It was screened with a phenotypic screening approach, tested both in vivo and ex vivo rodent models. It showed a high ... The search for another thienopyridine analog with a better activity/toxicity ratio in animals started as soon as ticlopidine ... Disturbance in this system can lead to cerebrovascular, cardiovascular and peripheral vascular diseases where it can lead to a ... "Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease". ...

87-91 M.D. Sonin "Filariata of Animals and man and diseases caused by them, Part 3, Filariidae, Onchocercinae". Fundamentals of ... Acanthocheilonema viteae is a filarial nematode that infects the rodents species. A. Viteaeis also used as a model species in ... Sonin M D 1975 Filariata of animals and man and diseases caused by them. Part III. Filariidae, Onchocercinae. Amerind ... 127-130 Sonin M D 1975 Filariata of animals and man and diseases caused by them. Part III. Filariidae, Onchocercinae. Amerind ...

... transplantation of interneurons led to the restoration of memory and cognitive function in an Alzheimer's disease mouse model ... As the animal continues to have its innate biological clock, other exogenous cues are factored in that enable the animal to ... Daan, Serge; Pittendrigh, Colin S. (1976-10-01). "A Functional analysis of circadian pacemakers in nocturnal rodents". Journal ... For example, having a pulse of light during a diurnal animal's rest phase could lead to a change in period and rhythmicity, ...

Animal studies have found that adolescent mice, but not adult mice, consume more alcohol in the presence of peers than when ... Evidence from rodent studies indicates the dopaminergic system, the pathway connecting the ventral tegmental area to the ... According to the Center for Disease Control, in 2014 about 40% of all adolescent deaths (ages 15-19 years) were caused by ... Other models similar to the dual systems model are the maturational imbalance model, the driven dual systems model, and the ...

... autoimmune diseases and host defense has led to the experimental targeting of the IL-17A pathway in animal models of diseases ... In rodents, IL-17A used to be referred to as CTLA8, after the similarity with a viral gene (O40633). The protein encoded by ... This disease and its animal model experimental autoimmune encephalomyelitis (EAE) have historically been associated with the ... lessons from animal models". Arthritis Research & Therapy. 7 (1): 29-37. doi:10.1186/ar1478. PMC 1064899. PMID 15642151. ...

Holbrook MR, Aronson JF, Campbell GA, Jones S, Feldmann H, Barrett AD (January 2005). "An animal model for the tickborne ... The main hosts of OHFV are rodents like the non-native muskrat. OHFV originates in ticks, who then transmit it to rodents by ... "Omsk hemorrhagic fever (OHF)". Viral Hemorrhagic Fevers (VHFs). Centers for Disease Control and Prevention. 9 December 2013. ( ...

Studies in Alzheimer's disease animal models, in stroke patients and in human retina pigment epithelial cells (RPE) have shown ... reduce brain infarction and stroke in a rodent model. 10-Epi-PD1 (ent-AT-NPD1: i.e. 10S,17S-Dihydroxy-4Z,7Z,11E,13E,15Z,19Z- ... Specifically, PD1 in Alzheimer's disease models has been shown to respond to the increased concentration of the pro- ... reduce the infiltration of neutrophils into the peritoneum in a mouse model of inflammatory disease; b) stimulate the ...

"CDC - Diseases directly transmitted by rodents - Rodents". Centers for Disease Control. 2011-06-07. Archived from the original ... Rodent tails-particularly in rat models-have been implicated with a thermoregulation function that follows from its anatomical ... Rats are seen as vicious, unclean, parasitic animals that steal food and spread disease. In 1522, the rats in Autun, France ... The characteristic long tail of most rodents is a feature that has been extensively studied in various rat species models, ...

... has focused on animal models of the disease, its mechanisms, ways to diagnose and track it, and treatments. Many models have ... The most studied model for ALS is the rodent, mouse model, which provide the most complex representation of nervous system that ... Many animals have been used over the years to study ALS and to search for a potential therapy. The animal models can be C. ... "Rodent models of amyotrophic lateral sclerosis". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832 (9): ...

Rodents nest in accumulated tires and can transmit diseases such as Hantavirus. When tires are burned, they can smolder for ... The two-stage process model of littering behavior describes the different ways in which people litter. The model was proposed ... Also, animals can get trapped in the rubbish and be in serious discomfort. For example, the plastic used to hold beverage cans ... Animals may get trapped or poisoned with litter in their habitats. Cigarette butts and filters are a threat to wildlife and ...

... and rodents or other animals seeking shelter and dry land. Puerto Rico is at a particularly elevated risk of infectious disease ... Surveillance and predictive modeling efforts utilizing Geographic Information Science can help predict locations of future ... Diseases transmitted from animals to humans are collectively known as zoonotic diseases. With climate change increasing the ... Leptospirosis, caused by an infection of Leptospira bacteria, is likely the most ubiquitous disease transmitted between animals ...

This model has limits, however, because the fitness advantage of limited virulence is primarily a function of a limited number ... "Cereal Disease Laboratory : Ug99 an emerging virulent stem rust race". Agricultural Research Service of the U.S. Department of ... or animals). In many cases the organism will be a pathogen of humans, livestock, crops, or other organisms we depend upon (e.g ... researchers unintentionally changed characteristics of the mousepox virus while trying to develop a virus to sterilize rodents ...

... and polycystic kidney disease. The protective role of EETs in these animal model diseases may reflect, at least in part, their ... In animal (primarily rodent) models, EETs dilate smaller sized resistance arteries involved in causing hypertension as well as ... These interventions also gave beneficial results in animal models of non-alcoholic fatty liver disease and certain types ... Indeed, studies on in vivo animal and in vitro animal and human cell model systems indicate that the ETEs reduce infarct (i.e. ...

... has been used to create animal models of epilepsy. Different animal models of epilepsy have been characterized in rodents that ... Instead of referring to it as the sacred disease, he used the term great disease, giving rise to the modern term grand mal, ... Guillemain, I., Kahane, P. & Depaulis, A. Animal models to study aetiopathology of epilepsy: what are the features to model? ... Among these models, the strain of GAERS (Genetic Absence Epilepsy Rats from Strasbourg) was characterized in the 80' and has ...

This results suggest that DP1 can promote or suppress allergic responses depending on the animal model tested and, perhaps, the ... The PGD2-DP1 pathway is involved in the regulation of non-rapid eye movement sleep in rodents: infusion of PGD2 into the ... Human Genomics studies have associated Single-nucleotide polymorphism variants with an increased incidence of allergic diseases ... Th1/Th2 Model for helper T cells and T helper cell#Limitations to the Th1/Th2 model. DH1 activation also promotes allergic ...

3) Obese, diabetic male C57BL6/J mice and db/db obese, diabetic mice (an animal disease model) have fear-associated learning ... blocked the development of fibrosis in rodent kidney, liver, heart, lung, pancreas, and skin models of pathological fibrosis. 3 ... These studies, which are preclinical studies on cultured cells and animal models of disease plus some clinical studies, are ... 5) GW9508 reduced the cognitive deficits in A-beta AD mice (i.e. a mouse model of Alzheimer's disease); this reduction was ...

... class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed ... although no hyperthermia was observed in rodent models of heart failure treated with BCTC, SB-366791 or AMG-9810. Post ... These SPMs also dampen pain perception arising from various inflammation-based causes in animal models. The mechanism behind ... In a mouse model, TRPV1 affect dendritic cell maturation and function, however, further studies are needed to clarify this ...

It is assumed that, with gene-transfer techniques, it is possible (in experimental settings using animal models) to alter CNS ... This could be done in order to cure diseases (gene therapy), prevent the possibility of getting a particular disease (similarly ... Reduction of p11, a serotonin receptor binding protein, in the nucleus accumbens led to depression-like behaviour in rodents, ... In recent years, it was possible to modify ethanol intake in animal models. Specifically, this was done by targeting the ...

It is a gregarious animal and lives in small family groups. It is the first and only known rodent species that exhibit ... potentially serving as a great candidate model to study menstrual related diseases. It exhibits a 9-day cycle, and is the first ... Cairo spiny mice are social animals and live in a group with a dominant male. Breeding mostly takes place in the rainy season, ... Pinheiro, G; Prata, DF; Araujo, IM; Tiscornia, G (2018). "The African spiny mouse (Acomys spp.) as an emerging model for ...

The most common infectious disease in gerbils is Tyzzer's disease, a bacterial disease, which stress can make animals more ... These rodents are susceptible to carrying diseases and infections some transmitted sexually, much the subject of many ... Buckmaster, Paul S. (2006). "Inherited Epilepsy in Mongolian Gerbils". Models of Seizures and Epilepsy. pp. 273-294. doi: ... "Animal Health Center Vets in Valdosta, GA". Animal Health Center Vets in Valdosta, GA. Retrieved 3 June 2018. "Gerbil FAQ". ...

... a strategy has been used to generate TRPV6 loss-of-function models to examine the role of the channel in animal physiology. ... In rodents, TRPV6 mRNA is expressed in the labyrinth and spongy zone as well as placenta-unattached areas of the uterus. The ... The disease is caused by mutations in which compromise the function of the encoded protein pendrin - an anion Cl−/HCO3 − ... reduces cancer growth in cell and animal models. This anti-cancer agent has recently completed a Phase I clinical safety trial ...

DUE-B sequence homologs found among a variety of animal species- fish, amphibians, and rodents. DUE-B's have disordered C- ... A common yeast model system that well-represents eukaryotic replication is Saccharomyces cerevisiae. It possesses autonomously ... This can be recovered in disease-related (ATTCT)(n) length expansions of the DUE sequence. If DUE activity regained in excess, ... Genetic Instabilities and Neurological Diseases (Second ed.). Burlington: Academic Press. pp. 447-460. doi:10.1016/B978- ...

