1993). "Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: localization of genes and pseudogenes ... 2002). "The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through ... "Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase". Proc. Natl. Acad. Sci. U.S.A ... Aoki N, Matsuda T (2002). "A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated ...
Like other steroid nuclear receptors, the full-length protein, isoform B, can be divided into 4 functional regions, namely a ... "Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers". Cell. 57 (7): 1147 ... Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (Nov 1995). "Sequence and characterization of a coactivator for the steroid hormone ... I. Preliminary characterization of cytoplasmic components". The Journal of Biological Chemistry. 245 (22): 6085-96. doi:10.1016 ...
The amino acid sequence of the encoded protein shares a 90% homology to the isoforms HSPA1A and HSPA1B. As a Hsp70 protein, it ... forming a number of plasma membrane-bounded apoptotic bodies which contain nuclear and or cytoplasmic elements. The ... Goate AM, Cooper DN, Hall C, Leung TK, Solomon E, Lim L (Feb 1987). "Localization of a human heat-shock HSP 70 gene sequence to ... In order to properly fold non-native proteins, this protein interacts with the hydrophobic peptide segments of proteins in an ...
cDNA sequence and localization of gene to chromosome 16". J. Biol. Chem. 263 (27): 13572-8. doi:10.1016/S0021-9258(18)68280-8. ... This protein-protein interaction between p53 and NQO1 was non-catalytic. Ornithine decarboxylase (ODC), is a labile protein ... Crystallographic and nuclear magnetic resonance data show that the reason for this different behaviour is found in a flexible C ... This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD- ...
Note that the term "nucleoporin" refers to unrelated proteins that facilitate transport through nuclear pores in the nuclear ... the alternative method of sequencing protein primary structure may also be used instead. Porins are water-filled pores and ... Rath P, Saurel O, Tropis M, Daffé M, Demange P, Milon A (November 2013). "NMR localization of the O-mycoloylation on PorH, a ... on the cytoplasmic side and long loops of amino acids on the other. The β strands lie in an antiparallel fashion and form a ...
... proteins which also acts downstream to promote p27 nuclear localization and decrease levels of COP9 subunit 5(COPS5) which ... "Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization". J. Biol. Chem. 277 (32): ... The p27Kip1 gene has a DNA sequence similar to other members of the "Cip/Kip" family which include the p21Cip1/Waf1 and p57Kip2 ... This occurs when p27 is phosphorylated on Ser(10) which allows for CRM1, a nuclear export carrier protein, to bind to and ...
The matrix protein (M1) and membrane protein (M2) share a segment, as do the non-structural protein (NS1) and the nuclear ... Nucleic acid sequencing methods can identify infection by obtaining the nucleic acid sequence of viral samples to identify the ... which is initiated by the accumulation of M1 proteins at the cytoplasmic side of the membrane. The viral genome is incorporated ... RNPs are then imported into the nucleus with the help of viral localization signals. There, the viral RNA polymerase ...
... protein synthesis (known as the sequence hypothesis), the role of RNA (the adaptor hypothesis) as well as the existence of ... J, Brachet (1942). "La localization des acides pentosenucleiques dans les tissues animaux et les oufs d'Amphibiens en voie de ... "the relationship between plasma genes and nuclear genes [postulated by Sol Spiegelman and Martin David Kamen in 1946] could be ... these control the production of cytoplasmic enzymes. In truth, the enzymic equipment results simultaneously from the effect of ...
The protein sequence is predicted to contain a signal peptide (1 aa to 24 aa), an extracellular domain (25 aa to 100 aa), a ... Microfibrillar-associated protein 3 (MFAP3) has a function that is not fully understood but may be involved in nuclear ... Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus. C19orf18 protein has been ... transmembrane domain (101 aa to 121 aa), and a cytoplasmic domain (122 aa to 215 aa). PSORTII and CELLO predicted that the ...
