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*  ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35 is a protein in humans that is encoded by the ARHGEF35 gene. "Entrez Gene: Rho ... guanine nucleotide exchange factor (GEF) 35". Retrieved 2013-02-17. ...
*  ARHGEF5
Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5". Human ARHGEF5 genome location and ARHGEF5 gene details ... 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nat. Struct. Biol. 9 (6): 468-75 ... The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the ...
*  ARHGEF4
Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4". "Dysmorphology data for Arhgef4". Wellcome Trust Sanger ... The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat ...
*  ARHGEF1
Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1". Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, ... "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem. 271 (41): 25452-8. doi:10.1074/ ... "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports ...
*  ARHGEF10
The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10. Rho GTPases play a fundamental role in ... Mohl M, Winkler S, Wieland T, Lutz S (Aug 2006). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor ... "Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10". Human ARHGEF10 genome location and ARHGEF10 gene ... "Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10". ...
*  ARHGEF7
Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene. Rho GTPase play a ... "Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7". Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, ... a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth ... density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 ...
*  ARHGEF11
Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. Rho GTPases play a ... "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The ... "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The ... "A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the ...
*  ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene. Rho GTPases play a fundamental role in ... ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3". Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002 ... Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and ... "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964-72. doi:10.1074/jbc ...
*  Guanine nucleotide exchange factor
Schmidt A, Hall A (July 2002). "Guanine nucleotide exchange factors for Rho GTPases: turning on the switch". Genes & ... RCC1 is the guanine nucleotide exchange factor for Ran GTPase. It localizes to the nucleus and catalyzes the activation of Ran ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small ... G proteins Guanine Nucleotide exchange factor Small GTPases Cherfils J, Zeghouf M (January 2013). "Regulation of small GTPases ...
*  ARHGEF2
Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2". Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl ... a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases". J Biol Chem. 273 (52): 34954-60. doi: ... of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". J. Biol. Chem. 276 (50): 47530-41. doi: ...
*  ARHGEF12
"Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor ... Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. Rho GTPases play a ... "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". ... "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". ...
*  PLXNB1
"Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. ... "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. ... "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. ... "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. ...
*  Titin
Young P, Ehler E, Gautel M (July 2001). "Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved ... Within the gene are found a large number of PEVK exons 84 to 99 nucleotides in length which code for conserved 28- to 33- ...
*  Obscurin
... a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly". The Journal of Cell Biology ... a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly". The Journal of Cell Biology ... differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth". Biochemical and Biophysical Research ...
*  Alan Hall
"Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Cell: ... but not other Rho-activated pathways. This led to the conclusion that CNK1 couples specific Rho exchange factors to the JNK MAP ... Ga13 activates p115 Rho GEF, which in turn activates Rho), but it was also known that Gaq does not activate p115 Rho GEF, and ... Indeed, Rho-dependent response is stimulated by the action of growth factors on Rac protein. In 1993 he moved to University ...
*  GEFT
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates ... Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced ... "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. ... and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089-101. doi:10.1128/ ...
*  CNKSR1
"Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol ... Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways ... linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736-46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC ...
*  MAP3K10
"Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol ... This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) ... "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem. 234 (2 ...
*  RHOA
... "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. ... conducted simultaneously via guanine nucleotide exchange factors and GTPase activating factor). RhoA is activated primarily by ... Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002). "XPLN, a guanine nucleotide exchange factor for ... "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". J. Biol ...
*  FGD4
2007). "Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4". Am. J. ... 2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H ...
*  MCF2L
... encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways". The EMBO Journal. 13 (20 ... "Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1". The Journal ... Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene. Model organisms have been used ... Ieguchi K, Ueda S, Kataoka T, Satoh T (Aug 2007). "Role of the guanine nucleotide exchange factor Ost in negative regulation of ...
*  RhoGEF domain
... is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called " ... Hart, M. J.; Eva, A.; Evans, T.; Aaronson, S. A.; Cerione, R. A. (1991). "Catalysis of guanine nucleotide exchange on the ... "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange ... Guanine-nucleotide dissociation stimulator, CDC24 InterPro: IPR001331 ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ...
*  Neutrophil
"ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in ... Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks). In neutrophils, lipid products of PI3Ks regulate activation of Rho ... Spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal ... In leukocytes responding to a chemoattractant, the cellular polarity is regulated by activities of small Rho guanosine ...
*  CLN8
"Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10". ...
*  Bacterial effector protein
"The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor ... "The Enteropathogenic E. Coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors". PLoS ... "GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin ... microbes are also suspected to deploy bacterial outer membrane vesicles to translocate effector proteins and virulence factors ...
*  Dock10
It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors, which function as activators ... Meller N, Merlot S, Guda C (2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937-46. doi:10.1242/jcs ... February 2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in ... 2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". ...