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*  Serotonin-norepinephrine-dopamine reuptake inhibitor
Although their primary mechanisms of action are as NMDA receptor antagonists, ketamine and phencyclidine are also SNDRIs and ... Nichols, DE; Nichols, CD (2008). "Serotonin receptors". Chemical Reviews. 108 (5): 1614-41. doi:10.1021/cr078224o. PMID ... They are an extension of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors ( ... A serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of ...
*  5-HT receptor
Smriga M, Torii K (2003). "L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated ... The 7 general serotonin receptor classes include a total of 14 known serotonin receptors. The specific types have been ... The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin ... The genes coding for serotonin receptors are expressed across the mammalian brain. Genes coding for different receptors types ...
*  Ondansetron
Sirota P, Mosheva T, Shabtay H, Giladi N, Korczyn AD (February 2000). "Use of the selective serotonin 3 receptor antagonist ... It does not have any effect on dopamine receptors or muscarinic receptors. Ondansetron was first used medically in 1990. It is ... Serotonin is released by the enterochromaffin cells of the small intestine in response to chemotherapeutic agents and may ... Its apparent benefits despite a lack of any significant antagonistic properties at dopamine receptors or the 5-HT2A receptor ...
*  Lurosetron
... (INN) is a serotonin 5-HT3 receptor antagonist. Prakash SP, Cable KM, Correa ID, Fellows L, Montgomery S, Newman JJ ... Synthesis of isotopically labelled pyridoindolone 5-HT3 receptor antagonists. Journal of Labelled Compounds and ...
*  Miodrag Radulovacki
"Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag ... This approach was of interest since Michel Jouvet's Monoamine Theory of Sleep, with serotonin as the sleep inducing agent, was ... "Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag ... "Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists", Inventors: David W. Carley and ...
*  Ramosetron
... (INN) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. Ramosetron is also ... 90 (2): 472-5. doi:10.1097/00000539-200002000-00043. PMID 10648342. http://www.astellas.com/en/corporate/news/detail/astellas- ...
*  Antiemetic
... is a commercially available NK1 Receptor antagonist Casopitant is an investigational NK1 receptor antagonist Rolapitant (Varubi ... H1 histamine receptor antagonists) are effective in many conditions, including motion sickness, morning sickness in pregnancy, ... is an antidepressant that also has antiemetic effects and is also a potent histamine H1 receptor antagonist, Ki=1.6 nM. ... Dopamine antagonists act in the brain and are used to treat nausea and vomiting associated with neoplastic disease, radiation ...
*  Dolasetron
... of prevention and are frequently used in combination with other drugs such as corticosteroids and the NK1 receptor antagonist ... Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following ... This drug does not have any effect on dopamine receptors or muscarinic receptors. Dolasetron breaks down slowly, staying in the ... for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis Unlike most other 5HT3 antagonists, ...
*  Granisetron
Billio, A; Morello, E; Clarke, MJ (January 20, 2010). "Serotonin receptor antagonists for highly emetogenic chemotherapy in ... This drug does not have any effect on dopamine receptors or muscarinic receptors. Granisetron was developed by chemists working ... Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy ...
*  Ricasetron
... (BRL-46470) is a drug which acts as a selective antagonist at the serotonin 5-HT3 receptor. It has antiemetic ... Link CG, Leigh TJ, Dennison JK (April 1993). "The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on ... de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C (December 1993). "Absence of amnestic effect of an anxiolytic 5-HT3 ... antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam". Behavioural Brain Research. 59 (1-2): 141- ...
*  Postoperative nausea and vomiting
... receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis". BMC Medicine. 13: 142. doi ... There are multiple neurotransmitters such as histamine, dopamine, serotonin, acetylcholine, and the more recently discovered ...
