... leading to inadequate amounts of DNA replication components. These losses can contribute to the DNA damage response (DDR). ... The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. ... Mechanisms that process damaged DNA in coordination with the replisome in order to maintain replication fork progression are ... When this occurs, reassembly of the fork is initiated in order to repair the damaged DNA end. The replication fork consists of ...

... as well as replication fork stability during unperturbed DNA replication and in response to replication blocks. ATR is ... brain AP site Direct DNA damage DNA DNA adduct DNA damage theory of aging DNA repair DNA replication Free radical damage to DNA ... G2 checkpoint checks for damaged DNA and DNA replication completeness. Damage to DNA that occurs naturally can result from ... This reflects the accumulation of DNA damage with age. DNA damage accumulation with age is further described in DNA damage ...

... linking the replication checkpoint response to genome stability". Aging. 3 (3): 311-8. doi:10.18632/aging.100293. PMC 3091524. ... DNA damages and mutations are related because DNA damages often cause errors of DNA synthesis during replication or repair and ... they concluded that while the complexity of responses to DNA damage remains only partly understood, the idea that DNA damage ... If a DNA repair protein is deficient, unrepaired DNA damages tend to accumulate. Such accumulated DNA damages appear to cause ...

They are involved in DNA replication and damage response. Components include: core protein complex (FANCA, FANCB, FANCC, FANCE ... Naim V, Rosselli F (September 2009). "The FANC pathway and mitosis: a replication legacy". Cell Cycle. 8 (18): 2907-11. doi: ... v t e (Articles with short description, Short description matches Wikidata, DNA repair, Protein families, All stub articles, ...

Myung, Kyungjae (May 2018). "Eukaryotic 4Rs: DNA replication, repair, recombination, and damage response". Mutation Research. ... GRC DNA damage, Mutagenesis and Cancer) 2008: US Government Service Award (5 years), NHGRI, NIH 2006: Society of Biomedical ... Myung Kyungjae is a biologist researching DNA repair pathways at the molecular level. He is a Distinguished Professor at the ...

... are thought to drive innate immune response. Alternatively, ribonucleotides might induce DNA-damage response signaling that by ... Misincorporated ribonucleotide induce DNA damage. It is not that the ribonucleotides do not prevent replication; but rather ... DNA damage response signaling activated maybe by incorporation of ribonucleotides in difficult to replicate regions or near ... It was hypothesized that growth arrest was a consequence of a p53-dependent DNA damage response associated with the ...

In particular, the G2 checkpoint arrests cells in G2 in response to DNA damage through inhibitory regulation of CDK1. During ... DNA replication produces two nearly identical sister chromatids. DNA double-strand breaks that arise after replication has ... Transcription begins at the end of S phase after DNA replication, in response to phosphorylation of transcription factors such ... which is stabilized in response to DNA damage. CDK1 is directly inhibited by three transcriptional targets of p53: p21, Gadd45 ...

LexA forms de facto a two-component regulatory system with RecA, which senses DNA damage at stalled replication forks, forming ... that represses SOS response genes coding primarily for error-prone DNA polymerases, DNA repair enzymes and cell division ... Bacteria require topoisomerases such as DNA gyrase or topoisomerase IV for DNA replication. Antibiotics such as ciprofloxacin ... DNA damage can be inflicted by the action of antibiotics, bacteriophages, and UV light. Of potential clinical interest is the ...

"PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291-7. doi:10.1038/ ...

"PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291-7. doi:10.1038/ ... Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996). "Serine phosphorylation of death agonist BAD in response to survival ...

"PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291-7. doi:10.1038/ ... "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291-7. doi:10.1038/ ... In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 ... 2013). "Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of ...

MVM induces a DNA damage response (DDR) during infection which is required for effective replication. The ATM pathway is ... "Parvovirus Minute Virus of Mice Induces a DNA Damage Response That Facilitates Viral Replication". PLOS Pathogens. 6 (10): ... It is not known if viral proteins or active viral replication activate the DDR, but UV-inactivated MVM does not induce a ... NS1 functions as a required replication protein and is known to have helicase activity, ATPase activity and nickase activity. ...

DNA damage response, and apoptosis. It is heavily implicated in the DNA replication pathway through its regulation of genes in ... TOPBP1 primarily regulates the DNA damage repair response through its ability to activate the damage response kinase, ataxia- ... This showed a DNA damage specific role for TOPBP1 recruitment at both replication sites and non-replication sites. To mediate ... August 2001). "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response". The Journal of ...

When the replication-fork collides with the trapped topoisomerase-I, DNA damage occurs. The unbroken DNA strand breaks and ... The accumulation of trapped topoisomerase-I complexes is a known response to apoptotic stimuli. This disruption prevents DNA ... Once topoisomerase-I creates a single strand break, the DNA can rotate in front of the advancing replication fork. In ... The enzymes bind to the DNA and cut the phosphate backbone, allowing the DNA to be unwound. Topotecan unsilences the paternal ...

Binz SK, Sheehan AM, Wold MS (2005). "Replication protein A phosphorylation and the cellular response to DNA damage". DNA ... DNA-binding subunit Replication protein A Replication protein A2 Replication protein A3 Single-stranded binding protein GRCh38 ... "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates ... "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates ...

