"The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin". The EMBO Journal. 22 (24): 6430- ... This protein is a type I membrane glycoprotein in the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors ... In addition, two hydrophobic loops have been detected in this domain and act to anchor the protein in the cell membrane. ... Sortilin has also been shown to undergo a conformational change and form a protein dimer in acidic conditions similar to ones ...

"Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase". ... The lysosomal transporter and integral membrane protein LIMP-2 (Lysosomal Integral Membrane Protein 2) was shown to bind GCase ... and sphingolipid-activating protein in HepG2 cells". The Journal of Biological Chemistry. 266 (8): 4862-8. doi:10.1016/S0021- ... A study in I-cell disease fibroblasts (in which the phosphotransferase that puts Mannose 6-phosphate on proteins to target them ...

... stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids". Annu Rev Cell Dev ... is homologous to saposin and belongs to the saposin-like protein family (SAPLIP). Although the PSI is grouped along proteins in ... The underlying function of proteins belonging to the SAPLIP group is to interact with membrane bilayers, either by perturbation ... Saposins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) SCOP 47844 (Swaposins) (Plant proteins). ...

... sphingolipid activator protein-1 (SAP-1), sulfatide activator protein, GM1 ganglioside activator, dispersin, and nonspecific. ... 1986). "Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator". Biochem. Biophys ... 1990). "The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein ... "Distribution of saposin proteins (sphingolipid activator proteins) in lysosomal storage and other diseases". Proc. Natl. Acad. ...

However, in order for this reaction to be carried out, a sphingolipid activator protein such as saposin B must be present. ... New Insights into Cellular Functions and Mechanisms of Protein Recognition". Lipid-mediated Protein Signaling. Advances in ... ApoE is a protein that is involved in the transport of many lipids, including cholesterol, and thus, regulates how much ... The vaccinia virus has been shown to be able to bind to sulfatide through the L5 and A27 membrane proteins on the virus. It has ...

... linked to the accumulation of subunit c of mitochondrial ATP synthase and a small amount of sphingolipid activator proteins in ... This protein is a 286 amino acid transmembrane protein that has not been identified before, meaning that it is unique to ... The cause of the disease is a missense mutation on chromosome 8. The creation of a new protein occurs, and the lipid content of ... The primary mutation (Arg24Gly) creates the protein CLN8. A total of 1 in every 135 people of Finnish descent were reported to ...

Protein C inhibitor, Pseudomonas exotoxin A, RAP, Ricin A, SHC1, and Sphingolipid activator protein, SYNJ2BP. Tat, Thrombin, ... In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various ... To elaborate, LRP1 mainly contributes to regulate protein activity by binding target proteins as a co-receptor, in conjunction ... These repeats bind extracellular matrix proteins, growth factors, proteases, protease inhibitor complexes, and other proteins ...

... surfactant protein B, and the 4 sphingolipid activator proteins (saposins). The larger subunit, of 50 kDa, contains the active ... It is a protein of about 60 kDa that has two disulfide-linked subunits. The smaller subunit, of about 14 kDa (including ... glycosylation), is a member of the SAPLIP (saposin-like protein) family along with amoebapore, granulysin, acid ...

Tan, X., Wright, D., Liu, S., Hovens, C., O'Brien, T., & Shultz, S. (2016). Sodium selenate, a protein phosphatase 2A activator ... seem to react with sphingolipids to liberate ceramide (Dobrowsky, R.T. 1992). The ceramide from this cycle can activate CAPP ... Known CAPPs include members of the protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) families. CAPPs are a subset ... SET proteins, such as I2PP2A have been shown to associate with nucleoporins to form fusion proteins that can inhibit the ...

