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*  Repressor
The lacI gene synthesizes LacI repressor protein. The LacI repressor protein represses lacZYA by binding to the operator ... An example of a repressor protein is the methionine repressor MetJ. MetJ interacts with DNA bases via a pair of α-helices. MetJ ... An RNA-binding repressor binds to the mRNA and prevents translation of the mRNA into protein. This blocking of expression is ... lacZYA transcribes the proteins needed for lactose breakdown. lacI synthesizes the repressor of the lacZYA gene. The gene lacI ...
*  Trp operon
In the lac operon, allolactose binds to the repressor protein, allowing gene transcription, while in the trp operon, tryptophan ... Within the operon's regulatory sequence, the operator is blocked by the repressor protein in the presence of tryptophan ( ... When tryptophan is present, these tryptophan repressor dimers bind to tryptophan, causing a change in the repressor ... trp R has a promoter where RNA polymerase binds and synthesizes mRNA for a regulatory protein. The protein that is synthesized ...
*  Fatty acid synthesis
This second pathway is regulated by repressor protein DesT. DesT is also a repressor of fabAB expression for anaerobic ... Two DesR-P proteins will dimerize and bind to the DNA promoters of the des gene and recruit RNA polymerase to begin ... It acts as an activator of fabA and fabB transcription and as a repressor for the β-oxidation regulon. In contrast, FabR acts ... Another pathway uses two proteins, DesC and DesB, together to act as a Δ9-desaturase, which inserts a double bond into a ...
*  Adaptive enzyme
Then there's the repressor protein that turns genes off. The inducer can remove this repressor, turning genes back on. The ... Lastly, the regulatory gene is the gene for the repressor protein. An example of inducible enzyme is COX-2 which is synthesized ... operator is a section of DNA where the repressor binds to shut off certain genes; the promoter is the section of DNA where the ...
*  Regulator gene
... regulator genes often code for repressor proteins. Repressor proteins bind to operators or promoters, preventing RNA polymerase ... a gene which binds repressor proteins thus inhibiting the translation of RNA to protein via RNA polymerase). In prokaryotes, ... Inducers cause repressor proteins to change shape or otherwise become unable to bind DNA, allowing RNA polymerase to continue ... An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operator gene ( ...
*  Operator (biology)
The protein that does this is called a repressor. Repressors bind to operators to prevent transcription. The main operator (O1 ... The repressor protein physically obstructs the RNA polymerase from transcribing the genes. An inducer (small molecule) can ... displace a repressor (protein) from the operator site (DNA), resulting in an uninhibited operon. Alternatively, a corepressor ... can bind to the repressor to allow its binding to the operator site. A good example of this type of regulation is seen for the ...
*  Jun dimerization protein
"The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members ... Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. The Jun dimerization protein is a ... Other proteins such as interferon regulatory factor-2-binding protein-1 (IRF2BP1). CCAAT/enhancer-binding protein gamma (C/EBPγ ... "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Molecular and Cellular Biology. ...
*  Nuclear receptor co-repressor 1
... the other human protein that is a member of that family is Nuclear receptor co-repressor 2. Nuclear receptor co-repressor 1 has ... The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1 ... is a protein that in humans is encoded by the NCOR1 gene. NCOR1 is a transcriptional coregulatory protein which contains ... "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Hum. Mol. ...
*  RUNX1T1
Nuclear receptor co-repressor 2, PRKAR2A, and Zinc finger and BTB domain-containing protein 16. GRCh38: Ensembl release 89: ... Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. The protein encoded by this gene is a putative zinc ... with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines". Jpn. J. Cancer Res. 90 ( ... "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439-47. ...
*  CBFA2T2
"Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439-47. ... Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene. In acute myeloid leukemia, especially in the M2 ... Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG (2004). "E protein silencing by the leukemogenic AML1-ETO fusion protein". ... "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439-47. ...
*  NAB1
2000). "The human transcriptional repressor protein NAB1: expression and biological activity". Biochim. Biophys. Acta. 1493 (3 ... NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene. NAB1 has been shown to interact with Zif268. ... "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization ... 2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics ...
*  CBFA2T3
"Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439-47. ... Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene. The t(16;21)(q24;q22) translocation is a rare but ... "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439-47. ... CBFA2T3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CBFA2T3 genome location and ...
*  TetR
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to ... TetR protein family members are mostly transcriptional repressors, meaning that they prevent the expression of certain genes at ... The expression of tc resistance genes is regulated by Tet Repressor Protein. More specifically, TetR represses the expression ... TetR is one of many proteins in the TetR protein family, which is so named because TetR is the most well characterized member. ...
*  Corepressor
In prokaryotes, the term corepressor is used to denote the activating ligand of a repressor protein. For example, the E. coli ... Co-Repressor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... The repressor in turn binds to a gene promoter (a sequence of DNA adjacent to the regulated gene), thereby blocking ... In eukaryotes, a corepressor is a protein that binds to transcription factors. In the absence of corepressors and in the ...
*  EIF4EBP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic ... Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in ... Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by ... Feigenblum D, Schneider RJ (1996). "Cap-binding protein (eukaryotic initiation factor 4E) and 4E-inactivating protein BP-1 ...
*  Operon
In the case of a repressor, the repressor protein physically obstructs the RNA polymerase from transcribing the genes. ... Repressor proteins are produced by a regulator gene, but they are unable to bind to the operator in their normal conformation. ... The activated repressor protein binds to the operator and prevents transcription. The trp operon, involved in the synthesis of ... In the lac operon, lactose binds to the repressor protein and prevents it from repressing gene transcription, while in the trp ...
*  HHEX
Bess KL, Swingler TE, Rivett AJ, Gaston K, Jayaraman PS (Sep 2003). "The transcriptional repressor protein PRH interacts with ... Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene. This gene encodes a ... "The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co- ... "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis ...
*  Gene structure
For example, some repressor proteins can bind to the core promoter to prevent polymerase binding. For genes with multiple ... Repressor proteins bound to the operator sequence physically obstructs the RNA polymerase enzyme, preventing transcription. ... which translates the protein-coding region into a string of amino acids that fold to form the final protein product. In the ... An additional layer of regulation occurs for protein coding genes after the mRNA has been processed to prepare it for ...
*  MECOM
"Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins". The Journal of Biological Chemistry. ... EVI1 has also been shown to directly interact with C-terminal-binding protein (CtBP, a known transcriptional repressor) through ... MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ...
*  SAP30
"Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Human ... Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene. Histone ... Proteins of the SAP30 family (SAP30 proteins) have a functional nucleolar localization signal and they are able to target Sin3A ... The DNA binding of SAP30 proteins is regulated by the nuclear signalling lipids, phosphoinositides (PI). SAP30 proteins provide ...
*  SIN3A
Methyl-CpG-binding domain protein 2, Nuclear receptor co-repressor 2, OGT, PHF12, Promyelocytic leukemia protein, RBBP4, RBBP7 ... Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene. The protein encoded by this ... Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone ... It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate ...
*  SNAI2
The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin ... The human embryonic protein SNAI2, commonly known as SLUG, is a zinc finger transcriptional repressor which downregulates ... Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene. This gene encodes a member of the Snail ... "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells". The Journal of Biological Chemistry. ...
*  Cro repressor family
In molecular biology, the Cro repressor family of proteins includes the bacteriophage lambda Cro repressor. Bacteriophage ... The crystal structure of the lambda Cro repressor reveals a HTH DNA-binding protein with an alpha/beta fold that differs from ... Ohlendorf DH, Tronrud DE, Matthews BW (July 1998). "Refined structure of Cro repressor protein from bacteriophage lambda ... Together the Cro and cI repressors form a helix-turn-helix (HTH) superfamily. The lambda Cro repressor binds to DNA as a highly ...
*  Polycomb Group Proteins and Cancer
Polycomb group proteins (PcG) function as transcriptional repressors that silence specific sets of genes through chromatin ... signaling proteins to change their cellular location, affecting protein activity, and promoting or preventing protein ... The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of ... An E3 uibiquitin ligase complex composed of Cullin 3 (CUL3), speckle-type POZ protein (SPOP), and RING-box protein 1 (RBX1) has ...
*  Deinococcus deserti
IrrE is a metalloprotease that cleaves repressor protein DdrO". Molecular Microbiology. 94: 434-449. doi:10.1111/mmi.12774. ... RecAC and RecAP are functional proteins that allow repair of massive DNA damage after exposure of D. deserti to high doses of ... A total of 341 protein N termini were confidently identified in the D. deserti TMPP-labeled proteome. Among these, 63 were not ... This database comprised 65,801 hypothetical protein sequences with a large fraction of short ORFs (68% of the ORFs have less ...
*  NFIX
... has been shown to interact with SKI protein and it is also known to interact with AP-1. NFI-X3 has been shown to interact ... Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by ... Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates ... NFIX protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
*  Gene
... conversely silencers bind repressor proteins and make the DNA less available for RNA polymerase. The transcribed pre-mRNA ... A typical protein-coding gene is first copied into RNA as an intermediate in the manufacture of the final protein product. In ... From DNA to Protein 6.1: DNA to RNA 6.2: RNA to Protein Ch 7: Control of Gene Expression 7.1: An Overview of Gene Control 7.2: ... 46,000 protein-coding genes. The total number of protein-coding genes (the Earth's proteome) is estimated to be 5 million ...