July 2007). "Non-transcriptional control of DNA replication by c-Myc". Nature. 448 (7152): 445-451. Bibcode:2007Natur.448..445D ... There are instances where transcriptional factors, such as the Yamanaka factors, are still needed to aid in heterokaryon cell ... 2007-12-06). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ... 2006). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary ...

July 2007). "Non-transcriptional control of DNA replication by c-Myc". Nature. 448 (7152): 445-451. Bibcode:2007Natur.448..445D ... September 2008). "Mechanism of replication-coupled DNA interstrand crosslink repair". Cell. 134 (6): 969-980. doi:10.1016/j. ... Transgenic Xenopus for studying transcriptional regulation of human disease genes: Xenopus embryos develop rapidly, so ... replication fork stalling (ATR) or DNA interstrand crosslinks (FA proteins and ATR). Notably, several mechanisms and components ...

"Non-transcriptional control of DNA replication by c-Myc". Nature. 448 (7152): 445-51. Bibcode:2007Natur.448..445D. doi:10.1038/ ... Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (April 2001). "Mechanism for the transcriptional repression by c-Myc ... In addition, myc has a direct role in the control of DNA replication. This activity could contribute to DNA amplification in ... It can also act as a transcriptional repressor. By binding Miz-1 transcription factor and displacing the p300 co-activator, it ...

Hiratani I, Takebayashi S, Lu J, Gilbert DM (2009) Replication timing and transcriptional control: beyond cause and effect-- ... The temporal order of replication of all the segments in the genome, called its replication-timing program, can now be easily ... Another intriguing aspect of replication timing is that the temporal order of replication is disrupted in most cancers and in ... Replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated. In eukaryotic ...

"Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer". Proceedings of the ... The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is ... Although DNA replication is essential for genetic inheritance, defined, site-specific replication origins are technically not a ... Why have metazoan replication origins diverged from the DNA sequence-specific recognition paradigm that determines replication ...

At this point, once the virus enters a host cell it will be prepared to begin the process of replication. Anti-RNP antibodies ... Ribonucleoprotein particles are distinct intracellular foci for post-transcriptional regulation. These particles play an ... Cox MM, Goodman MF, Kreuzer KN, Sherratt DJ, Sandler SJ, Marians KJ (2000). "The importance of repairing stalled replication ... The deoxyribonucleoproteins participate in regulating DNA replication and transcription. Deoxyribonucleoproteins are also ...

... "pT181 plasmid replication is regulated by a countertranscript-driven transcriptional attenuator". Cell. 59 (2): 395-404. doi: ...

Near its C-terminus, NS1 contains an acidic transcriptional activation domain. This domain acts to upregulate transcription ... After the replication fork is repositioned, replication continues toward the left end, using the newly synthesized DNA strand ... Rolling hairpin replication (RHR) is a unidirectional, strand displacement form of DNA replication used by parvoviruses, a ... Interference with host DNA replication may be due to direct effects on host replication proteins that are not essential for ...

"A second post-transcriptional trans-activator gene required for HTLV-III replication". Nature. 321 (6068): 412-7. Bibcode: ... Since Rev is absolutely necessary for HIV-1 replication and it is expressed early on in infection, it has been suggested that ... February 1997). "High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T ...

"A Second post-Transcriptional Trans-activator Gene required for HTLV III Replication". Nature. 321 (6068): 412-417. Bibcode: ... Retrovirus replication continued to be a focus of his early research as a Harvard professor. This research led to fundamental ... Haseltine, WA (1988). "Replication and Pathogenesis of the AIDS Virus. (Plenary Lecture presented at the IVth International ... Sodroski, JG; Rosen CR; Goh WC; Haseltine WA (1985). "The Human T-Cell Leukemia Virus x-lor Region Encodes a Transcriptional ...

Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (Apr 2001). "Tip60 is a cell-type-specific transcriptional ... KAT5 binds to HIV-1 Tat transactivator and helps to promote HIV replication. TIP60 regulates diverse cellular pathways ... For example, overexpressed E2F1, a transcriptional factor, is implicated in melanoma progression. More research needs to be ... and functions as a transcriptional co-repressor". The Biochemical Journal. 374 (Pt 1): 165-73. doi:10.1042/BJ20030087. PMC ...

Iron is necessary for the upregulation of transcriptional elements for cell replication and repair. Lack of iron can cause ...

Mycobacterium tuberculosis enhances HIV-1 replication by transcriptional activation at the long terminal repeat. J Clin Invest ... Hoshino Y, Hoshino S, Nakata K, Honda Y, Tse D, Shioda T, Rom WN, and Weiden M. Maximal HIV-1 replication in alveolar ... enhancing HIV-1 replication. J Exp Med. 1998; 188(7): 1-11. PMID: 9763605. Rom WN, Pinkerton KE, Martin WJ, Forastiere F. ... tuberculosis enhances human immunodeficiency virus-1 replication in the lung. Am J Respir Crit Care Med 1997; 155:996-1003. ...

These include DNA damage repair, DNA replication, transcriptional regulation, and cell cycle checkpoint activation. TOPBP1 ... In contrast, when replication forks were stalled by hydroxyurea to generate DNA replication stress, TOPBP1/BRCA1 were found at ... Replication stress occurs when the replication fork stalls and is unable to progress. This phenomenon may be caused by ... TOPBP1 was found in complex with BRCA1 at sites independent from replication forks (i.e identified by the DNA replication clamp ...

Among E2F transcriptional targets are cyclins, CDKs, checkpoints regulators, DNA repair and replication proteins. Nonetheless, ... and chromosomal replication (replication origin-binding protein HsOrc1 and MCM5). When cells are not proliferating, E2F DNA ... E2F-6 acts as a transcriptional repressor, but through a distinct, pocket protein independent manner. E2F-6 mediates repression ... Antagonized by E2F3a, a transcriptional program has been discovered that functions through the coordination of multiple genes ...

In humans, replication protein A is the best-understood member of this family and is used in processes where the double helix ... Li Z, Van Calcar S, Qu C, Cavenee W, Zhang M, Ren B (2003). "A global transcriptional regulatory role for c-Myc in Burkitt's ... Iftode C, Daniely Y, Borowiec J (1999). "Replication protein A (RPA): the eukaryotic SSB". Crit Rev Biochem Mol Biol. 34 (3): ... Myers L, Kornberg R (2000). "Mediator of transcriptional regulation". Annu Rev Biochem. 69 (1): 729-49. doi:10.1146/annurev. ...

They play an important role in DNA replication and repair, transcriptional regulation, and viral infection. Binding site ... Annotation of eukaryotic genomes has an extra layer of difficulty due to RNA splicing, a post-transcriptional process in which ...

The BAH domain might therefore play an important role by linking DNA methylation, replication and transcriptional regulation. ... replication and transcriptional regulation". FEBS Lett. 446 (1): 189-93. doi:10.1016/S0014-5793(99)00132-5. PMID 10100640. ... as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein ...

November 2022). "DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in ... November 2022). "DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in ... Under-expression and inhibition of DDX41 have been shown to lead to the formation of an R-loop which results in transcriptional ... In the nucleus, DDX41 is believed to regulate the transcriptional elongation process signaling Pol II to slow down the ...

Other sequences are used in replication or during interphase with the physical structure of the chromosome. Ori, or Origin: ... act as barriers against transcriptional silencing; provide a location for the adaptive amplification of genes; and be involved ... Origins of replication. MAR: Matrix attachment regions, where the DNA attaches to the nuclear matrix. Regions of the genome ... are involved in protecting the end from degradation and end-to-end fusions and in completing replication. The subtelomeric ...

Once the early genes have liberated adequate virus proteins, replication machinery, and replication substrates, replication of ... E1A is mostly intrinsically disordered protein and contains CR3 domain which is critical for transcriptional activation. DNA ... A terminal protein that is covalently bound to the 5' end of the adenovirus genome acts as a primer for replication. The viral ... The adenovirus life cycle is separated by the DNA replication process into two phases: an early and a late phase. In both ...

pRb has the ability to reversibly inhibit DNA replication through transcriptional repression of DNA replication factors. pRb is ... Within 72-96 hours of active pRb induction in A2-4 cells, the target DNA replication factor proteins-MCMs, RPA34, DBF4, RFCp37 ... Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (May 1998). "Negative regulation of DNA replication by the ... Vandel L, Nicolas E, Vaute O, Ferreira R, Ait-Si-Ali S, Trouche D (October 2001). "Transcriptional repression by the ...

HPV recruits SMC1 along with a transcriptional factor, CTCF, to enable replication of the virus's genome. SMC1 is crucially ...

This replication difference occurred in a single round of infection. This was shown to be due to decreased transcriptional ... The lack of an in vitro cell culture system that demonstrated a deficit in replication upon infection with viruses in the ... These infected human dendritic cells showed a slower rate of replication when deprived of the Vpr protein in HIV-1 cells. ... Vpr is also immunosuppressive due to its ability to sequester a proinflammatory transcriptional activator in the cytoplasm. HIV ...

Cdt1 is usually upregulated by E2F-mediated transcriptional activation and by binding of human acetylase to Orc1. Proteolytic ... Cells with replication stress activate replication checkpoints so that S phase is delayed and slows down the transition to G2/M ... DNA replication control mechanisms cooperate to prevent the relicensing of replication origins and to activate cell cycle and ... Replication of DNA always begins at an origin of replication. In yeast, the origins contain autonomously replicating sequences ...

Cho JM, Song DJ, Bergeron J, Benlimame N, Wold MS, Alaoui-Jamali MA (Sep 2000). "RBT1, a novel transcriptional co-activator, ... Single-stranded binding protein Replication protein A Replication protein A1 Replication protein A3 GRCh38: Ensembl release 89 ... Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene. RPA2 has been shown to interact ... "Entrez Gene: RPA2 Replication protein A2, 32kDa". Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, ...

DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells". Stem Cells. 35 (2): 299-310. doi:10.1002/stem.2529. ... Transcriptional regulation is a complex process involving the binding of transcriptional machinery to regulatory proteins- ... DNA replication is a highly conserved process involving the copying of genetic information from parent one generation to the ... Transcriptional regulation additionally focuses on the epigenetic regulation of a target locus, as the epigenetic status of the ...

Such treatment causes a loss of the virus replication ability. However, even this replication-deficient virus can induce the ... A 3' leader sequence acts as a transcriptional promoter. Between these non-coding regions are located six genes, which encode ... A replication-defective and persistent Sendai virus can be used as a platform for a durable expression of microRNAs, which were ... SeV replication occurs exclusively in the cytoplasm of the host cell. The virus is using its own RNA polymerase. One ...

Jiang W, Wells NJ, Hunter T (May 1999). "Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6". Proceedings ... After its phosphorylation, pRb releases its binding partner E2F, a transcriptional activator, which in turn activates DNA ... replication. The CDK6 complex ensures a point of switch to commit to division responding to external signals, like mitogens and ...

Viral replication is cytoplasmic. Entry into the host cell is achieved by virus attaching to host cell. Replication follows the ... Negative-stranded RNA virus transcription, using polymerase stuttering, through co-transcriptional RNA editing is the method of ...