July 2007). "A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network ... competition with coactivators and the direct effects of its transcriptional repressor function. A crystal structure of the LBD- ... The small heterodimer partner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in ... Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: ...

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in ... by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor ... Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. ... CDK9 CREB-binding protein Cyclin A1 Cyclin-dependent kinase inhibitor 1C EP300 PARP1 Retinoblastoma-like protein 1 GRCh38: ...

... protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors ... Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene. This gene encodes a nuclear ... Shimojo M, Hersh LB (2003). "REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor". Mol. Cell. ... "Entrez Gene: Prickle planar cell polarity protein 1". Retrieved 2017-08-08. Katoh M, Katoh M (2003). "Identification and ...

... of identified clock components are transcriptional activators or repressors that modulate protein stability and nuclear ... Reversible phosphorylation regulates important processes such as nuclear entry, formation of protein complexes and protein ... Methylation of a protein structure adds a methyl group and regulates the protein function or gene expression and in histone ... CCA1/LHY and TOC1 proteins repress the expression of each other's genes. The result is that as CCA1/LHY protein levels start to ...

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop- ... "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling". ... Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene. ... HEY1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) FactorBook HEY1 This article ...

The bZIP-containing Nuclear factor interleukin 3 regulated protein (NFIL3) is a transcription repressor which play multiple ... Heterodimeric bZIP proteins differ from homodimeric bZIP and from each other in protein-protein interaction affinity. These ... found in proteins other than transcription factors and are thought to be one of the general protein modules for protein-protein ... The mechanism of transcriptional regulation by bZIP proteins has been studied in detail. Most bZIP proteins show high binding ...

"DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic ... By virtue of their ankyrin repeat domains, the IκB proteins mask the nuclear localization signals (NLS) of NF-κB proteins and ... Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA ... In addition, p50 and p52 homodimers also bind to the nuclear protein Bcl-3, and such complexes can function as transcriptional ...

... where it forms a transcriptional repressor complex with nuclear proteins to reduce the expression of genes involved in ... A nuclear localisation signal on the NF-κB protein allows it to be transported through the nuclear pore and into the nucleus, ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ... Bickmore W. "The Nuclear Protein Database". Medical Research Council Human Genetics Unit. Information on nuclear components. " ...

Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene. This gene encodes a nuclear protein ... Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node ... This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Six transcripts encoding different ... Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315- ...

CCAAT-displacement protein (CDP) and nuclear transcription factor Y (NF-Y) have multiple binding sites within the promoter ... September 2001). "The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and ... S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for lipid ... The protein contains a C-(X)2-C motif (CLLC), which is mostly present in metal-binding proteins and oxidoreductases. A sorting- ...

NCOR may also refer to: Nuclear receptor co-repressor 1 (NCOR1), a protein Nuclear receptor co-repressor 2 (NCOR2), a protein ...

... has been predicted to be a nuclear protein with 94.1% reliability. It also contains possible nuclear localization signal ... This protein is likely a transcriptional repressor from the E-box binding factors family TR4/TR2 - These proteins are part of a ... The proteins encoded by the TMPIT proteins are predicted to be transmembrane proteins. However, there is lack of literature to ... Nur 77 - This protein is also known as NGFIB (Nerve growth factor IB) and belongs to a family of nuclear receptors. It is ...

This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation- ... "The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36". Nature. 442 (7100): 312-6. ... This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H ... Zhang D, Yoon HG, Wong J (August 2005). "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human ...

These three domains are a common feature of nuclear receptor proteins. The Rev-Erb proteins are unique from other nuclear ... Instead, Rev-Erbα interacts via its LBD with Nuclear Receptor Co-Repressor (NCoR) and another closely related co-repressor ... This protein has also been implicated in the integrity of cartilage. Out of all known nuclear receptors, Rev-erbα is the most ... The NR1D1 (nuclear receptor subfamily 1 group D member 1) gene, located on chromosome 17, encodes the protein REV-ERBɑ in ...

The DNA binding of SAP30 proteins is regulated by the nuclear signalling lipids, phosphoinositides (PI). SAP30 proteins provide ... SAP30 has been shown to interact with: HDAC1, Histone deacetylase 2, ING1 and Nuclear receptor co-repressor 1, RBBP4, RBBP7, ... Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene. Histone ... Proteins of the SAP30 family (SAP30 proteins) have a functional nucleolar localization signal and they are able to target Sin3A ...

... nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and ... interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor ... Polycomb protein EED is a protein that in humans is encoded by the EED gene. Polycomb protein EED is a member of the Polycomb- ... MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, ...

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates ... Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by ... "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A". FEBS Lett. 484 (2): 118-124. ... Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein". J. ...

... encodes a nuclear protein, which belongs to a highly conserved family of WD40 repeat. This gene is present in many protein ... This protein is also part of a co-repressor complex which is an important component of transcriptional silencing. This gene is ... CREB-binding protein, also known as CREBBP or CBP, is a protein that is encoded by the CREBBP gene in humans. The CREB protein ... Proteins RbAp48 is a key player in the assembly of nucleosomes. RbAp48 protein is a subunit of the chromatin-assembly factor-1 ...

Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a ... "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. ... Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD (2002). "Protein Interactions Targeting the Latency-Associated Nuclear ... Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene. DNA methylation is the major ...

Another protein shown to have significant interactions with ataxin 1 is the leucine-rich acidic nuclear protein or LANP. Its ... Modeling of the ataxin 1 protein has shown possible binding sites for growth factor independent transcription repressor 1 (Gfi- ... Molecular chaperones are introduced proteins that may have interactions with the mutant protein that reduce toxicity by various ... however rodent model studies have shown significantly later formation of nuclear inclusions of mutant proteins in cerebellum ...

Nuclear receptor co-repressor 2, Promyelocytic leukemia protein RUNX1T1, Retinoic acid receptor alpha, SIN3A, SIN3B, and ZBTB32 ... 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. ... 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. ... Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. This gene is a ...

2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein ... interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor ... 2001). "The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein ... Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene. This gene, through ...

Isotope-detected 1 H NMR studies of proteins: A general strategy for editing interproton nuclear Overhauser effects by ... heteronuclear decoupling, with application to phage λ repressor. Proceedings of the National Academy of Sciences, U.S.A. 83(5): ... 1969 Nuclear spin thermodynamics in the rotating frame. Science 164(3883):1015-1023. 1970 With R. K. Gupta. Double nuclear ... Nuclear spin-lattice relaxation in metals. Physical Review 116(3):583-591. 1963. Pure nuclear electric quadrupole resonance in ...

Nuclear receptor co-repressor 2, Promyelocytic leukemia protein and Src, and TEAD1. MKL1 Nuclear actin functions GRCh38: ... This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the ... "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. 21 ... as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". J. ...

... and the mPER proteins are necessary for CRY nuclear translocation. This work provided the first portrayal of a negative ... function as the primary transcriptional repressors of clock gene expression, ... CRY1 protein is a circadian photoreceptor that, when exposed to light, causes TIM degradation, allowing light to gain access to ... TIM, PER, and CRY2 proteins are translated and form complexes in the cytoplasm. 24 hours later, CRY2 returns to the nucleus and ...

The high nuclear levels of b-catenin results from the high accumulation of the disheveled protein at the vegetal pole of the ... PIE-1 is localized in the P2 cell lineage and is a general repressor of transcription. SKN-1 is repressed in P2 cells and is ... These proteins are known to be ligands for the Notch protein. GLP-1, a Notch protein, is also required for specification of the ... mom-2 is a member of the Wnt family of proteins (i.e. the signal) and mom-5 is a member of the frizzled family of proteins (i.e ...

The SKI protein is a nuclear proto-oncogene that is associated with tumors at high cellular concentrations. SKI has been shown ... of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced ... The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Smad-3 and CReB ... The SnoN protein was identified as a similar protein and is often discussed in conjugation with the Ski protein in publications ...

... the other human protein that is a member of that family is Nuclear receptor co-repressor 2. Nuclear receptor co-repressor 1 has ... The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1 ... Hence NCOR1 assists nuclear receptors in the down regulation of gene expression. Loss of function of this protein significantly ... NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 ...

... encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 ... of highly conserved transcriptional repressors required for long-term silencing of genes that regulate cell fate determination ... human cerebral protein 6 (hucep 6) human cerebral protein-13 (hucep-13) In humans, BAP1 is encoded by the BAP1 gene located on ... "BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization". Cancer ...

"Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein ... "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338-42. doi:10.1038/4315. PMID ... Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a ... a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target ...