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*  Son of Sevenless
SOS1 Protein at the US National Library of Medicine Medical Subject Headings (MeSH) ExPASy Proteomics Server: SOS. ... This may be explained because the SOS1 protein adopts an auto-inhibited conformation dependent on multiple domain-to-domain ... Noonan syndrome mutations in SOS1 are distributed in clusters positioned throughout the SOS1 coding region. Biochemically, ... "An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro". Cell. 73 (1): 169- ...
*  List of MeSH codes (D12.776)
... son of sevenless proteins MeSH D12.776.402.300.700.700.330 - sos1 protein MeSH D12.776.402.300.700.700.600 - son of sevenless ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
*  Hereditary gingival fibromatosis
... the chromosome loses four important proline-rich SH-3 binding domains in the carboxyl-terminal region of the SOS1 protein. As a ... Genetic HGF1 - Caused by a mutation in the SOS1 gene localized on chromosome 2p21-p22 HGF2 - Caused by a mutation in the SOS1 ... researchers described the SOS1 gene and proved for the first time that a single-nucleotide-insertion mutation of the SOS1 gene ... meaning there is a mutation in SOS1. This causes a problem because SOS1 introduces a frameshift mutation and creates a ...
*  SOS1
Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG (July 2000). "Direct interaction of SOS1 Ras exchange protein with the SH3 ... Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. RAS genes (e.g., MIM 190020) encode ... Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the ' ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ...
*  Guanine nucleotide exchange factor
SOS1 binds GRB2 at the plasma membrane after EGF receptor activation. SOS1 activates the small G protein Ras. eIF-2b is a ... GEFs are multi-domain proteins and interact with other proteins inside the cell through these domains. Adaptor proteins can ... For example, SOS1, the Ras GEF in the MAPK/ERK pathway, is recruited by the adaptor protein GRB2 in response to EGF receptor ... The GEF SOS1 activates Ras, whose target is the kinase Raf. Raf is a proto-oncogene because mutations in this protein have been ...
*  BAG3
Lymphocyte cytosolic protein 2, PDGFRA, PLD2, RHOA, SOS1, TUB, TrkA, TrkB, VAV1, and Wiskott-Aldrich syndrome protein. GRCh38: ... Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG (July 2000). "Direct interaction of SOS1 Ras exchange protein with the SH3 ... BAG3 balances protein synthesis and protein degradation under mechanical stress. PLCG1 has been shown to interact with: FGFR1, ... Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein ...
*  PLCG1
Lymphocyte cytosolic protein 2, PDGFRA, PLD2, RHOA, SOS1, TUB, TrkA, TrkB, VAV1, and Wiskott-Aldrich syndrome protein. ... Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG (July 2000). "Direct interaction of SOS1 Ras exchange protein with the SH3 ... Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. The protein encoded by ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ...
*  Clonal hypereosinophilia
In consequence, the receptor remains continuously active in attracting docking proteins such as SOS1 and STAT proteins which ... The FLT3 gene codes for the cluster of differentiation antigen 135 (i.e. CD135) protein or FLT3 protein. This protein is a ... The ACSL6 gene encodes a protein, CSL6 acyl-CoA synthetase long-chain family member 6 (or ACSL6 protein). This protein is a ... BCR encodes the breakpoint cluster region protein. This protein possess Serine/threonine-specific protein kinase activity and ...
*  MLLT4
... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... Afadin is a protein that in humans is encoded by the MLLT4 gene. AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell ... Bégay-Müller V, Ansieau S, Leutz A (Jun 2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL ... Boettner B, Govek EE, Cross J, Van Aelst L (Aug 2000). "The junctional multidomain protein AF-6 is a binding partner of the ...
*  MRAS
... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the ... "MRAS - Ras-related protein M-Ras precursor - Homo sapiens (Human) - MRAS gene & protein". www.uniprot.org. Retrieved 2016-10-10 ...
*  Signal transduction
Activated RTKs in turn activate small G proteins that activate guanine nucleotide exchange factors such as SOS1. Once activated ... Other activated proteins interact with adaptor proteins that facilitate signaling protein interactions and coordination of ... most commonly protein phosphorylation catalysed by protein kinases, which ultimately results in a cellular response. Proteins ... The activated G protein subunits detach from the receptor and initiate signaling from many downstream effector proteins such as ...
*  14-3-3 protein
Raf-1 Bad - see Bcl-2 Bax Cdc25 Akt SOS1 - see RSK YWHAB - "14-3-3 beta" YWHAE - "14-3-3 epsilon" YWHAG - "14-3-3 gamma" YWHAH ... 14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have ... A phylogenetic analysis of 27 plant species clustered the 14-3-3 proteins into four groups. 14-3-3 proteins activate the auto- ... 14-3-3 proteins play an isoform-specific role in class switch recombination. They are believed to interact with the protein ...
*  GRAP
This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N- ... GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. This gene encodes a member of the GRB2/ ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). "GC-GAP, a Rho family GTPase-activating protein that ... This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 ...
*  List of MeSH codes (D12.776.476)
... sos1 protein MeSH D12.776.476.375.100.100 -- gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.476.375.100.200 -- gtp- ... smad1 protein MeSH D12.776.476.024.417.500.200 -- smad2 protein MeSH D12.776.476.024.417.500.300 -- smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.476.024.417.249.600 -- smad6 protein MeSH D12.776.476.024.417.249.700 -- smad7 protein ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.476.375.100.300 -- gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ...
*  List of MeSH codes (D12.644)
... son of sevenless protein, drosophila MeSH D12.644.360.325.300.700.700.630 --- sos1 protein MeSH D12.644.360.350 --- guanylate ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  HRAS
In turn HRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example SOS1, which forces the ... The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein ... The altered HRAS protein is permanently activated within the cell. This overactive protein directs the cell to grow and divide ... this mutation substitutes one protein building block (amino acid) for another amino acid in the HRAS protein. Specifically, the ...
*  Cardiofaciocutaneous syndrome
Shp2, the protein product of the PTPN11, appears to regulate the MAP kinase pathway at or above the level of SOS1. SOS1 in turn ... SOS1 has been demonstrated to be a target of negative feedback by ERK and p90RSK. Thus, any activating mutation downstream of ... Genes that are mutated in all three of these syndromes encode proteins that function in the MAP kinase pathway. Mutations that ... Mutations that cause Noonan syndrome have been found in PTPN11 and SOS1. The relative severity of CFC when compared to Noonan ...
*  Ribosomal s6 kinase
Ribosomal Protein S6 Kinases, 90-kDa at the US National Library of Medicine Medical Subject Headings (MeSH) Ribosomal Protein ... RSK phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This interaction of ... Erikson, Eleanor; Maller, James L. (1985). "A Protein Kinase from Xenopus Eggs Specific for Ribosomal Protein S6". PNAS. 82 (3 ... including other ribosomal proteins. Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 ( ...
*  KRAS
... can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class (such as SOS1), which forces the release of ... but can be increased dramatically by an accessory protein of the GTPase-activating protein (GAP) class, for example RasGAP.[ ... There are two protein products of the KRAS gene in mammalian cells that result from the use of alternative exon 4 (exon 4A and ... These proteins all are regulated in the same manner and appear to differ in their sites of action within the cell.[citation ...
*  ABI1
... is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 ... Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of ... Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene. ... In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as ...
*  PTPN11
SOS1, STAT3, STAT5A, and STAT5B. CagA is a protein and virulence factor inserted by Helicobacter pylori into gastric epithelia ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs ... Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), SHP-2, or ...
*  GRB2
SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein. MAPK/ERK pathway GRCh38: Ensembl release 89 ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... GRB2 Adaptor Protein at the US National Library of Medicine Medical Subject Headings (MeSH) The Grb2 protein page on The SH2 ... In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal ...
*  Fibroblast growth factor receptor 1
These proteins have continuously active FGFR1-derived tyrosine kinase and thereby continuously stimulated the cell growth and ... SOS1, and/or c-Raf to reduce or inhibit further cell stimulation by activated FGFR1 as well as other tyrosine kinase receptors ... FGF-induced activation of FGFR1 also stimulates the activation of sprouty proteins SPRY1, SPRY2, SPRY3, and/or SPRY4 which in ... Elevated expression of FGFR1 protein was detected in 10 of 10 human Rhabdomyosarcoma tumors and 4 of 4 human cell lines derived ...
*  Adapter molecule crk
... and SOS1. CrkL, "Crk-like" protein GRCh38: Ensembl release 89: ENSG00000167193 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... 1994). "CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor- ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ...
*  PAG1
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It ... 2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70-4. doi:10.1038/ng1926. PMID ... a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in ... Wen, S T; Van Etten R A (Oct 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3- ...
*  Noonan syndrome
Mutations in the Ras/mitogen activated protein kinase signaling pathways are known to be responsible for ~70% of NS cases. A ... 2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70-4. doi:10.1038/ng1926. PMID ... 2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465-8 ...