... end of the messenger RNA require the presence of a trans-spliced leader sequence. Spliced leader sequences are short sequences ... Huang XY, Hirsh D (November 1989). "A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans". Proc. ... Spliced leaders have been seen in trypanosomatids, Euglena, flatworms, Caenorhabditis. Some species contain only one spliced ... Total RNA is purified from the specimen of interest. Poly A messenger RNA is then purified from total RNA and subsequently ...

... splice site upstream. When the 5' outron in spliced, the 5' splice site of the spliced leader RNA is branched to the outron and ... In Ascaris, the spliced leader sequence is needed to the RNA gene can be transcribed. The Spliced leader sequence may be ... Trans-splicing differs from cis-splicing in that there is no 5' splice site on the pre-mRNA. Instead the 5' splice site is ... a capped splice leader RNA is transcribed, and simultaneously, genes are transcribed in long polycistrons. The capped splice ...

Possess Spliced Leader RNA Genes Similar to the Kinetoplastida". The Journal of Eukaryotic Microbiology. 48 (3): 325-331. doi: ... The Diplonemidae genome contains a spliced leader RNA gene, which confirms their use of mRNA spliceosome-dependent trans ... Instead, fragments are transcribed and spliced together using their own specialized trans splicing machinery. Once spliced ... which discovered that diplonemidae possess a functional splice leader RNA that is characteristic of the kinetoplastids. ...

Trans-splicing is a form of RNA processing. The acquisition of a spliced leader from an SL RNA is an inter-molecular reaction ... "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria ... SL2 RNA is a non-coding RNA involved in trans splicing in lower eukaryotes. ... Page for SL2 RNA at Rfam v t e (GO template errors, Non-coding RNA, All stub articles, Molecular and cellular biology stubs). ...

... located within the spliced leader RNA (SLA). The cluster genes are produced as polycistronic RNA. Small nucleolar RNA TBR2 ... "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and ... It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA TBR7 belongs to the C/D box ... Page for Small nucleolar RNA TBR7 at Rfam v t e (GO template errors, Small nuclear RNA, All stub articles, Molecular and ...

... located within the spliced leader RNA (SLA). The cluster genes are produced as polycistronic RNA. Small nucleolar RNA TBR2 ... "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and ... "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA ... Page for Small nucleolar RNA TBR5 at Rfam v t e (Wikipedia articles that are too technical from March 2010, All articles that ...

... located within the spliced leader RNA (SLA). The cluster genes are produced as polycistronic RNAs. Small nucleolar RNA TBR2 ... "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and ... It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA TBR17 belongs to the C/D box ... Page for Small nucleolar RNA TBR17 at Rfam v t e (GO template errors, Small nuclear RNA, All stub articles, Molecular and ...

The SL1 RNA is involved in trans-splicing, which is a form of RNA processing. The acquisition of a spliced leader from an SL ... "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria ... Page for SL1 RNA at Rfam v t e (GO template errors, Non-coding RNA, All stub articles, Molecular and cellular biology stubs). ... This family represents the SL1 RNA. The gene encoding SL1 RNA is commonly, but not always, located in the spacer region between ...

These have names like CEOP5460 and are manually curated using evidence from the SL2 trans-spliced leader sequence sites. There ... They may be pseudogenes of coding genes or of non-coding RNA and may be whole or fragments of a gene and may or may not express ... However, other data types (e.g. protein alignments, ab initio prediction programs, trans-splice leader sites, poly-A signals ... if there is alternative splicing in the UTRs, which would not change the protein sequence, the alternatively spliced ...

... acceptor splice site on the outron, and a 5' donor splice site (GU dinucleotide) located on a separate RNA molecule, the SL RNA ... Stover, Nicholas A.; Kaye, Michelle S.; Cavalcanti, Andre R. O. (2006-01-10). "Spliced leader trans-splicing". Current Biology ... Nuclear machinery then resolves this 'Y' branching structure by trans-splicing the SL RNA sequence to the 3′ trans-splice ... Such a trans-splice site is essentially defined as an acceptor (3') splice site without an upstream donor (5') splice site. In ...

"Trypanosome spliced-leader-associated RNA (SLA1) localization and implications for spliced-leader RNA biogenesis". Eukaryotic ... TB11Cs2H1 is a unique H/ACA RNA, it is also known as the splice leader associated RNA (SLA1). It was demonstrated that although ... Liang XH, Xu YX, Michaeli S (February 2002). "The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has ... TB11Cs2H1 is a member of the H/ACA-like class of non-coding RNA (ncRNA) molecules that guide the sites of modification of ...

Zhang, H; Campbell, DA; Sturm, NR; Dungan, CF; Lin, S (2011). "Spliced leader RNAs, mitochondrial gene frameshifts and multi- ... 1991). "Ribosomal RNA sequences of Sarcocystis muris, Theilera annulata, and Crypthecodinium cohnii reveal evolutionary ... and this was confirmed in the early 1990s by comparisons of ribosomal RNA sequences, most notably by Gajadhar et al. Cavalier- ...

Targets include ribosomal and spliceosomal RNAs as well as the Trypanosoma spliced leader RNA (SL RNA) as possibly other, still ... Kiss T (April 2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2 ... Ganot P, Caizergues-Ferrer M, Kiss T (April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily ... Page for Small nucleolar RNA SNORA75 at Rfam v t e (Articles with short description, Short description matches Wikidata, GO ...

... splicing reactions between a protein coding RNA and a universal sequence result in the attachment of a splice-leader to the 5' ... This is accomplished through RNA splicing. The exons of these 25,000 genes can be spliced in many different ways to create ... SplitSeek allows de novo prediction of splice junctions in short-read RNA-seq data, suitable for detection of novel splicing ... CRAC integrates genomic locations and local coverage to enable splice junction or fusion RNA predictions directly from RNA-seq ...

... a functional role for U5 snRNA in spliced leader addition trans-splicing and the identification of novel Sm snRNPs". RNA. 2 (8 ... Page for SmY spliceosomal RNA at Rfam (Non-coding RNA, Small nuclear RNA, RNA splicing, Nematode nucleic acids). ... Jones TA, Otto W, Marz M, Eddy SR, Stadler PF (2009). "A survey of nematode SmY RNAs". RNA Biol. 6 (1): 5-8. doi:10.4161/rna. ... U3 snoRNA and the spliced leader RNAs transcripts (SL1 and SL2) all contain a very similar consensus SM binding sequence (AAU4- ...

... discovery of RNA splicing William H. Dietz, MD (B.A. 1996) - Director, Division of Centers for Disease Control and Prevention ( ... "Albany Native to Head College: Brother John R. Paige Will Become Leader of School Near Notre Dame". AllBusiness.com. Retrieved ... and leader in Nova Scotia, Canada B. T. Roberts (university honors) - co-founder, Free Methodist Church of North America A. ... Wesleyan's all-time leader in hits Eric Mangini (1994) - former head coach, Cleveland Browns, New York Jets; NFL analyst Vince ...

In stressful environments, T. brucei produces exosomes containing the spliced leader RNA and uses the endosomal sorting ... The Commission comprised George Carmichael Low from the London School of Hygiene and Tropical Medicine as the leader, his ...

... in Israel to obtain his master's degree in the Department of Biophysics studying spliced leader RNA in Leishmania parasites. ... His research brought together his expertise in RNA and cancer by developing new technologies in RNA interference (RNAi) and ... Joseph Steiner Prize for his contributions in the field of small RNAs and Cancer. Further, he received VIDI and VICI awards ... Agami is known for his work utilizing RNA-based and functional genomics technologies in cancer research. He was the inventor of ...

He then carried out his PhD research working with Jean Beggs on yeast RNA splicing at Imperial College London and Edinburgh ... He is a senior group leader at the Cancer Research UK Cambridge Institute and associate group leader at the Gurdon Institute, ... He returned to the UK in 1991 as a Junior Group Leader at the then Wellcome-CRC Institute, now the Gurdon Institute. Jackson's ...

Known RNA leaders are Histidine operon leader, Leucine operon leader, Threonine operon leader and the Tryptophan operon leader ... these are called self-splicing RNAs. There are two main groups of self-splicing RNAs: group I catalytic intron and group II ... VegT RNA, Oskar RNA, ENOD40, p53 RNA and SR1 RNA. Bifunctional RNAs have recently been the subject of a special issue of ... "Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA". RNA. 12 (5): 699-706. doi:10.1261/rna. ...