Cytochrome c peroxidase is used as a soluble, easily purified model for cytochrome c oxidase. Ascorbate peroxidase Chloride ... Protein families that serve as peroxidases include: Haem-using haem peroxidase and the related animal heme-dependent ... whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. Amyloid beta, when bound to heme, has ... relationship to the cytopathologies of Alzheimer's disease". Proceedings of the National Academy of Sciences of the United ...

Animal models, Pleistocene rodents, Quaternary mammals of South America, Extant Pleistocene first appearances). ... Similar to the inherited genetic diseases of other breeds of animal (such as hip dysplasia in canines), a number of genetic ... The animals were used so frequently as model organisms in the 19th and 20th centuries that the epithet guinea pig came into use ... They also are used in traditional healing rituals by folk doctors, or curanderos, who use the animals to diagnose diseases such ...

Intravenous delivery of 5-10 mg/kg in rodent models has shown a plasma half-life of around 40-60 minutes while intraperitoneal ... In many current animal studies the compound is dissolved in a lipid emollient and delivered through intraperitoneal injection. ... Parkinson's disease, and convulsive disorders like epilepsy. Honokiol disrupts the interfaces post synaptic density protein ( ... and Inhibits Brain Tumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model". PLOS ONE. 6 ( ...

Hynek Wichterle, Mathis modelled amyotrophic lateral sclerosis (A.L.S.) using stem cell-derived motor neurons. During her time ... "Apple, Google, and Facebook Are Raiding Animal Research Labs". Bloomberg.com. June 18, 2019. "A Game-Changing AI Tool for ... by the end of her PhD regarding the essential role played by the somatosensory cortex in forelimb motor adaptation in rodents. ... which offered a novel protocol for generating human limb-innervating neural subtypes in vitro for use in neurological disease ...

Otherwise, clinical experience and animal models shows the relative safety of accidental and experimental NSTX intoxication ( ... It can be approximately described using one of the classical model of neurotoxic disease, known from ancient times as red tide ... Some investigations demonstrated anesthetic effect lasting over one week after single injection in rodents, using extended ... Centers for Disease Control and Prevention (CDC). CDC's Laboratory Response to Toxins (accessed: May 8, 2012) [3] Wang DZ ( ...

Rodents (primarily mice and rats) are the most common mammalian model systems used for studying gnotobiosis and are widely used ... Guinea pigs were the first germ-free animal model described in 1896 by George Nuttall and Hans Thierfelder, establishing ... Basic M, Bleich A (2018). "Gnotobiology". The Gut Microbiome in Health and Disease. Cham: Springer International Publishing. pp ... Martín R, Bermúdez-Humarán LG, Langella P (2016). "Gnotobiotic Rodents: An In Vivo Model for the Study of Microbe-Microbe ...

Research in animal models such as rodents has found many genes that are required for normal brain growth. For example, the ... Dumas L, Sikela JM (2009). "DUF1220 domains, cognitive disease, and human brain evolution". Cold Spring Harb. Symp. Quant. Biol ... "Trisomy 13 , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases.info.nih.gov. Retrieved 2020 ... "Facts about Microcephaly". Centers for Disease Control and Prevention. 2016-12-07. Retrieved 2019-08-02. Crespi, B.; Stead, P ...

Large-scale, parallel recordings with tens of implanted electrodes are possible, at least in rodents, during animal behavior. ... An alternative means of predicting cell-electrode behavior is by modeling the system using a geometry-based finite element ... Deep brain stimulation (DBS) has been effective at treating movement disorders such as Parkinson's disease, and cochlear ... ISBN 0-387-25857-4. Buitenweg, J. R.; Rutten, W. L.; Marani, E. (2003). "Geometry-based finite element modeling of the ...

Soon after, MPTP was tested in animal models for its efficacy in inducing Parkinson's disease (with success). MPTP induced ... In other animals, such as rodents, the induction of Parkinson's by MPTP is incomplete or requires much higher and frequent ... Today, MPTP remains the most favored method to induce Parkinson's disease in animal models. The substantia nigra was discovered ... The motor role of the pars compacta may involve fine motor control, as has been confirmed in animal models with lesions in that ...

eggs.[citation needed] The selective liver damage by C. hepatica in rodents has been used in model systems to study the ... Usually, Capillaria hepatica is found in rodents, monkeys and other animals. Capillaria hepatica is rarely found in humans and ... "Parasites and Health: Capillariasis". Center for Disease Control. Retrieved 14 September 2011. Bancroft, T. L. (1893). "On the ... Up to 938,000 eggs have been reported from the liver of a single rodent host. The eggs in the liver exist in a state of ...