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*  Protein kinase C
Amended FDA Protocol Submitted for Phase 2b Trial of Advanced Alzheimer's Therapy. Aug 2016 protein kinase c at the US National ... membrane-bound receptor for activated protein kinase C proteins). The protein kinase C enzymes are known for their long-term ... Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in ... The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A, since it contains basic amino acids ...
*  SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. Skp2 contains 424 residues in ... "Entrez Gene: SKP2 S-phase kinase-associated protein 2 (p45)". Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ ( ... Fang FM, Chien CY, Li CF, Shiu WY, Chen CH, Huang HY (January 2009). "Effect of S-phase kinase-associated protein 2 expression ... G2 phase, and the initial part of the M phase. The degradation of p27 via Skp2 requires the accessory protein CKS1B. To prevent ...
*  SKP1A
It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and ... S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene. This gene encodes a protein that ... "Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)". Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ ... The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level ...
*  Skp1
... (S-phase kinase-associated protein 1) is a small protein of approximately 160 amino acids. As a core component of the SCF- ... Hellmann, H. and Estelle, M. (2002) Plant development: regulation by protein degradation. Science, 297, 793-797.. ... type E3 ubiquitin ligases that mediate protein degradation by the 26S proteosome, Skp1 plays key roles in cell-cycle ...
*  KIF23
"Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1". Mol. Cell. Biol. 15 (12): ... Kinesin-like protein KIF23 is a protein that in humans is encoded by the KIF23 gene. KIF23 (also known as Kinesin-6, CHO1/MKLP1 ... Boman AL, Kuai J, Zhu X, Chen J, Kuriyama R, Kahn RA (October 1999). "Arf proteins bind to mitotic kinesin-like protein 1 ( ... "Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1". J. Cell Sci. 117 (Pt 15): 3233 ...
*  CKS1B
"Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human ... Protein destruction: Adapting roles for Cks proteins. Cur Biol. 11: R431-R435 Xu, K., Belunis, C., et al. 2003. Protein-protein ... Cyclin-dependent kinases regulatory subunit 1 is a protein that in humans is encoded by the CKS1B gene. The CKS1B protein binds ... 1996). "Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1". ...
*  Akt/PKB signaling pathway
S-phase kinase-associated protein 2 (Skp2) - Ser72 phosphorylation enhances E3 ligase activity and cytosolic localisation, ... Akt also phosphorylates MAP kinase kinase kinases (MAPKKK) upstream of the stress-activated protein kinase (SAPK) pathway. ... Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B). Initial stimulation by one of the ... of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase- ...
*  Long-term potentiation
Serrano P, Yao Y, Sacktor T (2005). "Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term ... One such molecule may be protein kinase Mζ (PKMζ), a persistently active kinase whose synthesis increases following LTP ... Two phases of L-LTP exist: the first depends upon protein synthesis, while the second depends upon both gene transcription and ... Frey U, Krug M, Reymann K, Matthies H (1988). "Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP ...
*  Protein kinase C zeta type
Serrano P, Yao Y, Sacktor TC (2005). "Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term ... "Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1". Science. 281 (5385): 2042-5 ... "Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications ... "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta ...
*  PKC alpha
"Correlation between protein kinase C alpha activity and membrane phase behavior". Biophysical Journal. 76 (2): 916-27. doi: ... Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of ... Protein kinase C-alpha (PKC-α) is a specific member of the protein kinase family. These enzymes are characterized by their ... PKC-α is unique in its mode of regulation compared to other kinases within this family. In general, the protein kinase family ...
*  PLK3
"Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions". J. Biol. Chem. 272 (45): ... "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically ... Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory ... a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J ...
*  Eric Klann
Klann, E., Chen, S.-J. and Sweatt, J.D. (1991) Persistent protein kinase activation in the maintenance phase of long-term ... Klann, E., Roberson, E.D., Knapp, L.T., and Sweatt, J.D. (1998) A role for superoxide in protein kinase C activation and ... Klann, E., Chen, S.-J., and Sweatt, J.D. (1993) Mechanism of protein kinase C activation during the induction and maintenance ... Klann was the first to demonstrate that persistent protein kinase activity was associated with long-lasting synaptic plasticity ...
*  GSPT1
"G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". ... "A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain". The ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... "Entrez Gene: GSPT1 G1 to S phase transition 1". Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, ...