Two of them are subunits of hexosaminidase A; the third is a small glycolipid transport protein, the GM2 activator protein ( ... that breaks down sphingolipids. When hexosaminidase A is no longer functioning properly, the lipids accumulate in the brain and ... Enzymes are protein catalysts for chemical reactions; as catalysts, they speed up reactions without being used up in the ... Deficiency in any one of these proteins leads to ganglioside storage, primarily in the lysosomes of neurons. Tay-Sachs disease ...

... activator protein), in order to promote the transcription of the CD69 gene. The CD69 protein is subject to post-translational ... S1P is a sphingolipid metabolite that is abundant in the bloodstream and, upon binding to S1PR1, promotes lymphocyte egress ... CD69+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD69 genome location and ... CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene. It is an early ...

The encoded protein includes a 27-residue signal peptide followed by the 264-residue mature protein. IGFBP-3 shares with the ... September 2004). "Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling ... "Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal ... Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene ...

... sphingolipids, and glycosylphosphatidylinositol-anchored proteins. Early researchers suspected that HHV-6 virions mature in the ... These gene products are believed to be transcription activators and may be regulated by the expression of viral micro RNAs. ... The molecular mimicry hypothesis, in which T cells are essentially confusing an HHV-6 viral protein with myelin basic protein, ... The CD46 protein possesses a single variable region, as a result of alternative splicing. As such, at least fourteen isoforms ...

Smith, E. R.; Merrill, A. H.; Obeid, L. M.; Hannun, Y. A. (2000). "Effects of sphingosine and other sphingolipids on protein ... PAF is a potent activator of platelet aggregation, inflammation, and anaphylaxis. It is similar to the ubiquitous membrane ... Sph is also known to interact with protein targets such as the protein kinase H homologue (PKH) and the yeast protein kinase ( ... A specific protein kinase phosphorylates 14-3-3, otherwise known as sphingosine-dependent protein kinase 1 (SDK1), only in the ...

A low level of the protein albumin in the blood is common.[citation needed] The serum C reactive protein, erythrocyte ... Activated macrophages secrete ferritin and plasminogen activator leading to hyperfibrinolysis. The blood count typically shows ... November 2013). "Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in ... Syntaxin binding protein 2)/UNC18-2 Nearly half of the cases of type 2 familial hemophagocytic lymphohistiocytosis are due to ...

"The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and ... It is also the precursor to numerous other metabolites, including sphingolipids and folate, which is the principal donor of one ... D-Serine is functionally a more potent activator of synaptic NMDARs than glycine, and mounting evidence suggests that it serves ... Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which ...

... mammalian stress-activated protein kinase interacting protein 1 (mSIN1), and protein observed with rictor 1 and 2 (Protor1/2) ... "Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila ... has been linked to promotion of hepatocellular carcinoma through stimulation of glycerophospholipid and sphingolipid synthesis ... January 1998). "Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein ...

Protein kinase A also has the ability to phosphorylate ACC, with a much greater ability to phosphorylate ACC2 than ACC1. Ser80 ... Other allosteric activators include glutamate and other dicarboxylic acids. Long and short chain fatty acyl CoAs are negative ... functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 ... Peng IC, Chen Z, Hsu PH, Su MI, Tsai MD, Shyy JY (April 2010). "Glucagon Activates the AMP‐Activated Protein Kinase/Acetyl‐CoA ...

The cAMP produced is a second messenger in cellular metabolism and is an allosteric activator of protein kinase A. Protein ... and sphingolipid-rich microdomains of the plasma membrane called lipid rafts. As many of the downstream transducer and effector ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... G proteins are subsequently inactivated by GTPase activating proteins, known as RGS proteins. GPCRs include one or more ...

Scientists report that sphingolipids accumulate in muscle during aging whose genetic inhibition or ceramide-blockers such as ... 2012 It was discovered that protein Sirtuin 6 (SIRT6) regulates the lifespan of male mice (but not female mice). 2013 The pan- ... March 2014). "The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet". Cell Reports. 6 (5 ... Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R (December 2004). "The AMP-activated protein kinase AAK-2 links energy ...