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*  Serotonin-norepinephrine-dopamine reuptake inhibitor
Nichols, DE; Nichols, CD (2008). "Serotonin receptors". Chemical Reviews. 108 (5): 1614-41. doi:10.1021/cr078224o. PMID ... Data from clinical studies have shown that DA agonists, such as bromocriptine, pramipexole and ropinirole, exhibit ... They are an extension of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors ( ... A serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of ...
*  5-HT2B receptor
Serotonin transporter: 5-HT2B receptors regulate serotonin release via the serotonin transporter, and are important both to ... "The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo". British Journal of ... 5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the ... Research claims serotonin 5-HT2B receptors have effect on liver regeneration. 5-HT receptor GRCh38: Ensembl release 89: ...
*  5-HT receptor
LSD (a psychedelic) is a 5-HT1A, 5-HT2A, 5-HT2C, 5-HT5A, 5-HT5, 5-HT6 agonist. The genes coding for serotonin receptors are ... 5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand- ... The 7 general serotonin receptor classes include a total of 14 known serotonin receptors. The specific types have been ... 5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors are found in the central and peripheral nervous systems ...
*  5-HT2C receptor agonist
5-HT receptor 5-HT2 receptor 5-HT2C receptor Serotonin receptor agonist Serotonin antagonist Serotonin Lorcaserin Vabicaserin ... The serotonin receptor agonist mCPP has a significant affinity for 5-HT2C receptors. mCPP patients experience multiple side ... Later, animal studies showed that serotonin receptor agonists might act as a mediator of satiety. Serotonin has been implicated ... Lorcaserin is a full agonist for 5-HT2C and 5-HT2B receptors and partial agonist for 5-HT2A receptors (75% of the maximal ...
*  Osemozotan
... a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons". Biological & ... acting as a full agonist at presynaptic and a partial agonist at postsynaptic 5-HT1A receptors. 5-HT1A receptor stimulation ... "An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non- ... Ago, Y.; Nakamura, S.; Uda, M.; Kajii, Y.; Abe, M.; Baba, A.; Matsuda, T. (2006). "Attenuation by the 5-HT1A receptor agonist ...
*  Serotonin receptor agonist
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner ... Most of these drugs also act as agonists of other serotonin receptors. Not all 5-HT2A receptor agonists are psychoactive. The ... Activation of the 5-HT2A receptor is also implicated in serotonin syndrome caused by indirect serotonin receptor agonists like ... which is an agonist of both the 5-HT2A receptor and many other serotonin receptors, has never been associated with serotonin ...
*  Serotonin receptor antagonist
... and many other organs and has been used in hypertension and psychosis Serotonin receptor agonist Lindley, C.; Blower, P. (2000 ... A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action at serotonin (5-HT) receptors. ... "Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis". American Journal of Health-System ... that although some non-selective serotonin antagonists may have an particular affinity for a specific 5-HT receptor (and thus ...
*  Indirect agonist
Fenfluramine is an indirect agonist of serotonin receptors. Fenfluramine binds to the serotonin transporter, blocking serotonin ... Cocaine is a monoamine transporter blocker and, thus, an indirect agonist of dopamine receptors. Cocaine binds the dopamine ... In pharmacology, an indirect agonist or indirect-acting agonist is a substance that enhances the release or action of an ... Baumann MH, Ayestas MA, Dersch CM, Partilla JS, Rothman RB (2000). "Serotonin transporters, serotonin release, and the ...
*  Meta-Chlorophenylpiperazine
It behaves as an agonist at most serotonin receptors. mCPP has been shown to act not only as a serotonin reuptake inhibitor but ... Charney DS, Woods SW, Goodman WK, Heninger GR (1987). "Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP ... It acts as a partial agonist of the human 5-HT2C receptor but as an antagonist of the human 5-HT2A and 5-HT2B receptors. In ... Hayashi A, Suzuki M, Sasamata M, Miyata K (March 2005). "Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats ...
