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*  Serotonin-norepinephrine-dopamine reuptake inhibitor
Patients taking strong dopaminergic antagonists such as those used in the treatment of psychosis are more likely than the ... They are an extension of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors ( ... A serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of ... 2011). "SEP-225289 serotonin and dopamine transporter occupancy: A PET study". Journal of Nuclear Medicine. 52 (7): 1150-5. doi ...
*  5-HT2B receptor
Serotonin transporter: 5-HT2B receptors regulate serotonin release via the serotonin transporter, and are important both to ... Metadoxine: a 5ht2b antagonist and GABA-activity modulator SDZ SER-082: a mixed 5-HT2B/C antagonist EGIS-7625: high selectivity ... that is also a 5-HT2B antagonist and a dual 5-HT2A/C agonist Tegaserod: primarily a 5-HT4 agonist, but also a 5-HT2B antagonist ... mixed 5-HT2B/C antagonist and PAM at α7 nAChR SB-215,505 SB-228,357 LY-266,097 LY-272,015 Cariprazine 5-HT2B antagonists have ...
*  5-HT receptor
Smriga M, Torii K (2003). "L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated ... The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin ... Pharmacology Corner > Serotonin (5-HT): receptors, agonists and antagonists By Flavio Guzmán, M.D. on 9/08/09 "BRINTELLIX™ ( ... The 7 general serotonin receptor classes include a total of 14 known serotonin receptors. The specific types have been ...
*  Cyproheptadine
Of the serotonin receptors, it is an especially potent antagonist of the 5-HT2 receptors, and this underlies its effectiveness ... such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of high levels of serotonin in ... in the treatment of serotonin syndrome. Cyproheptadine is known to be an antagonist or inverse agonist of all of the receptors ... It is sometimes used off-label in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms ...
*  Serotonin syndrome
If this is not sufficient, a serotonin antagonist such as cyproheptadine may be used. In those with a high body temperature ... The serotonin antagonist cyproheptadine is the recommended initial therapy, although there have been no controlled trials ... Nisijima K, Yoshino T, Yui K, Katoh S (January 2001). "Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the ... Management is based primarily on stopping the usage of the precipitating drugs, the administration of serotonin antagonists ...
*  5-HT2C receptor agonist
5-HT receptor 5-HT2 receptor 5-HT2C receptor Serotonin receptor agonist Serotonin antagonist Serotonin Lorcaserin Vabicaserin ... In the late 1960s, non-selective serotonin receptor antagonists demonstrated a relationship between serotonin receptors and ... Serotonin plays an important role in numerous physiological conditions. 5-HT2 receptor antagonists have long been known, but ... Serotonin 5-HT2 receptors are stimulated by monoamine neurotransmitters including serotonin, dopamine and norepinephrine. 5-HT2 ...
*  Serotonin antagonist and reuptake inhibitor
mCPP is an antagonist of the 5-HT2A and 5-HT2B receptors and an agonist of the 5-HT1A, 5-HT2C, and 5-HT3 receptors. Serotonin ... Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as ... They act by antagonizing serotonin receptors such as 5-HT2A and inhibiting the reuptake of serotonin, norepinephrine, and/or ... a related drug but does not fit into this class as it does not function as a serotonin antagonist, acting solely as a 5-HT1A ...
*  Serotonin receptor antagonist
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action at serotonin (5-HT) receptors. ... the antidepressant mirtazapine acts as a 5-HT3 antagonist. Please note, that although some non-selective serotonin antagonists ... Serotonin Antagonists at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82012702. ... "Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis". American Journal of Health-System ...
*  Iprazochrome
It is a serotonin antagonist. Hampf G (1989). "Effect of serotonin antagonists on patients with atypical facial pain". J ...
*  Homochlorcyclizine
... a serotonin antagonist". Journal of Allergy. 31: 237-47. PMID 14409112. ...
*  Para-Methoxyamphetamine
Serotonin antagonists and dantrolene may be used as required. Despite the seriousness of the condition, the majority of ... However, relative to MDMA, it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake ... Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3, ... PMA acts as a selective serotonin releasing agent (SSRA) with weak effects on dopamine and norepinephrine transporters. ...
*  2-Bromo-LSD
Zivin JA, Venditto JA (April 1984). "Experimental CNS ischemia: serotonin antagonists reduce or prevent damage". Neurology. 34 ... It was found to bind to many of the same receptor targets as LSD, but acting as a neutral antagonist rather than an agonist. ... Harvey JA (2003). "Role of the serotonin 5-HT(2A) receptor in learning". Learning & Memory (Cold Spring Harbor, N.Y.). 10 (5): ...
*  Akathisia
... due to increased serotonin signalling within the central nervous system. This also explains why serotonin antagonists are often ... These include benzodiazepines, β-adrenergic blockers, and serotonin antagonists. Another major cause of the syndrome is the ... and serotonin antagonists (e.g., cyproheptadine) as an alternative. Published epidemiological data for akathisia are mostly ... Laoutidis, ZG; Luckhaus, C (May 2014). "5-HT2A receptor antagonists for the treatment of neuroleptic-induced akathisia: a ...
*  Dimetotiazine
It is a serotonin antagonist and histamine antagonist. Shimazawa, M; Hara, H; Watano, T; Sukamoto, T (August 1995). "Effects of ...
