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*  ARHGDIB
Scherle P, Behrens T, Staudt LM (September 1993). "Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient ... expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins". Proc Natl ...
*  MDia1
A mouse embryo cDNA library was screened to identify a RhoA-GTP-binding protein using a yeast two-hybrid system. Further it was ... shown that p140mDia1 binds to the GTP-bound form of RhoA only by precipitation from Swiss 3T3 cell lysates. Watanabe et al. ... Rho-GTP binds to the GDB domain and disrupts the DAD-DID-interaction thus promoting actin assembly. But this requires high ... Several binding proteins can regulate mDia1 localization and activity: ABI1: Helps to localize mDia1 to lamellipodia, filopodia ...
*  KCNA2
Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium ... Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium ... "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of ... Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 ...
*  Yersinia pseudotuberculosis
YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA". J. ... A transmembrane protein, invasin, facilitates these functions by binding to host cell αβ1 integrins. Through this binding, the ... bound state whereas YopE and YpkA convert Rho proteins to their inactive GDP-bound states by expressing GTPase activity. YpkA ... Subsequent internalization of bound bacteria occurs when the actin-depolymerising Yops are not being expressed. The protein ...
*  Clostridium botulinum C3 toxin
Their specificity is for the small GTP-binding proteins RhoA, RhoB, and RhoC, which are ADP-ribosylated on an asparagine ... Many bacterial toxins nucleotide-binding modify by ADP-ribosylation proteins involved in essential cell functions, leading to ... Clostridium botulinum C3 exoenzyme is a toxin that causes the addition of one or more ADP-ribose moieties to Rho-like proteins ... The molecular basis of the action of these enzymes consists in binding of nicotinamide adenine dinucleotide (NAD), splitting ...
*  CCRL1
... requirement of GTP-binding proteins ARF and RhoA". J. Immunol. 160 (4): 1894-900. PMID 9469451. Gosling J, Dairaghi DJ, Wang Y ... The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type ... This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/ ... Schweickart VL, Epp A, Raport CJ, Gray PW (2000). "CCR11 is a functional receptor for the monocyte chemoattractant protein ...
*  M-RIP
... putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7 ... putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7 ... A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484-93. doi:10.1074/jbc. ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ...
*  CENTD1
... effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". ... ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene. The protein encoded by ... This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. ... While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of ...
*  ARHGAP29
... a protein that mediates the cyclical regulation of small GTP binding proteins such as RhoA. ARHGAP29 is expressed in the ... "A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1". J Biol Chem. ... Myagmar, BE; Umikawa, M; Asato, T; Taira, K; Oshiro, M; Hino, A; Takei, K; Uezato, H; Kariya, K (2005). "PARG1, a protein- ... ARHGAP29 is a gene located on chromosome 1p22 that encodes Rho GTPase activating protein (GAP) 29, ...
*  RHOA
Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium ... RhoA contains both inactive GDP-bound and active GTP-bound conformational states; these states alternate between the active and ... with the N-terminal containing most of the protein coding for GTP binding and hydrolysis. The C-terminal of RhoA is modified ... putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7 ...
*  ROCK1
G-protein RhoE binds to the N-terminus of ROCK1 and inhibits its activity by preventing RhoA binding. Small G-proteins, Gem and ... When a substrate such as GTP-bound RhoA binds to the Rho-binding region of the coiled-coil domain, the interactions between the ... ROCK1 is activated when bound to the GTP-bound form of RhoA. The human ROCK1 gene is located on human chromosome 18 with ... GTPase-RhoA binding can increase the activity of ROCK1 by 1.5-2-fold. Without RhoA binding, lipids such as arachidonic acid or ...
*  DLC1
... functions to enhance the GTPase activity of the Rho-GTPase proteins RhoA and Cdc42, promoting the hydrolysis of their bound GTP ... its ability to enhance activated GTP-bound Rho-GTPases' (specifically, RhoA and Cdc42) intrinsic ability to convert their GTP ... The activity of RhoA regulates the formation of actin stress fibers and focal adhesions - complexes of many proteins located at ... The addition of DLC1 to tumor cells lines which are deficient in DLC1 expression reduces the RhoA-GTP levels in the cells, ...
*  T-cell lymphoma invasion and metastasis-inducing protein 1
TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In ... Guillemot L, Paschoud S, Jond L, Foglia A, Citi S (Oct 2008). "Paracingulin regulates the activity of Rac1 and RhoA GTPases by ... UMich Orientation of Proteins in Membranes protein/pdbid-1foe - Calculated spatial position of TIAM1-RAC2 complex in membrane. ... T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene. TIAM1 is ...
*  Clostridium difficile toxin A
Just I, Selzer J, von Eichel-Streiber C, Aktories K (March 1995). "The low molecular mass GTP-binding protein Rho is affected ... and an inactive GDP-bound state. Guanine exchange factors (GEFs) regulate the exchange of GTP and GDP. TcdA glucosylates RhoA ... The glucosylation prevents proper binding of GTP and blocks activation. TcdA acts preferentially on the GDP-bound form of the ... Small GTPases such as Rho, Rac, and Cdc42 regulate their activity by alternating between an active GTP-bound state, ...