*  Lupus headache
Bernatsky S, Pineau CA, Lee JL, Clarke AE (2006). "Headache, Raynaud's syndrome and serotonin receptor agonists in systemic ...
*  Alpha-Ethyltryptamine
... with serotonin being the primary neurotransmitter affected. In addition, it acts as a non-selective serotonin receptor agonist ... As with many other serotonin releasing agents, injury can occur when excessive doses are taken or when combined with drugs such ... Huang XM, Johnson MP, Nichols DE (July 1991). "Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase)". ... Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia ...
*  Alpha-Methyltryptamine
... and as a non-selective serotonin receptor agonist. αMT has been shown as a reversible inhibitor of the enzyme monoamine oxidase ... Like many other serotonin releasing agents, αMT's analogue αET has been shown to produce long-lasting serotonergic ... Greig, M. E.; Walk, R. A.; Gibbons, A. J. (1959). "The effect of three tryptamine derivatives on serotonin metabolism in vitro ... Dexamphetamine did not enhance the 5-hydroxytryptophan-induced rise of serotonin at any level. A typical dose of harmaline for ...
*  Eplivanserin
... is an inverse agonist on the serotonin receptor subtype 5-HT2A. In contrast to older sedating drugs acting on 5- ... Teergarden, BR; Al Shamma, H; Xiong, Y (2008). "5-HT2A Inverse-Agonists for the Treatment of Insomnia". Current Topics in ... histamine and adrenergic receptors. In a placebo controlled Phase II clinical trial with 351 subjects, eplivanserin reduced the ... HT2A receptors (e.g., mirtazapine, clozapine, risperidone), eplivanserin has practically no affinity to dopamine, ...
*  Medicinal fungi
Many fungi synthesize the partial, non-selective, serotonin receptor agonist/analog psilocin. A number of other fungal species ... Fucose and mannose fragments of fungal cell wall are antagonists of VEGF-receptors Alexander Fleming led the way to the beta- ... Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (January 2007). "Dopamine agonists and the risk of cardiac-valve ...
*  Zolmitriptan
... is a selective serotonin receptor agonist of the 1B and 1D subtypes. It is a triptan, used in the acute treatment ... should not be used within 24 hours of treatment with another 5-HT1 agonist, or an ergotamine-containing or ergot-type ... is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. ""2008 Top 200 generic drugs by ...
*  5-(Nonyloxy)tryptamine
... a novel high-affinity 5-HT1D beta serotonin receptor agonist". Journal of Medicinal Chemistry. 37 (18): 2828-30. doi:10.1021/ ... 5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1B receptor. Increasing the O- ... "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors". Journal of Medicinal Chemistry. 39 (1): 314-22. ... and around 300-fold selectivity over the related 5-HT1A receptor. 5-Benzyloxytryptamine 5-Carboxamidotryptamine 5-Ethoxy-DMT ...
*  BW-723C86
... is actually a mixed 5-HT2B/5-HT2C agonist, and while it has good selectivity over 5-HT2A and other serotonin receptor ... "A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent". International Journal of Molecular Sciences. 17 ... BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist. It has anxiolytic effects in animal studies ... "Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety". British Journal of Pharmacology. 117 (7): ...
*  Lisuride
... is a dopamine and a partial agonist for several serotonin receptors. It is an antagonist at the serotonin 5-HT2B ... It has a high affinity for the dopamine D2, D3 and D4 receptors, as well as serotonin 5-HT1A and 5-HT2A/C receptors. While ... a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction ... 2008). "Identification of a serotonin/glutamate receptor complex implicated in psychosis". Nature. 452 (7183): 93-7. doi: ...
*  Skin whitening
2016). "A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent". Int. J. Mol. Sci. 17 (4): 546. doi: ... "Serotonin induces melanogenesis via serotonin receptor 2A". Br. J. Dermatol. 165 (6): 1344-8. doi:10.1111/j.1365-2133.2011. ... 1175 Melanocytes express serotonin receptors and are capable of producing serotonin. Pharmacological interference with the ... Serotonin itself is a weak inhibitor of tyrosinase with 0.11 times the potency of kojic acid. Nonetheless, serotonin increases ...