*  Altanserin
There is thus obtained the serotonin antagonist altanserin (6). ABX, Altanserin, Radeberg, Germany. Lemaire C, Cantineau R, ... Other ligands for other parts of the serotonin system used in PET studies are, e.g., DASB, ketanserin, and WAY-100635. As of ... May 2009). "Brain serotonin 2A receptor binding: Relations to body mass index, tobacco and alcohol use". NeuroImage. 46 (1): 23 ... September 1995). "Serotonin 5HT2 receptor imaging in the human brain using positron emission tomography and a new radioligand ...
*  Triazoledione
Serotonin antagonist and reuptake inhibitor Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American ... Triazoledione shows significant affinity for the serotonin 5-HT1A and 5-HT2A receptors, the α1-adrenergic receptor, and the ... It shows negligible affinity for the serotonin and norepinephrine transporters and the muscarinic acetylcholine receptors. ...
*  Hydroxynefazodone
Serotonin antagonist and reuptake inhibitor Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American ...
*  Hypericum perforatum
... a serotonin-noradrenaline reuptake inhibitor (SNRI; venlafaxine), a low-dose serotonin antagonist and reuptake inhibitor (SARI ... Combining both St John's wort and SSRI antidepressants could lead to increased serotonin levels causing serotonin syndrome. It ... In combination with other drugs that may elevate 5-HT (serotonin) levels in the central nervous system (CNS), St John's wort ... In network meta-analysis, tricyclic and tetracyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), ...
*  Timeline of cholera
Sjöqvist, A; Cassuto, J; Jodal, M; Lundgren, O. "Actions of serotonin antagonists on cholera-toxin-induced intestinal fluid ... Smith, Howard S.; Cox, Lorraine R.; Smith, Eric J. "5-HT3 receptor antagonists for the treatment of nausea/vomiting". Annals of ...
*  Vomiting
Hence, anticholinergics, antihistamines, dopamine antagonists, serotonin antagonists, and cannabinoids are used as antiemetics ... The neurotransmitters that regulate vomiting are poorly understood, but inhibitors of dopamine, histamine, and serotonin are ... opioids selective serotonin reuptake inhibitors many chemotherapy drugs some entheogens (such as peyote or ayahuasca) Illness ( ... serotonin 5-HT3 receptors, opioid receptors, acetylcholine receptors, and receptors for substance P. Stimulation of different ...
*  Trazodone
It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. Trazodone also has sedating ...
*  Pizotifen
... is a serotonin antagonist acting mainly at the 5-HT2A and 5HT2C receptors. It also has some activity as an ... Animal studies also suggest that pizotyline could be used in the treatment of serotonin syndrome or MDMA overdose in a similar ...
*  MS-245
Young R, Bondareva T, Wesolowska A, Young S, Glennon RA (September 2006). "Effect of the 5-HT(6) serotonin antagonist MS-245 on ... "Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling ... It acts as a selective 5-HT6 receptor antagonist with a Ki of 2.3 nM, and was derived through structure-activity relationship ... It has been used as a lead compound for further development of tryptamine-derived 5-HT6 antagonists. In animal studies it has ...
*  Mepiprazole
It acts as a 5-HT2A and α1-adrenergic receptor antagonist and inhibits the reuptake and induces the release of serotonin, ... Cohen ML, Fuller RW, Kurz KD (1983). "Evidence that blood pressure reduction by serotonin antagonists is related to alpha ... and has been described as a serotonin antagonist and reuptake inhibitor (SARI). Controlled clinical trials of mepiprazole in ...
*  Benzoctamine
Cohen, ML; Fuller, RW; Kurz, KD (Sep-Oct 1983). "Evidence that blood pressure reduction by serotonin antagonists is related to ... One study showed that benzoctamine, a serotonin and alpha-adrenergic antagonist, does not reduce blood pressure through a ... that serotonin antagonism was not sufficient to reduce blood pressure by using the highly selective serotonin antagonist 1-(1- ... In addition to serotonin it has also been shown to decrease epinephrine, dopamine, and norepinephrine turnover by antagonizing ...
*  List of investigational anxiolytics
5-HT2A receptor antagonist [4] Vilazodone (EMD-68843, SB-659746A; Viibryd) - 5-HT1A receptor partial agonist and serotonin ... CRF1 receptor antagonist [19] Vilazodone (EMD-68843, SB-659746A; Viibryd) - 5-HT1A receptor partial agonist and serotonin ... and α1-adrenergic receptor antagonist [12] Midomafetamine (MDMA; "ecstasy") - serotonin-norepinephrine-dopamine releasing agent ... Agomelatine (AGO-178; Valdoxan) - melatonin MT1 and MT2 receptor agonist, 5-HT2C receptor antagonist[1] Riluzole sublingual ( ...
*  Antidepressant
... a serotonin-noradrenaline reuptake inhibitor (SNRI; venlafaxine), a low-dose serotonin antagonist and reuptake inhibitor (SARI ... serotonin-norepinephrine reuptake inhibitor, serotonin antagonist and reuptake inhibitors, noradrenaline reuptake inhibitors, ... Almost any medication involved with serotonin regulation has the potential to cause serotonin toxicity (also known as serotonin ... Serotonin antagonist and reuptake inhibitors (SARIs) while mainly used as antidepressants, are also anxiolytics and hypnotics. ...