*  GTPase-activating protein
... which targets small GTPases such as RhoA, Rac1, and Rac2. The GAPs that act on small GTP-binding proteins of the Ras ... The activity of G proteins comes from their ability to bind guanosine triphosphate (GTP). Binding of GTP inherently changes the ... G proteins can weakly hydrolyse GTP, breaking a phosphate bond to make GDP. In the GDP-bound state, the G proteins are ... GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to ...
*  ARHGAP5
Foster R, Hu KQ, Shaywitz DA, Settleman J (1994). "p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly". Mol. ... "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106-15. doi:10.1016/S0960-9822(03) ... Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene. Rho GTPase activating protein 5 ... a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding ...
*  List of MeSH codes (D12.776.476)
... rac gtp-binding proteins MeSH D12.776.476.525.700.100.100 -- rac1 gtp-binding protein MeSH D12.776.476.525.700.200 -- rhoa gtp- ... rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp-binding protein MeSH D12.776.476.525.400.100 -- rab3 gtp- ... rab3a gtp-binding protein MeSH D12.776.476.525.400.150 -- rab4 gtp-binding proteins MeSH D12.776.476.525.400.200 -- rab5 gtp- ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.476.375.100.200 -- gtp-binding protein alpha subunits, gi-go MeSH ...
*  SH3BP1
Zhang B, Zheng Y (1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1 ... SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene. GRCh38: Ensembl release 89: ... SH3BP1 SH3-domain binding protein 1". Cicchetti P, Mayer BJ, Thiel G, Baltimore D (1992). "Identification of a protein that ... Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J Biol Chem. 277 (31): 28238-46. doi: ...
*  Stress fiber
Ridley, Anne J.; Hall, Alan (August 1992). "The small GTP-binding protein rho regulates the assembly of focal adhesions and ... RhoA (sometimes referred to as just 'Rho') is responsible for the formation of stress fibers, and its activity in stress fiber ... Ridley, Anne J.; Hall, Alan (August 1992). "The small GTP-binding protein rho regulates the assembly of focal adhesions and ... When GTP-bound, Rac will cause the formation of lamellipodia, and Cdc42 will cause the formation of filopodia, thus promoting ...
*  Membrane ruffling
The GTP-binding protein Rac is the regulator of this membrane ruffling. Changes in the Polyphosphoinositide metabolism and ... The ruffling of membranes is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and ... A number of actin-binding and organizing proteins localize to membrane ruffles and potentially target to transducing molecules ...
*  Rho-associated protein kinase
The kinase activity is switched on when Rho-GTP binds to the Rho-binding domain of ROCK, disrupting the autoinhibitory ... Leung T, Chen XQ, Manser E, Lim L (October 1996). "The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is ... glial fibrillaric acidic protein), NF-L (neurofilament L protein) F-actin binding proteins: Adducin, EF-1α (elongation factor, ... 2. Other functions and targets RhoA-GTP stimulates the phospholipid phosphatase activity of PTEN (phosphatase and tensin ...
*  CDC42
"Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the ... which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase GTP hydrolysis activity ... cdc42 GTP-Binding Protein at the US National Library of Medicine Medical Subject Headings (MeSH) CDC42 Info with links in the ... Its sequence domains include a P-loop containing nucleoside triphosphate hydrolase and a small GTP-binding protein domain. ...
*  CENTG3
2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476-2488. ... A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484-51493. doi:10.1074/jbc ... mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein". J ... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene. ...
*  AAMP (gene)
The protein contains a WD40 domain which permits multi-proteins complexes formation and a heparin-binding domain which mediates ... it activates RhoA, which activates Rho-kinase (this one generates GTP) and it finally leads to increased smooth muscle cell ... Angio-associated, migratory cell protein, also known as AAMP, is a protein which in humans is encoded by the AAMP gene.. This ... Beckner ME, Peterson VA, Moul DE (May 1999). "Angio-associated migratory cell protein is expressed as an extracellular protein ...
*  Guanine nucleotide exchange factor
eIF-2b regenerates the GTP-bound form of eIF-2 for an additional cycle in protein synthesis initiation, i.e., its binding to ... Ras-GRF1 Kalirin Ephexin5 is a RhoA GEF involved in neuronal synapse development. G proteins Guanine Nucleotide exchange factor ... GTP generally binds in its place, as the cytosolic ratio of GTP is much higher than GDP at 10:1. The binding of GTP to the ... Cherfils J, Chardin P (August 1999). "GEFs: structural basis for their activation of small GTP-binding proteins". Trends in ...
*  RHOB
Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... 2002). "RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... RHOB is a member of the Rho GTP-binding protein family. RHOB has been shown to interact with CIT, ARHGEF3, ARHGDIG and RHPN2. ...