This protein contains a P-loop motif that binds GTP and a highly conserved 17-residue targeting sequence responsible for its ... forming a number of plasma membrane-bounded apoptotic bodies which contain nuclear and or cytoplasmic elements. The ... localization to the mitochondria. Of interest, many of the phosphorylation sites on this protein are highly conserved and ... 28S ribosomal protein S29, mitochondrial, also known as death-associated protein 3 (DAP3), is a protein that in humans is ...
The recognition that these proteins were members of a broad family first came from protein sequence comparisons and their cross ... region is located on the concave side of the core region and is important for providing a binding site for cytoplasmic proteins ... Tomas A, Moss S (2003). "Calcium- and Cell Cycle-dependent Association of Annexin 11 with the Nuclear Envelope". J. Biol. Chem ... Creutz CE, Snyder SL, Daigle SN, Redick J (March 1996). "Identification, localization, and functional implications of an ...
In addition to single proteins, other protein complexes interact with the exosome. One of those is the cytoplasmic Ski complex ... The nuclear exosome associates with RNA binding proteins (e.g. MPP6/Mpp6 and C1D/Rrp47 in humans/yeast) that are required for ... These two proteins most likely degrade different RNA substrates due to their different cellular localization, with one being ... Mian, IS (1997). "Comparative sequence analysis of ribonucleases HII, III, II PH and D". Nucleic Acids Research. 25 (16): 3187- ...
mRNA carrying a single protein sequence (common in eukaryotes) is monocistronic whilst mRNA carrying multiple protein sequences ... These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), ... Major locations are the cytoplasm for soluble cytoplasmic proteins and the membrane of the endoplasmic reticulum for proteins ... Investigation of localization is particularly important for the study of development in multicellular organisms and as an ...
Targets of the Kaposi's Sarcoma-Associated Herpesvirus Rta Lytic Switch Protein by Conditional Nuclear Localization". Journal ... A cytoplasmic form of LANA may inhibit activation of immune responses. ORF74 - vGPCR ORF75 - FGARAT PAN, polyadenylated nuclear ... Starting from these fragments, this research team was then able to sequence the entire genome of the virus less than two years ... a G protein-coupled receptor, interferon regulatory factor and Flice inhibitory protein (FLIP), as well as DNA synthesis ...
Alarmin IL-33 is constitutively expressed as a nuclear protein in all epithelial and endothelial cells, but also in secondary ... Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T (December 1992). "Nucleotide sequence of a complementary ... "Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V". Biochemical and ... and soluble ST2 that originates from another promoter region of the il1rl1 gene and lacks the transmembrane and cytoplasmic ...
"Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH ... a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". The Journal of Biological Chemistry. 276 ( ... Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (July 1997). "Genomic structure and chromosomal localization of the gene ... "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell ...
A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919-30. doi:10.1016/S0092- ... Kang Q, Cao Y, Zolkiewska A (2001). "Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain ... "Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome". BMC Med. Genet. 15 (1): 51. doi:10.1186 ... "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene ...
Many proteins that are active in the nucleus contain nuclear localization signals that direct them to the nucleus. But, for ... When injected into plants, these proteins can enter the nucleus of the plant cell, bind plant promoter sequences, and activate ... Mef2 II.B.3.b latent cytoplasmic factors - inactive form reside in the cytoplasm, but, when activated, are translocated into ... Cdx protein family DNA-binding protein Inhibitor of DNA-binding protein Mapper(2) Nuclear receptor, a class of ligand activated ...
They are generally intracellular receptors (typically cytoplasmic or nuclear) and initiate signal transduction for steroid ... Host-pathogen interface Retinoic acid JAK-STAT signaling pathway Imd pathway Localisation signal Oscillation Protein dynamics ... The amplifying of a signal is one of the benefits to this multiple step sequence. Other benefits include more opportunities for ... The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor ...
