... it has been proposed that Rho kinase inhibitors may be a therapeutic option, although no specific rho kinase inhibitors are ... "Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of ... It has been shown that statins such as Lipitor are useful as Rho kinase inhibitors. Therefore, statins may be helpful for the ... Recent research suggests that rho kinase inhibitors may be ineffective in treating TTC7A Deficiency. Recent research shows that ...
Rho kinase inhibitor Williams RD, Novack GD, van Haarlem T, Kopczynski C (November 2011). "Ocular hypotensive effect of the Rho ... Verosudil (AR-12286) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, and has been ... Skaat A, Jasien JV, Ritch R (September 2016). "Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients ... kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension". American Journal of Ophthalmology. 152 (5): 834- ...
"Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1". Journal of Biological ... Zarubin, Tyler; Han, Jiahuai (January 2005). "Activation and signaling of the p38 MAP kinase pathway". Cell Research. 15 (1): ... "Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual ...
RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. Am J Respir Crit Care Med. 179(12):1151 ...
Isobe T, Mizuno K, Kaneko Y, Ohta M, Koide T, Tanabe S (August 2014). "Effects of K-115, a rho-kinase inhibitor, on aqueous ... Okumura N, Okazaki Y, Inoue R, Kakutani K, Nakano S, Kinoshita S, Koizumi N (March 2016). "Effect of the Rho-Associated Kinase ... Ripasudil (trade name Glanatec), a derivative of fasudil, is a rho kinase inhibitor drug (previously known as K-115) used for ... Okumura N, Okazaki Y, Inoue R, Nakano S, Fullwood NJ, Kinoshita S, Koizumi N (November 2015). "Rho-Associated Kinase Inhibitor ...
Studies have shown that the Rho/Rho-kinase signaling pathway is more active in individuals with diabetes and that this ... Therefore, over-activity of the Rho/Rho-kinase signaling pathway may inhibit nerve conduction. Motor nerve conduction velocity ... "The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper ...
Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a ... the GTPase regulator associated with focal adhesion kinase, are mediated by Rho". J. Cell Sci. 112 (2): 231-42. doi:10.1242/jcs ... "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Mol. Cell. Biol. ... the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen ...
This results in upregulation of RhoA/RhoC, Rho kinase activation and tumour cell invasion. MicroRNA Gene expression Hox genes ... leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion". The Journal of Biological Chemistry. ... "Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E- ...
"A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1". ... Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or ... The TrkB receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable ... "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain". Cell. 61 ...
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear ... The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear ... "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". Wilkes MC, Murphy SJ, ... "Proteome analysis of erythrocytes lacking AMP-activated protein kinase reveals a role of PAK2 kinase in eryptosis". Journal of ...
Once MAG (or Nogo) has bound to NgR, NgR activates the rho kinase (ROCK) pathway. The activation of the rho kinase pathway ...
June 2000). "Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase". FEBS ... Zemlickova E, Johannes FJ, Aitken A, Dubois T (March 2004). "Association of CPI-17 with protein kinase C and casein kinase I". ... Multiple kinases are identified to phosphorylate CPI-17, such as PKC, ROCK, PKN, ZIPK, ILK, and PAK. Agonist stimulation of ... Lartey J, Smith M, Pawade J, Strachan B, Mellor H, López Bernal A (June 2007). "Up-regulation of myometrial RHO effector ...
Sawada N, Liao JK (March 2014). "Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in ... Inhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be ... Monitoring liver enzymes and creatine kinase is especially prudent in those on high-dose statins or in those on statin/fibrate ...
... (Azaindole-1) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, with an IC50 of 0.6 ... Rho kinase inhibitor Kast R, Schirok H, Figueroa-Pérez S, Mittendorf J, Gnoth MJ, Apeler H, et al. (December 2007). " ... July 2012). "The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the ... Lasker GF, Pankey EA, Allain AV, Murthy SN, Stasch JP, Kadowitz PJ (February 2013). "The selective Rho-kinase inhibitor ...
... kinase activity is positively regulated by androgen receptor, p38MAPK, 5-fluorouracil and atypical Rho family GTPase Chp/ ... "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase". The Journal of Biological Chemistry. 280 (5): ... Shepelev MV, Korobko IV (January 2012). "Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV". ... "Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain". Journal ...