... is a component of the replication fork and essential for DNA damage repair pathways. Regulating DNA repair pathways is ... It is involved in coordinating the Chk1-directed DNA damage/cell cycle checkpoint response by regulating the stability of the ... XPA is involved in recognising DNA damage and provides a scaffold for other repair factors to bind at the damage site. HERC2 ... Yuan J, Luo K, Deng M, Li Y, Yin P, Gao B, Fang Y, Wu P, Liu T, Lou Z (December 2014). "HERC2-USP20 axis regulates DNA damage ...

... response to chromosome replication stress and DNA damage to maintain genomic stability. Her lab was the first to use reverse- ... Wang's lab also investigated how cells respond to chromosome replication stress and DNA damage to maintain the cells' genomic ... Wang's research investigated the biochemical mechanisms of enzymes and proteins involving in chromosome DNA replication; and ... These residues were later supported by crystallographic analysis of a viral DNA polymerase in the family B DNA polymerases. The ...

"Adozelesin Triggers DNA Damage Response Pathways and Arrests SV40 DNA Replication through Replication Protein A Inactivation". ... It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ... "Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase ...

"PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291-7. doi:10.1038/ ... In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two ... PCNA helps hold DNA polymerase delta (Pol δ) to DNA. PCNA is clamped to DNA through the action of replication factor C (RFC), ... Since DNA polymerase epsilon is involved in resynthesis of excised damaged DNA strands during DNA repair, PCNA is important for ...

During recovery from DNA replication and DNA damage, βTrCP instead targets Claspin in a Plk1-dependent manner. βTrCP has also ... "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426 (6962): 87-91. Bibcode:2003Natur. ... "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426 (6962): 87-91. Bibcode:2003Natur. ... "SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response". Molecular Cell. ...

... is a chromatin-binding protein that functions in the DNA damage response. FMR1 occupies sites on meiotic chromosomes and ... Trinucleotide repeat expansion is likely a consequence of strand slippage either during DNA repair or DNA replication. ... "A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response". Cell. 157 (4): 869-81 ... regulates the dynamics of the DNA damage response machinery during spermatogenesis. The FMR1 gene can be found on the long (q) ...

During recovery from DNA replication and DNA damage, βTrCP instead targets Claspin in a Plk1-dependent manner. βTrCP has also ... "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426 (6962): 87-91. Bibcode:2003Natur. ... "SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response". Molecular Cell. ... SCFβTrCP-mediated degradation of eEF2K couples protein synthesis elongation to the G2 DNA damage checkpoint. Kruiswijk F., ...

DNA damage tends to accumulate. Such excess DNA damage can increase mutational errors during DNA replication due to error-prone ... The DNA damage response to double strand DNA breaks (DSB) is mediated in part by histone modifications. At a DSB, MRE11-RAD50- ... Reduced DNA repair likely allows accumulation of DNA damages. Error prone translesion synthesis past some of these DNA damages ... DNA damages can also give rise to epigenetic alterations during faulty DNA repair processes. The DNA damages that accumulate ...

DNA damage tends to accumulate. Such excess DNA damage can increase mutational errors during DNA replication due to error-prone ... the stability and integrity of the human genome are maintained by the DNA-damage response (DDR) system. Un-repaired DNA damage ... the action of exogenous mutagens or endogenous DNA damage. The machinery of replication and genome maintenance can be damaged ... DNA Damage, DNA Repair and Cancer". In Chen, Clark (ed.). New Research Directions in DNA Repair. p. 413. ISBN 978-953-51-1114-6 ...

"A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta". The Journal of Biological Chemistry ... the E3 ligase CRL4Cdt2 can degrade POLD4/p12 during normal DNA replication and in the presence of DNA damage. POLD4/p12 can ... Cell cycle block in these phases typically indicates presence of DNA damage and activation of DNA damage checkpoints. POLD1 ... regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase". The Journal of ...

DNA damage response (DDR) is the overarching mechanism which mediates the cell's detection and response to DNA damage. This ... Thirdly, the cleavage of different DNA structures such as reversed or blocked DNA replication forks, R-loops and DNA ... Blackford AN, Jackson SP (June 2017). "ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response". Molecular ... DNA polymerase and other accessory factors follows by replacing the missing DNA via DNA synthesis. Ligase then attaches the DNA ...

"Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry ... Alkyl base lesions can arrest replication, interrupt transcription, or signal the activation of cell cycle checkpoints or ... In DNA repair, the Ada regulon is a set of genes whose expression is essential to adaptive response (also known as "Ada ... DNA bases damaged by alkylation are removed by distinct strategies. The alkylating agents from a group of mutagens and ...

DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression ... It has been shown to induce DNA damage response associated with the activation of EBV lytic cycle; the DNA damage response in ... It acts as an essential transcriptional regulator that is required for wild-type levels of lytic DNA replication. Binding sites ... 2010).A subset of replication proteins enhances origin recognition and lytic replication by the Epstein-Barr virus ZEBRA ...

"BRCT domain-containing protein TopBP1 functions in DNA replication and damage response". J. Biol. Chem. 276 (32): 30399-406. ... Fuss J, Linn S (2002). "Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication ... localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. England. 31 (19): 5568-75. ... localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568-75. doi: ...

The p16-pRB pathway can be activated by the DNA Damage Response, but is usually secondary to the p53 response in such cases. ... Telomere-dependent senescence is caused by the shortening of telomeres due to the end-replication problem of DNA replication. ... DNA-damage-initiated senescence is caused by major DNA damage (usually double-stranded breaks) that trigger pathways that keep ... Research has shown that the pathway is primarily activated by stimuli that generate a DNA Damage Response, and therefore is a ...