*  PLK2
Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is ... Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene. Serum-inducible kinase is a ... 1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated ... family of serine/threonine protein kinases that have a role in normal cell division.[supplied by OMIM] GRCh38: Ensembl release ...
*  Metaplasticity
... a critical role for protein kinase A in synaptic tagging". Eur. J. Neurosci. 23 (7): 1784-94. doi:10.1111/j.1460-9568.2006. ... Young JZ, Isiegas C, Abel T, Nguyen PV (April 2006). "Metaplasticity of the late-phase of long-term potentiation: ... When new receptor proteins are being expressed and synthesized they must also be transported to the synaptic membrane, and some ... Bone morphogenetic proteins, BMPs, were originally found to cause a differentiation in bone formation; however, they have ...
*  Nucleolar phosphoprotein p130
"Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid ... Li D, Meier UT, Dobrowolska G, Krebs EG (1997). "Specific interaction between casein kinase 2 and the nucleolar protein Nopp140 ... Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene. Nucleolar phosphoprotein p130 has been ... with the pocket proteins pRb, p107 and p130". Oncogene. 20 (39): 5533-7. doi:10.1038/sj.onc.1204823. PMID 11571651. Chiu CM, ...
*  Kadmon Corporation
An inhibitor of several protein kinases, tesevatinib (XL647, KD019) entered Phase II clinical trial for certain indications of ... 2012). "Phase II Study of the Multitargeted Tyrosine Kinase Inhibitor XL647 in Patients with Non-Small-Cell Lung Cancer". ... XL844 is an inhibitor of protein kinases Chk1 and Chk2 and may increase the sensitivity of cancer cells to radiation therapy. ... "A Phase II Multicenter, Randomized, Placebo Controlled, Double Blinded Clinical Study of KD018 as a Modulator of Irinotecan ...
*  MAK (gene)
1993). "Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated ... The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is ... Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene. ... Matsushime H, Jinno A, Takagi N, Shibuya M (1990). "A novel mammalian protein kinase gene (mak) is highly expressed in ...
*  Atg1
... which then is followed by a kinase-dependent phase, that contains protein dynamics at the PAS. There is much evidence ... The encoded protein with a mass of 101.7 kDa has a length of 897 amino acids and includes a protein serine/threonin kinase ... the kinase-independent recruitment of downstream Atg proteins (i.e. PAS organization) and a kinase-dependent function in ... In a non-kinase role it is - through complex formation with Atg13 and Atg17 - directly controlled by the TOR kinase, a sensor ...
*  Cyclin-dependent kinase inhibitor protein
CDIs are involved in cell cycle arrest at the G1 phase. Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996 ... A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor ... Cyclin-Dependent Kinase Inhibitor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... 43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813-22. doi:10.1038/sj.onc. ...
*  S phase
When the replication fork comes upon damaged DNA, ATR, a protein kinase is activated. This kinase initiates several complex ... S phase (synthesis phase) is the part of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. ... S phase index (SPI) S-fraction or S-phase fraction (oncology/pathology prognosis) Bell, S.P. and Dutta, A.: DNA replication in ... There is also a check point in s phase(proved from research) The major event in S-phase is DNA replication. The goal of this ...
*  MAPK3
"The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene. 26 (22 ... Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this gene ... "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis ... "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305-11. ...
*  Ralimetinib
It is a p38 mitogen-activated protein kinase inhibitor. A phase II trial for treatment of ovarian cancer is expected to be ...
*  Cyclin-dependent kinase 1
Gyuris J, Golemis E, Chertkov H, Brent R (November 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates ... Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, ... Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ... "Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle". J. Biol. Chem. 267 (28): 20317-25 ...
*  Cyclin-dependent kinase 3
Gyuris J, Golemis E, Chertkov H, Brent R (1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". ... Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene. CDK3 complements cdc28 mutants of ... 1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk ... Meikrantz W, Schlegel R (1996). "Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases". J ...
*  G1 phase
Once the required proteins and growth are complete, the cell enters the next phase of the cell cycle, S phase. The duration of ... Biochemical triggers known as cyclin-dependent kinases (Cdks) switch on cell cycles events at the corrected time and in the ... G1 phase ends when the cell moves into the S phase of interphase. G1 phase together with the S phase and G2 phase comprise the ... The g1 phase, or Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. In ...
*  Fyn-related kinase
This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. FRK has ... Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene. The ... Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer". Int. J. Cancer. 54 (4 ... Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer ...