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*  PEDF
Near the C-terminus at residues 365-390 lies the reactive center loop (RCL) which is normally involved in serine protease ... They found that PEDF was a previously uncharacterized protein and a member of the serpin (serine protease inhibitor) family. ... neurotrophic activity and identification as a member of the serine protease inhibitor gene family". Proceedings of the National ...
*  Protein primary structure
Typically, the hydroxyl group of a serine (rarely, threonine) or the thiol group of a cysteine residue will attack the carbonyl ... A phosphate group can be attached to the sidechain hydroxyl group of serine, threonine and tyrosine residues, adding a negative ...
*  Serine
... proteases are a common type of protease. D-Serine, synthesized in neurons by serine racemase from L-serine (its ... Serine hydroxymethyltransferase (SHMT = serine transhydroxymethylase) also catalyzes the reversible conversions of L-serine to ... Pure D-serine is an off-white crystalline powder with a very faint musty aroma. D-Serine is sweet with an additional minor sour ... Serine deficiency disorders are rare defects in the biosynthesis of the amino acid L-serine. At present three disorders have ...
*  Serine hydroxymethyltransferase
Once the serine is bound to PLP, the nucleophilic amines on THF then attacks the free formaldehyde to make the carbinolamine ... Serine hydroxymethyltransferase (SHMT) is a Pyridoxal phosphate (PLP) (Vitamin B6) dependent enzyme (EC 2.1.2.1) which plays an ... The N-terminal amine of serine makes a nucleophilic attack on the aldimine between the SHMT lysine and the PLP aldehyde to form ... However, THF is not an obligate substrate for SHMT, meaning the cleavage of serine and other ß-hydroxy amino acids (such as ...
*  Serine racemase
... is an enzyme which generates D-serine from L-serine. D-serine acts as a neuronal signaling molecule by ... In humans, the serine racemase protein is encoded by the SRR gene. Mammalian serine racemase is a pyridoxal 5'-phosphate ... dependent enzyme that catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, ... "Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate". FEBS Letters. 535 (1-3): 44-8. doi:10.1016 ...
*  Serine hydrolase
Unlike other non-catalytic serines, the nucleophilic serine of these hydrolases is typically activated by a proton relay ... Superfamilies of serine hydrolases includes: Serine proteases, including trypsin, chymotrypsin, and subtilisin Extracellular ... Serine hydrolases are one of the largest known enzyme classes comprising approximately ~200 enzymes or 1% of the genes in the ... A defining characteristic of these enzymes is the presence of a nucleophilic serine in their active site, which is used for the ...
*  Serine protease
... s (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the ... Serine Peptidase Serine Proteases site at Saint Louis University (SLU) Serine proteases at the US National Library of Medicine ... The serine -OH attacks the carbonyl carbon, and the nitrogen of the histidine accepts the hydrogen from the -OH of the [serine ... Serine proteases are paired with serine protease inhibitors, which turn off their activity when they are no longer needed. ...
*  Serine dehydratase
L-serine ammonia-lyase Serine deaminase L-hydroxyaminoacid dehydratase L-serine deaminase L-serine dehydratase L-serine hydro- ... Serine dehydratase or L-serine ammonia lyase (SDH) is in the β-family of pyridoxal phosphate-dependent (PLP) enzymes. SDH is ... In panel 3 of Figure 5) The COOH group of serine is positioned tightly in the SDH enzyme so that the serine molecule is ... L-Serine dehydratase condenses homocysteine with serine to form cystathionine. The foregoing paragraph is however mistaken as ...
*  Serine 3-dehydrogenase
In enzymology, a serine 3-dehydrogenase (EC 1.1.1.276) is an enzyme that catalyzes the chemical reaction L-serine + NADP+ ⇌ {\ ... The systematic name of this enzyme class is L-serine:NADP+ 3-oxidoreductase. Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, ... Chowdhury EK, Higuchi K, Nagata S, Misono H (1997). "A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium ... the two substrates of this enzyme are L-serine and NADP+, whereas its 3 products are 2-ammoniomalonate semialdehyde, NADPH, and ...
