Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene. SOX-9 recognizes the sequence CCTTGAG along ... Determining Factors SRY and SOX9". The molecular action of testis-determining factors SRY and SOX9. pp. 57-66, discussion 66-7 ... Overview of all the structural information available in the PDB for UniProt: P48436 (Human Transcription factor SOX-9) at the ... Overview of all the structural information available in the PDB for UniProt: Q04887 (Mouse Transcription factor SOX-9) at the ...

2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. ... In Sertoli cells with the SOX9 protein it elevates the level of AMH transcription. In Leydig cells it activates the gene ... "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. ... SF 1 (transcription factor) appears to be active in masculining both the Leydig cells and Sertoli cells. ...

... as an indicator of SOX9 transcription factor activity". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1862 ... Tripathi, K; Parnaik, VK (2008). "Differential dynamics of splicing factor SC35 during the cell cycle". Journal of Biosciences ... the rate of recovery will be retarded by a factor related to the association and disassociation coefficients of binding. This ...

... as an indicator of SOX9 transcription factor activity". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1862 ... Plant transcription factor database TcoF-DB: Database of transcription co-factors and transcription factor interactions ... This is also true with transcription factors: Not only do transcription factors control the rates of transcription to regulate ... DNA within nucleosomes is inaccessible to many transcription factors. Some transcription factors, so-called pioneer factors are ...

Liu CF, Lefebvre V (September 2015). "The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super- ... High levels of many transcription factors and co-factors are seen at super-enhancers (e.g., CDK7, BRD4, and Mediator). This ... ChIP-Seq experiments targeting master transcription factors and co-factors like Mediator or BRD4 have been used, but the most ... including binding transcription factor proteins, looping to target genes, and activating transcription. Three notable traits of ...

SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its ... SOX9 protein then initiates a positive feedback loop, involving SOX9 acting as its own transcription factor and resulting in ... SRY accomplishes this by upregulating SOX9, a transcription factor with a DNA-binding site very similar to SRY's. SOX9 leads to ... There is also a link between SRY encoded transcription factor SOX9 and campomelic dysplasia (CD). This missense mutation causes ...

An important genetic component of this process is Sox9, a HMG box transcription factor, which marks progenitor cells for ... Inactivation of the Sox9 gene will result in the loss of all Cartilage, and thus Chondroblast, formation. This factor is also ... suppressed which allows it to accumulate and eventually go into the cell nucleus to bind to the LEF/TCF transcription factors ... Extrinsic environmental factors act upstream in determining what cell type will form out of any particular mesenchymal ...

This cell fate commitment is due to the expression of Sox9 (Sry-related HMB box transcription factor 9) and suppression of ... One gene Onecut1/Hnf6 (onecut domain family member 1 transcription factor) is also responsible for the timely expression of ... This transcription factor has been shown to give rise to the multipotent stem cell lineages contributing to the endocrine, ... a focus on the role of transcription factors". Hormone Research in Paediatrics. 77 (4): 205-213. doi:10.1159/000337219. PMID ...

... transcription factor for the subsequent induction of the pro-invasive transcription factors Snai2 (Slug), Sox9 or Twist. ...

This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors. The encoded protein acts as ... It regulates differentiation and migration of neural crest cells along with other genes (e.g. FOXD3, SOX9 and SOX10, BMPs) in ... Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes the ... Stegmann K, Boecker J, Kosan C, Ermert A, Kunz J, Koch MC (August 1999). "Human transcription factor SLUG: mutation analysis in ...

... and transcription factors such as sox2 and sox9. Recent research has suggested that most foregut malformations are due to ...

The SOX9 gene codes for a protein transcription factor which, when expressed at the embryonic stage, plays an important role in ... When the SRY gene of the Y chromosome is expressed in human embryos, a cascade of gene interactions controlled by SOX9 begins ... Four major classes of heterozygous SOX9 mutations can cause CMD: amino acid substitutions in the HMG-box, truncations or ... Long-term survivors of CMD are significantly more likely to have translocation and inversion mutations upstream of SOX9 rather ...

... has been predicted to contain a number of transcription factor binding sites including binding sites for transcription factors ... Barrionuevo F, Scherer G (March 2010). "SOX E genes: SOX9 and SOX8 in mammalian testis development". The International Journal ... Actual transcription factor functional studies show binding of the C16ORF82 promoter by ARNT, ELF5, SMAD4, and STAT3. C16orf82 ... Lachmann A, Xu H, Krishnan J, Berger SI, Mazloom AR, Ma'ayan A (October 2010). "ChEA: transcription factor regulation inferred ...

In the skin epidermis, SOX family transcription factor, SOX9, also behaves as a pioneer factor that governs hair follicle cell ... Pioneer factors can function passively, by acting as a bookmark for the cell to recruit other transcription factors to specific ... Pioneer factors can exhibit their greatest range of effects on transcription through the modulation of epigenetic factors by ... Pioneer factors are transcription factors that can directly bind condensed chromatin. They can have positive and negative ...

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a ... Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type ... Cao S, Liu J, Song L, Ma X (Mar 2005). "The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression ... Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and ...

For example, the SRY gene on the Y chromosome encodes the transcription factor TDF and is vital for male sex determination ... TDF functions by activating the SOX9 gene on chromosome 17, so mutations of the SOX9 gene can cause humans with an ordinary Y ...

