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*  Retinoblastoma protein
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that ... "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proc. ... GeneReviews/NIH/NCBI/UW entry on Retinoblastoma Retinoblastoma Genetics Drosophila Retinoblastoma-family protein - The ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ...
*  Retinoblastoma-like protein 2
... is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been ... Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and ... Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". ... Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". ...
*  Retinoblastoma-like protein 1
Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded ... Xiao ZX, Ginsberg D, Ewen M, Livingston DM (May 1996). "Regulation of the retinoblastoma protein-related protein p107 by G1 ... "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ... Retinoblastoma-like protein 1 has been shown to interact with: BEGAIN, BRCA1, BRF1, Cyclin A2, Cyclin-dependent kinase 2, E2F1 ...
*  Nicholas Dyson
The Dyson Lab studies the retinoblastoma protein. Working as a post-doctoral fellow in the laboratory of Dr. Ed Harlow, Dyson ... demonstrated that the retinoblastoma protein can form complexes in vitro with the E7 oncoprotein of Human papilloma virus type- ... "The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product". Science. 243 (4893): 934-7. ...
*  DNA polymerase alpha catalytic subunit
DNA dependent polymerase alpha (Pol α) has been shown to interact with Retinoblastoma protein, PARP1 and RBMS1. DNA Polymerase ... Takemura M, Kitagawa T, Izuta S, Wasa J, Takai A, Akiyama T, Yoshida S (November 1997). "Phosphorylated retinoblastoma protein ... Niki T, Galli I, Ariga H, Iguchi-Ariga SM (June 2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, ... Coverley D, Kenny MK, Lane DP, Wood RD (1992). "A role for the human single-stranded DNA binding protein HSSB/RPA in an early ...
*  Histone deacetylase inhibitor
HDACs are involved in the pathway by which the retinoblastoma protein (pRb) suppresses cell proliferation. The pRb protein is ... Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (February 1998). "Retinoblastoma protein recruits histone ... Non-histone proteins such as transcription factors are also targets for acetylation with varying functional effects. ... through modulating that the acetylation/deactylation of histones and/or non-histone proteins such as transcription factors. ...
*  Cyclin-dependent kinase complex
CDKCs bind and phosphorylate members of the retinoblastoma (Rb) protein family. Members of the Rb protein family are tumor ... Functions of the retinoblastoma protein. Bioessays. 1999 Nov;21(11):950-8. Lundberg AS, Weinberg RA. Functional inactivation of ... Activity of CDKCs is controlled by phosphorylation of target proteins, as well as binding of inhibitory proteins. Although ... is a protein complex formed by the association of an inactive catalytic subunit of a protein kinase, cyclin-dependent kinase ( ...
*  HDAC1
Retinoblastoma protein, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, SAP30, SATB1, SIN3A, SIN3B, SPEN, SUDS3, ... It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell ... Nicolas E, Ait-Si-Ali S, Trouche D (August 2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein ... Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (February 1998). "Retinoblastoma protein recruits histone ...
*  Tony Kouzarides
Kouzarides, T.; Brehm, A.; Miska, E. A.; McCance, D. J.; Reid, J. L.; Bannister, A. J. (1998). "Retinoblastoma protein recruits ... Kouzarides, T.; Brehm, A.; Miska, E. A.; McCance, D. J.; Reid, J. L.; Bannister, A. J. (1998). "Retinoblastoma protein recruits ... "The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in ... Bartke, T.; Vermeulen, M.; Xhemalce, B.; Robson, S. C.; Mann, M.; Kouzarides, T. (2010). "Nucleosome-Interacting Proteins ...
*  RBBP9
The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell ... "Entrez Gene: RBBP9 retinoblastoma binding protein 9". Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). " ... RBBP9 has been shown to interact with Retinoblastoma protein. GRCh38: Ensembl release 89: ENSG00000089050 - Ensembl, May 2017 ... "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): ...
*  USP4
... has been shown to interact with Retinoblastoma protein. GRCh38: Ensembl release 89: ENSG00000114316 - Ensembl, May 2017 ... 2001). "The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein". Oncogene. 20 (39): 5538-5542. doi:10.1038/ ... In the mouse and human the USP4 protein is encoded by a gene containing 22 exons. This protein is a member of cysteine ... Ubiquitin specific protease 4 (USP4) is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the ...
