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*  Small nuclear RNA
The 3' stem structure is necessary for recognition by the survival of motor neuron (SMN) protein. This complex assembles the ... the U4/U5/U6 tri-snRNP complex binds to complex A to form the structure known as complex B. After rearrangement, complex C is ... protein-RNA complex that consists of five small nuclear RNAs (U1, U2, U4, U5, and U6) and over 150 proteins. The snRNAs, along ... including Sm proteins, a family of nuclear proteins). The most common snRNA components of these complexes are known, ...
*  Mir-92 microRNA precursor family
... of a group of 40 other miRNAs and two key proteins that make up a ribonucleic protein analogous to the SMN protein complex. SWN ... Deletions and loss of function to the SMN complex has been correlated with the neurodegenerative disease spinal muscular ... As there is a relatively small number of miRNAs encoded in the human genome compared with the number of protein coding genes, ... Also present in the same cosediment peak was the eIF2C2 protein belonging to the family Argonaute. The Argonautes are involved ...
*  Gem-associated protein 4
... a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc ... Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene. The product of this gene is part of the SMN ... The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced ... "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of ...
*  Gem-associated protein 5
... is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays ... a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631-6. doi:10.1074/jbc. ... Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G (2006). "The Gemin5 protein of the SMN complex identifies snRNAs". Mol. ... Battle DJ, Kasim M, Wang J, Dreyfuss G (2007). "SMN-independent subunits of the SMN complex. Identification of a small nuclear ...
*  Galectin-1
"Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 (17): 3595 ... Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. LGALS1 contains four exons. The galectin-1 protein is 135 ... Having 6 cysteine residues, the oxidation state has a significant effect on the protein structure. The oxidized form is ... The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions ...
*  Small nuclear ribonucleoprotein D1
... a novel WD repeat protein component of the SMN complex that binds Sm proteins". The Journal of Biological Chemistry. 277 (7): ... "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Research. 29 (17 ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/s0092- ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ...
*  Gem-associated protein 2
2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6 ... Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that ... 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset ... 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 ( ...
*  SNRPD3
... a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 ... The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre- ...
*  Small nuclear ribonucleoprotein polypeptide E
... a novel WD repeat protein component of the SMN complex that binds Sm proteins". The Journal of Biological Chemistry. 277 (7): ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177-86. ... Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP ...
*  DDX20
SMN) complex. This DEAD box protein is one of the gem-associated proteins (GEMIN3) that interacts directly with SMN. SMN is the ... a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc ... a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc ... "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of ...
*  Small nuclear ribonucleoprotein D2
2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631-6 ... 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset ... "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ...
*  U7 small nuclear RNA
... interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J Biol Chem. 280 (41): 34435-34440. doi:10.1074/jbc. ... assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): ... "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre- ... Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain ...
*  LSM10
... interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". The Journal of Biological Chemistry. 280 (41): 34435-40 ... U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene. LSM10 has been shown to ... assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes & Development. ... "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein". The EMBO Journal. 20 (19 ...
*  CLNS1A
... interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J. Biol. Chem. 280 (41): 34435-40. doi:10.1074/jbc. ... Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 ... Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein ... a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289-300. ...
*  Survival of motor neuron
... such as hnRNP U protein and the small nucleolar RNA binding protein. SMN complex refers to the entire multi-protein complex ... a novel WD repeat protein component of the SMN complex that binds Sm proteins". The Journal of Biological Chemistry. 277 (7): ... This protein forms heteromeric complexes with proteins such as GEMIN2 and GEMIN4, and also interacts with several proteins ... survival of motor neuron protein, includes at least six other proteins (gem-associated proteins 2-7) SMN has been shown to ...
*  Survival motor neuron domain containing 1
SMN)-related protein, a constituent of the spliceosome complex". Hum Mol Genet. 7 (13): 2149-56. doi:10.1093/hmg/7.13.2149. ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 ( ... Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene. GRCh38: Ensembl ...
*  Gideon Dreyfuss
... a Novel WD Repeat Protein Component of the SMN Complex That Binds Sm Proteins". Journal of Biological Chemistry. 277 (7): 5631- ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-1021. doi:10.1016/S0092- ... A primary research goal of the lab is to elucidate the function of Survival of Motor Neuron protein, SMN, which assembles a ... A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177-1186 ...
*  ZNF259
Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG (July 2002). "SMN, the spinal muscular atrophy protein, forms a pre- ... import snRNP complex with snurportin1 and importin beta". Human Molecular Genetics. 11 (15): 1785-95. doi:10.1093/hmg/11.15. ... Zinc finger protein ZPR1 is a protein that in humans is encoded by the ZNF259 gene. GRCh38: Ensembl release 89: ENSG00000109917 ... SMN) protein to Cajal bodies". Molecular and Cellular Biology. 25 (7): 2744-56. doi:10.1128/MCB.25.7.2744-2756.2005. PMC ...
*  KPNB1
Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG (July 2002). "SMN, the spinal muscular atrophy protein, forms a pre- ... In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore ... a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex". Mol. Biol. Cell. 8 (12): 2379-90. ... "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import ...
*  SMN1
... is a gene that encodes the SMN protein in humans. SMN1 is the telomeric copy of the gene encoding the SMN protein; the ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... Paushkin S, Gubitz AK, Massenet S, Dreyfuss G (June 2002). "The SMN complex, an assemblyosome of ribonucleoproteins". Current ... SMN) protein in mammalian neural cells and tissues". Proceedings of the National Academy of Sciences of the United States of ...
*  SNRPB2
... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: ... Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 ... 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. ...
*  SPN1
2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Hum. ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ... Snurportin1 is a protein that in humans is encoded by the SNUPN gene. The nuclear import of the spliceosomal snRNPs U1, U2, U4 ... The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor ...
*  SNRPB
... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-21. doi:10.1016/S0092- ... "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein". J. Mol. Cell ... is a protein that in humans is encoded by the SNRPB gene. The protein encoded by this gene is one of several nuclear proteins ... A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177-86. doi:10.1083/jcb. ...
*  SnRNP
Gem-associated proteins: GEMIN2, GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8) forming the SMN complex. It is here that the ... snRNPs (pronounced "snurps"), or small nuclear ribonucleo proteins, are RNA-protein complexes that combine with unmodified pre- ... mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA ... The structure of U6 UsnRNA was solved in complex with a specific protein Prp24 (4N0T), as well as a structure of its 3'- ...
*  Gem-associated protein 7
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus ... Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.The gem-associated proteins are those found ... Gem-associated protein 7 has been shown to interact with SMN1 and Gem-associated protein 6. GRCh38: Ensembl release 89: ... Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi: ...
*  RBMX
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and ... Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene. This gene belongs to the ... Hofmann Y, Wirth B (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with ... Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and ...