Diviani D, Soderling J, Scott JD (November 2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho- ... Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science. ... RHOB is a member of the Rho GTP-binding protein family. RHOB has been shown to interact with CIT, ARHGEF3, ARHGDIG and RHPN2. ... Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Research ...
"The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291-302. doi ... Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J (2003). "A novel Rho GTPase-activating-protein interacts with Gem, a ... 1995). "Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases". Proc. Natl. Acad. Sci. U.S.A. 91 ( ... "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): ...
Daam1 then activates the small G-protein Rho through a guanine exchange factor. Rho activates Rho-associated kinase (ROCK), ... glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). It degrades β-catenin by targeting it for ubiquitination, which ... Calcineurin activates TAK1 and NLK kinase, which can interfere with TCF/β-Catenin signaling in the canonical Wnt pathway. ... Examples include lipoprotein receptor-related protein (LRP)-5/6, receptor tyrosine kinase (RTK), and ROR2. Upon activation of ...
Diviani D, Soderling J, Scott JD (November 2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho- ... Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins ... Bourguignon LY, Singleton PA, Zhu H, Diedrich F (August 2003). "Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase ... Thumkeo D, Watanabe S, Narumiya S (Oct-Nov 2013). "Physiological roles of Rho and Rho effectors in mammals". European Journal ...
Downstream of LPA receptor activation, the small GTPase Rho can be activated, subsequently activating Rho kinase. This can lead ...
Other signalling pathways regulating PaSC activation include PI3K, RHO kinase and TGF-β/SMAD-related pathways. Following ... Protein kinases such as MAPKs are primary mediators of activating signals initiated by the growth factors, angiotensin II and ... p38 kinase and JNK. The inhibition of the majority of MAPK pathways leads to a reduction in the activation and proliferation of ... vitro experiments indicate that PaSCs influence the activation and proliferation process for mitogen activated protein kinase ( ...
"The Arabidopsis Rho of Plants GTPase ROP1 Is a Potential Calcium-Dependent Protein Kinase (CDPK) Substrate". Plants (published ... Rho-related GTPases from plants, otherwise known as ROPs, are involved in cell polarity through the regulation of cytoskeleton ... ROP proteins are a type of monomeric G proteins found in plants belonging to the Rho family. ROP binding to GTP or GDP ... Unlike mammalian cells, plant cells do not contain heterotrimeric G proteins like Cdc42, Rac, and Rho that are known to ...
"An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Molecular and ... Pratt RL, Kinch MS (October 2002). "Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade". ... "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of ... Janus kinase 1, Janus kinase 2, KHDRBS1, Linker of activated T cells, Lymphocyte cytosolic protein 2, MAP2, MAP3K1 MAP4K1, ...
PAK proteins are critical effectors that link the Rho family of GTPases (Rho GTPases) to cytoskeleton reorganization and ... Shin YJ, Kim YB, Kim JH (September 2013). "Protein kinase CK2 phosphorylates and activates p21-activated kinase 1". Molecular ... STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl transferase V, B-Raf proto-oncogene, casein kinase 2 ... "The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1". The Journal of Biological ...
Activation of the cell-cycle kinase (e.g. Rho-kinases) during telophase initiates constriction of the actomyosin ring by ... Rho-kinases such as ROCK1 has been found to regulate actomyosin contraction through phosphorylation of the myosin light chain ( ... Chen, C. T.; Hehnly, H.; Doxsey, S. J. (2012). "Orchestrating vesicle transport, ESCRTs and kinase surveillance during ...
... prevents Rho-kinase and NF-κB induced renal parenchymal fibrosis and provides long term renal protection. ...
"Diabetes Causes Bone Marrow Endothelial Barrier Dysfunction by Activation of the RhoA-Rho-Associated Kinase Signaling Pathway ...
Rho kinase inhibitor Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, et al. (November 2009). "A chemical platform ... Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail ...
"Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP". J. Biol ... 2003). "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport". EMBO J. 22 (11): ...
"Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase". J. ... "MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of ... "Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, ... Vincent S, Settleman J (1997). "The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin ...