... binding to antigen and its downstream signaling pathway, they actively proliferate and form a large clone of effector cells. ... Clones of memory T cells expressing a specific T cell receptor can persist for decades in our body. Since memory T cells have ... cells, stem memory TSCM cells, and virtual memory T cells. The single unifying theme for all memory T cell subtypes is that ... Historically, memory T cells were thought to belong to either the effector (TEM cells) or central memory (TCM cells) subtypes, ...

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... cell motility, and cell invasion by attenuating EGFR and, downstream the signaling pathway, AKT. Thus, treatments promoting ... Ohtsuka K, Hata M (2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and ... 2002). "hTid-1, a human DnaJ protein, modulates the interferon signaling pathway". J. Biol. Chem. 276 (52): 49034-42. doi: ... 2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMC ...

Horng T, Barton GM, Medzhitov R (Sep 2001). "TIRAP: an adapter molecule in the Toll signaling pathway". Nature Immunology. 2 (9 ... an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and ... Ohtsuka K, Hata M (Apr 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification ... Lin Y, Sun Z (Apr 2015). "In vivo pancreatic β-cell-specific expression of antiaging gene Klotho: a novel approach for ...

"CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component ... "Molecular cloning and expression of an IL-6 signal transducer, gp130". Cell. 63 (6): 1149-1157. doi:10.1016/0092-8674(90)90411- ... signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell ... "Molecular cloning and expression of an IL-6 signal transducer, gp130". Cell. 63 (6): 1149-57. doi:10.1016/0092-8674(90)90411-7 ...

Perlmann T, Jansson L (April 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and ... "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line". Journal of Immunology. 154 (8 ... Perlmann T, Jansson L (April 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and ... Sacchetti P, Carpentier R, Ségard P, Olivé-Cren C, Lefebvre P (2006). "Multiple signaling pathways regulate the transcriptional ...

This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth ... Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and ... Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced ... The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML. STAT5B has been shown to ...

... for the JNK signaling pathway". The Journal of Biological Chemistry. 277 (26): 23919-26. doi:10.1074/jbc.M200838200. PMID ... Cell Biology. 35 (2): 226-34. doi:10.1016/S1357-2725(02)00127-9. PMID 12479873. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, ... "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3". The International Journal of ... Hagiwara M (June 2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway ...

"Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and ... "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". ... "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". ... Cannarile L, Zollo O, D'Adamio F, Ayroldi E, Marchetti C, Tabilio A, Bruscoli S, Riccardi C (Feb 2001). "Cloning, chromosomal ...

WNT signalling pathway). But only Gorlin syndrome and the SHH pathway is thought to incorporate the mode of action of the miR- ... Further evidence came when transfecting MCF-7 cells with a GFP reporter cloned to contain the ERβ1 3' UTR region. Flow ... that the mir-92 miRNA and associated family members are providing functional roles to the cell cycle and to cell signalling, ... PTCH is the receptor for Sonic hedgehog (SHH). This SHH signalling pathway is crucial during early development and SSH is the ...

The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA ... Zhang DD (2007). "Mechanistic studies of the Nrf2-Keap1 signaling pathway". Drug Metabolism Reviews. 38 (4): 769-89. CiteSeerX ... July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324-32. doi:10.1101/gr. ... doi:10.1016/j.cell.2019.06.003. PMC 6625921. PMID 31257023. Lee OH, Jain AK, Papusha V, Jaiswal AK (December 2007). "An auto- ...

... of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell ... 1993). "Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1". Mol. Cell. ... Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase ... 1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science. 267 (5198): 682-5 ...

These genetic abnormalities effect the Wnt signaling pathway, regulation of the cell cycle, RNA metabolism, protein folding, ... slow development of plasma cell/plasma cell precursor genetic abnormalities which initially create a clone of cells that cause ... 2x109 plasma cells per liter or, alternatively, >20% of nucleated blood cells being plasma cells. More recently, the Group has ... Plasma cell leukemia (PCL) is a plasma cell dyscrasia, i.e. a disease involving the malignant degeneration of a subtype of ...

PLD was first cloned from HeLa cell cDNA in 1995, while mammalian PLD1 was first cloned from a rat in 1997. Phosphatidylcholine ... PC-specific PLD activity has been implicated in numerous cellular pathways, including membrane trafficking, signal transduction ... PLD1 may play a role in some cells in the endocytosis of signaling receptors or exocytosis of signaling molecules. For example ... one experiment in B cells showed that limiting PLD1 led to significantly reduced endocytosis of the B cell receptor. Another ...

... then these clones, which are no longer receiving Hh signaling, would have the same affinity as the other posterior cells in ... through the activation of signaling pathways such as Hedgehog (Hh) and Decapentaplegic (Dpp). The presence of engrailed in the ... Cells in the posterior compartment produce Hh, but only anterior cells can transduce the signal.Optomotor-blind (omb) is ... inactive Hh signaling induces a junctional behavior that aligns the cell bonds of where these opposing cell types meet. ...

... signaling pathway (oncogenic) was shown. Increased activity of STAT3 in cancer cells, leads to changes in the function of ... "Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated ... "Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway". Cellular Immunology. ... signaling pathway". Cell. 77 (1): 63-71. doi:10.1016/0092-8674(94)90235-6. PMID 7512451. S2CID 42211976. Tkach M, Rosemblit C, ...

