Loading...
*  Antisense RNA
Kole R, Krainer AR, Altman S (January 2012). "RNA therapeutics: beyond RNA interference and antisense oligonucleotides". Nature ... RNA I and RNA II forms a duplex which introduces a conformational change of RNA II. Consequently, RNA II cannot hybridize with ... RNA-RNA interactions either in nucleus or cytoplasm and RNA-protein interactions (epigenetic). Antisense RNAs can be ... The replication of ColE1 relies on the transcription of a primer RNA named RNA II. Once RNA II is transcribed, it hybridizes to ...
*  Long non-coding RNA
Ogawa Y, Sun BK, Lee JT (June 2008). "Intersection of the RNA interference and X-inactivation pathways". Science. 320 (5881): ... short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. However ... an ncRNA repressor of RNA polymerase II transcription". RNA. 13 (4): 583-96. doi:10.1261/rna.310307. PMC 1831867 . PMID ... Yang S, Tutton S, Pierce E, Yoon K (November 2001). "Specific double-stranded RNA interference in undifferentiated mouse ...
*  DNA-directed RNA interference
Any RNA, including endogenous mRNAs or viral RNAs, can be silenced by designing constructs to express double-stranded RNA ... DNA-directed RNA interference (ddRNAi) is a gene-silencing technique that utilizes DNA constructs to activate an animal cell's ... Zou, W.; Song, Z.; Guo, Q.; Liu, C.; Zhang, Z.; Zhang, Y. (2011). "Intrathecal Lentiviral-Mediated RNA Interference Targeting ... endogenous RNA interference (RNAi) pathways. DNA constructs are designed to express self-complementary double-stranded RNAs, ...
*  RNA interference
... are central to RNA interference. RNAs are the direct products of genes, and these small RNAs can bind to other specific ... RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing ... The table below shows different drugs using RNA interference and what their phases and status is in clinical trials. RNA ... Wall, NR; Shi, Y (October 25, 2003). "Small RNA: can RNA interference be exploited for therapy?". Lancet. 362: 1401-1403. doi: ...
*  RasiRNA
... is key to the regulatory mechanism of many organisms as part of the RNA interference pathway. Small RNAs guiding RNA ... Repeat associated small interfering RNA (rasiRNA) is a class of small RNA that is involved in the RNA interference (RNAi) ... RNA interference. Genes and Dev. 15: 485-490. Belgnaoui, S. M., R. G. Gosden, O J. Semmes, A. Haoudi. 2006. Human LINE-I ... RasiRNA are in fact Piwi-interacting RNAs (piRNAs), which are small RNA molecules that interact with Piwi proteins. Piwi ...
*  Persomics
2012.] "RNA Interference (RNAi)". Adapt. Mary Muers, Simon Fenwick, Louisa Flintoft, and Kerri Smith. Prod. James Butcher, ... By directing gene silencing, siRNAs act as RNA interference, effectively inhibiting expression of a gene in question. Since the ...
*  David Baulcombe
"Advanced Information: RNA interference". The Nobel Prize in Physiology or Medicine 2006. Retrieved 25 January 2007. "No. 59090 ... Dalmay, T.; Hamilton, A.; Rudd, S.; Angell, S.; Baulcombe, D. (2000). "An RNA-dependent RNA polymerase gene in Arabidopsis is ... With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA-mediated gene silencing ... Hamilton, A.; Voinnet, O.; Chappell, L.; Baulcombe, D. (2002). "Two classes of short interfering RNA in RNA silencing". The ...
*  Microprocessor complex
It has been suggested based on phylogenetic analysis that the key components of RNA interference based on exogenous substrates ... Broadly defined, both pathways constitute RNA interference. Gene regulation by miRNA is widespread across many genomes - by ... Wilson, RC; Doudna, JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217-39. doi:10.1146 ... RNA. 22 (2): 175-83. doi:10.1261/rna.054684.115. PMID 26683315. Nguyen, TA; Jo, MH; Choi, YG; Park, J; Kwon, SC; Hohng, S; Kim ...
*  XPO5
"Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs". RNA. 11 (2): 220-6. doi: ... Wilson RC, Doudna JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217-39. doi:10.1146/ ... RNA. 10 (2): 185-91. doi:10.1261/rna.5167604. PMC 1370530 . PMID 14730017. Chen T, Brownawell AM, Macara IG (Aug 2004). " ... allowing XPO5 to recognize the RNA as pre-miRNA. Because these interactions involve only the RNA phosphate backbone, they are ...
*  Short hairpin RNA
Xiang, Shuanglin; Fruehauf, Johannes; Li, Chiang J (2006). "Short hairpin RNA-expressing bacteria elicit RNA interference in ... A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that ... Wang, Zhaohui; Rao, Donald D.; Senzer, Neil; Nemunaitis, John (2011). "RNA Interference and Cancer Therapy". Pharmaceutical ... Small interfering RNA Paddison, PJ; Caudy, AA; Bernstein, E; Hannon, GJ; Conklin, DS (15 April 2002). "Short hairpin RNAs ( ...
*  RNA-induced transcriptional silencing
... (RITS) is a form of RNA interference by which short RNA molecules - such as small ... Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, Moazed D, Grewal S (2004). "RITS acts in cis to promote RNA interference- ... Volpe T, Schramke V, Hamilton G, White S, Teng G, Martienssen R, Allshire R (2003). "RNA interference is required for normal ... Volpe, Tom; Martienssen, Robert A. (2011-09-01). "RNA Interference and Heterochromatin Assembly". Cold Spring Harbor ...