*  Serine-pyruvate transaminase
In enzymology, a serine-pyruvate transaminase (EC 2.6.1.51) is an enzyme that catalyzes the chemical reaction L-serine + ... The systematic name of this enzyme class is L-serine:pyruvate aminotransferase. Other names in common use include SPT, and ... This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate. As of late ... Cheung GP, Rosenblum IY, Sallach HJ (1968). "Comparative studies of enzymes related to serine metabolism in higher plants". ...
*  Serine-ethanolaminephosphate phosphodiesterase
... serine + ethanolamine phosphate Thus, the two substrates of this enzyme are serine phosphoethanolamine and H2O, whereas its two ... In enzymology, a serine-ethanolaminephosphate phosphodiesterase (EC 3.1.4.13) is an enzyme that catalyzes the chemical reaction ... HAGERMAN DD, ROSENBERG H, ENNOR AH, SCHIFF P, INOUE S (1965). "THE ISOLATION AND PROPERTIES OF CHICKEN KIDNEY SERINE ... The systematic name of this enzyme class is serine-phosphoethanolamine ethanolaminephosphohydrolase. Other names in common use ...
*  Serine-glyoxylate transaminase
In enzymology, a serine-glyoxylate transaminase (EC 2.6.1.45) is an enzyme that catalyzes the chemical reaction L-serine + ... The systematic name of this enzyme class is L-serine:glyoxylate aminotransferase. This enzyme participates in glycine, serine ... Smith IK (1973). "Purification and characterization of serine:glyoxylate aminotransferase from kidney bean (Phaseolus vulgaris ... the two substrates of this enzyme are L-serine and glyoxylate, whereas its two products are 3-hydroxypyruvate and glycine. This ...
*  Serine-tRNA ligase
In enzymology, a serine-tRNA ligase (EC 6.1.1.11) is an enzyme that catalyzes the chemical reaction ATP + L-serine + tRNASer ... and serine translase. This enzyme participates in glycine, serine and threonine metabolism and aminoacyl-trna biosynthesis. As ... The systematic name of this enzyme class is L-serine:tRNASer ligase (AMP-forming). Other names in common use include seryl-tRNA ... Ohama T, Yang DC, Hatfield DL (1994). "Selenocysteine tRNA and serine tRNA are aminoacylated by the same synthetase, but may ...
*  Serine C-palmitoyltransferase
... serine palmitoyltransferase, SPT, 3-oxosphinganine synthetase, and acyl-CoA:serine C-2 acyltransferase decarboxylating. Serine ... Serine C-palmitoyltransferase is expressed in a large number of species from bacteria to humans. The bacterial enzyme is a ... In enzymology, a serine C-palmitoyltransferase (EC 2.3.1.50) is an enzyme that catalyzes the chemical reaction: palmitoyl-CoA ... Gable K, Slife H, Bacikova D, Monaghan E, Dunn TM (March 2000). "Tsc3p is an 80-amino acid protein associated with serine ...
*  Serine 2-dehydrogenase
In enzymology, a serine 2-dehydrogenase (EC 1.4.1.7) is an enzyme that catalyzes the chemical reaction L-serine + H2O + NAD+ ... Other names in common use include L-serine:NAD+ oxidoreductase (deaminating), and serine dehydrogenase. Kretovich VL, ... The systematic name of this enzyme class is L-serine:NAD+ 2-oxidoreductase (deaminating). ... displaystyle \rightleftharpoons } 3-hydroxypyruvate + NH3 + NADH + H+ The 3 substrates of this enzyme are L-serine, H2O, and ...
