Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the lysosome/vacuole. ... an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation". J. Biol. Chem. 282 (11): 8036-43. ... a gene essential for autophagocytosis in the yeast Saccharomyces cerevisiae". J. Bacteriol. 179 (4): 1068-76. doi:10.1128/jb. ... The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the ...
The Smf1 protein of Saccharomyces cerevisiae appears to catalyze high-affinity (KM = 0.3 μm) Mn2+ uptake while the closely ... "Expansion of the APC superfamily of secondary carriers". Proteins. 82 (10): 2797-811. doi:10.1002/prot.24643. PMC 4177346. PMID ... It is found in apical membranes of intestinal epithelial cells but also in late endosomes and lysosomes. In contrast to the ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ...
Non-human protein homologs for cystinosin include ERS1 in Saccharomyces cerevisiae (yeast cells) and the Caenorhabditis elegans ... The type and extent of mutation determines the type and severity of cystinosis in the carrier. This is a result of the degree ... in the encoded cystinosin protein results in an inhibition or loss in its ability to transport cystine out of the lysosome. ... CTNS is the gene that encodes the protein cystinosin in humans. Cystinosin is a lysosomal seven-transmembrane protein that ...
... is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family ... Hassett RF, Romeo AM, Kosman DJ (March 1998). "Regulation of high affinity iron uptake in the yeast Saccharomyces cerevisiae. ... is localized to late endosomes and lysosomes in HEp-2 cells". The Journal of Biological Chemistry. 275 (29): 22220-8. doi: ... Kishi F, Tabuchi M (October 1998). "Human natural resistance-associated macrophage protein 2: gene cloning and protein ...
The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed ... MPTP has been detected in mitochondria from plants, yeasts, such as Saccharomyces cerevisiae, birds, such as guinea fowl and ... Varanyuwatana, P.; Halestrap, A. P. (2012). "The roles of phosphate and the phosphate carrier in the mitochondrial permeability ... regulated opening of the MPT pore may minimize cell injury by causing ROS-producing mitochondria to undergo selective lysosome- ...
... argued that proteins were merely carriers for the true enzymes and that proteins per se were incapable of catalysis. In 1926, ... "Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster". The Journal of Cell ... the neutral cytoplasm and the acidic lysosome) or oxidative state (e.g., oxidizing periplasm or reducing cytoplasm) which in ... These families have been documented in dozens of different protein and protein family databases such as Pfam. Non-homologous ...
... was expressed in cells as a fusion protein with several known stress granule-associated proteins. Proteins in close proximity ... Buchan JR, Muhlrad D, Parker R (November 2008). "P bodies promote stress granule assembly in Saccharomyces cerevisiae". The ... December 2014). "Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly". Cell Death and ... Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers ...