Ammer AG, Weed SA (September 2008). "Cortactin branches out: roles in regulating protrusive actin dynamics". Cell Motil. ... Once activated in this way, it can bind to filamentous actin (F-actin) with the fourth of its cortactin repeats. As the ... Activated like this, it still associates with Arp2/3 and F-actin, but will also allow other actin NPFs, most importantly N-WASp ... Cortactin-assisted Arp2/3-nucleated actin branches are most prominent in the actin cortex, around the periphery of the cell. A ...

Both of these components are ATPases that consist of Arp7 and Arp9, which are proteins that are similar to actin. The subunits ... Chai B, Huang J, Cairns BR, Laurent BC (July 2005). "Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers ... They also have opposing roles, specifically when interacting with the PHO8 promoter. RSC works to guarantee the placement of ... Hopson S, Thompson MJ (October 2017). "BAF180: Its Roles in DNA Repair and Consequences in Cancer". ACS Chemical Biology. 12 ( ...

Cdc42 was assumed to encourage filopodia elongation and block actin depolymerization. RhoA was considered to encourage actin ... Each Rho protein affects numerous proteins downstream, all of which having roles in various cell processes. Over 60 targets of ... The actin formation required to close the wounds in young chicks is controlled by Rho GTPase proteins, since, after injection ... The actin filaments control the formation of the phagocytic cup, and active Rac1 and Cdc42 have been implicated in this ...

... binds to actin filaments and contains a phosphotyrosine-binding (PTB) domain at the C-terminus, which interacts with the ... Analysis of knockout mice has demonstrated critical roles of tensin in renal function, muscle regeneration, and cell migration ... Evidence is now[when?] emerging to suggest tensin is an important component linking the ECM, the actin cytoskeleton, and signal ... Le Clainche, C; Carlier, MF (2008). "Regulation of actin assembly associated with protrusion and adhesion in cell migration". ...

2003). "The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers". Mol. Biol. ... 2003). "Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/ ... Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to ... Palmgren S, Vartiainen M, Lappalainen P (2002). "Twinfilin, a molecular mailman for actin monomers". J. Cell Sci. 115 (Pt 5): ...

Strauss, RE; Gourdie, RG (December 2020). "Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction ... Disease also seems to have an effect on the ability of gap junctions to fulfill their roles in wound healing. The oral ... There are also more complex studies that try to combine our understanding of the simultaneous roles of gap junctions in both ... In the 1980s, more subtle but no less important roles of gap junction communication have been investigated. It was discovered ...

Tang DD (2017). "The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle ... The actin polymers then push the membrane as they grow, forming the pseudopod. The pseudopodium can then adhere to a surface ... Rho GTPases are able to activate WASp which in turn activate Arp2/3 complex which serve as nucleation sites for actin ... For example, an increase in membrane tension inhibits actin assembly and protrusion formation. It was demonstrated that the ...

"Actin Filaments And Microtubules Play Different Roles During Bristle Elongation In Drosophila". Journal Of Cell Science, vol ... Further, it was demonstrated the amount of actin polymerization was also limited by the area where actin had the ability to ... This represented the first time that this actin polymerization had been observed in parasites. Later research went on to show ... Tilney also conducted research focused on Toxoplasma gondii and how its invasive stages acted in an actin-dependent fashion. To ...

Proteins can have structural and/or functional roles. For instance, movements of the proteins actin and myosin ultimately are ... This concept has been revised in light of emerging novel roles for RNA. Chemical biology seeks to develop new tools based on ... Their Changing Roles from Alchemical Times to the Mid-Twentieth Century. Chemical Heritage Foundation. ISBN 978-0-941901-27-7. ... as well as play important roles in cell to cell interactions and communications.[citation needed] The simplest type of ...

The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676-83. doi:10.1074/jbc.M107768200. PMID 11751930. DeMarco SJ, Chicka ... "Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton". J. Clin. Invest. ... The roles of SGK1 and NHERF2". J. Biol. Chem. United States. 277 (10): 7676-83. doi:10.1074/jbc.M107768200. ISSN 0021-9258. ... "Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton". J. Clin. Invest. ...