*  5-HT3 antagonist
Sirota P, Mosheva T, Shabtay H, Giladi N, Korczyn AD (2000). "Use of the selective serotonin 3 receptor antagonist ondansetron ... doi:10.1093/annonc/mdi805 Lindley C, Blower P (2000). "Oral serotonin type 3-receptor antagonists for prevention of ... "Comparison of clinical efficacy of serotonin receptor antagonists in highly emetogenic chemotherapy". Cochrane Database of ... Picarelli at the University of Edinburgh proposed the existence of two serotonin receptor subtypes, the M and D receptors (thus ...
*  Tropisetron
... (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following ... role of alpha7 nicotinic receptors". European Journal of Pharmacology. 609 (1-3): 74-7. doi:10.1016/j.ejphar.2008.12.051. PMID ... is a potent and selective alpha7 nicotinic receptor partial agonist". Bioorganic & Medicinal Chemistry Letters. 11 (3): 319-21 ... The drug is available in a 5 mg oral preparation or in 2 mg intravenous form. It is marketed by Novartis in Europe, Australia, ...
*  Litoxetine
It acts as a potent serotonin reuptake inhibitor (Ki for SERT = 7 nM) and modest 5-HT3 receptor antagonist (Ki = 315 nM). It ... 80-. ISBN 978-3-0348-8391-7. Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ (March 1993). "Litoxetine: a selective 5- ... has antiemetic activity, and unlike the selective serotonin reuptake inhibitors (SSRIs), appears to have a negligible incidence ... HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology. ...
*  5-HT3 receptor
1000x selectivity over other serotonin receptors SR-57227 Varenicline YM-31636 Antagonists for the receptor (sorted by their ... or serotonin) receptors which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal ... "Characterization of the Novel Human Serotonin Receptor Subunits 5-HT3C, 5- HT3D and 5-HT3E". Mol Pharmacol. 72 (Mar 28): 8-17. ... These agents are not agonists at the receptor, but increase the affinity or efficacy of the receptors for an agonist: Indole ...
*  Palonosetron
Billio, A; Morello, E; Clarke, MJ (Jan 20, 2010). "Serotonin receptor antagonists for highly emetogenic chemotherapy in adults ... receptor antagonist for chemotherapy-induced nausea and vomiting". Proceedings (Baylor University. Medical Center). 19 (4): 413 ... These drugs act by blocking serotonin from binding to the 5-HT3 receptor. Orally taken palonosetron is absorbed well from the ... There are case reports about serotonin syndrome when the drug is combined with serotonergic substances such as selective ...
*  Criticism of the Food and Drug Administration
4] [5] Executive Summary of the 2006 IOM Report The Future of Drug Safety: Promoting and Protecting the Health of the Public ... 5) in the F344 rat". Food Chem Toxicol. 25 (12): 891-6. doi:10.1016/0278-6915(87)90281-X. PMID 3692395. CS1 maint: Multiple ... The FDA has received criticism for its approval of certain coal tar derived food dyes such as FDC yellow 5 and 6, which are ... This effectively killed the common use of droperidol and made way for heavy usage of the much more expensive non-generic 5-HT3 ...
*  Zacopride
Faustman, William O. (1992). "Zacopride in Schizophrenia: A Single-blind Serotonin Type 3 Antagonist Trial". Archives of ... "Effect of the serotonin-4 receptor agonist zacopride on aldosterone secretion from the human adrenal cortex: in vivo and in ... Zacopride is a potent antagonist at the 5-HT3 receptor and an agonist at the 5-HT4 receptor. It has anxiolytic and nootropic ... 40 (4): 302-5. doi:10.1111/j.2042-7158.1988.tb05254.x. PMID 2900320. Fontana, DJ; Daniels, SE; Eglen, RM; Wong, EH (1996). " ...
*  Timeline of cholera
Sjöqvist, A; Cassuto, J; Jodal, M; Lundgren, O. "Actions of serotonin antagonists on cholera-toxin-induced intestinal fluid ... Retrieved April 5, 2016. Rossel, Sven Hakon. Hans Christian Andersen: Danish Writer and Citizen of the World. p. 55. Retrieved ... Smith, Howard S.; Cox, Lorraine R.; Smith, Eric J. "5-HT3 receptor antagonists for the treatment of nausea/vomiting". Annals of ...