*  Serine octamer cluster
The Serine octamer cluster in physical chemistry is an unusually stable cluster consisting of eight serine molecules (Ser) ... A racemic serine solution produces a minimum amount of cluster and with solutions of both enantiomers a maximum amount is ... The same octamer ions are also produced by rapid evaporation of a serine solution on a hot (200-250 °C) metal surface or by ... A cycle can be maintained in which each turn results in an incremental enrichment in L-serine. Many such cycles eventually ...
*  Protein-serine epimerase
D-serine Hence, this enzyme has one substrate, [protein]-L-serine, and one product, [protein]-D-serine. This enzyme belongs to ... The systematic name of this enzyme class is [protein]-serine epimerase. This enzyme is also called protein-serine racemase. As ... In enzymology, a protein-serine epimerase (EC 5.1.1.16) is an enzyme that catalyzes the chemical reaction [protein]-L-serine ...
*  Serine-phosphoethanolamine synthase
Other names in common use include serine ethanolamine phosphate synthetase, serine ethanolamine phosphodiester synthase, serine ... L-serine-phosphoethanolamine Thus, the two substrates of this enzyme are CDP-ethanolamine and L-serine, whereas its two ... In enzymology, a serine-phosphoethanolamine synthase (EC 2.7.8.4) is an enzyme that catalyzes the chemical reaction CDP- ... Allen AK, Rosenberg H (1968). "The mechanism of action and some properties of serine ethanolamine phosphate synthetase". ...
*  Serine O-acetyltransferase
Other names in common use include SATase, L-serine acetyltransferase, serine acetyltransferase, and serine transacetylase. This ... Smith IK, Thompson JF (1971). "Purification and characterization of L-serine transacetylase and O-acetyl-L-serine sulfhydrylase ... O-acetyl-L-serine Thus, the two substrates of this enzyme are acetyl-CoA and L-serine, whereas its two products are CoA and O- ... In enzymology, a serine O-acetyltransferase (EC 2.3.1.30) is an enzyme that catalyzes the chemical reaction acetyl-CoA + L- ...
*  Diphosphate-serine phosphotransferase
Other names in common use include pyrophosphate-serine phosphotransferase, and pyrophosphate-L-serine phosphotransferase. Cagen ... O-phospho-L-serine Thus, the two substrates of this enzyme are diphosphate and L-serine, whereas its two products are phosphate ... In enzymology, a diphosphate-serine phosphotransferase (EC 2.7.1.80) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is diphosphate:L-serine O-phosphotransferase. ...
*  IgA specific serine endopeptidase
... where the X in the squence preferably is a Proline or Serine; the Y = Threonine, Serine or Alanine; and Z preferably is ... IgA-specific serine endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A ...
*  Serine/threonine kinase 35
... is a protein that in humans is encoded by the STK35 gene. The protein encoded by this gene is a ... Serine/threonine kinase 35". Retrieved 2012-02-18. Vallenius, T.; Mäkelä, T. P. (2002). "Clik1: A novel kinase targeted to ...
*  Protein serine/threonine phosphatase
... (PSP) is a form of phosphoprotein phosphatase that acts upon phosphorylated serine/ ... Serine and threonine are amino acids which have similar side-chain compositions that contain a hydroxyl group and thus can be ... Serine and threonine phosphates are stable under physiological conditions, so a phosphatase enzyme has to remove the phosphate ... The addition of the phosphate group can be reversed by enzymes called serine/threonine phosphatases. The addition and removal ...
*  HtrA serine peptidase 2
Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, ... Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This protein is involved in ... HtrA serine peptidase 2 has been shown to interact with MAPK14, XIAP and BIRC2. GRCh38: Ensembl release 89: ENSG00000115317 - ... "Entrez Gene: HTRA2 HtrA serine peptidase 2". Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, ...
*  ATM serine/threonine kinase
... , symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double- ... "Serine-protein kinase ATM - Homo sapiens (Human)". Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in ... Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, Yen Y (November 2008). "ATM-mediated serine 72 phosphorylation stabilizes ...