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*  Tacrolimus
... sirolimus) on Rapa Nui (Easter Island) in 1975. It is produced by a soil bacterium, Streptomyces tsukubaensis. The name ... sirolimus also causes lung damage), and various neuropsychiatric problems such as loss of appetite, insomnia, posterior ...
*  Restenosis
The 2006 SIROCCO trial compared the sirolimus drug-eluting stent with a bare nitinol stent for atherosclerotic lesions of the ...
*  Sirolimus
... seems to lower the cancer risk in some transplant patients. Sirolimus was shown to inhibit the progression of dermal ... Sirolimus blocks this pathway. The safety and efficacy of sirolimus treatment of LAM were investigated in clinical trials that ... The antiproliferative effects of sirolimus may have a role in treating cancer. When dosed appropriately, sirolimus can enhance ... and Tor2 as the targets of sirolimus and provided robust support that the FKBP12-sirolimus complex binds to and inhibits Tor1 ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: S: Sirolimus
Sirolimus is a macrocyclic lactone produced by Streptomyces hygroscopicus. It is also commonly known as Rapamycin or Rapamune. ... Sirolimus is a macrocyclic lactone produced by Streptomyces hygroscopicus. It is also commonly known as Rapamycin or Rapamune. ...
*  Streptomyces rapamycinicus
... produces sirolimus. Baranasic, D.; Gacesa, R.; Starcevic, A.; Zucko, J.; Blazic, M.; Horvat, M.; ...
*  MTOR inhibitors
In 2003, the U.S. Food and Drug Administration approved sirolimus-eluting coronary stents, which are used in patients with ... "CYPHER™ Sirolimus-eluting Coronary Stent - P020026". Food and Drug Administration. Retrieved 25 September 2012. "Torisel". ... The natural antibiotic, rapamycin or sirolimus, a cytostatic agent, has been used in combination therapy with corticosteroids ... The structural characteristics common to temsirolimus and sirolimus; the pipecolic acid, tricarbonyl region from C13-C15, and ...
*  Cypher stent
"CYPHER™ Sirolimus-eluting Coronary Stent - P020026". FDA.gov. U.S. Food and Drug Administration. Retrieved 1 Aug 2016. "J&J to ... Sirolimus: Anti-proliferative effects "Learn about CYPHER Stent, the latest advance in stent technology". Cordis Corporation. ... An anti-rejection-type medication, sirolimus, helps to limit the overgrowth of normal cells while the artery heals which ...
*  PTEN (gene)
e.g. rapamycin, sirolimus and temsirolimus. Cell lines with known PTEN mutations include: prostate: LNCaP, PC-3 kidney: 786-O ...
*  Cedecea
H. Mawardi; M. Pavlakis; D.S. Mandelbrot; S.B. Woo (2010). "Sirolimus oral ulcer with Cedecea davisae superinfection". Transpl ... Mawardi, H., Pavlakis, M., Mandelbrot, D., Woo, S. B. (2010). Sirolimus oral ulcer with Cedecea davisae superinfection. Transpl ...
*  Hives
Sirolimus and mycophenolate have less evidence for their use in the treatment of chronic hives but reports have shown them to ... Morgan M (2009). "Treatment of refractory chronic urticaria with sirolimus". Arch Dermatol. 145 (6): 637. doi:10.1001/ ... Immunosuppressants used for CU include cyclosporine, tacrolimus, sirolimus, and mycophenolate. Calcineurin inhibitors, such as ... At this point, anti-inflammatory medications (dapsone, sulfasalazine), immunosuppressants (cyclosporin, sirolimus) or other ...
*  Primary effusion lymphoma
Sirolimus has been proposed as a treatment option. List of hematologic conditions Swerdlow, Steven H.; International Agency for ...
*  Genous
The Combo Dual Therapy Stent is a coronary stent that combines Genous with an antiproliferative, biodegradable sirolimus drug ... Sirolimus-Eluting Stent Found 'Safe,' and 'Effective.'" Cardiology News. "Dual-Therapy Stenting: The Next Step in the Evolution ...
