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*  Rho kinase inhibitor
... s (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho ... Jul 2007). "Rho Kinase (ROCK) Inhibitors". J Cardiovasc Pharmacol. 50 (1): 17-24. doi:10.1097/FJC.0b013e318070d1bd. Wang SK, ... GSK429286A@pubchem Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. 2016. ... Rho kinase inhibitors". Clin Ophthalmol. 8: 883-90. doi:10.2147/OPTH.S41000. PMC 4025933 . PMID 24872673. Patel RA, Forinash KD ...
*  Rho-associated protein kinase
... (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is ... November 1998). "Roles of Rho-associated Kinase in Cytokinesis; Mutations in Rho-associated Kinase Phosphorylation Sites Impair ... binding kinases (MRCK) and citron kinase. All of these kinases are composed of a N-terminal kinase domain, a coiled-coil ... Thus, the kinase activity is off when ROCK is intramolecularly folded. The kinase activity is switched on when Rho-GTP binds to ...
*  Glaucoma
Play media Rho kinase inhibitors, such as ripasudil, work by inhibition of the actin cytoskeleton, resulting in the ... Sean K Wang, Robert T Chang (2014). "An emerging treatment option for glaucoma: Rho kinase inhibitors". Clin Ophthalmol. 8: 883 ... of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase ...
*  Y-27632
... is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways. Y-27632 ... Selective probe of ROCK/Rho-kinase". Jikken Igaku. 17 (7): 850-855. Uehata, M; Ishizaki, T; Satoh, H; Ono, T; Kawahara, T; ... 1997). "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension". Nature. 389 (6654 ... "The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media ...
*  ROCK1
"Rho-Associated, Coiled-Coil Containing Protein Kinase 1". Hahmann C, Schroeter T (January 2010). "Rho-kinase inhibitors as ... ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common ... Rho kinase GRCh38: Ensembl release 89: ENSG00000067900 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024290 - ... Amano M, Fukata Y, Kaibuchi K (November 2000). "Regulation and functions of Rho-associated kinase". Experimental Cell Research ...
*  DPYSL2
2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways ...
*  Nicorandil
... including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to ... which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an ... Rho-kinase also decreases nitric oxide synthase activity, which reduces nitric oxide concentrations. Lower levels of nitric ... Takemoto, M; Sun, J; Hiroki, J; Shimokawa, H; Liao, JK (Jul 2, 2002). "Rho-kinase mediates hypoxia-induced downregulation of ...
*  Anaphase
Hickson, Gilles R X; Arnaud Echard; Patrick H O'Farrell (2006). "Rho-kinase Controls Cell Shape Changes during Cytokinesis". ... which is required for the function of metaphase cyclin-dependent kinases (M-Cdks). Interphase Prophase Prometaphase Metaphase ...
*  Fasudil
Nagumo H, Sasaki Y, Ono Y, Okamoto H, Seto M, Takuwa Y (Jan 2000). "Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin ... Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of ... Fasudil (HA-1077) is a selective RhoA/Rho kinase (ROCK) inhibitor. ROCK is an enzyme that plays an important role in mediating ... Ocaranza MP, Rivera P, Novoa U, Pinto M, González L, Chiong M, Lavandero S, Jalil JE (Apr 2011). "Rho kinase inhibition ...
*  RHOA
Due to pathophysiological overlap of RhoA and Rho-kinase in asthma, both RhoA and Rho-kinase have become promising new target ... Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 ( ... RhoA and Rho kinase mechanisms have been linked to diabetes due to the up-regulated expression of targets within type 1 and 2 ... Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, ...
*  AAMP (gene)
... which activates Rho-kinase (this one generates GTP) and it finally leads to increased smooth muscle cell migration and division ... with other signaling pathway like RhoA/Rho-kinase signaling.. A malfunction can therefore lead to different diseases (see ... "AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling". Annals of Biomedical Engineering ...
*  Calponin 1
Calmodulin-dependent kinase II and Rho-kinase are also found to phosphorylate calponin at Ser175 and Thr184 in vitro. Of these ... the main site of regulatory phosphorylation by calmodulin-dependent kinase II and Rho-kinase is Ser175. Dephosphorylation of ... "Identification of calponin as a novel substrate of Rho-kinase". Biochemical and Biophysical Research Communications. 273 (1): ... Nonetheless, CH domain in calponin was found to bind to extra-cellular regulated kinase (ERK) for calponin to play a possible ...