*  ARID4A
It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB ... ARID4A has been shown to interact with Retinoblastoma protein. GRCh38: Ensembl release 89: ENSG00000032219 - Ensembl, May 2017 ... The protein encoded by this gene is a ubiquitously expressed nuclear protein. ... "Characterization of the retinoblastoma binding proteins RBP1 and RBP2". Oncogene. 8 (11): 3149-56. PMID 8414517. Otterson GA, ...
*  Fyn-related kinase
Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer ... The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and ... FRK has been shown to interact with retinoblastoma protein. GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  LIN9
Lin-9 homolog is a protein that is encoded by the LIN9 gene in humans. LIN9 has been shown to interact with the retinoblastoma ... Osterloh L, von Eyss B, Schmit F, Rein L, Hübner D, Samans B, Hauser S, Gaubatz S (Jan 2007). "The human synMuv-like protein ... a pRB-associated protein". The EMBO Journal. 23 (23): 4627-38. doi:10.1038/sj.emboj.7600470. PMC 533054 . PMID 15538385. " ... "Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target ...
*  Cyclin D/Cdk4
... the Cyclin D/Cdk4 complex phosphorylates Retinoblastoma protein (pRb). Once the Retinoblastoma protein has been phosphorylated ... Under non-dividing conditions (when the cell is in the G0 phase of the cell cycle), Retinoblastoma protein (Rb) is bound with ... The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or ... First and foremost, under non-dividing conditions multiple proteins can inhibit the Cyclin D/Cdk4 complex by binding Cdk4 and ...
*  Cyclin E1
Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992). "Regulation of retinoblastoma protein functions by ... This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to ... G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to ... Retinoblastoma-like protein 2, and SMARCA4. Cyclin E GRCh38: Ensembl release 89: ENSG00000105173 - Ensembl, May 2017 GRCm38: ...
*  E2F1
This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell ... Nicolas E, Ait-Si-Ali S, Trouche D (August 2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein ... E2F Retinoblastoma protein GRCh38: Ensembl release 89: ENSG00000101412 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. The protein encoded by this gene is a member ...
*  HDAC3
Nicolas E, Ait-Si-Ali S, Trouche D (August 2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein ... independent repression activities to retinoblastoma family proteins". Mol. Cell. Biol. 19 (10): 6632-41. doi:10.1128/mcb.19.10. ... "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342-50. doi: ... HDAC3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
*  RBBP4
It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This ... "Entrez Gene: RBBP4 retinoblastoma-binding protein 4". Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small ... "RBBP4 retinoblastoma binding protein 4 [Homo sapiens (human)]". Home - Gene - NCBI. Bethesda, MD: National Center for ... Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. This ...
*  Cyclin D1
... is composed of the following protein domains and motifs: retinoblastoma protein (pRb) binding motif; cyclin box ... The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). Cyclin D1-CDK4 ... Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (May 1993). "Physical interaction of the retinoblastoma protein ... Ikeguchi M, Sakatani T, Ueta T, Kaibara N (Sep 2001). "Cyclin D1 expression and retinoblastoma gene protein (pRB) expression in ...
*  Cyclin D3
Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (1993). "Physical interaction of the retinoblastoma protein with ... This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 ... G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene. The protein encoded by this gene belongs to ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ...
*  Cyclin-dependent kinase 1
Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E (1992). "The retinoblastoma protein is phosphorylated on multiple ... Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that ... Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, ... Cdk1-cyclin complexes are also governed by direct binding of Cdk inhibitor proteins (CKIs). One such protein, already discussed ...
*  TAF1
Siegert JL, Rushton JJ, Sellers WR, Kaelin WG, Robbins PD (November 2000). "Cyclin D1 suppresses retinoblastoma protein- ... TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ...
*  TP53BP1
Choubey D, Lengyel P (Mar 1995). "Binding of an interferon-inducible protein (p202) to the retinoblastoma protein". The Journal ... Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by ... "Entrez Gene: TP53BP1 tumor protein p53 binding protein 1". Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der ... inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that ...
*  HBP1
2000). "Involvement of Retinoblastoma Protein and HBP1 in Histone H10 Gene Expression". Mol. Cell. Biol. 20 (18): 6627-37. doi: ... HBP1 has been shown to interact with SIN3A and Retinoblastoma protein. ENSG00000283847 GRCh38: Ensembl release 89: ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  PSMD7
To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... retinoblastoma (Rb). and von Hippel-Lindau tumor suppressor (VHL), as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ... The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ...