In a series of articles, they studied the mechanism of autism-related chromatin regulators using a cellular, mouse, and fly ... They also identify genes that are affected by the sex chromosomes and show differences in essentiality between males and ... Shohat, Shahar; Vol, Ethel; Shifman, Sagiv (2022-11-23). "Gene essentiality in cancer cell lines is modified by the sex ... Herman, Neta; Kadener, Sebastian; Shifman, Sagiv (2022-12-06). "The chromatin factor ROW cooperates with BEAF ‐32 in regulating ...
Lee joined the faculty at Harvard in 1997 and devoted her studies to noncoding RNA and sex chromosome dynamics during ... by recruiting chromatin modifying activities to the locus, making the lncRNAs excellent drug design targets. She founded RaNA ...
At puberty, sex hormones may exert epigenetic changes (via DNA methylation) on gene expression, thus accounting for higher ... Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (May 2007). "Recovery of learning and memory is associated with chromatin ... Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (Apr 2006). "Sustained hippocampal chromatin regulation in a ... These alterations may be epigenetic scars in the chromatin that contribute to the persistent epigenetic changes found in ...
... the sex chromosomes. Although the XX/XY sex chromosome system is the most common among eutherian species, it is not universal. ... A resolution of several kilobases can be achieved on interphase chromatin. A limitation is that hybridization efficiencies ... d. Metaphase spread of the Transcaucasian Mole Vole female (Ellobius lutescens, 2n = 17, X0 in both sexes). Tjio, HJ LA; Levan ... f. C-banded chromosomes of the southern vole (Microtus rossiaemeridionalis, 2n = 54) with very large C-bands on both sex ...
Through chromatin immunoprecipitation (ChIP) followed by next-generation sequencing or microarray, some SALL4 targets have been ... screens Sall4 can also bind other important pluripotency proteins such as Nanog and sex determining region Y (SRY)-box 2 ...
Transcriptional regulator ATRX contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin ... Tang P, Park DJ, Marshall Graves JA, Harley VR (September 2004). "ATRX and sex differentiation". Trends in Endocrinology and ... In addition, ATRX undergoes cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association ... January 2012). "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma". Nature. 482 (7384 ...
Her thesis titled, "Methylation and chromatin conformation of adenovirus type 12 DNA sequences in transformed cells," dealt ... Redfield, Rosemary J. (2001). "Do bacteria have sex?". Nature Reviews Genetics. 2 (8): 634-639. doi:10.1038/35084593. ISSN 1471 ... Redfield, Rosemary J. (1980). Methylation and chromatin conformation of adenovirus type 12 DNA sequences in transformed cells ( ... with the chromatin structure and SDNA methylation. Redfield received her PhD in Biological Sciences from Stanford University ...
The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. ... Females had abnormal peripheral blood lymphocytes data and both sexes displayed increased bone strength and mineral content. ... domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin ... "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly ...
... sex of an individual was determined by the internal organs, and the external organs determined the "perceived" sex of an ... chromatin remodeling, or the recruitment of general transcription factors associated with RNA polymerase II holocomplex. Target ... Human embryos develop similarly for the first six weeks, regardless of genetic sex (46,XX or 46,XY karyotype); the only way to ... By the sixth week, the indifferent gonads begin to differentiate according to genetic sex. If the karyotype is 46,XY, testes ...
Rothenberg describes her upbringing as "sex-blind". She credits her parents with giving her a strong sense of one's potential ... She has modeled the gene networks involved and the interactions of transcription factors and chromatin. She identified that ...
Study: Daily sex helps to reduce sperm DNA damage and improve fertility Archived 2011-09-18 at the Wayback Machine the European ... impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin ... 7 December 2008). "It's official: Men really are the weaker sex". The Independent. Archived from the original on December 8, ... Neither do any substantial fluctuations in sex hormones explain the intercourse advantage. It is hypothesized that sexual ...
... or when a gene is located on a sex chromosome in the heterogametic sex (in which the sex chromosomes do not exist in matching ... chromatin A complex of DNA, RNA, and protein found in eukaryotic cells that is the primary substance comprising chromosomes. ... thereby equalizing the expression of sex-linked genes so that the members of each sex receive the same or similar amounts of ... Unlike the sex chromosomes, the autosomes in a diploid cell exist in pairs, with the members of each pair having the same ...
... and autosomal means that they are not sex chromomes. Two sex chromosome (in green rectangle at bottom right in the schematic ... Chromatin diminution (founding father: Theodor Boveri). In this process, found in some copepods and roundworms such as Ascaris ... The sex of an unborn fetus can be predicted by observation of interphase cells (see amniotic centesis and Barr body). Six ... In the germ-line (the sex cells) the chromosome number is n (humans: n = 23).p28 Thus, in humans 2n = 46. So, in normal diploid ...
... that sex is the heterozygous sex". Empirical evidence supports a role for heteromorphic sex chromosomes in hybrid sterility and ... inheritance of siRNAs is stable and maintains chromatin and genome stability, potentially buffering against a transcriptomic ... In taxa with well-differentiated sex chromosomes, Haldane's rule has shown to be close to universal, and heteromorphic sex ... Most plants, as well as many groups of animals, lack heteromorphic sex chromosomes. The absence of heteromorphic sex ...
"Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology ... The DNA-binding motif suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations ... which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation". American Journal ...
Alteration of sex hormone levels were also concluded to result from a high BMI status, with affected hormones such as inhibin B ... benefits of zinc in the semen stem from its multifaceted contributions to the stability of the membranes and sperm chromatin. ... Normal ejaculate when a man is not drained from prior sex and is suitably aroused is around 1.5-6 mL, although this varies ...