*  Nerve conduction velocity
Studies have shown that the Rho/Rho-kinase signaling pathway is more active in individuals with diabetes and that this ... Therefore, over-activity of the Rho/Rho-kinase signaling pathway may inhibit nerve conduction. Motor nerve conduction velocity ... "The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper ...
*  Mir-10 microRNA precursor family
This results in upregulation of RhoA/RhoC, Rho kinase activation and tumour cell invasion. MicroRNA Gene expression Hox genes ... Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion". Journal of Biological Chemistry. 285 ...
*  CCM2
Borikova, A. L.; Dibble, C. F.; Sciaky, N.; Welch, C. M.; Abell, A. N.; Bencharit, S.; Johnson, G. L. (2010). "Rho Kinase ... This protein is also involved in regulating the cellular localization of the KRIT1 protein and acts with the Rho Kinase ... The normal function of malcavernin is to act as a scaffold for a variety of signaling complexes including p38 MAP Kinase. ... "The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases". Nature Medicine. 15 (2): ...
*  Fuchs' dystrophy
"Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction". Scientific Reports. 6: 26113. doi:10.1038 ... with subsequent Rho-Associated Kinase (ROCK) inhibition of endothelial cell division may offer a viable medical treatment. A ...
*  KRIT1
Borikova AL, Dibble CF, Sciaky N, Welch CM, Abell AN, Bencharit S, Johnson GL (Apr 2010). "Rho kinase inhibition rescues the ... "The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain". The Journal of ...
*  TNNT2
Vahebi S, Kobayashi T, Warren CM, de Tombe PP, Solaro RJ (Apr 2005). "Functional effects of rho-kinase-dependent ... Kinases responsible for each phosphorylation, functional effects, and references are also listed. Point mutations in TNNT2 gene ... Pfleiderer P, Sumandea MP, Rybin VO, Wang C, Steinberg SF (2009). "Raf-1: a novel cardiac troponin T kinase". Journal of Muscle ... Villar-Palasi C, Kumon A (Jul 1981). "Purification and properties of dog cardiac troponin T kinase". The Journal of Biological ...
*  ROCK2
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. The protein ... Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". ... Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21. ... This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. GRCh38: Ensembl release 89: ENSG00000134318 - ...
*  GTPase
G protein-coupled receptors Rho-kinase Scheffzek K, Ahmadian MR (December 2005). "GTPase activating proteins: structural and ... Rho, Rab, Arf and Ran. The Rho subfamily is further divided into RHOA, RAC1, and CDC42. These GTPases play an important role in ... October 2002). "Rho protein inactivation induced apoptosis of cultured human endothelial cells". Am. J. Physiol. Lung Cell Mol ...
*  Induced stem cells
Schlegel and Liu demonstrated that the combination of feeder cells and a Rho kinase inhibitor (Y-27632) induces normal and ... 2010) Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor Suprynowicz, F. A.; Upadhyay, G.; Krawczyk, E ... Kurosawa, H. (2012). "Application of Rho-associated protein kinase (ROCK) inhibitor to human pluripotent stem cells". Journal ... Cocktail of small molecules, Y-27632, A-83-01 (a TGFβ kinase/activin receptor like kinase (ALK5) inhibitor), and CHIR99021 ( ...
*  Ripasudil
... (trade name Glanatec), a derivative of fasudil, is a rho kinase inhibitor drug (previously known as K-115) used for ... In short, "ripasudil showed much more potent and selective Rho-kinase inhibitory activity than fasudil". According to a report ... Tanihara, H (2014). "Phase 3 randomized clinical studies of a Rho kinase inhibitor, K-115, in combination with timolol or ... It is a selective Rho-associated coiled/coil-containing protein kinase (ROCK1) inhibitor, where ROCK1 is "an important ...
*  PPP1R12A
1996). "Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)". Science. 273 (5272): 245-8. doi: ... Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin ... Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. PPP1R12A has been shown to interact with ... Somlyo AP (1999). "Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser". J. Physiol. 516 (3): 630. doi: ...
*  ADD1
1999). "Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility". J. Cell Biol. 145 (2): 347-61. doi: ... Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing ... Matsuoka Y, Li X, Bennett V (1998). "Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS- ... Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C". J. Biol. Chem. 271 (41): ...
*  Thiazide
"Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitisation linked to Rho kinase". ...
*  RHOB
Diviani D, Soderling J, Scott JD (2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated ... Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science. ... RHOB is a member of the Rho GTP-binding protein family. RHOB has been shown to interact with CIT, ARHGEF3, ARHGDIG and RHPN2. ... Chardin P, Madaule P, Tavitian A (1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Res. 16 (6): ...