He was known for his work on the mechanism of RNA splicing and structures of the spliceosome. Nagai studied at Osaka University ... In 1987 he became a tenured group leader at the LMB and was joint head of the Division of Structural Studies from 2000 to 2010 ... a large macromolecular machine that catalyses RNA splicing in eukaryotes, including components of the U2 snRNP and the Sm ... "Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin ...

RNA polymerase - RNA splicing - RNAi - RNase - RNase protection assay - rRNA - rRNA (guanine-N2-)-methyltransferase - RT-PCR - ... PyrC leader - pyrimidine random primed synthesis - reading frame - recessive - recognition sequence - recombinant DNA - ... SP6 RNA polymerase - SpAB protein domain - spectral karyotype - splicing - Simple Sequence Repeats (SSR) - SPR domain - SQ2397 ... CAT RNA-binding domain - catalase-related immune-responsive domain - CCAAT box - Cd2+-exporting ATPase - cDNA - cDNA clone - ...

to either be "between the major splice donor site (in the r region of the viral RNA) and the gag start codon or between the ... They found mutants made with deletions in the 5' end of the gag gene and in the 5' untranslated leader region had a 7-fold and ... The RNA encapsidation (packaging) signal participates in the process of RNA packaging and aids in making viral packaging and ... RNA packaging is characterized by an initial recognition event between the Gag polyprotein and the RNA encapsidation (packaging ...

"Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator ... Baralle, FE (1983). "The functional significance of leader and trailer sequences in eukaryotic mRNAs". International Review of ... His studies on how genes are processed described the first sequences within exons that control splicing, exonic splicing ... Mardon, H. J.; Sebastio, G.; Baralle, F. E. (12 October 1987). "A role for exon sequences in alternative splicing of the human ...

He has investigated how RNA interference (RNAi) mediates heterochromatin formation and shown that splicing factors contribute ... for 18 months before joining the MRC Human Genetics Unit as a junior group leader. While at CSHL he decided to switch his focus ... "Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast". EMBO Reports. 11 (2): ... He has provided insight into how transcription and resulting non-coding RNA might influence the assembly of specialised CENP-A ...

... a recipient of Howard Hughes Medical Institute's Future Scientists Fellowship for his work on RNA splicing Shu Jie Lam - ... third leader of the Ngee Heng Kongsi of Johor Capitan China Chung Keng Quee - leader of the "Five Associations" or Go-Kuan and ... the second leader of the Ngee Heng Kongsi of Johor, one of the Kangchu Johor; Jalan Tan Hiok Nee in Johor Bahru is named after ... Johor Bahru and also the first leader of Ngee Heng Kongsi of Johor Kapitan China Seah Tee Heng - third Kapitan China of Johor, ...

... a recipient of Howard Hughes Medical Institute's Future Scientists Fellowship for his work on RNA splicing Shu Jie Lam, ... warrior and leader of Ngee Heng Kongsi, ordered the 4,000 members of its brotherhood to relocate in Johor Albert Kwok Fen Nam ( ... 1921-1944), warrior and leader of the "Kinabalu Guerrillas" against Japanese occupation Leftenan Adnan (1915-1942), warrior ...

... working on the functional roles of the RNA structure in living cells. She has also been an Honorary Group Leader at the ... splicing and polyadenylation), phase separation, translation, and RNA degradation. Yiliang's group has also developed new ... "Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants" (PDF). Molecular Plant. " ... The group revealed the functional importance of RNA structure in long noncoding RNAs. She is a member of the editorial board of ...

He researched the mechanisms of RNA splicing and RNA interference. His 2006 dissertation was titled Building the Drosophila RNA ... "Reflections of a reluctant leader - with John Pham, editor of Cell". Listen Notes. Retrieved 2021-10-08. (Articles with short ... Pham, John W. (2006). Building the Drosophila RNA-induced silencing complex (Thesis). OCLC 124095747. " ...

Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. ... Alternatively spliced transcript variants encoding different isoforms have been described. GRCh38: Ensembl release 89: ... 1998). "Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells". Exp. Cell ... which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are ...