*  Arnold Demain
... sirolimus) and antitumour antibiotic, fumagillin; statins; pigments; vaccines (developing media with non-animal components for ...
*  OrbusNeich
London, Susan (14 November 2011). "Bioengineered, Sirolimus-Eluting Stent Found 'Safe,' and 'Effective.'" Cardiology News. http ... sirolimus drug elution from a biodegradable polymer, was shown to be as effective as a paclitaxel-eluting stent in controlling ... a randomized comparison of a combination sirolimus-eluting endothelial progenitor cell capture stent with a paclitaxel-eluting ...
*  Dual therapy stent
... biodegradable sirolimus drug elution. The Combo Stent has received CE Mark approval "Dual-Therapy Stenting: The Next Step in ... Sirolimus-Eluting Stent Found 'Safe,' and 'Effective.'" Cardiology News. First Dual-Therapy Stent Nets CE Mark (Cardiology ...
*  Drug-eluting stent
The first successful trials were of sirolimus-eluting stents. A clinical trial in 2002 led to approval of the sirolimus-eluting ... 2003). "Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery". New England ... Sirolimus, paclitaxel, and everolimus were previously used for other medical applications and have been included in licensed ... In meta-analyses of the sirolimus- and paclitaxel-eluting stent trials, a small but statistically higher risk of thrombosis was ...
*  Zotarolimus
It is a semi-synthetic derivative of sirolimus (rapamycin). It was designed for use in stents with phosphorylcholine as a ...
*  Neurofibroma
Sirolimus is an antibiotic developed as an antifungal agent. It inhibits mTOR signalling. It is being studied to treat ... The combination of erlotinib with sirolimus is being studied to treat low-grade gliomas. Early research has shown potential for ... "Sirolimus to Treat Plexiform Neurofibromas in Patients With Neurofibromatosis Type I" at ClinicalTrials.gov Clinical trial ... number NCT00634270 for "A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform ...
*  Streptomyces isolates
Sirolimus (Rapamycin), ascomycin, and tacrolimus were isolated from Streptomyces. Pimecrolimus is a derivative of ascomycin. ...
*  Kidney transplantation
Some recipients may instead take ciclosporin, sirolimus, or azathioprine. The risk of early rejection of the transplanted ... These food products are known to interact with the transplant medications, specifically tacrolimus, cyclosporin and sirolimus; ...
*  Autoimmune lymphoproliferative syndrome
Sirolimus may not be as immune suppressive in normal lymphocytes as other agents. Some patients have had improvement in immune ... Sirolimus (rapamycin, rapamune) which is a mTOR (mammalian target of rapamycin) inhibitor can be active in most patients and ... Hypothetically, Sirolimus may have lower risk of secondary cancers as opposed to other immune suppressants and requires ... 2009). "Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome". ...
*  Valentin Fuster
Poon, Michael; Badimon, Juan Jose; Fuster, Valentin (2002). "Viewpoint Overcoming restenosis with sirolimus: From alphabet soup ...
*  Immunosuppressive drug
Everolimus is an analog of sirolimus and also is an mTOR inhibitor. IFN-β suppresses the production of Th1 cytokines and the ... Sirolimus (rapamycin, trade name Rapamune) is a macrolide lactone, produced by the actinomycete bacterium Streptomyces ... Therefore, sirolimus acts synergistically with ciclosporin and, in combination with other immunosuppressants, has few side ... In a similar manner, Sirolimus prevents B cell differentiation into plasma cells, reducing production of IgM, IgG, and IgA ...
*  Immunophilins
... are targeted by immunosuppressive drugs such as sirolimus, cyclosporin, and tacrolimus. For these drugs in ...
*  Temsirolimus
It is a derivative and prodrug of sirolimus and is sold as Torisel. Temsirolimus is a specific inhibitor of mTOR and interferes ... Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; therefore, ...