The transcription factor Sox9 can be found in multiple sites in the body (pancreas, central nervous system, intestines) and it ... suggesting that there must be other factors and signalling pathways regulating Sox9 activity. Once Sox9 activity is lost, ... by blocking the Runx2 factor through Smad3 activation. Sox9 stimulates differentiation into chondrocytes. Sox9 blocked ... Runx2 (which may also be known as Cbfa1), and Osx (a zinc finger containing transcription factor) are necessary for ...

... clear regulatory role of Sp7 in the decision process made by mesenchymal stem cells to progress from their original highly Sox9 ... factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts". Journal of ... Transcription factor Sp7, also called osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of ... Sp12+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ...

... is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. It ... Sox9, Sox10 and HNK-1. PAX7 is expressed in the palatal shelf of the maxilla, Meckel's cartilage, mesencephalon, nasal cavity, ... "Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR". ... Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural ...

... development of testes in some areas by beginning a series of events starting with the upregulation of the transcription factor ... SOX9), and in other areas not being active (causing the growth of ovarian tissues). Thus, testicular and ovarian tissues will ... One common cause of intersex traits is the crossing over of the testis-determining factor (SRY) from the Y chromosome to the X ...

Some evidence suggests that genetic dysregulation of the SOX9 gene (which encodes the SOX-9 transcription factor) and/or the ... One theory for the etiology of PRS is that, early in the first trimester of gestation, some mechanical factor causes the neck ... Selvi, R; Mukunda Priyanka, A (2013). "Role of SOX9 in the Etiology of Pierre-Robin Syndrome". Iranian Journal of Basic Medical ... possibly at the SOX9 gene or the KCNJ2 gene) have all been implicated in PRS. ...

For chondrogenic cells, the treatment showed increased expression of the transcription factor Sox9, which plays a key role in ... Xylt1 is an essential gene in regards to chondrocytes and proper skeletal formation, and is a key factor in the close ... The non-mutated FGFR-3 gene is responsible for the expression of fibroblast growth factors(FGFs) which has to maintain a ... Two proteins, bone morphogenetic protein 4(BMP-4) and fibroblast growth factor 2(FGF2) have been seen to influence the amount ...

RhoA proteins help potentiate the transcription independent of ternary complex factors when activated while simultaneously ... RhoA signaling and modulation of actin polymerization also regulates Sox9 expression via controlling transcriptional Sox9 ... These regulation pathways activate protein kinases, which subsequently modulate transcription factor activity. RhoA ... conducted simultaneously via guanine nucleotide exchange factors and GTPase activating factor). RhoA is activated primarily by ...

Twist, a bHLH transcription factor, is required for mesenchyme differentiation of the pharyngeal arch structures. Id is a ... Sox9 and Sox10 regulate neural crest differentiation by activating many cell-type-specific effectors including Mitf, P0, Cx32, ... Signaling events that establish the neural plate border lead to the expression of a set of transcription factors delineated ... Outside of the tightly regulated network of neural crest specifiers are two other transcription factors Twist and Id. ...

It can form a transcriptional complex with TDF to up-regulate transcription of the Sox9 gene. Its targets include genes at ... The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity ... Mutations to CDK7 prevent interaction with the basal transcription factor, TFIIH, and formation of CDK-activating kinase ... Transcription capacity of SF-1 can be influenced by post-translational modification. Specifically, phosphorylation of serine ...

... primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require ... April 2020). "Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer". Clinical ... Escárcega RO, Fuentes-Alexandro S, García-Carrasco M, Gatica A, Zamora A (March 2007). "The transcription factor nuclear factor ... Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA ...

SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong ... SOX9, SOX10 SoxF: SOX7, SOX17, SOX18 SoxG: SOX15 SoxH: SOX30 Body plan Evolutionary developmental biology FOX proteins Hox gene ... Sox 2 is also a transcription factor in the maintenance of pluripotency in both Early Embryos and ES Cells. Granule cells then ... transcription factors". Int. J. Biochem. Cell Biol. 39 (12): 2195-214. doi:10.1016/j.biocel.2007.05.019. PMC 2080623. PMID ...

Georges A, L'Hôte D, Todeschini AL, Auguste A, Legois B, Zider A, Veitia RA (November 2014). "The transcription factor FOXL2 ... In addition, the FOXL2 protein will prevent the formation of testes by suppressing expression of SOX9. In mice, FOXL2 is also ... FOXL2 (OMIM 605597) is a transcription factor belonging to the forkhead box (FOX) superfamily, characterized by the forkhead ... September 2011). "Mutational probing of the forkhead domain of the transcription factor FOXL2 provides insights into the ...

Viger RS, Mertineit C, Trasler JM, Nemer M (July 1998). "Transcription factor GATA-4 is expressed in a sexually dimorphic ... AMH is activated by SOX9 in the Sertoli cells of the male fetus. Its expression inhibits the development of the female ... transcription GATA factors, sex-reversal gene DAX1, and follicle-stimulating hormone (FSH). Mutations in both the AMH gene and ... Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA (June 1994). "Nuclear receptor steroidogenic factor 1 regulates the ...

... regulates synergistic transcription between Ad4BP/SF-1 and Sox9". Mol. Endocrinol. 18 (10): 2451-62. doi:10.1210/me.2004-0173. ... modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) ...