... former political party in Brunei Retinoblastoma protein, pRb, an important tumour-suppressor gene in retinoblastoma ...
... directly in oncogenesis because of its ability to bind to the tumour-suppressing protein p53 and to the retinoblastoma protein ... Encoded by ORF73, LANA-1 is one of few HHV-8 encoded proteins that is highly expressed in all latently infected tumour cells; ... Friborg J, Kong W, Hottiger MO, Nabel GJ (1999). "p53 inhibition by the LANA protein of KSHV protects against cell death". ... It is the most immunodominant KSHV protein identified by Western-blotting as 222-234 kDa double bands migrate slower than the ...
Through a 12-amino acid sequence in its N-terminus (N-12a.a.), SALL4 binds to retinoblastoma binding protein 4 (RBBP4), a ... box 2 protein (Sox2). Together these proteins can affect each other's expression patterns as well as their own, thus forming a ... metastasis-associated proteins (MTA), methyl-CpG-binding domain proteins (MBD2 or MBD3), and histone deacetylases (HDAC1 and ... protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells". The Journal ...
... a childhood cancer of the eyes caused by a mutation in the retinoblastoma protein Retinoblastoma protein, a tumor suppressor ... protein Rubidium, symbol Rb, a chemical element Reflected binary code, Gray code Request Block, a task-related control block in ...
It was demonstrated that C-1-P perpetuates the phosphorylation of glycogen synthase kinase-3 β and retinoblastoma protein, ... Ceramide transport proteins (CERTs) transport ceramides to CERK for phosphorylation. Phosphorylation of ceramides to produce ... "Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis". J. ...
... retinoblastoma protein) RB1 (associates with histone deacetylase-1 and -2) RCOR (REST corepressor) RCOR1 (RCOR1) RCOR2 (RCOR2) ... Many coactivator proteins have intrinsic histone acetyltransferase (HAT) catalytic activity or recruit other proteins with this ... receptor-interacting protein 140) NRIP1 YAP WWTR1 (TAZ) SWI/SNF family chromatin structure remodeling complex ISWI protein ... These HAT proteins are able to acetylate the amine group in the sidechain of histone lysine residues which makes lysine much ...
... may refer to: Nucleolar phosphoprotein p130 Pottier P.130 Coccinelle, a French light aircraft Retinoblastoma-like protein ...
... consists of three proteins: RB - Retinoblastoma protein p107 - Retinoblastoma-like protein 1 p130 - ... v t e (Articles with short description, Short description matches Wikidata, All stub articles, Protein stubs, Protein families) ... Retinoblastoma-like protein 2 They play crucial roles in the metazoan cell cycle through interaction with members of the E2F ... Cobrinik D (2005). "Pocket proteins and cell cycle control". Oncogene. 24 (17): 2796-809. doi:10.1038/sj.onc.1208619. PMID ...
Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells U.S. Patent 6,946,259 ... However, a lot of proteins are overexpressed in cancer cells and correlate with shorter survival. Therefore, the remaining ... the first monoclonal antibody that blocks a cancer-causing protein, and developed it into a life-saving therapy for women with ... Therapeutic use of the retinoblastoma susceptibility gene product U.S. Patent 5,837,520 - Method of purification of viral ...
Similarly, in glioblastoma, siRNA-mediated silencing of 13 predicted PTEN ceRNAs including Retinoblastoma protein (RB1), RUNX1 ... The CD44 3'UTR has been shown to regulate expression of the CD44 protein and cell cycle regulation protein, CDC42, by ... or RNA-binding proteins (RBPs). Similarly, competition by ceRNAs for RNA-binding proteins has also been reported in eukaryotic ... Additionally, PTEN's non protein-coding pseudogene, PTENP1, is able to affect PTEN expression, downstream PI3K signaling and ...
Retinoblastoma protein, and SKI protein. GRCh38: Ensembl release 89: ENSG00000100603 - Ensembl, May 2017 GRCm38: Ensembl ... SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene. This gene, a member of the SNW gene ... "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". The ... "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". The ...
CDK9 CREB-binding protein Cyclin A1 Cyclin-dependent kinase inhibitor 1C EP300 PARP1 Retinoblastoma-like protein 1 GRCh38: ... Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. The protein encoded by this gene, a member of ... The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses ... MYBL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...
... a lamp standard Retinoblastoma-like protein 1 P107, a state regional road in Latvia This disambiguation page lists articles ...
... or the retinoblastoma protein, the first known growth-suppressor gene. 1989 Rings of Neptune The rings of Neptune were ... 1972 Opiate receptors Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous ... proteins, and fats were necessary to keep cattle healthy. By 1917 one of these substances was independently discovered by Elmer ...
... an effect which reduces the ability of retinoblastoma protein to inhibit the synthesis of DNA and thereby cell division. ... LTBR1 and LTBR2 encode for proteins with 45% amino acid identity that belong to the G protein-coupled receptor superfamily. The ... BLT2 receptors, similar to BLT1 receptors, are G protein coupled receptors that, when ligand-bound, activate G proteins that ... Protein kinase B (also known as Akt), c-Jun N-terminal kinases (JNKs), Janus kinase (JAK)-STAT protein (i.e. signal transducer ...
They bind to and inactivate the best known of these mechanisms, the tumor suppressor proteins p53 and retinoblastoma protein ... The pRb protein is inactivated by E7 in HPV+OPC, but in HPV-OPC it is the p16 tumour suppressor part of the pRb tumour ... The gene encoding p53 is inactivated by E6 at the protein level and is found as the wild type in HPV+OPC but mutated in HPV-OPC ... Its genome encodes the early (E) oncoproteins E5, E6 and E7 and the late (L) capsid proteins L1 and L2. The virus gains access ...
... and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53, retinoblastoma ... IFI16+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional ... 2004). "A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway ...
Retinoblastoma protein, Retinoic acid receptor alpha, Retinoid X receptor alpha, Src, TGS1, TUBA4A, TUBB, Thyroid hormone ... Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene. The protein encoded by this gene is a ... Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ...
LTag's transforming effect can largely be attributed to its ability to bind the retinoblastoma protein (Rb) and the tumor ... The ATPase domain also contains regions responsible for protein-protein interactions with host cell proteins, most notably ... without affecting these protein-protein interaction sites. LTag is a large protein whose domains can be detected and annotated ... Polyomavirus LTag proteins contain four well-conserved, globular protein domains: from N- to C-terminus, these are the J domain ...
L1 transcription is known to take place in human fetal brain and in neuroblastoma and retinoblastoma cell lines. L1 is also ... L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, ... It was first identified in 1984 by M. Schachner who found the protein in post-mitotic mice neurons. Mutations in the L1 protein ... This interaction allows L1 protein connect with the cell's cytoskeleton. Also, L1 protein cytoplasmic tail can bind adaptor 2 ( ...
"70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb. ... Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in ... This protein binds to nascent polypeptides to facilitate correct protein folding. In order to properly fold non-native proteins ... This gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 (Hsp70) family. As a Hsp70 protein ...
... the retinoblastoma protein that functions as a tumor suppressor protein; 2) deletions and/or mutations in the TP53 gene that ... proteins Pleomorphic rhabdomyosarcoma: Desmin and myogenin proteins. Defifferentiated liposarcoma: MDM2 and CDK4 proteins. ... The identifying proteins for UPS tumor cells are given in the preceding section. Identification proteins for tumors that have ... AMP deaminase 2 protein; the gains in AMPD2 protein immunoreactivity were associated with copy number gains in the AMPD2 gene ...
Ligand SLiMs often function as simple interfaces that recruit proteins to multi-protein complexes (e.g. the Retinoblastoma- ... linear motifs or minimotifs are short stretches of protein sequence that mediate protein-protein interaction. The first ... Linear motif mediated protein-protein interactions have shown promise in recent years as novel drug targets. Success stories ... Beuming T, Skrabanek L, Niv MY, Mukherjee P, Weinstein H (March 2005). "PDZBase: a protein-protein interaction database for PDZ ...
... proteins are tumor suppressors and loss-of-function mutations lead to carcinogenesis. INK4 proteins are highly similar in ... This leads to an inhibition of retinoblastoma (Rb) phosphorylation downstream. Therefore, the expression of p15INK4b or ... The other family of CKIs, CIP/KIP proteins are capable of inhibiting all CDKs. Enforced expression of INK4 proteins can lead to ... INK4 proteins are cell-cycle inhibitors. When they bind to CDK4 and CDK6, they induce an allosteric change that leads to the ...
Xiao ZX, Ginsberg D, Ewen M, Livingston DM (1996). "Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin- ... 1996). "Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions". Proc ... This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. ... Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. The protein encoded by this gene is a member ...
... of the retinoblastoma gene product RB and the enzymes, protein kinases B (AKT protein family) and C α (PKB and PKCα). Moreover ... Sph is also known to interact with protein targets such as the protein kinase H homologue (PKH) and the yeast protein kinase ( ... A specific protein kinase phosphorylates 14-3-3, otherwise known as sphingosine-dependent protein kinase 1 (SDK1), only in the ... Transferring to the GSL synthesis site is done with the help of a transport protein known as four phosphate adaptor protein 2 ( ...
... papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma ... "A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase". Proceedings of the National ... 1991 Scheffner, M.; Munger, K.; Byrne, J. C.; Howley, P. M. (1991). "The state of the p53 and retinoblastoma genes in human ... 1990 Huibregtse, J.M.; Scheffner, M.; Howley, P.M. (1991). "A cellular protein mediates association of p53 with the E6 ...
... and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein ... Retinol-binding protein 3, interstitial (RBP3), also known as interphotoreceptor retinoid-binding protein (IRBP), is a protein ... Liou GI, Ma DP, Yang YW, Geng L, Zhu C, Baehr W (May 1989). "Human interstitial retinoid-binding protein. Gene structure and ... The inter-photoreceptor retinoid-binding protein is a large glycoprotein known to bind retinoids and found primarily in the ...
... genes Prophage Prophase Prophylactic surgery Proplastid Propositus Prostate cancer Protease Protein Protein product Protein ... Restriction digest Restriction enzyme Restriction enzymes Restriction map Retinitis pigmentosa Retinoblastoma Retroviral ... Ala Alagille syndrome Albino Alcoholism Alkylating agent Allele Allele frequency Alleles Allopolyploid Allosteric protein ... Aaron Y-chromosomal Adam YAC Y-chromosome haplogroups in populations of the world Z-DNA Zinc finger Zinc-finger protein Zygote ...
The RPE65 protein is essential in the process of vision, as it contributes to the regeneration process of the visual pigment ... Retinoblastoma is the most common intraocular malignancy present in children younger than 5 years old. The eye cancer can be ... "Retinoblastoma". National Eye Institute. U.S. Department of Health and Human Services. 2022. Retrieved 2023-07-30. Kapoor VS, ... Wong ES, Choy RW, Zhang Y, Chu WK, Chen LJ, Pang CP, Yam JC (March 2022). "Global retinoblastoma survival and globe ...