... homologies and mechanistic implications of deduced amino acid sequences". Cell. 44 (4): 597-607. doi:10.1016/0092-8674(86)90269 ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...

... a constitutive nucleolar component sharing high sequence homologies to protein NO66". Eur. J. Cell Biol. 84 (2-3): 279-94. doi: ... 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40-5. doi:10.1038/ ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...

Persistent homology is closely related to spectral sequences. In particular the algorithm bringing a filtered complex to its ... The main tool is persistent homology, an adaptation of homology to point cloud data. Persistent homology has been applied to ... Taking the homology of each complex in this filtration gives a persistence module H i ( X r 0 ) → H i ( X r 1 ) → H i ( X r 2 ... The persistent homology group P H {\displaystyle PH} of a point cloud is the persistence module defined as P H k ( X ) = ∏ H k ...

Rina M, Markaki M, Bouriotis V (December 1994). "Sequence of the cloned bseCIM gene: M.BseCI reveals high homology to M.BanIII ... Recognition sequence: Sequence of DNA recognized by the enzyme and to which it specifically binds. Cut: Cutting site and DNA ... The recognition sequence and the cutting site usually match, but sometimes the cutting site can be dozens of nucleotides away ... A neoschizomer is a special type of isoschizomer that recognizes the same sequence as another, but cuts in a different manner. ...

Both human and bovine ACTH receptors are synthesized as 297 residue long proteins with 81% sequence homology. There are ... The full length sequence of MC2R includes seven hydrophobic domains that are predicted as transmembrane segments. In the third ... Mutations of ACTH can also contribute to this pathology: mutation of the "message sequence" inhibits cAMP production when bound ... Raikhinstein M, Zohar M, Hanukoglu I (February 1994). "cDNA cloning and sequence analysis of the bovine adrenocorticotropic ...

1989). "Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid ... Tailor PG, Govindan MV, Patel PC (1990). "Nucleotide sequence of human prostatic acid phosphatase determined from a full-length ... Sharief FS, Li SS (1994). "Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats". ... 1988). "Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase". FEBS Lett. 236 (2): 275-81 ...

Two other groups later cloned GAB2 by searching DNA database for protein with sequence homology to GAB1. GAB2 is a large multi- ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31-9 ... It acts as a docking station for the Src homology 2(SH2) domain that is contained in the adaptor protein families Crk, Grb2, ... Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of ...

Homology search refers to the process of searching a sequence database for RNAs that are similar to already known RNA sequences ... Any algorithm that is designed for homology search of nucleic acid sequences can be used, e.g., BLAST. However, such algorithms ... Strategies to do this have included the use of BLAST between two sequences or multiple sequences, exploited synteny via ... The first involves homology search, although these techniques are by definition unable to find new classes of ncRNAs. The ...

In contrast, the cytoplasmic domain tends to have high sequence homology and contains several well-known motifs. These motifs ...

Navarro E (Oct 1999). "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology ...

"Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochem ... Hao S, August A (August 2002). "The proline rich region of the Tec homology domain of ITK regulates its activity". FEBS Lett. ... Antoku K, Maser RS, Scully WJ, Delach SM, Johnson DE (Sep 2001). "Isolation of Bcl-2 binding proteins that exhibit homology ... "Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain ...

"Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochem ... an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in ... Sequencing revealed that the portion carried by the retrovirus encoded a tyrosine kinase binding domain, and that this was the ... "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell ...

... has protein sequence homology with DNA topoisomerase, so that DNA topoisomerase inhibitors are also GT198 inhibitors. ... Cho, Nam Woo; Dilley, Robert L.; Lampson, Michael A.; Greenberg, Roger A. (September 2014). "Interchromosomal Homology Searches ...

Based on sequence homology to type 1 and type 2 sea anemone toxins it is thought to delay channel inactivation by binding to ... Halcurin is structurally homologous with type 2 toxins, but also has sequence homology to type 1 toxins. Type 1 and 2 toxins ... The amino acid sequence of halcurin is: VACRCESDGP DVRSATFTGT VDLWNCNTGW HKCIATYTAV ASCCKKD; it consists of 47 amino acids and ... Based on the structural homology of halcurin to sea anemone neurotoxin type 1 and 2, it is likely to have a similar mode of ...

Such arguments are also used to show that the sequence in homology is exact at each group. Mayer-Vietoris sequence Hatcher, ... the zig-zag lemma asserts the existence of a particular long exact sequence in the homology groups of certain chain complexes. ... Such a sequence is shorthand for the following commutative diagram: where the rows are exact sequences and each column is a ... The name of the lemma arises from the "zig-zag" behavior of the maps in the sequence. A variant version of the zig-zag lemma is ...

... with high amino acid sequence homology (approximately 90% identity). The sequences of their promoter regions are also highly ... "Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity ... similar, though that of the eEF1A2 gene contains an additional 81 bp SV40 small antigen sequence at the 5′-end. The EEF1A1 5' ...

"Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes". BMC ...

Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate ...

The functional domains of these GEF families are not structurally related and do not share sequence homology. These GEF domains ... Pleckstrin homology domains (PH domains) are associated in tandem with DH domains in 64 of the 71 Dbl family members. The PH ... The CDC25 homology domain, also called the RasGEF domain, is the catalytic domain of many Ras GEFs, which activate Ras GTPases ... The DOCK family is a separate subset of GEFs from the Dbl family and bears no structural or sequence relation to the DH domain ...

Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to ... These three classes show undetectable sequence similarity with each other, but can still be compared using structural homology ... KPC-1 was re-sequenced in 2008 and found to be 100% homologous to published sequences of KPC-2). KPC-1 was found in North ... Amino acid sequence diversity is up to 10% in the VIM family, 15% in the IMP family, and 70% between VIM and IMP. Enzymes of ...

The potyvirus VPg has no sequence or structural homology to other VPg's such as those from poliovirus. In vitro, VPg-RNA ... This sequence motif is shared with other in vivo targets for myc and mutations in the E box repeats of eIF4E inactivated the ... Rychlik W, Domier LL, Gardner PR, Hellmann GM, Rhoads RE (February 1987). "Amino acid sequence of the mRNA cap-binding protein ...

... also has an extended C-terminal domain with little sequence homology to other BET family members. The two bromodomains in ... Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This ...

based on 26 clinical isolates from Belgium that shared 94-95% homology after 16S ribosomal RNA sequencing. The species ...

"A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2". Mateus, Jose ... Scientists at LJI also lead research into genomic sequencing of immune cells and high-resolution imaging of virus/antibody ...

... shows substantial sequence variation among species, with homology as low as 30% between orthologs. After induction by ... Haas AL, Ahrens P, Bright PM, Ankel H (August 1987). "Interferon induces a 15-kilodalton protein exhibiting marked homology to ... Molecular cloning and nucleotide and amino acid sequence". The Journal of Biological Chemistry. 261 (19): 8811-6. doi:10.1016/ ... The tertiary structure of ISG15 also resembles ubiquitin, despite only ~30% sequence identity. Specifically, this structure ...

Bao JJ, Reed-Fourquet L, Sifers RN, Kidd VJ, Woo SL (February 1988). "Molecular structure and sequence homology of a gene ... it was discovered that SERPINA2 did not have any promoter but did contain substantial homology to SERPINA1 gene sequence. ... The consensus sequence surrounding the reactive centre loop have diverged considerably so that now it contains tryptophan sarin ... 1988) describes in his studies that sequence with RNA splice sites are preserved in SERPINA2, and when expressed, it encodes a ...

... the sequences of these cytokines are highly conserved. For instance, the sequence homology between the corresponding human and ... Among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest sequence homology with IL-17A (55 and 40%, ... To the reference, the members of the IL-17 family do not exhibit a significant sequence homology with other cytokines. ... The protein encoded by IL17A is a founding member of IL-17 family (see below). IL17A protein exhibits a high homology with a ...

Off-target effects: Unintended silencing of genes that share sequence homology with expressed shRNAs can theoretically occur. ... This figure consists of a promoter sequence, driving expression of sense and antisense sequences separated by a loop sequence, ... Biomics Biotechnologies has evaluated around 5000 siRNA sequences of this gene for effective knockdown; five sequences were ... Natural sequence variations can render a single shRNA-target site unrecognizable, preventing RNA degradation. Multi-cassette ...

Homology is implied by sequence similarity between the DNA sequences of the pseudogene and a known gene. After aligning the two ... A high sequence identity means that it is highly likely that these two sequences diverged from a common ancestral sequence (are ... Pseudogenes are usually identified when genome sequence analysis finds gene-like sequences that lack regulatory sequences ... Pseudogene sequences may be transcribed into RNA at low levels, due to promoter elements inherited from the ancestral gene or ...

"Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". ... Hao S, August A (August 2002). "The proline rich region of the Tec homology domain of ITK regulates its activity". FEBS Letters ... The SH2 domains bind phosphorylated tyrosine residues on target proteins via their FLVR sequence motifs, activating the ... "Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain ...

... and sequence homology with other aspartic proteinases". The Journal of Biological Chemistry. 264 (28): 16748-53. doi:10.1016/ ... Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT (October 1989). "Human gastric cathepsin E. Predicted sequence, ...

... there is a long exact sequence in homology ⋯ ⟶ H n ( L ) ⟶ H n ( f ) H n ( M ) ⟶ H n ( g ) H n ( N ) ⟶ δ n H n − 1 ( L ) ⟶ H n ... The most common type of exact sequence is the short exact sequence. This is an exact sequence of the form A ↪ f B ↠ g C {\ ... A spectral sequence is a choice of a nonnegative integer r0 and a collection of three sequences: For all integers r ≥ r0, an ... manifestations of this theorem include the Mayer-Vietoris sequence and the long exact sequence for relative homology. ...

Coggins LW, Ma JQ, Slater AA, Campo MS (June 1985). "Sequence homologies between bovine papillomavirus genomes mapped by a ... although the nucleotide sequence may diverge by more than 50%. Phylogenetic algorithms that permit the comparison of homologies ... In fact, the sequence of HPV-13 closely resembles a papillomavirus of bonobos (also known as pygmy chimpanzees). It is not ... E6 is a 151 amino-acid peptide that incorporates a type 1 motif with a consensus sequence -(T/S)-(X)-(V/I)-COOH. It also has ...