*  2CBFly-NBOMe
It acts as a potent partial agonist for the 5HT2A serotonin receptor subtype. Analogues and derivatives of 2C-B: 25-NB: 25B- ... Hansen, Martin (2011). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging ... 2002). "Development of highly potent partial agonists and chiral antagonists as tools for the study of 5-HT2A-receptor mediated ... January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer- ...
*  Eletriptan
... is a serotonin receptor agonist, specifically an agonist of certain 5-HT1 family receptors. Eletriptan binds with ... Two theories have been proposed to explain the efficacy of 5-HT1 receptor agonists in migraine. One theory suggests that ... It has a modest affinity to the 5-HT[1A, 1E, 2B, 7] receptors, and little to no affinity at the 5-HT[2A, 2C, 3, 4, 5A, 6] ... This is due to the unusual side effect of coronary vasoconstriction due to serotonin 5HT1B antagonism, which can precipitate a ...
*  25C-NBOMe
Hansen, M. (2011). "Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of ... It acts as a potent agonist for the 5HT2A receptor, and has been studied in its 11C radiolabelled form as a potential ligand ... 2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". ... "Synthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT2A/2C Agonists". ACS Chemical Neuroscience. 5 ...
*  25B-NBOMe
Hansen, M. (2011). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of ... It acts as a potent partial agonist for the 5HT2A receptor. Anecdotal reports from users[citation needed] suggest 25B-NBOMe to ... As a 5-HT2A receptor agonist PET radioligand, [11C]Cimbi-36 was hypothesized to provide a more functional marker of these ... Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009. Silva ME, Heim R, ...
*  Benzylpiperazine
BZP also acts as a non-selective serotonin receptor agonist on a wide variety of serotonin receptors; binding to 5HT2A ... BZP has amphetamine-like actions on the serotonin reuptake transporter, which increase serotonin concentrations in the ... while partial agonist or antagonist effects at the 5HT2B receptors may explain some of BZPs peripheral side effects, as this ... and binding to 5HT3 receptors may explain the common side effect of headaches, as this receptor is known to be involved in the ...
*  Monoamine releasing agent
Several selective SDRAs are known however, though these compounds also act as non-selective serotonin receptor agonists. ... Serotonin-norepinephrine releasing agent (SNRA) Serotonin-dopamine releasing agent (SDRA) Serotonin-norepinephrine-dopamine ... MRAs can also bind to the intracellular receptor TAAR1 as agonists, which triggers a phosphorylation cascade via protein ... methamphetamine is also an agonist at σ1 receptor). Monoamine release agents can have a wide variety of effects depending upon ...
*  List of investigational anxiolytics
5-HT1A receptor partial agonist and serotonin reuptake inhibitor [20] AVN-101 - 5-HT6 receptor antagonist [21] BNC-210 (IW-2143 ... 5-HT2A receptor antagonist [4] Vilazodone (EMD-68843, SB-659746A; Viibryd) - 5-HT1A receptor partial agonist and serotonin ... 5-HT1A receptor agonist, 5-HT2A receptor antagonist [18] Verucerfont (GSK-561679, NBI-77860) - CRF1 receptor antagonist [19] ... Agomelatine (AGO-178; Valdoxan) - melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist[1] Riluzole sublingual ( ...
*  25B-NBOH
It acts as a potent serotonin receptor agonist with similar affinity to the better-known compound 25B-NBOMe at 5-HT2A and 5- ... Martin Hansen (2011). "Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging ... Braden, M. R.; Parrish, J. C.; Naylor, J. C.; Nichols, D. E. (2006). "Molecular interaction of serotonin 5-HT2A receptor ... "Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor". Journal of Computer-aided Molecular ...