... composed of the coiled-coil protein CfpA (Cytoplasmic filament protein A, Q56336), linked together by bridging components and ... crescentin has a rather large primary homology with IF proteins in addition to three-dimensional similarity - the sequence of ... a ubiquitous class of cytoskeletal proteins mediating polar localization of a cell wall synthase in Caulobacter crescentus". ... creS has a 25% identity match and 40% similarity to cytokeratin 19 and a 24% identity match and 40% similarity to nuclear lamin ...
Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS (December 2002). "RanBPM, a nuclear protein that interacts with ... Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic ... nuclear co-localization and modulation of transcriptional activity in neuronal cells". The Journal of Biological Chemistry. 277 ... that is independent of direct binding to its target DNA sequence is facilitated by recruitment via other DNA-binding proteins. ...
Proteins of the ERV1/ALR family are encoded by all eukaryotes and cytoplasmic DNA viruses for which the sequence data are ... Lisowsky T (March 1992). "Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast". ... Renan MJ, Reeves BR (1987). "Chromosomal localization of human endogenous retroviral element ERV1 to 18q22----q23 by in situ ... This protein interacts with Mia40 during the import of intermembrane space proteins including the small Tim proteins Cox17 and ...
... demonstrated a high level of heterogeneity seen at the single cell level for both protein expression and protein localization ... which identifies nuclear fragmentation or cytoplasmic blebbing associated with apoptosis. Measuring the ratio of traditional ... "RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis". Nature. 487 (7408): 510-3. ... Alternative methods exist which use engineered proteins instead of antibodies, such as the malaria VAR2CSA protein, which binds ...
An example SERD is fulvestrant which binds to the ER to block its dimerization and nuclear localization. The fulvestrant-ER ... where cytoplasmic GPER is associated with lower grade tumors and nuclear GPER with higher rates of metastasis. The signaling ... Advances in Protein Chemistry and Structural Biology, Intracellular Signalling Proteins, Academic Press, 116: 135-170, doi: ... ER is a transcription factor containing a DNA-binding domain which allows binding DNA at specific sequences called estrogen ...
"Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells". Cell Structure ... forming a number of plasma membrane-bounded apoptotic bodies which contain nuclear and or cytoplasmic elements. The ... Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in ... This protein binds to nascent polypeptides to facilitate correct protein folding. In order to properly fold non-native proteins ...
"The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22 (14): 3524-3535. doi: ... However, it is not found in all species based on searches of sequenced genomes. One or more Cdc14 genes are found in alveolates ... Ah-Fong, AMV; Judelson, HS (2011). "New Role for Cdc14 Phosphatase: Localization to Basal Bodies in the Oomycete Phytophthora ... Unlike CeCdc14, hCdc14A is not centrosomic in mitosis, but is cytoplasmic and centrosomic during interphase. HCdc14B was shown ...
The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141-50. ... In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that ... 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. ... 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. ...
This interaction has been proposed as essential for the stability and nuclear localization of FA core complex proteins. The ... "A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA". Blood. 98 (13): 3650-7. doi: ... Levran O, Erlich T, Magdalena N, Gregory JJ, Batish SD, Verlander PC, Auerbach AD (November 1997). "Sequence variation in the ... they are related by their assembly into a common nuclear protein complex. The FANCA gene encodes the protein for ...
To amplify any DNA sequence in a living organism, that sequence must be linked to an origin of replication, which is a sequence ... This may have important implications for cross-species nuclear transfer in which nuclear-mitochondrial incompatibilities may ... In practice, localization of the gene to a chromosome or genomic region does not necessarily enable one to isolate or amplify ... Scientists speculated that Dolly's death in 2003 was related to the shortening of telomeres, DNA-protein complexes that protect ...
... by facilitating the disassociation of nuclear mRNA binding proteins and replacement with cytoplasmic mRNA binding proteins. Cap ... Multiple sequence alignments of human MIF4GD and its orthologs showed two conserved amino acids throughout all sequences, which ... Due to its presumed localization in the cytoplasm, it is predicted that MIF4GD could be phosphorylated, acetylated, ... "A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation". Genes & ...