"Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ... "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ... The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein ...
The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell ... "Entrez Gene: RBBP9 retinoblastoma binding protein 9". Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). " ... Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and ... "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10". Biochemical Genetics. 40 (7-8): 273-82. doi: ...
It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This ... Zhang Q, Vo N, Goodman RH (2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and ... "Entrez Gene: RBBP4 retinoblastoma-binding protein 4". Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small ... Qian YW, Wang YC, Hollingsworth RE Jr, Jones D, Ling N, Lee EY (September 1993). "A retinoblastoma-binding protein related to a ...
Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene. The retinoblastoma tumor suppressor ... "Entrez Gene: RBBP6 retinoblastoma binding protein 6". Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (Dec 2008 ... "cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene ... pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated ...
Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and ... Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been ... Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". ... Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". ...
"Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ... Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and ... Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded ... Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". ...
It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB ... "Characterization of the retinoblastoma binding proteins RBP1 and RBP2". Oncogene. 8 (11): 3149-56. PMID 8414517. Otterson GA, ... forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses ... "Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer ...
Klose, Rob (2007). "The retinoblastoma binding protein RBP2 is an H3K4 demethylase". Cell. 128 (5): 889-900. doi:10.1016/j.cell ... where he studied the methyl CpG binding protein MeCP2, part of the DNA methylation system, which is associated with Rett ... Klose, Rob (2005). "DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG". Mol. Cell ... Klose, Rob (2013). "ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection". Biochem Soc Trans. 41 (3): ...
"Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ... "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein". Molecular and ... to retinoblastoma protein which regulates cell proliferation. It was formerly known as Retinoblastoma Binding Protein 2 (RBP2 ... The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, ...
"Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4". ... Armadillo repeat containing 12 is a protein that in humans is encoded by the ARMC12 gene that plays a crucial role in tumor ...
"Elements regulating the transcription of human interstitial retinoid-binding protein (IRBP) gene in cultured retinoblastoma ... "OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression". ... Homeobox protein OTX2 is a protein that in humans is encoded by the OTX2 gene. This gene encodes a member of the bicoid sub- ... The encoded protein acts as a transcription factor and plays a role in brain and sensory organ development. A similar protein ...
"The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein". Genes Dev. 8 (11): 1270 ... DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. The protein encoded by this gene ... Inhibitor of DNA-binding protein GRCh38: Ensembl release 89: ENSG00000115738 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A (2000). "Id2 is a retinoblastoma protein target and mediates signalling by ...
Mao S, Neale GA, Goorha RM (April 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". ... Mao S, Neale GA, Goorha RM (April 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". ... Bégay-Müller V, Ansieau S, Leutz A (June 2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL ... Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH (December 1997). "The LIM-domain binding protein Ldb1 and its partner LMO2 act ...
EBNA-3C can recruit a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb ... These genes also bind the host RBP-Jκ protein. ... v t e (Protein pages needing a picture, Viral nonstructural ... "Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ... The Epstein-Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein-Barr virus. A ...
"Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha ... Pur-alpha then binds to the Tat protein itself. Pur-alpha also binds Cyclin T1, a regulatory partner of Cdk9 protein kinase, ... and RNA-binding protein. PURA is expressed in every human tissue, where it exists as a protein of 322 amino acids. According to ... "The single-stranded DNA binding protein, Pur-alpha, binds HIV-1 TAR RNA and activates HIV-1 transcription". Gene. 210 (1): 37- ...
Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659 ... Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL ...
"The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated ... The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to ...
1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to ... "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... THOC1 has been shown to interact with Retinoblastoma protein. GRCh38: Ensembl release 89: ENSG00000079134 - Ensembl, May 2017 ...
"The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in ... "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". The Journal of Biological ... "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". The Journal of Biological ... The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their ...