The nucleus has finely granular chromatin and is vesiculated. Intermediate cells - two to three times larger than parabasal ... it helps differentiate the stages of the mammalian estrous cycle because the vaginal epithelium changes in response to sex ...
... but turning to sex determination. Meyer discovered the master gene involved in sex determination. Meyer's early work focused on ... "Sperm chromatin proteomics identifies evolutionarily conserved fertility factors". Nature. Springer Science and Business Media ... "Who's Who in Sex-Determination Research", Howard Hughes Medical Institute "Sex and Repression", Barbara Meyer profile at HHMI ... Her lab identified a gene they named xol-1 as the master switch for sex determination. Meyer's group also found that ...
To mitigate this, one of the X chromosomes is inactivated in females, so that each sex only has one set of X chromosome genes. ... Thus, Xist does not condense chromatin on the other X chromosome, letting it remain active. This does not occur on the other ... Lee JT (2002). "Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation". Nat. Genet. 32 ... Xist inactivates an X chromosome at random in female mice by condensing the chromatin, via histone methylation among other ...
... which induce spermatogenesis and aid the formation of secondary sex characteristics. From this point on, the secretion of FSH ... which recognize double strand breaks and modify chromatin, respectively. As a result, double strand breaks in meiotic cells, ...
The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease. Adding localised radiation ... chromatin is distributed close to the nuclear membrane). Almost all of these cells have an increased copy number of chromosome ... male sex, large number of involved nodal sites, advanced stage, age of 40 years or more, the presence of B symptoms, high ...
The primary chromatin binding region was shown to localize to the C-repeat region. The chromatin-binding region was ... Some methods involved in dosage compensation to inactivate one of the X chromosomes from one of the sexes are Tsix antisense ... The Xist RNA directly binds to the inactive X-chromosome through a chromatin binding region of the RNA transcript. The Xist ... One theory is that Tsix is involved in chromatin modification at the Xist locus and another is that transcription factors of ...
2007). "The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the ... ISBN 978-0-582-44496-6.[page needed] Schubert V, Ruban A, Houben A (2016). "Chromatin Ring Formation at Plant Centromeres". ... It shows 22 homologous autosomal chromosome pairs, both the female (XX) and male (XY) versions of the two sex chromosomes, as ... Gempe T, Hasselmann M, Schiøtt M, Hause G, Otte M, Beye M (October 2009). "Sex determination in honeybees: two separate ...
The additional 23rd pair is the sex chromosomes, X and Y. Note that the pair of sex chromosomes may or may not be homologous, ... The process of meiosis I is generally longer than meiosis II because it takes more time for the chromatin to replicate and for ... depending on the sex of the individual. For instance, females contain XX, thus have a homologous pair of sex chromosomes. This ... 1 pair of sex chromosomes). Conversely, males contain XY, which means that they have a non-homologous pair of sex chromosomes ...
ISBN 978-0-04-575015-3. Ohno, S. (1967). Sex Chromosomes and Sex-linked Genes. Springer-Verlag. ISBN 978-91-554-5776-1. Kellis ... but they in some cases lead to loss of chromatin segregation leading to chromatin conformation changes that in turn lead to ... "Whole-genome doubling drives oncogenic loss of chromatin segregation". Nature: 1-9. doi:10.1038/s41586-023-05794-2. ISSN 1476- ... "Retrogene Duplication and Expression Patterns Shaped by the Evolution of Sex Chromosomes in Malaria Mosquitoes". Genes. 13 (6 ...
The term sex chromosome aneuploidy summarizes conditions with an abnormal number of sex chromosomes, i.e., other than XX ( ... This is known as a chromatin bridge or an anaphase bridge. Mitotic nondisjunction results in somatic mosaicism, since only ... The term autosomal trisomy means that a chromosome other than the sex chromosomes X and Y is present in 3 copies instead of the ... Trisomy X is a form of sex chromosome aneuploidy where females have three instead of two X chromosomes. Most patients are only ...
This is also why individuals with Klinefelter syndrome, a disease in which more than two sex chromosomes are present in the ... PRC2 (Polycomb Repressive Complex 2) is a complex of proteins that repress chromatin by histone methylation and by working to ... PcG genes are responsible for repressing chromatin in Hox clusters meant to be inactivated in the differentiated cell. PcG ... Thus, PRC2 represses by two mechanisms: by directly altering the structure of the chromatin through methylation or by binding ...
... pioneer on sex chromosome anomalies Herschel L. Roman (1914-1989), US geneticist, innovated in analysis in maize and budding ... chromatin, nucleic acids David Botstein (born 1942), Swiss-born US molecular geneticist, brother of Leon Botstein Theodor ... X-inactivation and sex determination in mice Luigi Luca Cavalli-Sforza (1922-2018), Italian population geneticist at Stanford ... evolution of sex determining mechanisms Luther Burbank (1849-1926), US botanist, horticulturist, pioneer in agricultural ...
A. proteus possesses a thick-walled nucleus containing granular chromatin, and is therefore a eukaryote. Its membrane includes ... Hofstatter PG, Brown MW, Lahr DJ (November 2018). "Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa". Genome ...
Another role of STAG2 is to encode the stromal antigen 2 protein, which is involved in chromatin organization, transcription, ... April 2022). "STAG2 Protein Expression in Non-muscle-invasive Bladder Cancer: Associations with Sex, Genomic and Transcriptomic ... Chromatin. 13 (1): 32. doi:10.1186/s13072-020-00353-9. PMC 7418333. PMID 32778134. Athans S, Krishnan N, Ramakrishnan S, Cortes ...