They contain microfilaments (also called actin filaments) cross-linked into bundles by actin-bundling proteins, such as fascin ... Filopodia have roles in sensing, migration, neurite outgrowth, and cell-cell interaction.[further explanation needed] To close ... Within the lamellipodium, actin ribs are known as microspikes, and when they extend beyond the lamellipodia, they're known as ... Lehmann MJ, Sherer NM, Marks CB, Pypaert M, Mothes W (July 2005). "Actin- and myosin-driven movement of viruses along filopodia ...

Each of these isoforms of plastin have their own roles, dependent of the cell-type, in order to regulate the actin cytoskeleton ... and actin-binding domains that assist in assembling actin into higher-order bundles. Plastins have two actin-binding domains ( ... Plastin is part of a family of actin-bundling proteins, specifically the α-actinin family of actin-binding protein, which are ... Plastin, along with other actin-binding proteins, help stabilize and rearrange organization of actin cytoskeleton when present ...

Polypeptides include proteins and shorter polymers of amino acids; some major examples include collagen, actin, and fibrin. ... In addition to their many essential roles in living organisms, biopolymers have applications in many fields including the food ...

Liang, Y.; Niederstrasser, H.; Edwards, M.; Jackson, C. E.; Cooper, J. A. (2009). "Distinct Roles for CARMIL Isoforms in Cell ... "Mammalian CARMIL Inhibits Actin Filament Capping by Capping Protein". Developmental Cell. 9 (2): 209-221. doi:10.1016/j.devcel. ...

Citron-K is capable of physically and functionally interacting with the actin-binding protein anillin. Like active RhoA, ... Citron-K is expressed during neurogenesis and plays important roles in neuronal progenitor cell division. Recessive mutations ... actin, myosin light chain, and anillin. The N- terminal of the coiled- coil domain of Citron-K directly interacts with the 2nd ... F-actin, myosin II, and mDia2 and it has been shown that its depletion results in cleavage furrow instability. ...

α-Catenin can bind to β-catenin and can also bind filamentous actin (F-actin). β-Catenin binds directly to the cytoplasmic tail ... Catenins play roles in cellular organization and polarity long before the development and incorporation of Wnt signaling ... Through the interaction of β-catenin and α-catenin, actin and E-cadherin are linked, providing the cell with a means of stable ... Fukunaga Y, Liu H, Shimizu M, Komiya S, Kawasuji M, Nagafuchi A (2005). "Defining the roles of β-catenin and plakoglobin in ...

Recently an actin-like protein has been found in the gram-positive bacterium Bacillus thuringiensis, which forms a microtubule- ... The roles of the microtubule cytoskeleton include mechanical support, organization of the cytoplasm, transport, motility and ... This combination of roles makes microtubules important for organizing and moving intracellular constituents. The organization ... Here, nucleation of microtubules for structural roles and for generation of the mitotic spindle is not from a canonical ...

Madak-Erdogan, Zeynep; Ventrella, Rosa; Petry, Luke; Katzenellenbogen, Benita S (2014). "Novel Roles for ERK5 and Cofilin as ... Critical Mediators Linking ERα-Driven Transcription, Actin Reorganization, and Invasiveness in Breast Cancer". Molecular Cancer ... Harris, Heather A; Katzenellenbogen, John A; Katzenellenbogen, Benita S (2002). "Characterization of the Biological Roles of ... non-genomic actions of estrogens and the cross-talk between nuclear receptors and other cell signaling pathways and their roles ...

Its roles include the breakdown of filamentous actin released from dead cells, activation of macrophages, and localization of ... Furthermore, DBP is capable of removing one actin from a 2:1 actin-pGSN complex, restoring its ability to sever F-actin. F- ... "Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, ... Hemodialysis patients with low levels of pGSN and high levels of actin in blood had markedly higher mortality. Actin is a major ...

The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. EpCAM was first ... EpCAM mediates intercellular adhesion and associates with the actin cytoskeleton via EpICD. EpCAM has a negative impact on ...