*  Drug design
Angiotensin receptor antagonists Bcr-Abl tyrosine-kinase inhibitors Cannabinoid receptor antagonists CCR5 receptor antagonists ... selective serotonin reuptake inhibitors), a class of antidepressants Zanamivir, an antiviral drug 5-HT3 antagonists ... Additional examples include: Many of the atypical antipsychotics Cimetidine, the prototypical H2-receptor antagonist from which ... Small molecules (for example receptor agonists, antagonists, inverse agonists, or modulators; enzyme activators or inhibitors; ...
*  Trifluoromethylphenylpiperazine
Robertson DW, Bloomquist W, Wong DT, Cohen ML (1992). "mCPP but not TFMPP is an antagonist at cardiac 5HT3 receptors". Life ... Due to the serotonin agonist effects and increase in serotonin, norepinephrine, and dopamine levels produced by the BZP/TFMPP ... receptors, and functions as a full agonist at all sites except the 5-HT2A receptor, where it acts as a weak partial agonist or ... and evokes the release of serotonin. It has no effects on dopamine or norepinephrine reuptake or efflux. TFMPP is rarely used ...
*  5-HT2A receptor
Serotonin): Receptor Agonists and Antagonists". In Brunton LL, Lazo JS, Parker K. Goodman & Gilman's the Pharmacological Basis ... Serotonin receptors were split into two classes by Gaddum and Picarelli when it was discovered that some of the serotonin- ... Feng J, Cai X, Zhao J, Yan Z (September 2001). "Serotonin receptors modulate GABA(A) receptor channels through activation of ... as well as an antagonist on other serotonin receptors. Mirtazapine is a 5-HT2A, 5-HT2C, and 5-HT3 antagonist. Mirtazapine also ...
*  AS-8112
... is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the ... serotonin receptor 5-HT3. It has potent antiemetic effects in animal studies and has been investigated for potential medical ... receptor antagonist, in ferrets". European Journal of Pharmacology. 431 (3): 361-4. doi:10.1016/S0014-2999(01)01459-5. PMID ... pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity". Journal of Medicinal ...
*  Gastroparesis
Similarly, the dopamine receptor antagonist domperidone is also used to treat gastroparesis. Erythromycin is known to improve ... Mirtazapine acts on the same serotonin receptor (5-HT3) as does the popular anti-emetic ondansetron. Camicinal is a motilin ... Metoclopramide, a dopamine D2 receptor antagonist, increases contractility and resting tone within the GI tract to improve ... In addition, dopamine antagonist action in the central nervous system prevents nausea and vomiting. ...
*  Serotonin
"NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications ... There are various serotonin receptors. Serotonin is metabolized mainly to 5-HIAA, chiefly by the liver. Metabolism involves ... CS1 maint: Multiple names: authors list (link) "Serotonin, serotonin receptors and their actions in insects". Neurotransmitter ... that inhibit serotonin receptors. The observation does not contradict with the notion that the serotonin level goes down in ...
*  Atypical antipsychotic
Patients with increased histamine levels have been observed to have lower serotonin levels. However, the H1 receptor is linked ... Note: Unless otherwise specified, the drugs below serve as antagonists/inverse agonists at the receptors listed. Legend: ... receptors in order to effectively treat schizophrenia. D2 Receptor: Hyperactive dopaminergic activity on D2 receptors in the ... Antagonistic affinity for the H1 receptor also has an antidepressant effect. H1 antagonism blocks serotonin and norepinephrine ...
*  Xenon
... is a high-affinity glycine-site NMDA receptor antagonist. However, xenon is different from certain other NMDA receptor ... Xenon is a competitive inhibitor of the serotonin 5-HT3 receptor. While neither anesthetic nor antinociceptive, this reduces ... Xenon is a high affinity antagonist at the NMDA receptor glycine site. Xenon is cardioprotective in ischemia-reperfusion ... Xenon interacts with many different receptors and ion channels, and like many theoretically multi-modal inhalation anesthetics ...