Through a 12-amino acid sequence in its N-terminus (N-12a.a.), SALL4 binds to retinoblastoma binding protein 4 (RBBP4), a ... metastasis-associated proteins (MTA), methyl-CpG-binding domain proteins (MBD2 or MBD3), and histone deacetylases (HDAC1 and ... SALL4 has also been reported to bind T-box 5 protein (Tbx5) in cardiac tissues as well as genetically interact with Tbx5 in ... Other binding partners of SALL4 include promyelocytic leukemia zinc finger protein (PLZF) in sperm precursor cells, Rad50 ...
Upon the removal or inactivation on the placeholder protein bound to the enhancer, the recruitment of the additional group of ... Rajabi HN, Takahashi C, Ewen ME (Aug 2014). "Retinoblastoma protein and MyoD function together to effect the repression of Fra- ... MyoD has been shown to interact with: C-jun, CREB-binding protein, CSRP3, Cyclin-dependent kinase 4, Cyclin-dependent kinase ... MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle ...
"The binding domain structure of retinoblastoma-binding proteins". Protein Science. 2 (2): 155-64. doi:10.1002/pro.5560020204. ... The function of T-antigen is controlled by phosphorylation, which attenuates the binding to the SV40 origin. Protein-protein ... T-antigen also binds and inactivates tumor suppressor proteins (p53, p105-Rb). This causes the cells to leave G1 phase and ... The TAg has a CUL7-binding domain, a TP53-binding domain, a Zinc finger, and a Superfamily 3 ATPase/Helicase domain. It has two ...
"Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site". The ... It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was ... Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... The binding of Jun (AP-1) to a high-affinity AP-1 binding site in the jun promoter region induces jun transcription. This ...
... retinoblastoma protein (pRB) remains in its active, hypophosphorylated form and binds to the transcription factor E2F1, an ... The p16 protein is a cyclin dependent kinase inhibitor (CDK) inhibitor and it activates Rb tumor suppressor. p16 binds to CDK 4 ... SASP induces an unfolded protein response in the endoplasmic reticulum because of an accumulation of unfolded proteins, ... Proteins p53, p21, p16ink4a, and Bmi-1 have been termed as major senescence signalling factors, allowing them to serve as ...
The three pocket proteins are Retinoblastoma (Rb), p107, and p130, which bind to the E2F transcription factors to prevent ... The third pocket protein, Rb, binds to and represses E2F 1, E2F 2, and E2F 3, which are the E2F proteins with activating ... At this point, E2F 1-3 proteins bind to DNA and transcribe Cyclin A and Cdc 6. Cyclin-dependent kinase inhibitor 1B (CDKN1B), ... During early G1, there are three transcriptional repressors, known as pocket proteins, that bind to E2F transcription factors. ...
Whyte, P (1988). "Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma ... "Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product." ( ... Among Harlow's discoveries was the demonstration that the retinoblastoma protein interacts with viral transforming proteins, ... "The retinoblastoma protein is phosphorylated during specific phases of the cell cycle." Cell 58.6 (1989): 1097-1105. van den ...
2006). "The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta". J. Biol. Chem. 281 (2): 858-66. ... The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C ... 1998). "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta". Nature. 394 (6694): 697-700. ... "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa". Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein ...
"The retinoblastoma binding protein RBP2 is an H3K4 demethylase". Cell. 128 (5): 889-900. doi:10.1016/j.cell.2007.02.013. ISSN ... He continued to reveal the function of Tet proteins in zygotic DNA demethylation, germ cell development, and genomic imprinting ... By discovering two enzymatic activities of two PcG protein complexes, Zhang has contributed significantly to our current ... "Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification". Nature. 466 (7310): ...
... and retinoblastoma-binding protein". The Journal of Biological Chemistry. 280 (31): 28507-18. doi:10.1074/jbc.M413687200. PMID ... "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723-34 ... This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H ... Zhang D, Yoon HG, Wong J (August 2005). "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human ...
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of ... Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic ... AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene. ... 159 (4): 563-9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740. Fleischer TC, Yun UJ, Ayer DE (2003). "Identification ...