The Poincaré homology sphere results from +1 surgery on the right-handed trefoil knot. In 2003, lack of structure on the ... The connected sum of two oriented homology 3-spheres is a homology 3-sphere. A homology 3-sphere that cannot be written as a ... A rational homology sphere is defined similarly but using homology with rational coefficients. The Poincaré homology sphere ( ... In algebraic topology, a homology sphere is an n-manifold X having the homology groups of an n-sphere, for some integer n ≥ 1 ...
Alternate splicing results in multiple transcript variants encoding different isoforms. GRCh38: Ensembl release 89: ... Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene. This gene encodes a ... "Entrez Gene: Pleckstrin homology domain containing A4". Retrieved 2017-08-24. This article incorporates text from the United ... pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative ...
The singular homology is then the homology of the chain complex. The resulting homology groups are the same for all homotopy ... In some sense, singular homology is the "largest" homology theory, in that every homology theory on a subcategory of Top agrees ... Since the number of homology theories has become large (see Category:Homology theory), the terms Betti homology and Betti ... such a cleanup motivates the development of other homology theories such as cellular homology. More generally, the homology ...
As a result, Hox genes in most vertebrates are spread across multiple chromosomes: the HoxA-D clusters are the best studied. ... "Homology: From jaws to ears - an unusual example of a homology". UC Berkeley. Retrieved 15 December 2016. Hyde, Janet Shibley; ... Sattler, R. (1994). "Homology, homeosis, and process morphology in plants". In Hall, Brian Keith (ed.). Homology: the ... Panchen, A. L. (1999). "Homology - History of a Concept". Novartis Foundation Symposium 222 ‐ Homology. pp. 5-18. doi:10.1002/ ...
Where the homology is the result of gene duplication so that both copies have descended side by side during the history of an ... Such partial homology may result from a gene fusion event. Homologous sequences are orthologous if they are inferred to be ... Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the ... Where the homology is the result of speciation so that the history of the gene reflects the history of the species (for example ...
Serious local errors can arise in homology models where an insertion or deletion mutation or a gap in a solved structure result ... Results from the most recent CASP experiment suggest that "consensus" methods collecting the results of multiple fold ... and the plausibility of the resulting model. Thus, sometimes several homology models are produced for a single query sequence, ... Even low-accuracy homology models can be useful for these purposes, because their inaccuracies tend to be located in the loops ...
It is a remarkable fact that simplicial homology only depends on the associated topological space.: sec.8.6 As a result, it ... Computation of persistent homology involves analysis of homology at different resolutions, registering homology classes (holes ... Topological methods in scientific computing Computational homology (also cubical homology) (Simplicial homology, Computational ... Singular homology is a related theory that is better adapted to theory rather than computation. Singular homology is defined ...
Ablation of the Bahd1 gene in the mouse alters placental development and results in hypocholesterolemia, hypoglycemia and ... Bromo adjacent homology domain containing 1 (BAHD1) is a protein that in humans is encoded by the BAHD1 gene. BAHD1 is involved ...
In 1996 S. Piunikhin, D. Salamon and M. Schwarz summarized the results about the relation between Floer homology and quantum ... Seiberg-Witten Floer homology or monopole Floer homology is a homology theory of smooth 3-manifolds (equipped with a spinc ... Their homologies satisfy similar formal properties to the combinatorially-defined Khovanov homology.) These homologies are ... Several kinds of Floer homology are special cases of Lagrangian Floer homology. The symplectic Floer homology of a ...
To describe the resulting chain complex and its homology, introduce a generic Morse function on each critical submanifold. ... Morse homology also serves as a model for the various infinite-dimensional generalizations known as Floer homology theories. ... Another approach to proving the invariance of Morse homology is to relate it directly to singular homology. One can define a ... From the fact that the Morse homology is isomorphic to the singular homology, the Morse inequalities follow by considering the ...
This results in the formation of a quaternary structure that is characteristic of this protein. This TRFH domain also allows ... The TERF Homology Domain (TRFH; InterPro: IPR013867) is an area that helps to promote homodimerization of TERF2 with itself. ... As a result of removing this complex, several unwanted DNA damage response pathways are activated, including ATM kinase ... signaling, ATR kinase signaling, non-homologous end-joining (NHEJ), alt-NHEJ, C-NHEJ, 5' resection, and homology directed ...
1979). Furthermore, this hypothesis was based on results derived from low resolution serological and DNA homology methods. Thus ... The endogenous retroviruses with similar homology are; McERV, detected within Mus caroli, and Mus dunni endogenous virus (MDEV ... Immunological analysis highlights that MbRV shares 93% sequence homology with GaLV-SEATO which is significantly higher than ... thereby resulting in the development of GaLV within two gibbons (S-76 and S-77). The last hypothesis is based on the sequence ...
... homology-directed repair) and the conclusions from the results were that gene editing technologies are not mature enough ... Germline engineering results in changes in the genome being incorporated into every cell in the body of the offspring (or of ... The resulting cleavage event enables most genome-editing technologies to work. After a break is created, the cell seeks to ... The resulting embryos are usually cultured for 3-6 days, allowing them to reach the blastomere or blastocyst stage. Once ...
... is an automated homology modeling program. Alignments are obtained by combining, weighting and screening the results ... To perform homology modeling, the ESyPred3D program first searches for a template (a similar sequence of known structure), ... List of protein structure prediction software Protein structure prediction Homology modeling Lambert, C.; Leonard, N.; De Bolle ...
This result will then be used to build an alignment. After making words for the sequence of interest, the rest of the words are ... Therefore, it is necessary for remote homology. However, when compared to BLAST, it is more time consuming, not to mention that ... Results of PLAST are very similar to BLAST, but PLAST is significantly faster and capable of comparing large sets of sequences ... If this score is higher than a pre-determined T, the alignment will be included in the results given by BLAST. However, if this ...