*  WormBase
RNA interference) screens; Genetic maps, markers and polymorphisms; The C. elegans physical map; Gene expression profiles ( ... They may be pseudogenes of coding genes or of non-coding RNA and may be whole or fragments of a gene and may or may not express ... There are several classes of non-coding RNA gene classes in WormBase: tRNA genes are predicted by the program 'tRNAscan-SE'. ... or can express one or more non-coding RNA genes (ncRNA) or protein-coding sequences (CDS). Pseudogenes are genes that do not ...
*  RNA activation
Check, Erika (2007). "RNA interference: Hitting the on switch". Nature. 448 (7156): 855-8. doi:10.1038/448855a. PMID 17713502. ... In C. elegans, Argonaute CSR-1 interacts with 22G small RNAs derived from RNA-dependent RNA polymerase and antisense to ... The RNA-loaded Ago then recruits other proteins such as RHA, also known as nuclear DNA helicase II, and CTR9 to form an RNA- ... who also coined the term "RNAa" as a contrast to RNA interference (RNAi) to describe such gene activation phenomenon. Soon ...
*  Immune system
Ribonucleases and the RNA interference pathway are conserved across all eukaryotes, and are thought to play a role in the ... Stram Y, Kuzntzova L (Jun 2006). "Inhibition of viruses by RNA interference". Virus Genes. 32 (3): 299-306. doi:10.1007/s11262- ... which allows them to block virus replication through a form of RNA interference. Prokaryotes also possess other defense ... RNA silencing mechanisms are particularly important in this systemic response as they can block virus replication. Another ...
*  MicroRNA
miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions ... doi:10.1261/rna.2183803. PMC 1370393 . PMID 12592000. Science review of small RNA: Baulcombe D (2002). "DNA events. An RNA ... The let-7 RNA was found to be conserved in many species, leading to the suggestion that let-7 RNA and additional "small ... A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila ...
*  RNA silencing
... or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated ... Despite early focus in the literature on RNA interference (RNAi) as a core mechanism which occurs at the level of messenger RNA ... Karagiannis TC, El-Osta A (Oct 2005). "RNA interference and potential therapeutic applications of short interfering RNAs". ... RNA silencing mechanisms are highly conserved in most eukaryotes. The most common and well-studied example is RNA interference ...
*  DNA nanotechnology
Trafton, Anne (4 June 2012). "Researchers achieve RNA interference, in a lighter package". MIT News. Retrieved 22 September ... RNA nanotechnology: Guo, Peixuan (2010). "The Emerging Field of RNA Nanotechnology". Nature Nanotechnology. 5 (12): 833-842. ... A DNA tetrahedron was used to deliver RNA Interference (RNAi) in a mouse model, reported a team of researchers in MIT. Delivery ... The DNA nanostructure created by the team consists of six strands of DNA to form a tetrahedron, with one strand of RNA affixed ...
*  Sirna Therapeutics
was a San Francisco, California based biotechnology company that explored the use of RNA interference in human disease therapy ... Sah, D (2006). "Therapeutic potential of RNA interference for neurological disorders". Life Sci. 79 (19): 1773-80. doi:10.1016/ ... Sirna's development pipeline includes several small interfering RNA (siRNA) drugs, thought to stably silence the expression of ...
*  Tyler Jacks
Cre-lox-regulated conditional RNA interference from transgenes. PNAS (101):10380-10385. Tyler Jacks' lab at MIT Koch Institute ...
*  NSDHL
Guggenberger C, Ilgen D, Adamski J (2007). "Functional analysis of cholesterol biosynthesis by RNA interference". J. Steroid ...
*  Ranpirnase
The mechanism of action of ranpirnase tumor-selective cytotoxicity has been attributed to the RNA interference pathway, ... potentially through cleaving siRNA molecules; to cleavage of transfer RNA; and to interference with the NF-κB pathway. Despite ... "The cytotoxic ribonuclease onconase targets RNA interference (siRNA)". Cell cycle (Georgetown, Tex.). 7 (20): 3258-61. doi: ... protein superfamily and degrades RNA substrates with a sequence preference for uracil and guanine nucleotides. Along with ...
*  Developmental biology
2008). "Dissecting insect leg regeneration through RNA interference". Cellular and Molecular Life Sciences. 65: 64-72. doi: ...
*  Ebola virus disease treatment research
TKM-Ebola is an RNA interference drug candidate; a Phase II trial started on 11 March 2015 and stopped enrolling new subjects ... "Medscape: Ebola Virus RNA Evident in Semen for a year or longer". www.medscape.com. Medscape. Retrieved 1 September 2016. ...
*  Emopamil binding protein
"Functional analysis of cholesterol biosynthesis by RNA interference". J. Steroid Biochem. Mol. Biol. 104 (3-5): 105-9. doi: ...
*  Phillip Allen Sharp
Miskevich F.; Doench J.G.; Townsend M.T.; Sharp P.A.; Constantine-Paton M. (15 April 2006). "RNA Interference of Xenopus NMDAR ... History of RNA biology List of RNA biologists MIT Department of Biology The Official Site of Louisa Gross Horwitz Prize "The ... doi:10.1261/rna.2890305. PMC 1370808 . PMID 15987809. Sharp P.A. (June 2005). "The Discovery of Split Genes and RNA Splicing". ... Sharp's current research focuses on small RNAs and other types of non-coding RNAs. His laboratory works to identify the target ...
*  NFIX
... interference with transcriptional activation by NFI/CTF in a cell-type specific manner". Nucleic Acids Res. 22 (19): 3825-33. ... is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739-45. doi:10.1074/jbc.272.16.10739. PMID 9099724. ...
*  Ihor R. Lemischka
Dissecting self-renewal in stem cells with RNA interference. Nature 2006; 442: 533-538. PMID 16767105 Moore KA, Lemischka IR. ... PMID 16574858 Schaniel C, Li F, Schafer X, Moore T, Lemischka I, Paddison P. Delivery of short hairpin RNAs-triggers of gene ...