They are integral regulators of essential cell signaling pathways affecting cell growth, proliferation, differentiation, and ... Before the cloning and characterization of Sulf1 and Sulf2, HS composition was thought to be unchanging after localization to ... inhibited FGF-2 signaling, but did not affect HB-EGF, EGF, or insulin-like growth factor-1 (IGF-1) signaling, indicating cell ... pathway (in addition to other pathways). This results in several responses including cell proliferation and angiogenesis. ...

... while the intracellular C-terminus interacts with intracellular signaling proteins to initiate downstream signaling pathways. ... Thorens B (September 1992). "Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon- ... They can enhance beta cell survival, promote beta cell proliferation, and inhibit beta cell apoptosis, thus preserving beta ... van Eyll B, Lankat-Buttgereit B, Bode HP, Göke R, Göke B (July 1994). "Signal transduction of the GLP-1-receptor cloned from a ...

... focusing on the cellular role of osteopontin in regulating inflammatory signalling pathways in HIV infected macrophages. Brown ... is notable for cloning one of the first recombinant HIV viruses and developing a novel method to visualize HIV infected cells ... Osteopontin is a pro-inflammatory cytokine that is secreted by the two main cells in the brain that HIV infects, namely T cells ... Brown also explored the sec-dependent protein export pathway in mycobacterium, the main protein export pathway into the ...

Okamura's research group cloned mammalian Period genes, visualized clock oscillation at the single cell level in the central ... and proposed a time-signal neuronal pathway to the adrenal gland. He received a Medal of Honor with Purple Ribbon in 2007 for ... and the adrenal gland is the key organ in transforming circadian signals from nerve signals to the endocrine signals. Okamura's ... Cell. 155 (4): 793-806. doi:10.1016/j.cell.2013.10.026. PMID 24209618. "Prof Hitoshi Okamura". ISH 2012. "Okamura Laboratory". ...

... is an essential negative regulator of the Sonic hedgehog signaling pathway. The first understanding of biological ... opb is required for dorsal cell types and Shh is required for ventral cell types in the spinal cord. GRCh38: Ensembl release 89 ... Marcos I, Borrego S, Antiñolo G (December 2003). "Molecular cloning and characterization of human RAB23, a member of the group ... 2004). "Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway". Traffic ...

His laboratory examines molecular signaling pathways and the resulting DNA damage response in mammalian cells. These pathways ... D'Andrea, A. D.; Lodish, H. F.; Wong, G. G. (1989-04-21). "Expression cloning of the murine erythropoietin receptor". Cell. 57 ... D'Andrea's laboratory contributed significantly to the elucidation of a new DNA repair pathway, the FA/BRCA pathway, and ... Somatic disruption of genes in the FA/BRCA pathway account for the chromosome instability and drug sensitivity of many solid ...

2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells ... 2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMC ... 2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells". J. ...

Kishimoto discovered and cloned interleukin-6 and its receptor and delineated the signaling pathway used by IL-6 and the set of ... a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77 ... Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58:573-581, 1989. Akira, ... Later, this finding led to the discovery of the dichotomy of helper T cells, Th1 and Th2. On the basis of these early studies, ...

... cDNA cloning from human lung and the identification of alternative polyadenylation signals". Int. J. Biochem. Cell Biol. 33 (1 ... "Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells". Nat. Cell Biol. 8 (1): 46-54. doi:10.1038/ ... Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes ... 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): ...

Topham MK (2006). "Signaling roles of diacylglycerol kinases". J. Cell. Biochem. 97 (3): 474-84. doi:10.1002/jcb.20704. PMID ... "Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals". Curr. Opin. Neurobiol. 14 (3): ... Kai M, Sakane F, Imai S, Wada I, Kanoh H (Aug 1994). "Molecular cloning of a diacylglycerol kinase isozyme predominantly ... Luo B, Regier DS, Prescott SM, Topham MK (2005). "Diacylglycerol kinases". Cell. Signal. 16 (9): 983-9. doi:10.1016/j.cellsig. ...

"Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways". IntAct. Procaccio V, Wallace DC (May ... Dunbar DR, Shibasaki Y, Dobbie L, Andersson B, Brookes AJ (1997). "In situ hybridisation mapping of genomic clones for five ... human respiratory chain complex I genes". Cytogenetics and Cell Genetics. 78 (1): 21-4. doi:10.1159/000134618. PMID 9345899. ...

... reported that TP53 was a critical part of a signal transduction pathway that helped cells respond to DNA damage. In 1993, p53 ... The human TP53 gene was cloned in 1984 and the full length clone in 1985. It was initially presumed to be an oncogene due to ... In adult stem cells, p53 regulation is important for maintenance of stemness in adult stem cell niches. Mechanical signals such ... Suppression of p53 plays important roles in cancer stem cell phenotype, induced pluripotent stem cells and other stem cell ...

... pathway. This pathway normally regulates stress-induced cell death. It is also essential for development of nerval system by ... Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF (1997). "Cloning and expression of primate Daxx cDNAs and mapping of the ... Apoptosis signal-regulating kinase1). Another mechanism for exogenous Daxx import involves CRM1. This transport mechanism is ... and cell death. Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. When the cell is ...

... and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-648. doi:10.1016/j.cell.2006.09.026. PMID ... V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA ... "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324-1332. doi:10.1101/gr.2334104. PMC 442148 ... Demczuk S, Aledo R, Zucman J, Delattre O, Desmaze C, Dauphinot L, Jalbert P, Rouleau GA, Thomas G, Aurias A (1995). "Cloning of ...