... belongs to the class of small proteins with knottin folds resulting from the four disulfide bonds. The superfamily ... sequence homology with maurotoxin (MTX; α-KTx6.2). Most short-chain scorpion toxins contain three disulfide bridges, whereas ... resulting in blocking of the channel. Four disulfide bridges connect these terminals stabilizing the small protein. The pattern ...
... homology of these spaces: nearly all massless fields in the effective physics model are represented by certain (co)homology ... A Series of Modern Surveys in Mathematics [Results in Mathematics and Related Areas. 3rd Series. A Series of Modern Surveys in ... T. Hubsch and A. Rahman determined the (co)-homology of this ground state variety in all dimensions, found it compatible with ... Intersection homology and perverse sheaves, notes by Bruno Klingler. (All articles with unsourced statements, Articles with ...
As a result, Borel-Moore homology can be viewed as the relative homology of the one-point compactification with respect to the ... In topology, Borel−Moore homology or homology with closed support is a homology theory for locally compact spaces, introduced ... The singular homology of a topological space X is defined as the homology of the chain complex of singular chains, that is, ... In particular, a closed oriented submanifold defines a class in Borel-Moore homology, but not in ordinary homology unless the ...
Resulting sequence usually lack introns and often contain poly, sequences that are also integrated into the genome. Many ... See Homology of sequences in genetics). It is important (but often difficult) to differentiate between paralogs and orthologs ... Often the resulting genomic variation leads to gene dosage dependent neurological disorders such as Rett-like syndrome and ... If they are paralogs and resulted from a gene duplication event, their functions are likely to be too different. One or more ...
homology Similarity of features based on common evolutionary descent. hyperostosis A condition resulting in enlargement of ... denature The "unfolding" of a protein resulting in a lessening of its biological properties. In the case of some fish toxins, ...
Saunders Mac Lane, Homology. Reprint of the 1975 edition. Classics in Mathematics. Springer-Verlag, Berlin, 1995. x+422 pp. ... These two constructions turn out to yield isomorphic results, and so both may be used to calculate the Ext functor. Suppose R ... A continuous map of topological spaces gives rise to a homomorphism between their nth homology groups for all n. This basic ... In all these cases, there are natural differentials dn making Cn into a chain complex, whose homology reflects the structure of ...
... a combinatorially defined invariant that reproduces the results of relative contact homology. Tamas Kalman developed a ... Contact homology and one parameter families of Legendrian knots by Tamas Kalman (Symplectic topology, Morse theory, Homology ... Relative homology Lenhard Ng, Conormal bundles, contact homology, and knot invariants. Tobias Ekholm, John Etnyre, Michael G. ... The relative contact homology has been shown to be a strictly more powerful invariant than the "classical invariants", namely ...
The attempt to 'pre-digest' as much information as possible to simplify the ease of interpreting the results is a unique pillar ... and annotations homology to proteins involved in cell-cycle control. The PredictProtein web service is available at www. ... Users send a protein sequence and receive a single file with results from database comparisons and prediction methods. PP went ... The service is supported by a database of pre-calculated results that speed up the interaction time. The PredictProtein cloud ...
... resulting in the restoration of the original sequence. NHEJ modifies and ligates the damaged ends regardless of homology. In ... Since SSA results in the deletion of repetitive sequences, this could potentially lead to error-prone repair. Single-strand ... This explains why SDSA results in a non-crossover pathway. The remaining gap is filled in and the nick is attached by the ... As S and G2 phases of the cell cycle generate more chromatids, the increased availability of template access for HR results in ...
This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively ... Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly ...
The result of scientific investigation into these causes can lead to one of two insights into the underlying biology: Homology ... He emphasised that homology should also include partial homology and quantitative homology. This leads to a continuum ... Sattler, R., 1994, Homology, homeosis, and process morphology in plants. In: B.K. Hall (ed.) Homology: The hierarchical basis ... Secondary growth results in widening of a root or shoot from divisions of cells in a cambium. In addition to growth by cell ...
This will result in the desired change being inserted at the site of the DSB. While HDR based gene editing is similar to the ... There are two major pathways that repair DSB; non-homologous end joining (NHEJ) and homology directed repair (HDR). NHEJ uses a ... As a result, high degrees of expertise and lengthy and costly validations processes are required. TALE nucleases being the most ... In Zea mays, disruption of the target locus was achieved by ZFN-induced DSBs and the resulting NHEJ. ZFN was also used to drive ...
These symptoms could result from pendrin's effects on ion concentration in the airway surface liquid, possibly causing the ... The encoded protein has homology to sulfate transporters. Another little-understood role of pendrin is in airway ... This is probably the result of other bicarbonate or chloride transporters in the kidney compensating for any loss of pendrin ... Pendred syndrome is characterized by thyroid goiter and enlargement of the vestibular aqueduct resulting in deafness; however, ...
... the relative K-theory is isomorphic to relative topological cyclic homology (without tensoring both with Q). Their result also ... If Q is contained in A, then cyclic homology and topological cyclic homology of A agree.) This is in line with the fact that ( ... Homology of matrix Lie algebras over rings and the Hochschild homology. Uspekhi Mat. Nauk, 38(2(230)):217-218, 1983. ... Among them are entire cyclic homology due to Alain Connes, analytic cyclic homology due to Ralf Meyer or asymptotic and local ...
Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down- ... As discussed below nuclear receptors are classified according to mechanism or homology. Nuclear receptors are specific to ... As a result, there was an increased effort upon uncovering the state of the first nuclear receptor, and by 1997 an alternative ... This binding often results in deactivation of the second transcription factor in a process known as transrepression. One ...