (HTLV) with the adult T-cell leukemia/lymphoma subtype ... Devata, S; Wilcox, RA (June 2016). "Cutaneous T-Cell Lymphoma: A Review with a Focus on Targeted Agents". American Journal of ... Among the symptoms for the aforementioned types are: enlarged lymph nodes, an enlarged liver and spleen, and non-specific ...
... such as those infected with pathogens like the Epstein-Barr virus (EBV) or the Dengue virus. These mutations include those in ... Both forms are characterized by the overwhelming activation of normal T lymphocytes and macrophages, invariably leading to ... HLH clinically manifests with fever, enlargement of the liver and spleen, enlarged lymph nodes, yellow discoloration of the ... Treatment for these patients should focus on the underlying contributors. Additionally, treatment of the inflammation of HLH ...
The cathepsin A activity in lysates of metastatic lesions of malignant melanoma is significantly higher than in primary focus ... Chandran K (2005). "Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection". Science. 308 (5728): ... Deficiencies in this protein are linked to multiple forms of galactosialidosis. ... spleen cathepsin). Novinec, Marko; Lenarčič, Brigita (1 June 2013). "Papain-like peptidases: structure, function, and evolution ...
It can either occur in isolation or along with a primary focus (such as the lungs) in patients with disseminated tuberculosis. ... When the gastrointestinal tract is infected with the bacteria, epitheloid tubercles are formed in the lymphoid tissue of the ... Other rare sites, such as genitourinary system, duodenum, esophagus, stomach, spleen. The commonest route of spread to these ... "A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection". BMC Infectious ...
The tetraploid form has been linked to lower mortality rates. The cell type origin of this strain of DFTD is unknown. Increased ... It was found to be a huge retrovirus with similar viruses being found in human and canine cancer cells. Tasmanian devil cells ... This project aims to create a set of one thousand genetically representative devils, and is now a major focus of the insurance ... Tumours metastasise to regional lymph nodes involvement and systemically to the lungs, spleen and heart. A study found evidence ...
Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF (Jun 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A ... Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (Apr 2004). "HIV/SIV escape from immune surveillance: focus on Nef". ... Sidorenko SP, Law CL, Chandran KA, Clark EA (Jan 1995). "Human spleen tyrosine kinase p72Syk associates with the Src-family ... in hematopoietic cells and association with production of human T-cell lymphotropic virus type I". Proceedings of the National ...
... virus (RPV), a member of the genus Morbillivirus, is closely related to the measles and canine distemper viruses. ... This formed ideal habitat for tsetse fly, which carries sleeping sickness, and is unsuitable for livestock; "hence the European ... But for a hundred years thereafter in German-speaking countries there was intense focus on the problem of Rinderpest. In the ... In 1959, rinderpest vaccine was prepared at government laboratories in Abuko in The Gambia from the spleen of infected cattle. ...
Ulcers or nodules in the skin were found, as well as swelling and lesions of internal organs, including the spleen, liver, and ... A recent case of a form of phaeohyphomycosis infection was found in a dog in 2011. The Journal of the American Veterinary ... There were ulcerative lesions, multiple dark foci in the gills, and non-ulcerative dermal masses found. In critical cases, some ... as well as the greater similarity to host cells which are both eukaryotes than other pathogens such as bacteria or viruses. ...
... vivax parasitemia are erythrocytic forms in bone marrow and the spleen. Between 2018 and 2021, it was reported that vast ... There is evidence that P. vivax is itself infected by viruses. P. vivax was used between 1917 and the 1940s for malariotherapy ... To overcome this, recent efforts have focused on deducing the function of orphan hypothetical proteins whose functions have ... Gametes: Formed from gametocytes in mosquitoes. Zygote: Formed from combination of gametes Oocyst: Contains zygote, develops ...
However, other strains of this virus (Junin and Machupo viruses) are present in parts of South America and other strains ... On the other hand, Clone 13 is a variant of the Armstrong viral strain, isolated from the spleen and is consequently tropic for ... It was the original model when first studied focused on CD-8 T cells response towards LCMV infection. In addition, a better ... subclinical disease may be the most common form, as few natural outbreaks have been reported. In hamsters, approximately half ...
The five-year survival rate in the United States is 88.4%. FL is the most prevalent form of indolent lymphoma, accounting for ... Splenic MZL develops in the spleen and may spread to the blood. Chronic lymphocytic leukemia (CLL) and small cell lymphocytic ... focus on ibrutinib". Cancer Management and Research. 10: 615-624. doi:10.2147/CMAR.S133291. ISSN 1179-1322. PMC 5877869. PMID ... "Characteristics of indolent non-hodgkin lymphoma in patients with type 1 human immunodeficiency virus infection". Cancer. 94 (5 ...
... often forming a granuloma. Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs ... The infection and pathogenesis of the SARS-CoV-2 virus in the human patient largely remained unknown. Multinucleate giant cells ... Studies that observed that bone resorption could be restored by bone marrow and spleen transplants helped prove osteoclasts' ... The nuclei form a circle or semicircle similar to the shape of a horseshoe away from the center of the cell. Langhans giant ...
Sheene had come down with a debilitating virus at the Venezuelan round, but a string of podium finishes and a victory at the ... Roberts further irritated the FIM when he began talking to the press about forming a rival racing series to compete against the ... "Roberts Ruptures Spleen In Crash". The Hour. United Press International. 16 February 1979. p. 26. Retrieved 15 December 2010. ... Prior to his arrival in Europe, riders focused on attaining high entry speeds into corners, leaving braking until the last ...
CLL treatment focuses on controlling the disease and its symptoms rather than on an outright cure. In those without or only ... Enlargement of the spleen and low red blood cells (anemia) may also occur. It typically worsens gradually over years. Risk ... Exposure to Agent Orange increases the risk of CLL, and exposure to hepatitis C virus may increase the risk. There is no clear ... Chronic lymphocytic leukemia may also develop a Richter's transformation i.e. conversion to a far more aggressive form that has ...
Suppression of primary M, G, and A plaque-forming cell responses in mouse spleen cell cultures by class-specific antibody to ... More recent ecoimmunological research has focused on host pathogen defences traditionally considered "non-immunological", such ... dendritic cells and macrophages by the human immunodeficiency virus (HIV). Clinical immunologists also study ways to prevent ... The important lymphoid organs of the immune system are the thymus, bone marrow, and chief lymphatic tissues such as spleen, ...
Problem-focused coping is directed at managing the problem, whereas emotion-focused coping processes are directed at managing ... It is a form of the Middle English destresse, derived via Old French from the Latin stringere, "to draw tight". The word had ... Also with an increased level of stress, studies have proven evidence that it can reactivate latent herpes viruses. A link has ... The sympathetic nervous system innervates various immunological structures, such as bone marrow and the spleen, allowing for it ...