Tojkander, S.; Gateva, G.; Lappalainen, P. (April 29, 2012). "Actin stress fibers - assembly, dynamics and biological roles". ... Tojkander, S.; Gateva, G.; Lappalainen, P. (April 29, 2012). "Actin stress fibers - assembly, dynamics and biological roles". ... Tojkander, S.; Gateva, G.; Lappalainen, P. (April 29, 2012). "Actin stress fibers - assembly, dynamics and biological roles". ... Tojkander, S.; Gateva, G.; Lappalainen, P. (April 29, 2012). "Actin stress fibers - assembly, dynamics and biological roles". ...

Currently, +TIPs may play critical roles in more than just the general aspects known; also with other particular cell ... Microtubule plus-end trafficking proteins engage in microtubule actin crosstalk, such as the CLIP-170 (+TIP) that controls ... directly to the actin fiber. Moreover, +TIP complexes in budding yeast are utilized for myosin-based transport of microtubule ... actin polymerization-a necessity in mammalian phagocytosis. +TIPs have been known for an extravagant accumulation by the ...

... these roles include regulation of the actin cytoskeleton which is an associated role of postsynaptic lipid rafts. In studies it ... The function of BAALC is not fully understood yet, but has been suggested to have synaptic roles involving the post synaptic ... Evidence has shown the BAALC protein to be an intracellular protein with cytoskeleton network roles, ... and regulation of the actin cytoskeleton. The postsynaptic lipid raft possesses many proteins and is one of the major sites for ...

"Entrez Gene: ACTR2 ARP2 actin-related protein 2 homolog (yeast)". Bearer EL, Prakash JM, Li Z (2002). "Actin dynamics in ... 2002). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity ... 2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 ... "The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches ...

Important roles are played by actin binding proteins like actin-binding Rho-activating protein (ABRA), cofilin, and thymosin ... beta 4 which determine actin polymerization and maturation. Integrins and connexins are markedly up-regulated. A key role in ...

Hoshino H, Yoneda A, Kumagai F, Hasezawa S (2003). "Roles of actin-depleted zone and preprophase band in determining the ... The first sign is a clear, actin-free zone appearing around the nuclear envelope. This zone fills with microtubules nucleating ... Experiments with drugs destroying microfilaments indicate that actin may play a role in keeping the cellular "memory" of the ... It consists of microtubules and microfilaments (actin) and persists into prophase. Spindle formation occurs during prophase ...

... suggesting cell signalling roles and regulation of actin organisation. Teneurin-3 regulates the structural and functional ... transmembrane proteins with fundamental roles in development". Int. J. Biochem. Cell Biol. 39 (2): 292-7. doi:10.1016/j.biocel. ...

Erickson (2009) proposed how the roles of tubulin-like proteins and actin-like proteins in cell division became reversed in an ... FtsZ's role in cell division is analogous to that of actin in eukaryotic cell division, but, unlike the actin-myosin ring in ... ZipA or the actin homologue FtsA permit initial FtsZ localization to the membrane. Following localization to the membrane, ... He AS, Rohatgi PR, Hersh MN, Rosenberg SM (February 2006). "Roles of E. coli double-strand-break-repair proteins in stress- ...

Other proteins that are known to interact with NM IIA include the actin binding protein tropomyosin 4.2 and a novel actin ... but all three play distinct roles during vertebrate development and adulthood (for general reviews on NM IIs, see ). All NM IIs ... England K, Ashford D, Kidd D, Rumsby M (June 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". ... Actin, desmin, myosin, and tropomyosin". The American Journal of Pathology. 142 (1): 221-30. PMC 1886840. PMID 8424456. Lalwani ...

... that regulates the intensity of actin microfilament polymerization and the contractility of actin-myosin filaments, which ... This GTPase belongs to the superfamily of small GTP hydrolases, whose members play key roles in the amoeboid type of invasion, ... LIM-kinase, an enzyme whose substrate stabilizes actin, plays a role in the collective migration of tumor cells. This protein ... Developing changes in the cell shape are generated by the cortical actin cytoskeleton that is, in turn, controlled by small ...